Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1456 | 0.5842 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.234 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.234 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1456 | 0.5842 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.234 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.234 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1456 | 0.5842 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.234 | 1 | 0.5 |
Onchocerca volvulus | 0.0448 | 0.1105 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1456 | 0.5842 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0213 | 0 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.234 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.234 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.234 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0448 | 0.1105 | 0.1105 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1456 | 0.5842 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1456 | 0.5842 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0448 | 0.1105 | 0.1105 |
Echinococcus multilocularis | dihydrofolate reductase | 0.234 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3696 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.