Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RNA polymerase Rpb1 | 0.0038 | 0.0601 | 0.0601 |
Echinococcus multilocularis | DNA directed RNA polymerase I subunit RPA1 | 0.0068 | 0.1596 | 0.1596 |
Echinococcus granulosus | DNA directed RNA polymerase III subunit RPC1 | 0.0038 | 0.0601 | 0.0601 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.005 | 0.005 |
Toxoplasma gondii | DNA-directed RNA polymerase III RPC1 | 0.0038 | 0.0601 | 0.3179 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0314 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Plasmodium falciparum | RNA polymerase I | 0.0076 | 0.1891 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0166 | 0.4949 | 0.4949 |
Schistosoma mansoni | nuclear hormone receptor | 0.0148 | 0.4343 | 0.4343 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | nuclear hormone receptor | 0.0314 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0021 | 0 | 0.5 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT). | 0.0038 | 0.0601 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0314 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0166 | 0.4949 | 0.4949 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0314 | 1 | 1 |
Trichomonas vaginalis | RNA polymerase A, putative | 0.0068 | 0.1596 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0314 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0148 | 0.4343 | 0.4343 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0148 | 0.4343 | 0.3987 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0314 | 1 | 1 |
Schistosoma mansoni | plexin | 0.0022 | 0.005 | 0.005 |
Brugia malayi | tailless protein | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Leishmania major | RNA polymerase ii largest subunit | 0.0038 | 0.0601 | 0.3766 |
Echinococcus granulosus | plexin a4 | 0.0045 | 0.0831 | 0.0831 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0166 | 0.4949 | 0.4949 |
Onchocerca volvulus | 0.0148 | 0.4343 | 0.3987 | |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0166 | 0.4949 | 0.4949 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | nuclear receptor | 0.0148 | 0.4343 | 0.4343 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0314 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0314 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0166 | 0.4949 | 0.4949 |
Brugia malayi | nuclear hormone receptor | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0314 | 1 | 1 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta' | 0.0038 | 0.0601 | 1 |
Brugia malayi | Plexin repeat family protein | 0.0038 | 0.0593 | 0.0593 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0314 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0148 | 0.4343 | 0.4343 |
Echinococcus granulosus | DNA directed RNA polymerase I subunit RPA1 | 0.0068 | 0.1596 | 0.1596 |
Trypanosoma brucei | DNA-directed RNA polymerase III largest subunit, putative | 0.0024 | 0.0097 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0314 | 1 | 1 |
Brugia malayi | RNA polymerase Rpb1, domain 2 family protein | 0.0076 | 0.1891 | 0.1891 |
Brugia malayi | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.005 | 0.005 |
Schistosoma mansoni | DNA-directed RNA polymerase I | 0.0076 | 0.1891 | 0.1891 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Trypanosoma brucei | DNA-directed RNA polymerase I largest subunit | 0.0068 | 0.1596 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0314 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0148 | 0.4343 | 0.4343 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Toxoplasma gondii | DNA-directed RNA polymerase I RPA1 | 0.0076 | 0.1891 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1891 | 0.1891 |
Chlamydia trachomatis | DNA-directed RNA polymerase subunit beta' | 0.0038 | 0.0601 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | nuclear hormone receptor | 0.0314 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0148 | 0.4343 | 0.4343 |
Trypanosoma cruzi | DNA-directed rna polymerase I largest subunit, putative | 0.0068 | 0.1596 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0314 | 1 | 1 |
Treponema pallidum | DNA-directed RNA polymerase subunit beta' | 0.0038 | 0.0601 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0314 | 1 | 1 |
Trypanosoma cruzi | RNA polymerase IIA largest subunit, putative | 0.0038 | 0.0601 | 0.3766 |
Brugia malayi | RNA polymerase Rpb1, domain 1 family protein | 0.0038 | 0.0601 | 0.0601 |
Schistosoma mansoni | DNA-directed RNA polymerase II largest subunit | 0.0038 | 0.0601 | 0.0601 |
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.0038 | 0.0601 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | DNA-directed RNA polymerase II largest subunit | 0.0038 | 0.0601 | 0.0601 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0148 | 0.4343 | 0.3987 | |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0314 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0021 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0314 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0021 | 0 | 0.5 |
Brugia malayi | plexin A | 0.0045 | 0.0831 | 0.0831 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0314 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0314 | 1 | 1 |
Plasmodium vivax | DNA-directed RNA polymerase I 190 kDa polypeptide, putative | 0.0076 | 0.1891 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | DNA-directed rna polymerase I largest subunit, putative | 0.0068 | 0.1596 | 1 |
Echinococcus multilocularis | DNA directed RNA polymerase II subunit | 0.0038 | 0.0601 | 0.0601 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0314 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0021 | 0 | 0.5 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0148 | 0.4343 | 0.4343 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0314 | 1 | 1 |
Leishmania major | DNA-directed RNA polymerase III largest subunit , putative | 0.0038 | 0.0601 | 0.3766 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Toxoplasma gondii | DNA-directed RNA polymerase II RPB1 | 0.0038 | 0.0601 | 0.3179 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0314 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0593 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | plexin A | 0.0045 | 0.0831 | 0.0831 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | RNA polymerase Rpb1 | 0.0038 | 0.0601 | 0.0601 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0314 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0148 | 0.4343 | 0.4343 |
Giardia lamblia | RNA polymerase AI large subunit | 0.0076 | 0.1891 | 1 |
Brugia malayi | DNA-directed RNA polymerase II largest subunit, putative | 0.0038 | 0.0601 | 0.0601 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0166 | 0.4949 | 0.4949 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0314 | 1 | 1 |
Trypanosoma cruzi | DNA-directed RNA polymerase III subunit C1, putative | 0.0038 | 0.0601 | 0.3766 |
Schistosoma mansoni | plexin | 0.0038 | 0.0593 | 0.0593 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0314 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0148 | 0.4343 | 0.4343 |
Entamoeba histolytica | DNA-directed RNA polymerase I largest subunit, putative | 0.0076 | 0.1891 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0314 | 1 | 1 |
Echinococcus granulosus | DNA directed RNA polymerase II subunit | 0.0038 | 0.0601 | 0.0601 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Trypanosoma brucei | RNA polymerase IIA largest subunit | 0.0038 | 0.0601 | 0.3766 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0314 | 1 | 1 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | nuclear receptor NHR-88 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0148 | 0.4343 | 0.4343 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0314 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0148 | 0.4343 | 0.4343 |
Echinococcus multilocularis | DNA directed RNA polymerase III subunit RPC1 | 0.0038 | 0.0601 | 0.0601 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0314 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0021 | 0 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0314 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0314 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | ecdysone receptor | 0.0148 | 0.4343 | 0.4343 |
Trypanosoma brucei | DNA-directed RNA polymerase II subunit RPB1 | 0.0038 | 0.0601 | 0.3766 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0148 | 0.4343 | 0.3987 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0314 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0314 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0166 | 0.4949 | 0.4949 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0021 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Schistosoma mansoni | zinc finger protein | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | DR-78 | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | thyroid hormone receptor | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0166 | 0.4949 | 0.4949 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0314 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | DNA-directed RNA polymerase III subunit C1 | 0.0038 | 0.0601 | 0.3766 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Echinococcus multilocularis | plexin a4 | 0.0045 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Leishmania major | DNA-directed rna polymerase I largest subunit, putative | 0.0068 | 0.1596 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0314 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | 0 uM | In vitro antiproliferative activity of the compound against human DU-145 prostrate cell line; NS = Not significant | ChEMBL. | 14971893 |
GI50 (functional) | 0 uM | In vitro antiproliferative activity of the compound against human IGROV-ET ovarian cell line; NS = Not significant | ChEMBL. | 14971893 |
GI50 (functional) | 0 uM | In vitro antiproliferative activity of the compound against human MEL-28 melanoma cell line; NS = Not significant | ChEMBL. | 14971893 |
GI50 (functional) | 0 uM | In vitro antiproliferative activity of the compound against human A-549 NSCL cell line; NS = Not significant | ChEMBL. | 14971893 |
GI50 (functional) | 0 uM | In vitro antiproliferative activity of the compound against human PANC-1 pancreas cell line; NS = Not significant | ChEMBL. | 14971893 |
GI50 (functional) | 0 uM | In vitro antiproliferative activity of the compound against human HT-29 colon cell line; NS = Not significant | ChEMBL. | 14971893 |
GI50 (functional) | 0 uM | In vitro antiproliferative activity of the compound against human LOVO colon cell line; NS = Not significant | ChEMBL. | 14971893 |
GI50 (functional) | 0 uM | In vitro antiproliferative activity of the compound against human LOVO-DOX colon cell line; NS = Not significant | ChEMBL. | 14971893 |
GI50 (functional) | 0 uM | In vitro antiproliferative activity of the compound against human HeLa cervix cell line; NS = Not significant | ChEMBL. | 14971893 |
GI50 (functional) | 0 uM | In vitro antiproliferative activity of the compound against human HeLa-APL cervix cell line; NS = Not significant | ChEMBL. | 14971893 |
GI50 (functional) | = 0.1 uM | In vitro antiproliferative activity of the compound against human IGROV ovarian cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.1 uM | In vitro antiproliferative activity of the compound against human IGROV ovarian cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 5.2 uM | In vitro antiproliferative activity of the compound against human LN-caP prostrate cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 5.2 uM | In vitro antiproliferative activity of the compound against human LN-caP prostrate cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 7.6 uM | In vitro antiproliferative activity of the compound against human K-562 cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 7.6 uM | In vitro antiproliferative activity of the compound against human K-562 cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 9.7 uM | In vitro antiproliferative activity of the compound against human SK-BR-3 breast cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 9.7 uM | In vitro antiproliferative activity of the compound against human SK-BR-3 breast cell line | ChEMBL. | 14971893 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.