Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 0.0569 | 0.0459 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0902 | 0.0569 | 0.0562 |
Brugia malayi | Carboxylesterase family protein | 0.5339 | 0.8742 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0902 | 0.0569 | 0.0459 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 0.0569 | 0.0459 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.5598 | 0.9219 | 1 |
Echinococcus multilocularis | neuroligin | 0.0902 | 0.0569 | 0.0562 |
Schistosoma mansoni | acetylcholinesterase | 0.0902 | 0.0569 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 0.0569 | 0.0459 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0902 | 0.0569 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5339 | 0.8742 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5339 | 0.8742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 0.0569 | 0.0459 |
Brugia malayi | Carboxylesterase family protein | 0.5339 | 0.8742 | 1 |
Schistosoma mansoni | gliotactin | 0.0902 | 0.0569 | 0.0651 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0902 | 0.0569 | 0.0651 |
Onchocerca volvulus | Bile acid receptor homolog | 0.3335 | 0.505 | 1 |
Echinococcus granulosus | neuroligin | 0.0902 | 0.0569 | 0.0296 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0902 | 0.0569 | 0.0562 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0902 | 0.0569 | 0.0651 |
Loa Loa (eye worm) | carboxylesterase | 0.0902 | 0.0569 | 0.0459 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.1627 | 0.1904 | 0.1634 |
Loa Loa (eye worm) | carboxylesterase | 0.5339 | 0.8742 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0902 | 0.0569 | 0.0562 |
Echinococcus multilocularis | carboxylesterase 5A | 0.5339 | 0.8742 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0902 | 0.0569 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 0.0569 | 0.0459 |
Loa Loa (eye worm) | hypothetical protein | 0.1282 | 0.1269 | 0.1276 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0902 | 0.0569 | 0.0651 |
Brugia malayi | ecdysteroid receptor | 0.3335 | 0.505 | 0.5482 |
Echinococcus multilocularis | acetylcholinesterase | 0.5339 | 0.8742 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5339 | 0.8742 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0902 | 0.0569 | 0.0651 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0902 | 0.0569 | 0.0296 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0902 | 0.0569 | 0.0296 |
Echinococcus granulosus | acetylcholinesterase | 0.5339 | 0.8742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 0.0569 | 0.0459 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0767 | 0.0319 | 0.0365 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0902 | 0.0569 | 0.0651 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0902 | 0.0569 | 0.0296 |
Echinococcus granulosus | carboxylesterase 5A | 0.5339 | 0.8742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 0.0569 | 0.0459 |
Loa Loa (eye worm) | hypothetical protein | 0.3335 | 0.505 | 0.569 |
Echinococcus granulosus | acetylcholinesterase | 0.5339 | 0.8742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5339 | 0.8742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5339 | 0.8742 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.6022 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.