Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.0026 | 0.0315 | 0.0315 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.1554 | 0.1554 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0185 | 0.0185 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0189 | 0.0189 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 0.3837 | 0.3837 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0093 | 0.2521 | 0.2521 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.189 | 0.189 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0033 | 0.0549 | 0.0549 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0025 | 0.0259 | 0.0259 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0189 | 0.0189 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0033 | 0.0549 | 0.0367 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0025 | 0.0259 | 0.0259 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0033 | 0.0549 | 0.0367 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0127 | 0.3641 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0185 | 0.0185 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0033 | 0.0549 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0033 | 0.0549 | 0.0549 |
Toxoplasma gondii | hypothetical protein | 0.0033 | 0.0549 | 0.0367 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0068 | 0.0068 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.3837 | 0.3837 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1422 | 0.1422 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0068 | 0.0068 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0033 | 0.0549 | 0.0367 |
Brugia malayi | Hemopexin family protein | 0.0037 | 0.068 | 0.068 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0189 | 0.0013 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0033 | 0.0549 | 0.0367 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.0185 | 0.0185 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0127 | 0.3641 | 0.3518 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0022 | 0.0185 | 0.0185 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0285 | 0.8893 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0022 | 0.0185 | 0.0185 |
Onchocerca volvulus | Matrilysin homolog | 0.0058 | 0.1379 | 0.1217 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0033 | 0.0549 | 0.0549 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.1554 | 0.1554 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0033 | 0.0549 | 0.0549 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0085 | 0.2262 | 0.2262 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0033 | 0.0549 | 0.2645 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0549 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0185 | 0.0185 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0068 | 0.0068 |
Trypanosoma brucei | prolyl endopeptidase | 0.0318 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0068 | 0.0068 |
Echinococcus granulosus | neuroligin | 0.0022 | 0.0185 | 0.0185 |
Echinococcus multilocularis | neuroligin | 0.0022 | 0.0185 | 0.0185 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0068 | 0.0068 |
Leishmania major | oligopeptidase b | 0.0127 | 0.3641 | 0.3518 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0033 | 0.0549 | 0.0549 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0033 | 0.0549 | 0.0549 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.0185 | 0.0185 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0127 | 0.3641 | 0.3518 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.3837 | 0.3837 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0025 | 0.0259 | 0.0259 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0127 | 0.3641 | 0.3518 |
Schistosoma mansoni | acetylcholinesterase | 0.0022 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0259 | 0.0259 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0033 | 0.0549 | 0.0549 |
Trypanosoma brucei | oligopeptidase b | 0.0127 | 0.3641 | 0.3518 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1422 | 0.1422 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0093 | 0.2521 | 0.2521 |
Plasmodium falciparum | peptidase, putative | 0.0033 | 0.0549 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0189 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0318 | 1 | 1 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0127 | 0.3641 | 0.3518 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0033 | 0.0549 | 0.0549 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0033 | 0.0549 | 0.0367 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0033 | 0.0549 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.3837 | 0.3837 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0189 | 0.0189 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0022 | 0.0185 | 0.0185 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0033 | 0.0549 | 1 |
Loa Loa (eye worm) | plexin A | 0.002 | 0.0102 | 0.0102 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1422 | 0.1422 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0549 | 0.2645 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 0.3837 | 0.3837 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0315 | 0.0315 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0127 | 0.3641 | 0.3969 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0185 | 0.0185 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0185 | 0.0185 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0189 | 0.0189 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0033 | 0.0549 | 0.0549 |
Brugia malayi | Matrixin family protein | 0.0026 | 0.0315 | 0.0315 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0085 | 0.2262 | 0.2262 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0189 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0506 | 0.0506 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0068 | 0.0068 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0096 | 0.2618 | 0.2618 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0026 | 0.0315 | 0.0315 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0022 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0085 | 0.2262 | 0.2262 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0033 | 0.0549 | 0.0367 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0318 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0189 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0022 | 0.0185 | 0.0889 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0033 | 0.0549 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0185 | 0.0185 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0068 | 0.0068 |
Trypanosoma cruzi | oligopeptidase b | 0.0127 | 0.3641 | 0.3518 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0795 | 0.0795 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0189 | 0.091 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0185 | 0.0185 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0033 | 0.0549 | 1 |
Mycobacterium tuberculosis | Probable peptidase | 0.0127 | 0.3641 | 0.3969 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0185 | 0.0185 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0033 | 0.0549 | 0.0549 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0068 | 0.0068 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0318 | 1 | 1 |
Brugia malayi | plexin A | 0.002 | 0.0102 | 0.0102 |
Brugia malayi | Matrixin family protein | 0.0026 | 0.0315 | 0.0315 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.3837 | 0.3837 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1422 | 0.1422 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0033 | 0.0549 | 1 |
Brugia malayi | Matrixin family protein | 0.0026 | 0.0315 | 0.0315 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0079 | 0.2077 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0026 | 0.0315 | 0.0315 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0127 | 0.3641 | 1 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0033 | 0.0549 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0315 | 0.0315 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0033 | 0.0549 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0549 | 0.0549 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0079 | 0.2077 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0068 | 0.0068 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0025 | 0.0259 | 0.0259 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0185 | 0.0185 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0318 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0033 | 0.0549 | 0.0549 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0068 | 0.0068 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.3837 | 0.3837 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0795 | 0.0795 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0033 | 0.0549 | 0.2645 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 0.3837 | 0.3837 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0022 | 0.0185 | 0.0185 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0068 | 0.0068 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0022 | 0.0185 | 0.0185 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0189 | 0.0189 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0033 | 0.0549 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0032 | 0.0506 | 0.0929 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0033 | 0.0549 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0026 | 0.0315 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.068 | 0.068 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0318 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0033 | 0.0549 | 0.0367 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0033 | 0.0549 | 0.0549 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.3837 | 0.3837 |
Echinococcus granulosus | plexin a4 | 0.002 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0185 | 0.0185 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0033 | 0.0549 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0185 | 0.0185 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0033 | 0.0549 | 0.0549 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.3837 | 0.3837 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0189 | 0.091 |
Schistosoma mansoni | gliotactin | 0.0022 | 0.0185 | 0.0185 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0.0549 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0185 | 0.0185 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0058 | 0.1379 | 0.1217 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0185 | 0.0185 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.3837 | 0.3837 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0032 | 0.0506 | 0.0369 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0085 | 0.2262 | 0.2262 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0022 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0068 | 0.0068 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0127 | 0.3641 | 0.3518 |
Trypanosoma cruzi | oligopeptidase b | 0.0127 | 0.3641 | 0.3518 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 0.3837 | 0.3837 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0096 | 0.2618 | 0.2618 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0033 | 0.0549 | 0.0367 |
Onchocerca volvulus | 0.0037 | 0.068 | 0.0505 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0022 | 0.0185 | 0.0889 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0033 | 0.0549 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0025 | 0.0259 | 0.0259 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0795 | 0.0795 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0022 | 0.0185 | 0.0185 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0025 | 0.0259 | 0.0259 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 0.3837 | 0.3837 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0032 | 0.0506 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0315 | 0.0315 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0033 | 0.0549 | 0.0549 |
Echinococcus multilocularis | plexin a4 | 0.002 | 0.0102 | 0.0102 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0189 | 0.0189 |
Echinococcus granulosus | voltage gated potassium channel | 0.0025 | 0.0259 | 0.0259 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0033 | 0.0549 | 0.0367 |
Onchocerca volvulus | 0.0026 | 0.0315 | 0.0133 | |
Echinococcus granulosus | prolyl endopeptidase | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0058 | 0.1379 | 0.1379 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fu (ADMET) | = 2.7 % | Fraction unbound in human plasma | ChEMBL. | 21141896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.