Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.4263 | 0.4263 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0039 | 0.7857 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 1 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0039 | 0.7857 | 0.7857 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.4263 | 0.4263 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0039 | 0.7857 | 0.7758 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.7857 | 0.5 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0039 | 0.7857 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 1 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0039 | 0.7857 | 0.7857 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0039 | 0.7857 | 0.6263 |
Onchocerca volvulus | 0.0027 | 0.4263 | 0.5 | |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0039 | 0.7857 | 0.5 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0039 | 0.7857 | 0.7857 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.4263 | 0.4263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.4263 | 0.4263 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0039 | 0.7857 | 0.7857 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.7857 | 0.5 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0039 | 0.7857 | 0.7857 |
Echinococcus multilocularis | musashi | 0.0027 | 0.4263 | 0.4263 |
Echinococcus granulosus | lamin | 0.0027 | 0.4263 | 0.4263 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0039 | 0.7857 | 0.6263 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.4263 | 0.4001 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0039 | 0.7857 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0438 | 0.0438 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.4263 | 0.4263 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.4263 | 0.4001 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0039 | 0.7857 | 0.5 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.7857 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.4263 | 0.4263 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.4263 | 0.4263 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0039 | 0.7857 | 0.7857 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.7857 | 0.7857 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.4113 | 0.4113 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.7857 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.4263 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of P-gp (unknown origin) assessed as reduction in ATPase activity at 2.08 to 50 uM incubated over 20 mins by inorganic phosphate release assay | ChEMBL. | 25419978 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.