Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0029 | 0.0016 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.045 | 0.2059 | 0.3958 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0274 | 0.1208 | 0.1193 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.0525 | 0.0987 |
Echinococcus granulosus | prolyl endopeptidase | 0.0274 | 0.1208 | 0.2308 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0134 | 0.0525 | 0.0987 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0134 | 0.0525 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Onchocerca volvulus | Peroxidasin homolog | 0.0157 | 0.064 | 0.5299 |
Loa Loa (eye worm) | carboxylesterase | 0.0134 | 0.0525 | 0.0987 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0081 | 0.0271 | 0.0495 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0274 | 0.1208 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0157 | 0.064 | 0.1208 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.1092 | 0.5178 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0152 | 0.0616 | 0.1163 |
Plasmodium falciparum | peptidase, putative | 0.0029 | 0.0016 | 0.5 |
Echinococcus multilocularis | protein patched | 0.045 | 0.2059 | 0.3958 |
Brugia malayi | CHE-14 protein | 0.045 | 0.2059 | 0.3958 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0029 | 0.0016 | 0.0000000044783 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0274 | 0.1208 | 0.2308 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0478 | 0.2196 | 0.2184 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0029 | 0.0016 | 0.0133 |
Schistosoma mansoni | lipoxygenase | 0.0089 | 0.0311 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.2059 | 0.3958 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0109 | 0.0406 | 0.0755 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0152 | 0.0616 | 0.1163 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0274 | 0.1208 | 0.2308 |
Echinococcus multilocularis | protein dispatched 1 | 0.045 | 0.2059 | 0.3958 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0029 | 0.0016 | 0.5 |
Onchocerca volvulus | 0.0157 | 0.064 | 0.5299 | |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0045 | 0.0096 | 0.0155 |
Brugia malayi | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0109 | 0.0406 | 0.0755 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0029 | 0.0016 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.076 | 0.3563 | 0.6871 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0128 | 0.0497 | 0.0932 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0029 | 0.0016 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0157 | 0.064 | 0.0625 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.045 | 0.2059 | 0.3958 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.0525 | 0.0987 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0016 | 0.0000000086621 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0016 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.017 | 0.07 | 0.4443 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0274 | 0.1208 | 0.2308 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0152 | 0.0616 | 0.1163 |
Schistosoma mansoni | peroxidasin | 0.0157 | 0.064 | 0.0625 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.043 | 0.1963 | 0.195 |
Onchocerca volvulus | 0.0157 | 0.064 | 0.5299 | |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0109 | 0.0406 | 0.0755 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1092 | 0.5178 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0055 | 0.0144 | 0.0249 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0016 | 0.0000000086621 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0134 | 0.0525 | 0.0987 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0525 | 0.0987 |
Brugia malayi | Animal haem peroxidase family protein | 0.0157 | 0.064 | 0.1208 |
Brugia malayi | Animal haem peroxidase family protein | 0.0157 | 0.064 | 0.1208 |
Brugia malayi | Peroxidasin | 0.0157 | 0.064 | 0.1208 |
Schistosoma mansoni | lipoxygenase | 0.0128 | 0.0497 | 0.0482 |
Echinococcus multilocularis | acetylcholinesterase | 0.0134 | 0.0525 | 0.0987 |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.0525 | 0.0987 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0512 | 0.2364 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0157 | 0.064 | 0.5299 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0512 | 0.2364 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0157 | 0.064 | 0.5299 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.045 | 0.2059 | 0.3958 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0274 | 0.1208 | 0.1193 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0045 | 0.0096 | 0.0155 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1092 | 0.5178 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0157 | 0.064 | 0.1208 |
Toxoplasma gondii | hypothetical protein | 0.0052 | 0.0129 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Trypanosoma brucei | oligopeptidase b | 0.0109 | 0.0406 | 0.0755 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0109 | 0.0406 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.076 | 0.3563 | 0.6871 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.076 | 0.3563 | 0.6871 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0512 | 0.2364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Leishmania major | oligopeptidase b | 0.0109 | 0.0406 | 0.0755 |
Onchocerca volvulus | Dual oxidase homolog | 0.0157 | 0.064 | 0.5299 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.045 | 0.2059 | 0.3958 |
Brugia malayi | Animal haem peroxidase family protein | 0.0157 | 0.064 | 0.1208 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.045 | 0.2059 | 0.2046 |
Brugia malayi | Animal haem peroxidase family protein | 0.0157 | 0.064 | 0.1208 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1092 | 0.5178 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1092 | 0.5178 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0322 | 0.144 | 0.2758 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0274 | 0.1208 | 0.2308 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0109 | 0.0406 | 0.0755 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1092 | 0.5178 | 0.517 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0246 | 0.1068 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.017 | 0.07 | 0.0616 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0322 | 0.144 | 0.2758 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.076 | 0.3563 | 0.6871 |
Brugia malayi | Animal haem peroxidase family protein | 0.0157 | 0.064 | 0.1208 |
Toxoplasma gondii | prolyl endopeptidase | 0.0274 | 0.1208 | 0.5465 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0045 | 0.0096 | 0.0155 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0157 | 0.064 | 0.5299 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1208 | 0.2308 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0157 | 0.064 | 0.1208 |
Trypanosoma brucei | prolyl endopeptidase | 0.0274 | 0.1208 | 0.2308 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0157 | 0.064 | 0.1208 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0109 | 0.0406 | 0.0755 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0512 | 0.2364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.045 | 0.2059 | 0.3958 |
Echinococcus granulosus | Protein patched homolog 1 | 0.045 | 0.2059 | 0.3958 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0322 | 0.144 | 0.2758 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Brugia malayi | Blistered cuticle protein 3 | 0.0157 | 0.064 | 0.1208 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0157 | 0.064 | 0.1208 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.076 | 0.3563 | 0.3553 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Echinococcus multilocularis | peroxidasin | 0.0157 | 0.064 | 0.1208 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0525 | 0.0987 |
Echinococcus granulosus | acetylcholinesterase | 0.0134 | 0.0525 | 0.0987 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0478 | 0.2196 | 0.4224 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0045 | 0.0096 | 0.0155 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0081 | 0.0271 | 0.0495 |
Onchocerca volvulus | 0.0157 | 0.064 | 0.5299 | |
Brugia malayi | Carboxylesterase family protein | 0.0134 | 0.0525 | 0.0987 |
Echinococcus granulosus | peroxidasin | 0.0157 | 0.064 | 0.1208 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1092 | 0.5178 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1092 | 0.5178 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1092 | 0.5178 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1092 | 0.5178 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0029 | 0.0016 | 0.5 |
Schistosoma mansoni | patched 1 | 0.045 | 0.2059 | 0.2046 |
Trichomonas vaginalis | conserved hypothetical protein | 0.045 | 0.2059 | 0.8703 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Echinococcus granulosus | carboxylesterase 5A | 0.0134 | 0.0525 | 0.0987 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.064 | 0.1208 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0128 | 0.0497 | 0.0932 |
Onchocerca volvulus | Peroxidase homolog | 0.0157 | 0.064 | 0.5299 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0029 | 0.0016 | 0.5 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0478 | 0.2196 | 0.4224 |
Toxoplasma gondii | MAPEG family protein | 0.0478 | 0.2196 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0109 | 0.0406 | 0.0755 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0322 | 0.144 | 0.2758 |
Trypanosoma cruzi | oligopeptidase b | 0.0109 | 0.0406 | 0.0755 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKa | = 6.4 | pKa value of the compound was measured | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.