Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0237 | 0.0585 | 0.0183 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0641 | 0.3843 | 0.3843 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0585 | 0.0585 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0585 | 0.0585 |
Echinococcus multilocularis | acetylcholinesterase | 0.1404 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0215 | 0.041 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0237 | 0.0585 | 0.0585 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0237 | 0.0585 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0585 | 0.0183 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0237 | 0.0585 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0585 | 0.0585 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0237 | 0.0585 | 0.0183 |
Echinococcus granulosus | acetylcholinesterase | 0.1404 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0641 | 0.3843 | 0.3579 |
Schistosoma mansoni | acetylcholinesterase | 0.0237 | 0.0585 | 0.0183 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0237 | 0.0585 | 0.0183 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0237 | 0.0585 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0237 | 0.0585 | 0.0183 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0237 | 0.0585 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1404 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0585 | 0.0183 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0237 | 0.0585 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0641 | 0.3843 | 0.3843 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0585 | 0.0585 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0237 | 0.0585 | 0.0183 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0215 | 0.041 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0585 | 0.0585 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0585 | 0.0585 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0215 | 0.041 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0237 | 0.0585 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.1404 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0585 | 0.0585 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0641 | 0.3843 | 0.3579 |
Schistosoma mansoni | gliotactin | 0.0237 | 0.0585 | 0.0183 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0215 | 0.041 | 0.041 |
Echinococcus granulosus | acetylcholinesterase | 0.1404 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0237 | 0.0585 | 0.0183 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0237 | 0.0585 | 0.0183 |
Brugia malayi | hypothetical protein | 0.0237 | 0.0585 | 0.0585 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0237 | 0.0585 | 0.0183 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0215 | 0.041 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0237 | 0.0585 | 0.0585 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0641 | 0.3843 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1404 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0237 | 0.0585 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1404 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0585 | 0.0585 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0585 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0585 | 0.0585 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0215 | 0.041 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1404 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0585 | 0.0585 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0237 | 0.0585 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1404 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1404 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0641 | 0.3843 | 0.3579 |
Echinococcus multilocularis | acetylcholinesterase | 0.1404 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0215 | 0.041 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1404 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 76 uM | Inhibition of human recombinant MMP2 after 30 mins | ChEMBL. | 21189019 |
IC50 (binding) | = 204 uM | Inhibition of recombinant anthrax lethal factor after 30 mins by fluorescence assay | ChEMBL. | 21189019 |
Inhibition (binding) | = 94 % | Inhibition of human recombinant 5-lipoxygenase at 1 mM after 10 mins by fluorescence assay | ChEMBL. | 21189019 |
Inhibition (binding) | = 97 % | Inhibition of mushroom tyrosinase at 1 mM after 10 mins | ChEMBL. | 21189019 |
Inhibition (binding) | = 98 % | Inhibition of human recombinant MMP3 at 1 mM after 30 mins | ChEMBL. | 21189019 |
Inhibition (binding) | = 99 % | Inhibition of human recombinant MMP1 at 1 mM after 30 mins | ChEMBL. | 21189019 |
Inhibition (binding) | = 100 % | Inhibition of human recombinant MMP9 at 1 mM after 30 mins | ChEMBL. | 21189019 |
Inhibition (binding) | = 100 % | Inhibition of human recombinant MMP2 at 1 mM after 30 mins | ChEMBL. | 21189019 |
Inhibition (binding) | = 101 % | Inhibition of recombinant anthrax lethal factor at 1 mM after 30 mins by fluorescence assay | ChEMBL. | 21189019 |
Inhibition (binding) | = 102 % | Inhibition of human recombinant MMP8 at 1 mM after 30 mins | ChEMBL. | 21189019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.