Detailed information for compound 1490382

Basic information

Technical information
  • TDR Targets ID: 1490382
  • Name: 1-(4-hydroxynaphthalen-1-yl)-3-(4-methoxyphen yl)urea
  • MW: 308.331 | Formula: C18H16N2O3
  • H donors: 3 H acceptors: 2 LogP: 3.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)Nc1ccc(c2c1cccc2)O
  • InChi: 1S/C18H16N2O3/c1-23-13-8-6-12(7-9-13)19-18(22)20-16-10-11-17(21)15-5-3-2-4-14(15)16/h2-11,21H,1H3,(H2,19,20,22)
  • InChiKey: AQCIIDHDSXGFID-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-hydroxy-1-naphthyl)-3-(4-methoxyphenyl)urea
  • SMR000469572
  • PC-0626767
  • PCMD-CC-PAB-233
  • MLS001045569

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Starlite/ChEMBL No references
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. Get druggable targets OG5_130095 All targets in OG5_130095
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans replicative DNA helicase DnaB Get druggable targets OG5_131890 All targets in OG5_131890
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Chlamydia trachomatis replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Get druggable targets OG5_130095 All targets in OG5_130095
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum replicative DNA helicase (dnaB) Get druggable targets OG5_131890 All targets in OG5_131890
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Get druggable targets OG5_131890 All targets in OG5_131890
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Treponema pallidum recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Wolbachia endosymbiont of Brugia malayi recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Chlamydia trachomatis recombinase RecA Get druggable targets OG5_130095 All targets in OG5_130095
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni Replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis acylamino acid releasing enzyme 0.2051 0.0958 0.0958
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0005 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0001 0.0001
Brugia malayi RNA binding protein 0.0067 0.0023 0.0023
Onchocerca volvulus 0.0034 0.0007 0.0006
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0014 0.0013
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.2051 0.0958 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0003 0.0008
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0007 0.0007
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0035 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0113 0.0044 0.0044
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0001 0.0003
Onchocerca volvulus 0.0034 0.0007 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0494 0.0224 0.0224
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0022 0.0022
Entamoeba histolytica dipeptidyl-peptidase, putative 0.2051 0.0958 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Brugia malayi Serine protease Z688.6 precursor 0.0113 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0001
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0031 0.0031
Entamoeba histolytica dipeptidyl-peptidase, putative 0.2051 0.0958 1
Brugia malayi topoisomerase 0.0021 0.0001 0.0001
Trypanosoma cruzi oligopeptidase b 0.2796 0.131 0.3242
Echinococcus multilocularis ferritin 0.0035 0.0008 0.0007
Giardia lamblia Alanyl dipeptidyl peptidase 0.2051 0.0958 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0494 0.0224 0.0224
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0027 0.0076
Leishmania major cathepsin L-like protease 0.0034 0.0007 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0007 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0038 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0003 0.0007
Mycobacterium leprae Conserved hypothetical protein 0.1376 0.064 0.4882
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0015 0.0152
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Onchocerca volvulus 0.0203 0.0087 0.0086
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0003 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0003 0.0008
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0014 0.0032
Trypanosoma cruzi DNA repair protein, putative 0.004 0.001 0.0024
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0015 0.0041
Plasmodium vivax importin-beta 2, putative 0.0035 0.0008 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0003 0.0008
Echinococcus multilocularis chromobox protein 1 0.0084 0.0031 0.003
Schistosoma mansoni rotamase 0.0033 0.0007 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0014 0.0134
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0001 0.0001
Echinococcus granulosus prolyl endopeptidase 0.4329 0.2033 0.2032
Schistosoma mansoni ran 0.0026 0.0003 0.0003
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0113 0.0044 0.0108
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0007 0.0069
Echinococcus multilocularis chromobox protein 1 0.0084 0.0031 0.003
Trichomonas vaginalis set domain proteins, putative 0.0251 0.011 0.1139
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.2796 0.131 0.3242
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.2051 0.0958 0.2372
Trichomonas vaginalis ran, putative 0.0026 0.0003 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0113 0.0044 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0008 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0003 0.0003
Brugia malayi prolyl oligopeptidase family protein 0.2051 0.0958 0.0958
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0006
Leishmania major importin beta-1 subunit, putative 0.0028 0.0005 0.001
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0045 0.0045
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0002 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0002 0.0013
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0027 0.0076
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.8584 0.404 1
Leishmania major cathepsin L-like protease 0.0034 0.0007 0.0016
Brugia malayi Serine protease Z688.6 precursor 0.0113 0.0044 0.0044
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Brugia malayi TAR-binding protein 0.0067 0.0023 0.0023
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.2796 0.131 1
Wolbachia endosymbiont of Brugia malayi recombinase A 0.013 0.0053 0.0143
Loa Loa (eye worm) hypothetical protein 0.0037 0.0009 0.0009
Echinococcus granulosus cathepsin l1 0.0034 0.0007 0.0007
Onchocerca volvulus 0.0023 0.0002 0.0001
Brugia malayi cathepsin L-like precursor 0.0023 0.0002 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0153 0.0064 0.0063
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.7834 0.3686 1
Chlamydia trachomatis replicative DNA helicase 0.0467 0.0211 0.0587
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0007 0.0007
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0113 0.0044 0.0108
Entamoeba histolytica fatty acid elongase, putative 0.0993 0.046 0.4792
Brugia malayi Importin beta-1 subunit 0.0035 0.0008 0.0008
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0007 0.0016
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0027 0.0071
Onchocerca volvulus Prolyl endopeptidase homolog 0.4329 0.2033 0.2032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0007 0.0007
Brugia malayi Cathepsin L-like precursor 0.0034 0.0007 0.0007
Brugia malayi Pre-SET motif family protein 0.0221 0.0095 0.0095
Schistosoma mansoni hypothetical protein 0.0372 0.0167 0.0166
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0022 0.0022
Echinococcus granulosus expressed conserved protein 0.0098 0.0038 0.0037
Brugia malayi Cathepsin L-like precursor 0.0023 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0014 0.0134
Schistosoma mansoni DNA ligase IV 0.0021 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0023 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0015 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0001 0.0006
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0045 0.011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0022 0.0022
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0034 0.0033
Schistosoma mansoni topbp1 0.0021 0.0001 0.0001
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.0062 0.0061
Schistosoma mansoni ferritin 0.0035 0.0008 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0014 0.0014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0038 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0041
Onchocerca volvulus 0.0251 0.011 0.0109
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0113 0.0044 0.0457
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 2.1223 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0038 0.0037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0015 0.0041
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0001 0.0001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0003 0.0007
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0027 0.0027
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0007 0.0069
Onchocerca volvulus 0.0034 0.0007 0.0006
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.4329 0.2033 0.5032
Brugia malayi Heterochromatin protein 1 0.0084 0.0031 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0008 0.0075
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0045 0.0045
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0001 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0001 0.0001
Brugia malayi hypothetical protein 0.0252 0.011 0.011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0005 0.0041
Trypanosoma cruzi prolyl endopeptidase 0.4329 0.2033 0.5032
Brugia malayi MH2 domain containing protein 0.0034 0.0007 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0463
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0003 0.0008
Echinococcus multilocularis snurportin 1 0.0372 0.0167 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0153 0.0064 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0001 0.0001
Schistosoma mansoni apoferritin-2 0.0035 0.0008 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.2051 0.0958 0.2371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0009 0.0087
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Loa Loa (eye worm) Smad1 0.0034 0.0007 0.0007
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0005 0.0041
Mycobacterium ulcerans hypothetical protein 0.0025 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.2051 0.0958 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.2051 0.0958 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0027 0.0076
Entamoeba histolytica hypothetical protein, conserved 0.2051 0.0958 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0001 0.0001
Onchocerca volvulus 0.0182 0.0077 0.0076
Plasmodium falciparum importin beta, putative 0.0035 0.0008 0.0021
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0045 0.011
Echinococcus granulosus tar DNA binding protein 0.0067 0.0023 0.0022
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0006 0.0014
Entamoeba histolytica fatty acid elongase, putative 0.0993 0.046 0.4792
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0003 0.0006
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0035 0.0008 0.0018
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0014 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0463
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 2.1223 1 1
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0007 0.0006
Echinococcus granulosus Smad4 0.0034 0.0007 0.0006
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0045 0.0044
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0007 0.0007
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.7647 0.3597 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0001
Echinococcus multilocularis Dipeptidyl peptidase 9 0.8584 0.404 0.4039
Onchocerca volvulus 0.0034 0.0007 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Entamoeba histolytica hypothetical protein 0.0021 0.0001 0.0006
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.2051 0.0958 0.0958
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0113 0.0044 0.0457
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0001 0.0003
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.8584 0.404 1
Trypanosoma brucei oligopeptidase b 0.2796 0.131 0.3242
Toxoplasma gondii hypothetical protein 0.2051 0.0958 0.2598
Echinococcus granulosus Dipeptidyl peptidase 9 0.8584 0.404 0.4039
Giardia lamblia Thymus-specific serine protease precursor 0.0113 0.0044 0.0457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0002 0.0013
Brugia malayi MH2 domain containing protein 0.0494 0.0224 0.0224
Brugia malayi nuclear receptor NHR-88 0.0022 0.0001 0.0001
Schistosoma mansoni smad1 5 8 and 0.0034 0.0007 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.0129 0.0052 0.0127
Plasmodium vivax vivapain-2 0.0034 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0113 0.0044 0.0044
Schistosoma mansoni Replicative DNA helicase 0.0467 0.0211 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0003 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.009 0.009
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0113 0.0044 0.0044
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0003 0.0008
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.011 0.0109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0001 0.0001
Echinococcus granulosus tumor protein p63 0.139 0.0647 0.0646
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0001 0.0001
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0023 0.0022
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0007 0.0007
Onchocerca volvulus 0.0034 0.0007 0.0006
Brugia malayi prolyl oligopeptidase family protein 0.2051 0.0958 0.0958
Loa Loa (eye worm) RNA binding protein 0.0067 0.0023 0.0023
Schistosoma mansoni Smad4 0.0034 0.0007 0.0006
Schistosoma mansoni cellular tumor antigen P53 0.0203 0.0087 0.0087
Trichomonas vaginalis rotamase, putative 0.0033 0.0007 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0463
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0001 0.0001
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.2796 0.131 0.3641
Plasmodium vivax hypothetical protein, conserved 0.2051 0.0958 0.2664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0009 0.0087
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0003 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0008 0.0075
Schistosoma mansoni ferritin 0.0035 0.0008 0.0007
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.8584 0.404 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0004 0.0039
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0034 0.0007 0.0007
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0001
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0007 0.0069
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0001 0.0006
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0113 0.0044 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0023 0.0022
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0001 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0005 0.0041
Schistosoma mansoni apoferritin-2 0.0035 0.0008 0.0007
Toxoplasma gondii hypothetical protein 0.0026 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0007 0.0066
Echinococcus multilocularis protein patched 0.0045 0.0012 0.0012
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0001 0.0006
Brugia malayi nuclear hormone receptor 0.0022 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0006 0.0058
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0001 0.0001
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0035 0.0008 0.0021
Echinococcus granulosus ferritin 0.0035 0.0008 0.0007
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0041 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0018 0.018
Loa Loa (eye worm) hypothetical protein 0.0025 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0006 0.0006
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.7647 0.3597 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0209 0.009 0.009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0001 0.0001
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0113 0.0044 0.0457
Loa Loa (eye worm) hypothetical protein 0.2051 0.0958 0.0958
Schistosoma mansoni hypothetical protein 0.0066 0.0022 0.0022
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0035 0.0008 0.0021
Schistosoma mansoni importin beta-1 0.0035 0.0008 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0009 0.0087
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0007 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0007 0.0069
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0001 0.0006
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 2.1223 1 1
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0113 0.0044 0.0457
Entamoeba histolytica fatty acid elongase, putative 0.0993 0.046 0.4792
Brugia malayi Cathepsin L-like precursor 0.0034 0.0007 0.0007
Leishmania major oligopeptidase b 0.2796 0.131 0.3242
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.2051 0.0958 0.2598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0008 0.0075
Entamoeba histolytica Ran family GTPase 0.0026 0.0003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0009 0.0087
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.7647 0.3597 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0001 0.0001
Entamoeba histolytica prolyl oligopeptidase family protein 0.2051 0.0958 1
Giardia lamblia Kinase, PLK 0.0114 0.0045 0.0463
Echinococcus multilocularis microtubule associated protein 2 0.3492 0.1638 0.1637
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0041 0.0417
Onchocerca volvulus 0.0025 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0051 0.0015 0.0015
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0003 0.0015
Brugia malayi MH1 domain containing protein 0.0034 0.0007 0.0007
Brugia malayi MH1 domain containing protein 0.0034 0.0007 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.0095 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0001 0.0001
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0003 0.0006
Echinococcus multilocularis expressed protein 0.0035 0.0008 0.0007
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0014 0.0134
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0018 0.018
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.4093 0.1921 0.534
Trypanosoma cruzi DNA repair protein, putative 0.004 0.001 0.0024
Schistosoma mansoni patched 1 0.0045 0.0012 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0007 0.0016
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.2051 0.0958 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0007 0.0066
Echinococcus multilocularis tumor protein p63 0.139 0.0647 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0014 0.0134
Brugia malayi Cathepsin L-like precursor 0.0034 0.0007 0.0007
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0012 0.0012
Plasmodium vivax vivapain-2 0.0034 0.0007 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0066 0.0022 0.0022
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0007 0.0007
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.011 0.0109
Mycobacterium ulcerans recombinase A 0.013 0.0053 0.0146
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0001 0.0006
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0113 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0007 0.0069
Echinococcus multilocularis expressed conserved protein 0.0098 0.0038 0.0037
Mycobacterium ulcerans bacterioferritin BfrA 0.0035 0.0008 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0041
Echinococcus granulosus acylamino acid releasing enzyme 0.2051 0.0958 0.0958
Schistosoma mansoni ran 0.0026 0.0003 0.0003
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0001 0.0001
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Chlamydia trachomatis oxoacyl-ACP synthase III 0.7647 0.3597 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0006 0.0053
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.8584 0.404 0.4039
Loa Loa (eye worm) cysteine protease 0.0034 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0012 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0001 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0001 0.0001
Treponema pallidum recombinase A 0.013 0.0053 0.245
Echinococcus multilocularis cysteine protease 0.0034 0.0007 0.0007
Schistosoma mansoni microtubule-associated protein tau 0.3492 0.1638 0.1637
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0003 0.0009
Schistosoma mansoni ferritin light chain 0.0035 0.0008 0.0007
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.7647 0.3597 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0118 0.0047 0.0114
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0001 0.0001
Echinococcus multilocularis neuropeptide s receptor 0.0464 0.021 0.021
Brugia malayi MH2 domain containing protein 0.0034 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0003 0.0005
Loa Loa (eye worm) ctsf protein 0.0034 0.0007 0.0007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0001 0.0001
Loa Loa (eye worm) prolyl oligopeptidase 0.2051 0.0958 0.0958
Leishmania major cathepsin L-like protease 0.0129 0.0052 0.0127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0038 0.0037
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0003 0.0008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0038 0.0037
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0014 0.0032
Schistosoma mansoni kinase 0.0058 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0013 0.0012
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0001 0.0001
Schistosoma mansoni ferritin light chain 0.0035 0.0008 0.0007
Plasmodium falciparum peptidase, putative 0.2051 0.0958 0.2664
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0001 0.0001
Onchocerca volvulus 0.009 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0001 0.0001
Echinococcus granulosus chromobox protein 1 0.0084 0.0031 0.003
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0027 0.0073
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0003 0.0003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0006 0.0006
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0043 0.0012 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0463
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0007 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0001 0.0001
Loa Loa (eye worm) twinkle helicase 0.0133 0.0054 0.0054
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0031 0.0316
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0008 0.0007
Leishmania major cathepsin L-like protease 0.0129 0.0052 0.0127
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0001 0.0001
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0007 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0001 0.0006
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0045 0.0463
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0009 0.0021
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0034 0.0034
Echinococcus granulosus microtubule associated protein 2 0.3492 0.1638 0.1637
Loa Loa (eye worm) hypothetical protein 0.0143 0.0059 0.0059
Trypanosoma brucei prolyl endopeptidase 0.4329 0.2033 0.5032
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0014 0.0134
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0007 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0001 0.0001
Treponema pallidum replicative DNA helicase (dnaB) 0.0467 0.0211 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0007 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0001 0.0001
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0031 0.0316
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0003 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0001 0.0001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0006 0.0014
Mycobacterium ulcerans bacterioferritin BfrB 0.0035 0.0008 0.0021
Loa Loa (eye worm) prolyl oligopeptidase 2.1223 1 1
Schistosoma mansoni ferritin 0.0035 0.0008 0.0007
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0001 0.0003
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.4329 0.2033 0.2032
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0001 0.0001
Schistosoma mansoni smad1 5 8 and 0.0034 0.0007 0.0006
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.2796 0.131 0.3242
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0023 0.0022
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0001 0.0002
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0002 0.0002
Schistosoma mansoni coup transcription factor 0.0022 0.0001 0.0001
Plasmodium vivax SET domain protein, putative 0.0032 0.0006 0.0017
Echinococcus granulosus expressed protein 0.0033 0.0007 0.0006
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0001 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0027 0.0076
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0043 0.0012 0.0011
Entamoeba histolytica hypothetical protein 0.0025 0.0003 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0001 0.0001
Trypanosoma brucei prolyl oligopeptidase, putative 0.2796 0.131 0.3242
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0047 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.009 0.0034 0.0034
Brugia malayi steroid hormone receptor 0.0022 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0007 0.0069
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0008 0.0018
Leishmania major cathepsin L-like protease 0.0034 0.0007 0.0016
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.21 0.0982 0.0981
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.8584 0.404 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0001 0.0001
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0007 0.002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0003 0.0003
Mycobacterium tuberculosis Probable peptidase 0.2796 0.131 0.3641
Loa Loa (eye worm) fibroinase 0.0034 0.0007 0.0007
Echinococcus granulosus smad 0.0034 0.0007 0.0006
Trichomonas vaginalis ferritin, putative 0.0035 0.0008 0.0072
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0006 0.0013
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.7647 0.3597 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0007 0.0007
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0014 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0038 0.0037
Onchocerca volvulus 0.0037 0.0009 0.0007
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.013 0.0053 0.0393
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0001 0.0001
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0002 0.0003
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0003 0.0005
Chlamydia trachomatis DNA ligase 0.0021 0.0001 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0003 0.0003
Trypanosoma brucei polo-like protein kinase 0.0114 0.0045 0.011
Echinococcus granulosus expressed protein 0.0035 0.0008 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0052 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0003 0.0027
Trichomonas vaginalis rotamase, putative 0.0032 0.0006 0.006
Echinococcus multilocularis expressed protein 0.0033 0.0007 0.0006
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0003 0.0007
Entamoeba histolytica hypothetical protein 0.0153 0.0064 0.0657
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0006 0.0005
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0001 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0001 0.0001
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0007 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0001 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0003 0.0008
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.7647 0.3597 1
Giardia lamblia Serine peptidase, putative 0.0113 0.0044 0.0457
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0008 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0007 0.0006
Echinococcus granulosus importin subunit beta 1 0.0035 0.0008 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0003 0.0008
Brugia malayi DKFZp564C0469 protein 0.0021 0.0001 0.0001
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0007 0.0069
Schistosoma mansoni transcription factor LCR-F1 0.0153 0.0064 0.0063
Echinococcus granulosus neuropeptide s receptor 0.0464 0.021 0.021
Schistosoma mansoni smad1 5 8 and 0.0034 0.0007 0.0006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0007 0.0006
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0009 0.0021
Echinococcus granulosus chromobox protein 1 0.0084 0.0031 0.003
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0003 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0003 0.0008
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.7647 0.3597 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0015 0.0015
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0007 0.002
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0045 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0007 0.0069
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.0034 0.0007 0.0016
Schistosoma mansoni chromobox protein 0.0084 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0007 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0463
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.0034 0.0007 0.0016
Onchocerca volvulus 0.0034 0.0007 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0001 0.0001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0006 0.0014
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0001 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.2051 0.0958 0.2371
Echinococcus granulosus snurportin 1 0.0372 0.0167 0.0166
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0038 0.0038
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.4329 0.2033 0.2032
Loa Loa (eye worm) hypothetical protein 0.0203 0.0087 0.0087
Echinococcus multilocularis prolyl endopeptidase 0.4329 0.2033 0.2032
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0027 0.1248
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0012 0.0012
Entamoeba histolytica prolyl oligopeptidase family protein 0.2051 0.0958 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0013 0.0134
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0027 0.02
Loa Loa (eye worm) hypothetical protein 0.0182 0.0077 0.0077
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0004 0.0119
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0001 0.0001
Giardia lamblia GTOR 0.0047 0.0014 0.0134
Brugia malayi hypothetical protein 0.0021 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0066 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.4329 0.2033 0.2033
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0463
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0045 0.0044
Trypanosoma cruzi cruzipain precursor, putative 0.0129 0.0052 0.0127
Brugia malayi Cathepsin L-like precursor 0.0034 0.0007 0.0007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0007 0.0069
Brugia malayi hypothetical protein 0.0153 0.0064 0.0064
Giardia lamblia Replication factor C, subunit 1 0.0021 0.0001 0.0006
Giardia lamblia Alanyl dipeptidyl peptidase 0.2051 0.0958 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0463
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0009 0.0021
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0008 0.0017
Echinococcus granulosus nibrin 0.0021 0.0001 0.0001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.0041 0.0041
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0007 0.0006
Brugia malayi prolyl oligopeptidase family protein 0.4329 0.2033 0.2033
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0003 0.0026
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0003 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.0044 0.0457
Schistosoma mansoni ferritin 0.0035 0.0008 0.0007
Onchocerca volvulus 0.0051 0.0015 0.0014
Echinococcus multilocularis protein dispatched 1 0.0051 0.0015 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0003 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0001 0.0006
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0113 0.0044 0.0117
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.0062 0.0061
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0001 0.0001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0015 0.0105
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0167 0.0167
Entamoeba histolytica fatty acid elongase, putative 0.0993 0.046 0.4792
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0007 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0023 0.0022
Echinococcus multilocularis smad 0.0034 0.0007 0.0006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0003 0.0015
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0001 0.0001
Chlamydia trachomatis recombinase RecA 0.013 0.0053 0.0146
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0027 0.0027
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0004 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0008 0.0075
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0014 0.0013
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0467 0.0211 0.0587
Schistosoma mansoni hypothetical protein 0.0153 0.0064 0.0063
Echinococcus granulosus cathepsin l1 0.0023 0.0002 0.0001
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0034 0.0033
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0007 0.0007
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0003 0.0008
Schistosoma mansoni hypothetical protein 0.0043 0.0012 0.0011
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0034 0.0007 0.0007
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0006 0.0006
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.2279 0.1066 0.2962
Schistosoma mansoni smad 0.0034 0.0007 0.0006
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0113 0.0044 0.0044
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.2796 0.131 0.3242
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.001 0.01
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0467 0.0211 0.0584
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.2051 0.0958 0.0958
Loa Loa (eye worm) hypothetical protein 0.0105 0.0041 0.0041
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0034 0.0033
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0027 0.0071
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0027 0.0076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0001 0.0001
Trypanosoma cruzi oligopeptidase b 0.2796 0.131 0.3242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0052 0.0127
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0014 0.0032
Entamoeba histolytica fatty acid elongase, putative 0.0993 0.046 0.4792
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0001 0.0001
Brugia malayi CHE-14 protein 0.0045 0.0012 0.0012
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.8584 0.404 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0006 0.0015
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0015 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0007 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0055 0.0017 0.0017
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0045 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0007 0.0069
Schistosoma mansoni hypothetical protein 0.0143 0.0059 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0013 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0008 0.0075
Loa Loa (eye worm) hypothetical protein 0.5783 0.2719 0.2719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.0039 0.0095
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0027 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Schistosoma mansoni chromobox protein 0.0084 0.0031 0.003
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0113 0.0044 0.0044
Echinococcus granulosus neuropeptide receptor A26 0.0464 0.021 0.021
Echinococcus multilocularis Smad4 0.0034 0.0007 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0003 0.0027
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0066 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0001 0.0001
Brugia malayi prolyl oligopeptidase family protein 0.8584 0.404 0.404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Entamoeba histolytica hypothetical protein 0.0153 0.0064 0.0657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0001 0.0001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0013 0.0012
Toxoplasma gondii cathepsin CPL 0.0034 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0001
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3756 0.1763 0.4899
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0003 0.0008
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0001 0.0000001162
Echinococcus granulosus GPCR family 2 0.0066 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0009 0.0087
Echinococcus multilocularis cysteine protease 0.0034 0.0007 0.0007
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.21 0.0982 0.0981
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0003 0.0028
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0045 0.0044
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0003 0.0007
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0001 0.0001
Brugia malayi Serine carboxypeptidase S28 family protein 0.0113 0.0044 0.0044
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.0059 0.0059
Onchocerca volvulus 0.0034 0.0007 0.0006
Treponema pallidum bacterioferrin (TpF1) 0.0035 0.0008 0.0302
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0001 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0001 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0038 0.0038
Echinococcus multilocularis GPCR, family 2 0.0066 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0003 0.0008
Brugia malayi hypothetical protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0001 0.0001
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0015 0.0014
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0003 0.0008
Echinococcus multilocularis nibrin 0.0021 0.0001 0.0001
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0077 0.0027 0.0027
Brugia malayi Pre-SET motif family protein 0.0032 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0003 0.0003
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.2796 0.131 0.3641
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0252 0.011 0.011
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0007 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.009 0.009
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0041 0.004
Schistosoma mansoni survival motor neuron protein 0.0051 0.0015 0.0015
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0001 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0023 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0001 0.0001
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0467 0.0211 0.1605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0038 0.0037
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0043 0.0012 0.0011
Brugia malayi RNA, U transporter 1 0.0099 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0008 0.0075
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0015 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0003 0.0027
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0001 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0003 0.0015
Entamoeba histolytica hypothetical protein 0.0153 0.0064 0.0657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Entamoeba histolytica hypothetical protein 0.0153 0.0064 0.0657
Entamoeba histolytica cysteine protease, putative 0.0034 0.0007 0.0069
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 2.1223 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.2801 0.1312 0.1312
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.0044 0.0457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0008 0.0018
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0113 0.0044 0.0108
Schistosoma mansoni hypothetical protein 0.0066 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0005 0.0041
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0001 0.0006
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.21 0.0982 0.0981
Brugia malayi Probable ClpP-like protease 0.0077 0.0027 0.0027
Brugia malayi hypothetical protein 0.0182 0.0077 0.0077
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0003 0.0092
Brugia malayi Smad1 0.0034 0.0007 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0001 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0004 0.001
Entamoeba histolytica hypothetical protein 0.0028 0.0005 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0003 0.0027
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0023 0.0023
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0004 0.0019
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0006 0.0006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0023 0.0023
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2648 0.124 0.124
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.004 0.001 0.0024
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0001 0.0001
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0001 0.0001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0001 0.0001
Schistosoma mansoni topbp1 0.0021 0.0001 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0022 0.0022
Brugia malayi hypothetical protein 0.5783 0.2719 0.2719
Onchocerca volvulus 0.0113 0.0044 0.0043
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0007 0.0006
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0004 0.0039
Echinococcus multilocularis neuropeptide receptor A26 0.0464 0.021 0.021
Brugia malayi ecdysteroid receptor 0.0022 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0052 0.0128
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0006 0.0014
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Leishmania major GTP-binding protein, putative 0.0026 0.0003 0.0007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0001 0.0001
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.2796 0.131 0.3242
Onchocerca volvulus 0.0045 0.0013 0.0011
Brugia malayi chromobox protein homolog 3 0.0047 0.0013 0.0013
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0027 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0052 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0007 0.0069
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0113 0.0044 0.0457
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0113 0.0044 0.0457
Brugia malayi Cathepsin L-like precursor 0.0023 0.0002 0.0002
Toxoplasma gondii prolyl endopeptidase 0.4329 0.2033 0.5514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0003 0.0027

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 17.99 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
AC50 (functional) = 39.28 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
EC50 (functional) = 0.722 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950] ChEMBL. No reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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