Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1312 | 0.0338 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1312 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0583 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3082 | 0.4009 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.6816 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0583 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.1008 | 0.1479 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0583 | 0.5 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.5482 | 0.8042 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0583 | 0.0856 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1312 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.6816 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.6816 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.5482 | 0.8042 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.5482 | 0.7859 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3082 | 0.2306 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3082 | 0.4522 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.3411 | 0.5005 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3082 | 0.2306 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2544 | 0.3146 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2544 | 0.1708 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0583 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1312 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.1008 | 0.1479 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1312 | 0.0338 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.3411 | 0.2672 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2544 | 0.1708 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.5482 | 0.7859 |
Brugia malayi | RNA binding protein | 0.0063 | 0.3082 | 0.4522 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3082 | 0.2306 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1008 | 0.0682 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3082 | 0.4009 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0583 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0583 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2544 | 0.1708 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3082 | 0.2306 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3082 | 0.2306 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2544 | 0.1708 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1312 | 0.1925 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2544 | 0.1708 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1312 | 0.0338 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1312 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.1008 | 0.0682 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3082 | 0.4009 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3082 | 0.2306 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2544 | 0.1708 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3082 | 0.2306 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3411 | 0.4537 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2544 | 0.1708 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2544 | 0.3733 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1312 | 0.0338 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0583 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3082 | 0.4522 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0583 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 21.1923 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.