Detailed information for compound 1490527

Basic information

Technical information
  • TDR Targets ID: 1490527
  • Name: (2-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl )methanone
  • MW: 312.323 | Formula: C16H16N4O3
  • H donors: 0 H acceptors: 4 LogP: 2.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccccc1C(=O)N1CCN(CC1)c1ccccn1
  • InChi: 1S/C16H16N4O3/c21-16(13-5-1-2-6-14(13)20(22)23)19-11-9-18(10-12-19)15-7-3-4-8-17-15/h1-8H,9-12H2
  • InChiKey: VHUAGJOEHFJKDE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-nitrophenyl)-[4-(2-pyridyl)piperazin-1-yl]methanone
  • (2-nitrophenyl)-[4-(2-pyridyl)-1-piperazinyl]methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Brugia malayi topoisomerase 0.002 0.0026 0.0153
Schistosoma mansoni hypothetical protein 0.0397 0.237 0.567
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0946 0.5777 0.6353
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.4179 0.4179
Brugia malayi beta-lactamase family protein 0.0036 0.0129 0.0746
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0172
Echinococcus granulosus epidermal growth factor receptor 0.0148 0.0824 0.1971
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0172
Loa Loa (eye worm) hypothetical protein 0.0049 0.021 0.1216
Echinococcus multilocularis 0.0046 0.0189 0.0189
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0686 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.003 0.0172
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.003 0.0071
Echinococcus multilocularis Niemann Pick C1 protein 0.0421 0.2513 0.2513
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.0746
Schistosoma mansoni DNA ligase IV 0.002 0.0026 0.0063
Loa Loa (eye worm) TK/EGFR protein kinase 0.0148 0.0824 0.4762
Onchocerca volvulus 0.0036 0.0129 0.2138
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0026 0.0063
Brugia malayi hypothetical protein 0.002 0.0026 0.0153
Entamoeba histolytica fatty acid elongase, putative 0.0123 0.0667 0.3759
Brugia malayi hypothetical protein 0.0104 0.055 0.3179
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0686 0.1642
Brugia malayi amine oxidase, flavin-containing family protein 0.0104 0.055 0.3179
Brugia malayi ecdysteroid receptor 0.002 0.003 0.0172
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0084
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0294 0.173 1
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0026 0.0021
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.003 0.0071
Echinococcus granulosus lysine specific histone demethylase 1A 0.0104 0.055 0.1316
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0126 0.0687 0.3974
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0129 0.0199
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.0746
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.003 0.0172
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.003 0.0172
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.003 0.0172
Brugia malayi hypothetical protein 0.0236 0.1369 0.7914
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0077 0.0445
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Brugia malayi CXXC zinc finger family protein 0.0028 0.0077 0.0445
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.003 0.003
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0129 0.196
Onchocerca volvulus 0.0036 0.0129 0.2138
Loa Loa (eye worm) hypothetical protein 0.0155 0.0864 0.4993
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.003 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Mycobacterium tuberculosis Possible oxidoreductase 0.0104 0.055 0.0507
Echinococcus granulosus Protein patched homolog 1 0.0126 0.0687 0.1645
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.003 0.003
Echinococcus multilocularis epidermal growth factor receptor 0.008 0.0398 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.003 0.0172
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Echinococcus multilocularis geminin 0.0171 0.0964 0.0964
Schistosoma mansoni tyrosine kinase 0.0079 0.0393 0.094
Brugia malayi hypothetical protein 0.0018 0.0015 0.0084
Brugia malayi SWIRM domain containing protein 0.0104 0.055 0.3179
Echinococcus multilocularis FTZ F1 alpha 0.002 0.003 0.003
Echinococcus granulosus FTZ F1 alpha 0.002 0.003 0.0071
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Entamoeba histolytica fatty acid elongase, putative 0.0123 0.0667 0.3759
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0104 0.055 0.055
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0153
Loa Loa (eye worm) hypothetical protein 0.0104 0.055 0.3179
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0129 0.1553
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.003 0.0282
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.003 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0686 0.1642
Schistosoma mansoni survival motor neuron protein 0.0048 0.0203 0.0485
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.003 0.0071
Schistosoma mansoni hypothetical protein 0.0048 0.0203 0.0485
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Brugia malayi nuclear receptor NHR-88 0.002 0.003 0.0172
Echinococcus multilocularis Niemann Pick C1 protein 0.0294 0.173 0.173
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.003 0.0172
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0129 0.0746
Schistosoma mansoni thyroid hormone receptor 0.002 0.003 0.0071
Brugia malayi DKFZp564C0469 protein 0.002 0.0026 0.0153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0153
Echinococcus granulosus microtubule associated protein 2 0.0689 0.4179 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.003 0.0172
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0203 0.1172
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0299 0.1758 0.4206
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.003 0.0071
Echinococcus granulosus epidermal growth factor receptor 0.008 0.0398 0.0953
Onchocerca volvulus 0.0104 0.055 1
Brugia malayi hypothetical protein 0.0018 0.0015 0.0084
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Echinococcus granulosus geminin 0.0171 0.0964 0.2306
Entamoeba histolytica fatty acid elongase, putative 0.0123 0.0667 0.3759
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0172
Loa Loa (eye worm) hypothetical protein 0.0104 0.055 0.3179
Echinococcus multilocularis protein patched 0.0126 0.0687 0.0687
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1478 0.9079 1
Echinococcus multilocularis nibrin 0.002 0.0026 0.0026
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0686 0.3967
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0686 0.1642
Schistosoma mansoni cpg binding protein 0.0029 0.0087 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.003 0.0172
Schistosoma mansoni tyrosine kinase 0.0047 0.0198 0.0473
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0104 0.055 0.1316
Brugia malayi hypothetical protein 0.002 0.0026 0.0153
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.237 0.237
Brugia malayi Protein kinase domain containing protein 0.0047 0.0198 0.1144
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.003 0.0172
Loa Loa (eye worm) hypothetical protein 0.0104 0.055 0.3179
Schistosoma mansoni tyrosine kinase 0.0079 0.0393 0.094
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.003 0.0282
Loa Loa (eye worm) hypothetical protein 0.0104 0.055 0.3179
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.003 0.0071
Echinococcus granulosus lysine specific histone demethylase 1A 0.0104 0.055 0.1316
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Leishmania major UDP-galactopyranose mutase 0.0104 0.055 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0026 0.000002032
Loa Loa (eye worm) hypothetical protein 0.0049 0.0208 0.1201
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0153
Schistosoma mansoni amine oxidase 0.0104 0.055 0.1316
Echinococcus granulosus sterol regulatory element binding protein 0.0126 0.0687 0.1645
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0687 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.0746
Brugia malayi Steroid receptor seven-up type 2 0.002 0.003 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.003 0.0172
Mycobacterium tuberculosis Conserved hypothetical protein 0.0104 0.055 0.0507
Schistosoma mansoni hypothetical protein 0.0122 0.0659 0.1577
Schistosoma mansoni tyrosine kinase 0.0148 0.0824 0.1971
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0686 0.1642
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.003 0.003
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0946 0.5777 0.6802
Echinococcus multilocularis protein dispatched 1 0.0144 0.0798 0.0798
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0172
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.003 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.003 0.0172
Brugia malayi hypothetical protein 0.0018 0.0015 0.0084
Trypanosoma cruzi UDP-galactopyranose mutase 0.0104 0.055 1
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0084
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0946 0.5777 1
Brugia malayi beta-lactamase 0.0036 0.0129 0.0746
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0129 0.0113
Brugia malayi protein C24B5.3 0.0018 0.0015 0.0084
Echinococcus granulosus insulin receptor 0.0047 0.0198 0.0473
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.003 0.0071
Echinococcus granulosus cpg binding protein 0.0029 0.0087 0.0208
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.0746
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.003 0.0071
Brugia malayi Patched related family protein 12 0.0018 0.0015 0.0084
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0104 0.055 0.0929
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.003 0.0172
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Schistosoma mansoni hypothetical protein 0.0171 0.0964 0.2306
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.1369 0.1369
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0232 0.398
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.003 0.0172
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0104 0.055 0.0929
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Echinococcus granulosus expressed conserved protein 0.0276 0.1619 0.3874
Onchocerca volvulus 0.0049 0.021 0.3655
Schistosoma mansoni tyrosine kinase 0.0079 0.0393 0.094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0208 0.1201
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.003 0.0071
Brugia malayi RNA binding protein 0.0126 0.0686 0.3967
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0172
Plasmodium vivax hypothetical protein, conserved 0.0104 0.055 0.0929
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0104 0.055 0.0929
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.003 0.0071
Brugia malayi beta-lactamase family protein 0.0036 0.0129 0.0746
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0129 0.196
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0129 0.0129
Echinococcus multilocularis cpg binding protein 0.0029 0.0087 0.0087
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0129 0.0113
Entamoeba histolytica fatty acid elongase, putative 0.0123 0.0667 0.3759
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.0746
Brugia malayi Patched related family protein 10 0.0018 0.0015 0.0084
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.021 0.0503
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1374 0.8433 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0129 0.0746
Mycobacterium ulcerans monoamine oxidase 0.0104 0.055 0.0578
Mycobacterium leprae Probable lipase LipE 0.0036 0.0129 0.196
Schistosoma mansoni hypothetical protein 0.0122 0.0659 0.1577
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0172
Echinococcus multilocularis expressed conserved protein 0.0276 0.1619 0.1619
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0946 0.5777 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0129 0.0113
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0294 0.173 1
Brugia malayi nuclear hormone receptor 0.002 0.003 0.0172
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0946 0.5777 1
Schistosoma mansoni hypothetical protein 0.0122 0.0659 0.1577
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0026 0.0026
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0198 0.1144
Schistosoma mansoni cpg binding protein 0.0028 0.0077 0.0184
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0686 0.1642
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0153
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.4179 1
Brugia malayi Patched related family protein 4 0.0018 0.0015 0.0084
Schistosoma mansoni cpg binding protein 0.0029 0.0087 0.0208
Brugia malayi Patched protein homolog 1 0.0018 0.0015 0.0084
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.003 0.0071
Echinococcus multilocularis 0.0104 0.055 0.055
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0104 0.055 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0104 0.055 0.091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0129 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0129 0.1553
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0026 0.0153
Schistosoma mansoni topbp1 0.002 0.0026 0.0063
Echinococcus multilocularis tumor protein p63 0.0337 0.1997 0.1997
Onchocerca volvulus 0.0028 0.0077 0.1166
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.008 0.0398 0.0953
Plasmodium vivax hypothetical protein, conserved 0.0104 0.055 0.0929
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0208 0.1201
Loa Loa (eye worm) hypothetical protein 0.0236 0.1369 0.7914
Schistosoma mansoni topbp1 0.002 0.0026 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.003 0.003
Onchocerca volvulus 0.002 0.003 0.0282
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0198 0.0473
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.003 0.0071
Echinococcus granulosus nibrin 0.002 0.0026 0.0063
Mycobacterium ulcerans oxidoreductase 0.0104 0.055 0.0578
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0112 0.0645
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0026 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0208 0.1201
Echinococcus granulosus dnaJ subfamily B 0.0397 0.237 0.567
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0026 0.0153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0172
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0026 0.0217
Schistosoma mansoni tyrosine kinase 0.008 0.0398 0.0953
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1478 0.9079 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0129 0.196
Brugia malayi steroid hormone receptor 0.002 0.003 0.0172
Schistosoma mansoni hypothetical protein 0.0033 0.0112 0.0267
Brugia malayi Niemann-Pick C1 protein precursor 0.0294 0.173 1
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.003 0.003
Treponema pallidum DNA ligase (lig) 0.002 0.0026 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.1343 0.1462
Mycobacterium ulcerans lipase LipD 0.0036 0.0129 0.0113
Loa Loa (eye worm) hypothetical protein 0.0104 0.055 0.3179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0129 0.0309
Brugia malayi Myosin head containing protein 0.0018 0.0015 0.0084
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0104 0.055 0.0929
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.003 0.0172
Echinococcus granulosus replication factor c subunit 1 0.002 0.0026 0.0063
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0126 0.0687 0.3974
Entamoeba histolytica fatty acid elongase, putative 0.0123 0.0667 0.3759
Onchocerca volvulus 0.0048 0.0203 0.3513
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.003 0.0071
Echinococcus granulosus Niemann Pick C1 protein 0.0294 0.173 0.4139
Loa Loa (eye worm) patched family protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) beta-lactamase 0.0036 0.0129 0.0746
Brugia malayi Patched family protein 0.0018 0.0015 0.0084
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0026 0.0000052364
Echinococcus granulosus tar DNA binding protein 0.0126 0.0686 0.1642
Schistosoma mansoni tyrosine kinase 0.008 0.0398 0.0953
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.003 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.003 0.0172
Brugia malayi TAR-binding protein 0.0126 0.0686 0.3967
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Mycobacterium ulcerans hypothetical protein 0.0036 0.0129 0.0113
Toxoplasma gondii histone lysine-specific demethylase 0.0104 0.055 0.9807
Brugia malayi protein C24B5.3 0.0018 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0172
Loa Loa (eye worm) hypothetical protein 0.0033 0.0112 0.0645
Schistosoma mansoni hypothetical protein 0.0122 0.0659 0.1577
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0946 0.5777 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0126 0.0687 0.0687
Onchocerca volvulus Bile acid receptor homolog 0.002 0.003 0.0282
Echinococcus granulosus tumor protein p63 0.0337 0.1997 0.4779
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0946 0.5777 0.6353
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.003 0.0071
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0686 0.3967
Brugia malayi CHE-14 protein 0.0126 0.0687 0.3974
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0129 0.1553
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0129 0.0309
Schistosoma mansoni coup transcription factor 0.002 0.003 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.003 0.0172
Echinococcus granulosus Niemann Pick C1 protein 0.0421 0.2513 0.6014
Plasmodium falciparum protoporphyrinogen oxidase 0.0104 0.055 0.0929
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0129 0.0309
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0198 0.0198
Toxoplasma gondii ABC1 family protein 0.0036 0.0129 0.2097
Giardia lamblia Replication factor C, subunit 1 0.002 0.0026 0.5
Trypanosoma cruzi UDP-galactopyranose mutase 0.0104 0.055 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.003 0.0172
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.0746
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0153
Schistosoma mansoni tyrosine kinase 0.0047 0.0198 0.0473
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0106 0.0561 1
Trichomonas vaginalis esterase, putative 0.0036 0.0129 0.1553
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Schistosoma mansoni patched 1 0.0126 0.0687 0.1645
Onchocerca volvulus 0.0036 0.0129 0.2138
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.003 0.0071
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0129 0.1553
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.003 0.0172
Schistosoma mansoni nuclear hormone receptor 0.002 0.003 0.0071
Mycobacterium ulcerans dehydrogenase 0.0104 0.055 0.0578
Schistosoma mansoni hypothetical protein 0.0171 0.0964 0.2306
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.003 0.0172
Echinococcus multilocularis insulin receptor 0.0047 0.0198 0.0198
Echinococcus multilocularis epidermal growth factor receptor 0.0148 0.0824 0.0824
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.003 0.0071
Onchocerca volvulus 0.002 0.0026 0.0221
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0026 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0129 0.1553
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Echinococcus multilocularis protoporphyrinogen oxidase 0.0104 0.055 0.055
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0104 0.055 0.1316
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0104 0.055 0.0578
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.003 0.0172
Brugia malayi Furin-like cysteine rich region family protein 0.0148 0.0824 0.4762
Loa Loa (eye worm) RNA binding protein 0.0126 0.0686 0.3967
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0026 0.0000052364
Schistosoma mansoni amine oxidase 0.0104 0.055 0.1316
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.003 0.0172
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0946 0.5777 0.6353
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0104 0.055 0.3179
Brugia malayi hypothetical protein 0.0018 0.0015 0.0084
Schistosoma mansoni thyroid hormone receptor 0.002 0.003 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0686 0.3967
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0271 0.0649
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.1369 0.3275
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0026 0.0000052364

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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