Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thioredoxin glutathione reductase | 0.004 | 0.1848 | 0.2073 |
Brugia malayi | hypothetical protein | 0.0025 | 0.074 | 0.074 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.8914 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.8914 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0099 | 0.6483 | 1 |
Leishmania major | trypanothione reductase | 0.0039 | 0.1807 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0089 | 0.5708 | 0.8342 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1436 | 0.1436 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0089 | 0.5708 | 0.8342 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.1807 | 0.1807 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2673 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2673 | 0.2673 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.8914 | 0.8914 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0089 | 0.5708 | 0.8342 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.8914 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.8914 | 0.8914 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0039 | 0.1807 | 0.1807 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.8914 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0039 | 0.0039 |
Brugia malayi | RNA binding protein | 0.013 | 0.8914 | 0.8914 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.8914 | 0.8914 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1436 | 0.1436 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.1807 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0089 | 0.5708 | 0.8342 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.1807 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.074 | 0.074 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.1807 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0099 | 0.6483 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.8914 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.1807 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.1807 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.8914 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.8914 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0099 | 0.6483 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.004 | 0.1848 | 0.2073 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.1807 | 0.1807 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.1807 | 1 |
Brugia malayi | TAR-binding protein | 0.013 | 0.8914 | 0.8914 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0099 | 0.6483 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.8914 | 0.8914 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.1807 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.1807 | 0.1807 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0089 | 0.5708 | 0.8342 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0089 | 0.5708 | 0.8342 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2673 | 0.2673 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2673 | 0.2673 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1436 | 0.1611 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.