Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 108 nM | Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay | ChEMBL. | 21142180 |
IC50 (functional) | = 115 nM | Cytotoxicity against human HL60 cells after 72 hrs by MTS assay | ChEMBL. | 21142180 |
IC50 (functional) | = 224 nM | Cytotoxicity against human PC3 cells after 72 hrs by MTS assay | ChEMBL. | 21142180 |
IC50 (functional) | = 251 nM | Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay | ChEMBL. | 21142180 |
IC50 (functional) | = 255 nM | Cytotoxicity against human KB cells after 72 hrs by MTS assay | ChEMBL. | 21142180 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21142180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.