Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0361 | 1 | 1 | |
Echinococcus granulosus | protein kinase shaggy | 0.0361 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3223 | 0.3223 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0361 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0415 | 0.0415 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3223 | 0.3223 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0415 | 0.0415 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0361 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3223 | 0.3223 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0361 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0361 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.3223 | 0.3223 |
Brugia malayi | TAR-binding protein | 0.013 | 0.3223 | 0.3223 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0361 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0361 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0361 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0361 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0361 | 1 | 0.5 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0361 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0415 | 0.0415 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0361 | 1 | 0.5 |
Brugia malayi | RNA binding protein | 0.013 | 0.3223 | 0.3223 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0361 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0889 | 0.0889 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.4483 | 0.4483 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0889 | 0.0889 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.3223 | 0.3223 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.3223 | 0.3223 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3223 | 0.3223 |
Echinococcus multilocularis | geminin | 0.0173 | 0.4483 | 0.4483 |
Echinococcus multilocularis | protein kinase shaggy | 0.0361 | 1 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0361 | 1 | 0.5 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0361 | 1 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0361 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0889 | 0.0889 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.3223 | 0.3223 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0889 | 0.0889 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3223 | 0.3223 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.3223 | 0.3223 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0361 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.3223 | 0.3223 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0361 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0173 | 0.4483 | 0.4483 |
Trypanosoma brucei | protein kinase, putative | 0.0361 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.4483 | 0.4483 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 10 uM | Cytotoxicity against human BJ cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
LD50 (ADMET) | = 10 uM | Cytotoxicity against human HEK293 cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
LD50 (ADMET) | = 10 uM | Cytotoxicity against human HepG2 cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
LD50 (ADMET) | = 10 uM | Cytotoxicity against human Raji cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.