Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | < 10 % | Hepatotoxicity in NMRI mouse assessed as increase in liver weight at 400 mg/kg administered through oral gavage for 10 days | ChEMBL. | 19546364 |
Activity (ADMET) | < 10 % | Hepatotoxicity in NMRI mouse assessed as inflammatory infiltrates at 400 mg/kg administered through oral gavage for 5 days | ChEMBL. | 19546364 |
Activity (ADMET) | < 10 % | Hepatotoxicity in NMRI mouse assessed as inflammatory infiltrates at 400 mg/kg administered through oral gavage for 10 days | ChEMBL. | 19546364 |
Activity (ADMET) | < 10 % | Hepatotoxicity in NMRI mouse assessed as single-cell necrosis at 400 mg/kg administered through oral gavage for 5 days | ChEMBL. | 19546364 |
Activity (ADMET) | < 10 % | Hepatotoxicity in NMRI mouse assessed as single-cell necrosis at 400 mg/kg administered through oral gavage for 10 days | ChEMBL. | 19546364 |
Activity (ADMET) | < 10 % | Hepatotoxicity in NMRI mouse assessed as increase in mitosis at 400 mg/kg administered through oral gavage for 10 days | ChEMBL. | 19546364 |
Activity (ADMET) | < 10 % | Hepatotoxicity in NMRI mouse assessed as increase in mitosis at 400 mg/kg administered through oral gavage for 5 days | ChEMBL. | 19546364 |
Activity (ADMET) | < 10 % | Hepatotoxicity in NMRI mouse assessed as increase in liver weight at 400 mg/kg administered through oral gavage for 5 days | ChEMBL. | 19546364 |
Activity (binding) | = 75.9 % | Activity of human DHFR at 52 uM | ChEMBL. | 19546364 |
Activity (ADMET) | = 400 mg kg-1 | Toxicity in po dosed NMRI mouse | ChEMBL. | 19546364 |
AUC (ADMET) | = 5.59 ug.hr/ml | AUC (0 to t) in NMRI mouse blood at 25 mg/kg administered through oral gavage after 7 hrs | ChEMBL. | 19546364 |
Cmax (ADMET) | = 0.99 ug ml-1 | Cmax in NMRI mouse blood at 25 mg/kg administered through oral gavage measured after 7 hrs | ChEMBL. | 19546364 |
F (ADMET) | = 29 % | Oral bioavailability in NMRI mouse | ChEMBL. | 19546364 |
IC50 (ADMET) | = 12 uM | Cytotoxicity against human HeLa cells | ChEMBL. | 19546364 |
Tmax (ADMET) | = 6 hr | Tmax in NMRI mouse blood at 25 mg/kg administered through oral gavage measured after 7 hrs | ChEMBL. | 19546364 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19546364 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.