Detailed information for compound 1492293

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.956 | Formula: C23H30ClN3O3
  • H donors: 1 H acceptors: 1 LogP: 4.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)nccc2NCCN1CCC2(CC1)OCC1(OO2)CCCCC1
  • InChi: 1S/C23H30ClN3O3/c24-18-4-5-19-20(6-11-25-21(19)16-18)26-12-15-27-13-9-23(10-14-27)28-17-22(29-30-23)7-2-1-3-8-22/h4-6,11,16H,1-3,7-10,12-15,17H2,(H,25,26)
  • InChiKey: UJBKSCBIYZHSPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Echinococcus granulosus hyperpolarization activated cyclic 0.0204 0.0512 0.0512
Schistosoma mansoni opsin-like receptor 0.0091 0.0186 0.0186
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0046 0.0058 0.0058
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) norepinephrine transporter 0.0272 0.071 0.071
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0222 0.0567 0.0567
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0046 0.0058 0.0058
Echinococcus multilocularis ryanodine receptor 44f 0.0204 0.0512 0.0512
Onchocerca volvulus 0.0091 0.0186 0.1142
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0204 0.0512 1
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.0149 0.0355 0.6841
Echinococcus multilocularis short transient receptor potential channel 6 0.0204 0.0512 0.0512
Brugia malayi putative neuropeptide receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis transient receptor potential cation channel 0.0204 0.0512 0.0512
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0149 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Echinococcus granulosus hypothetical protein 0.0204 0.0512 0.0512
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0222 0.0567 0.0567
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.0186 0.0186
Schistosoma mansoni transient receptor potential channel 4 0.0204 0.0512 0.0512
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0031 0.0013 0.0013
Echinococcus granulosus voltage gated hydrogen channel 1 0.0204 0.0512 0.0512
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0046 0.0058 0.0058
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0149 0.0355 0.0355
Brugia malayi mKIAA0176 protein 0.0149 0.0355 0.0355
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.0186 0.0186
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0204 0.0512 0.0512
Schistosoma mansoni calcium-activated potassium channel 0.0602 0.1664 0.1664
Brugia malayi hypothetical protein 0.0091 0.0186 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.012 0.027 0.027
Loa Loa (eye worm) melatonin receptor type 1A 0.0091 0.0186 0.0186
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0222 0.0567 0.0567
Echinococcus granulosus potassium voltage gated channel protein 0.0353 0.0943 0.0943
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.016 0.0386 0.0386
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0222 0.0567 0.0567
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0222 0.0567 0.0567
Echinococcus multilocularis glycine receptor subunit beta 0.0222 0.0567 0.0567
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0204 0.0512 0.0512
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0204 0.0512 0.0512
Brugia malayi solute carrier family 40, member 1 0.0592 0.1633 0.1633
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0204 0.0512 0.0512
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0222 0.0567 0.0567
Echinococcus granulosus fmrfamide receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0091 0.0186 0.0186
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0222 0.0567 0.0567
Brugia malayi Calcitonin receptor-like protein seb-1 0.0505 0.1383 0.1383
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0591 0.1633 0.1633
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0204 0.0512 0.0512
Schistosoma mansoni voltage-gated potassium channel 0.0353 0.0943 0.0943
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0204 0.0512 0.0512
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0204 0.0512 0.0512
Loa Loa (eye worm) ion channel NompC 0.0204 0.0512 0.0512
Echinococcus multilocularis allatostatin A receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis potassium channel subfamily K 8 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0091 0.0186 0.0186
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0204 0.0512 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0353 0.0943 0.0943
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0186 0.0186
Echinococcus granulosus g protein coupled receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0031 0.0013 0.0081
Loa Loa (eye worm) voltage-gated calcium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.012 0.027 0.027
Onchocerca volvulus 0.012 0.027 0.1655
Onchocerca volvulus 0.0046 0.0058 0.0353
Brugia malayi hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni nAChR subunit 0.0222 0.0567 0.0567
Echinococcus multilocularis potassium voltage gated channel protein 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0046 0.0058 0.0058
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0204 0.0512 0.0512
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.012 0.027 0.027
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0204 0.0512 0.0512
Echinococcus granulosus ryanodine receptor 44f 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0046 0.0058 0.0058
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0091 0.0186 0.0186
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0058 0.1297
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.016 0.0386 0.0386
Schistosoma mansoni serine-type protease inhibitor 0.0876 0.2455 0.2455
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Brugia malayi Dopamine receptor protein 2 0.0091 0.0186 0.0186
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0222 0.0567 0.0567
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0103 0.0221 0.0221
Brugia malayi excitatory GABA receptor EXP-1A 0.0222 0.0567 0.0567
Schistosoma mansoni neurotransmitter gated ion channel 0.0103 0.0221 0.0221
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0031 0.0013 0.0013
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.012 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus granulosus transient receptor potential cation channel 0.0204 0.0512 0.0512
Echinococcus multilocularis short transient receptor potential channel 6 0.0204 0.0512 0.0512
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0046 0.0058 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Loa Loa (eye worm) TYRA-2 protein 0.0091 0.0186 0.0186
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0103 0.0221 0.0221
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0222 0.0567 0.0567
Schistosoma mansoni amine GPCR 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0091 0.0186 0.1142
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0149 0.0355 0.0355
Loa Loa (eye worm) GABA receptor subunit 0.012 0.027 0.027
Onchocerca volvulus 0.0149 0.0355 0.2173
Echinococcus multilocularis neuropeptide s receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni serine-type protease inhibitor 0.0876 0.2455 0.2455
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0204 0.0512 0.0512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0186 0.0186
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0149 0.0355 0.6841
Echinococcus granulosus twik family of potassium channels 0.0031 0.0013 0.0013
Echinococcus multilocularis glycine receptor subunit beta 0.0222 0.0567 0.0567
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0091 0.0186 0.0186
Echinococcus multilocularis dro:myosuppressin receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Echinococcus granulosus calcium activated potassium channel variant 0.0031 0.0013 0.0013
Schistosoma mansoni nAChR subunit 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.016 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0032 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Brugia malayi Cation transporter family protein 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0091 0.0186 0.0186
Brugia malayi G protein-coupled receptor 0.0091 0.0186 0.0186
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0046 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0091 0.0186 0.0186
Brugia malayi hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0512 0.0512
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0103 0.0221 0.0221
Onchocerca volvulus 0.0362 0.0969 0.5935
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0186 0.0186
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0103 0.0221 0.0221
Schistosoma mansoni hypothetical protein 0.0858 0.2404 0.2404
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0103 0.0221 0.0221
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0031 0.0013 0.0013
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0149 0.0355 0.6841
Schistosoma mansoni neuropeptide receptor 0.0091 0.0186 0.0186
Schistosoma mansoni voltage-gated potassium channel 0.0353 0.0943 0.0943
Brugia malayi K+ channel tetramerisation domain containing protein 0.0149 0.0355 0.0355
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0031 0.0013 0.0013
Echinococcus multilocularis G protein coupled receptor 139 0.1365 0.3866 0.3866
Echinococcus granulosus g protein coupled receptor 0.0091 0.0186 0.0186
Schistosoma mansoni amine GPCR 0.0091 0.0186 0.0186
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0512 0.0512
Trypanosoma cruzi potassium voltage-gated channel 0.0149 0.0355 0.6841
Schistosoma mansoni nAChR subunit 0.0103 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0362 0.0969 0.0969
Brugia malayi RE15519p 0.0091 0.0186 0.0186
Echinococcus granulosus neuropeptide receptor 0.0091 0.0186 0.0186
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0204 0.0512 1
Onchocerca volvulus 0.0091 0.0186 0.1142
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0186 0.0186
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.0186 0.0186
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0222 0.0567 0.0567
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Brugia malayi Serotonin receptor 0.0091 0.0186 0.0186
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0149 0.0355 0.6841
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0592 0.1633 1
Echinococcus multilocularis voltage gated potassium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.0186 0.0186
Loa Loa (eye worm) acetylcholine receptor protein 0.0103 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0362 0.0969 0.0969
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.0186 0.0186
Echinococcus granulosus neuropeptide receptor A26 0.0091 0.0186 0.0186
Schistosoma mansoni voltage-gated potassium channel 0.3488 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0091 0.0186 0.0186
Trypanosoma brucei potassium voltage-gated channel, putative 0.0149 0.0355 0.6841
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0091 0.0186 0.1142
Brugia malayi K+ channel tetramerisation domain containing protein 0.0149 0.0355 0.0355
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0204 0.0512 0.0512
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0091 0.0186 0.0186
Echinococcus granulosus serotonin receptor 0.0091 0.0186 0.0186
Echinococcus granulosus serotonin transporter 0.0272 0.071 0.071
Echinococcus multilocularis twik family of potassium channels 0.0031 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni acetylcholine receptor-related 0.0103 0.0221 0.0221
Schistosoma mansoni nAChR subunit 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0364 0.0975 0.0975
Schistosoma mansoni hypothetical protein 0.016 0.0386 0.0386
Brugia malayi Protein kinase domain containing protein 0.0524 0.1437 0.1437
Trypanosoma cruzi potassium voltage-gated channel, putative 0.0149 0.0355 0.6841
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus multilocularis nAChR subunit 0.0222 0.0567 0.0567
Onchocerca volvulus 0.0103 0.0221 0.1351
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) voltage-dependent calcium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.012 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0103 0.0221 0.1351
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0222 0.0567 0.0567
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Echinococcus granulosus somatostatin receptor 0.0091 0.0186 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0186 0.0186
Loa Loa (eye worm) TWK-28 protein 0.0031 0.0013 0.0013
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0091 0.0186 0.0186
Loa Loa (eye worm) ryanodine receptor 0.0204 0.0512 0.0512
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0046 0.0058 0.0058
Echinococcus multilocularis twik family of potassium channels 0.0031 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0512 0.0512
Onchocerca volvulus 0.0091 0.0186 0.1142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Schistosoma mansoni macroglobulin/complement 0.0034 0.0023 0.0023
Echinococcus granulosus tm gpcr rhodopsin 0.0591 0.1633 0.1633
Leishmania major hypothetical protein, conserved 0.0204 0.0512 0.1374
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0222 0.0567 0.0567
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0204 0.0512 0.0512
Echinococcus granulosus glycine receptor subunit beta 0.0222 0.0567 0.0567
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0091 0.0186 0.0186
Echinococcus granulosus calcium activated potassium channel 0.0204 0.0512 0.0512
Schistosoma mansoni calcium-activated potassium channel 0.0031 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0362 0.0969 0.5935
Echinococcus granulosus g-protein coupled receptor 0.0091 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0858 0.2404 0.2404
Plasmodium vivax kelch protein K13, putative 0.0149 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Schistosoma mansoni transient receptor potential channel 0.0204 0.0512 0.0512
Schistosoma mansoni biogenic amine receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0362 0.0969 0.5935
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0204 0.0512 0.0512
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0204 0.0512 0.0512
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0091 0.0186 0.0186
Echinococcus granulosus g protein coupled receptor 0.0091 0.0186 0.0186
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0091 0.0186 0.0186
Schistosoma mansoni calcium-activated potassium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0204 0.0512 0.0512
Onchocerca volvulus 0.0091 0.0186 0.1142
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0353 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Echinococcus granulosus alpha 1A adrenergic receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Echinococcus multilocularis neuropeptide receptor A26 0.0091 0.0186 0.0186
Schistosoma mansoni neurotransmitter gated ion channel 0.0103 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0046 0.0058 0.0058
Echinococcus multilocularis potassium voltage gated channel protein 0.3488 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0222 0.0567 0.0567
Brugia malayi neuropeptide F receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0364 0.0975 0.0975
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0512 0.0512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0186 0.0186
Brugia malayi olfactory channel protein osm-9 0.0204 0.0512 0.0512
Schistosoma mansoni hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0013 0.0013
Plasmodium falciparum kelch protein K13 0.0149 0.0355 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0204 0.0512 0.0512
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.012 0.027 0.027
Onchocerca volvulus 0.0222 0.0567 0.3471
Onchocerca volvulus 0.0091 0.0186 0.1142
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0013 0.0013
Plasmodium falciparum transporter, putative 0.0046 0.0058 0.1297
Onchocerca volvulus 0.0091 0.0186 0.1142
Echinococcus multilocularis transient receptor potential cation channel 0.0204 0.0512 0.0512
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0204 0.0512 1
Echinococcus granulosus potassium voltage gated channel protein 0.0204 0.0512 0.0512
Onchocerca volvulus 0.0149 0.0355 0.2173
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Leishmania major hypothetical protein, unknown function 0.0204 0.0512 0.1374
Echinococcus granulosus potassium channel subfamily K 8 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0272 0.071 0.071
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0204 0.0512 0.0512
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis expressed conserved protein 0.0042 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Echinococcus granulosus transient receptor potential gamma protein 0.0204 0.0512 0.0512
Onchocerca volvulus 0.0031 0.0013 0.0081
Brugia malayi hypothetical protein 0.0046 0.0058 0.0058
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0046 0.0058 0.0058
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0364 0.0975 0.0975
Echinococcus granulosus transient receptor potential cation channel 0.0204 0.0512 0.0512
Brugia malayi G-protein coupled receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0149 0.0355 0.0355
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0222 0.0567 0.0567
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0031 0.0013 0.0013
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis calcium activated potassium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Echinococcus multilocularis transient receptor potential cation channel 0.0204 0.0512 0.0512
Onchocerca volvulus 0.0091 0.0186 0.1142
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0091 0.0186 0.0186
Echinococcus granulosus G protein coupled receptor 139 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0091 0.0186 0.1142
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0091 0.0186 0.1142
Schistosoma mansoni adenoreceptor 0.0091 0.0186 0.0186
Echinococcus granulosus short transient receptor potential channel 6 0.0204 0.0512 0.0512
Onchocerca volvulus 0.0031 0.0013 0.0081
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Brugia malayi voltage-dependent calcium channel 0.0204 0.0512 0.0512
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0149 0.0355 0.0355
Schistosoma mansoni 60S ribosomal protein L21 0.0204 0.0512 0.0512
Echinococcus granulosus 7tm_1 domain containing protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0204 0.0512 0.0512
Echinococcus granulosus nAChR subunit 0.0222 0.0567 0.0567
Brugia malayi hypothetical protein 0.0103 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Onchocerca volvulus 0.0031 0.0013 0.0081
Echinococcus multilocularis voltage gated potassium channel 0.0353 0.0943 0.0943
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0204 0.0512 0.0512
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Brugia malayi hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) A-macroglobulin complement component family protein 0.0034 0.0023 0.0023
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0103 0.0221 0.0221
Echinococcus multilocularis GPCR, family 2 0.016 0.0386 0.0386
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0468 0.1275 0.1275
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0204 0.0512 0.0512
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0186 0.0186
Echinococcus multilocularis neuropeptide receptor 0.0091 0.0186 0.0186
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Echinococcus multilocularis nAChR subunit 0.012 0.027 0.027
Brugia malayi ORL1-like opioid receptor 0.0091 0.0186 0.0186
Toxoplasma gondii transporter, cation channel family protein 0.0204 0.0512 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni nAChR subunit 0.0222 0.0567 0.0567
Leishmania major calcium channel protein, putative,ion transporter, putative 0.1289 0.3646 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0222 0.0567 0.0567
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0149 0.0355 0.0355
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis hyperpolarization activated cyclic 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0222 0.0567 0.0567
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0204 0.0512 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0046 0.0058 0.0058
Echinococcus granulosus twik family of potassium channels 0.0031 0.0013 0.0013
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0204 0.0512 0.0512
Trypanosoma brucei btb/poz domain containing protein, putative 0.0149 0.0355 0.6841
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0204 0.0512 0.0512
Echinococcus multilocularis small conductance calcium activated potassium 0.0858 0.2404 0.2404
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0103 0.0221 0.0221
Echinococcus multilocularis voltage dependent calcium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0204 0.0512 0.0512
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0149 0.0355 0.0355
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0046 0.0058 0.0058
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0046 0.0058 0.0058
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0222 0.0567 0.0567
Echinococcus multilocularis g-protein coupled receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0272 0.071 0.071
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0512 0.0512
Echinococcus granulosus neuropeptide receptor 0.1365 0.3866 0.3866
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) LGC-31 protein 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Echinococcus multilocularis hyperpolarization activated cyclic 0.0204 0.0512 0.0512
Schistosoma mansoni opsin-like receptor 0.0091 0.0186 0.0186
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0204 0.0512 0.0512
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0046 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Brugia malayi cation channel family protein 0.0204 0.0512 0.0512
Brugia malayi hypothetical protein 0.0204 0.0512 0.0512
Brugia malayi hypothetical protein 0.0031 0.0013 0.0013
Schistosoma mansoni histamine h1 receptor 0.0091 0.0186 0.0186
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0364 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Treponema pallidum sodium- and chloride- dependent transporter 0.0272 0.071 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0353 0.0943 0.0943
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0364 0.0975 0.0975
Echinococcus granulosus transient receptor potential cation channel 0.0204 0.0512 0.0512
Echinococcus granulosus cd109 antigen 0.0032 0.0016 0.0016
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.016 0.0386 0.0386
Echinococcus granulosus potassium channel subfamily K 8 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0204 0.0512 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus granulosus expressed conserved protein 0.0042 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Brugia malayi Serotonin receptor 0.0091 0.0186 0.0186
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0362 0.0969 0.0969
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0355 0.0355
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.0149 0.0355 0.6841
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0031 0.0013 0.0013
Echinococcus multilocularis potassium channel subfamily K 8 0.0031 0.0013 0.0013
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.0186 0.0186
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0149 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0204 0.0512 0.0512
Brugia malayi hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0149 0.0355 0.2173
Echinococcus granulosus sodium and chloride dependent glycine 0.0046 0.0058 0.0058
Brugia malayi Dopamine receptor protein 1 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0222 0.0567 0.3471
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0046 0.0058 0.0058
Echinococcus multilocularis sodium leak channel non selective protein 0.0204 0.0512 0.0512
Echinococcus multilocularis serotonin transporter 0.0272 0.071 0.071
Onchocerca volvulus 0.012 0.027 0.1655
Echinococcus granulosus glycine receptor subunit beta 0.0222 0.0567 0.0567
Echinococcus multilocularis sex peptide receptor 0.0091 0.0186 0.0186
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0186 0.0186
Schistosoma mansoni sodium/chloride dependent transporter 0.0046 0.0058 0.0058
Onchocerca volvulus 0.0272 0.071 0.4351
Plasmodium falciparum amino acid transporter, putative 0.0046 0.0058 0.1297
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0091 0.0186 0.0186
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0149 0.0355 0.0355
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus granulosus sodium channel protein 0.1289 0.3646 0.3646
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0204 0.0512 0.0512
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0046 0.0058 0.0058
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0353 0.0943 0.0943
Echinococcus granulosus potassium voltage gated channel protein 0.3488 1 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0046 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0046 0.0058 0.0887
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0362 0.0969 0.0969
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0103 0.0221 0.0221
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0222 0.0567 0.0567
Echinococcus granulosus small conductance calcium activated potassium 0.0858 0.2404 0.2404
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0103 0.0221 0.0221
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0222 0.0567 0.0567
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis transfer RNA-Gly 0.0353 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.012 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0058 0.0058
Echinococcus multilocularis neuropeptide receptor 0.1365 0.3866 0.3866
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0091 0.0186 0.1142
Leishmania major hypothetical protein, conserved 0.0149 0.0355 0.094
Loa Loa (eye worm) hypothetical protein 0.0272 0.071 0.071
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0103 0.0221 0.0221
Echinococcus multilocularis sodium and chloride dependent glycine 0.0046 0.0058 0.0058
Schistosoma mansoni nAChR subunit 0.0103 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Echinococcus multilocularis conserved hypothetical protein 0.0204 0.0512 0.0512
Brugia malayi hypothetical protein 0.0103 0.0221 0.0221
Schistosoma mansoni voltage-gated potassium channel 0.3488 1 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0222 0.0567 0.0567
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0204 0.0512 0.0512
Brugia malayi Cation transporter family protein 0.0222 0.0567 0.0567
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.0186 0.0186
Leishmania major hypothetical protein, conserved 0.0149 0.0355 0.094
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0013 0.0013
Echinococcus granulosus orexin receptor type 2 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0353 0.0943 0.0943
Schistosoma mansoni voltage-gated potassium channel 0.0353 0.0943 0.0943
Echinococcus multilocularis potassium large conductance calcium activated 0.0204 0.0512 0.0512
Schistosoma mansoni voltage-gated potassium channel 0.0353 0.0943 0.0943
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0031 0.0013 0.0013
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Echinococcus multilocularis BTB:POZ domain containing protein 0.0149 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Onchocerca volvulus 0.0091 0.0186 0.1142
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0186 0.0186
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0222 0.0567 0.0567
Schistosoma mansoni hypothetical protein 0.016 0.0386 0.0386
Echinococcus granulosus BTB:POZ domain containing protein 0.0149 0.0355 0.0355
Schistosoma mansoni vesicular amine transporter 0.0353 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Brugia malayi neuropeptide F receptor 0.0091 0.0186 0.0186
Entamoeba histolytica hypothetical protein 0.012 0.027 1
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0524 0.1437 0.1437
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Schistosoma mansoni nAChR subunit 0.0222 0.0567 0.0567
Echinococcus granulosus TRP transient receptor potential channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Schistosoma mansoni two-pore calcium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Brugia malayi hypothetical protein 0.0103 0.0221 0.0221
Onchocerca volvulus 0.0103 0.0221 0.1351
Echinococcus granulosus transient receptor potential cation channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0813 0.2273 0.2273
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0149 0.0355 0.6841
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0204 0.0512 0.0512
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0204 0.0512 0.0512
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.3488 1 1
Brugia malayi K+ channel tetramerisation domain containing protein 0.0149 0.0355 0.0355
Onchocerca volvulus 0.0091 0.0186 0.1142
Onchocerca volvulus 0.0056 0.0086 0.0529
Echinococcus multilocularis two pore calcium channel protein 2 0.0204 0.0512 0.0512
Schistosoma mansoni transient receptor potential channel 0.0204 0.0512 0.0512
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0204 0.0512 0.0512
Schistosoma mansoni neuropeptide receptor 0.0091 0.0186 0.0186
Schistosoma mansoni ryanodine receptor related 0.0204 0.0512 0.0512
Toxoplasma gondii hypothetical protein 0.0204 0.0512 1
Echinococcus granulosus sex peptide receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) ACC-1 protein 0.0222 0.0567 0.0567
Toxoplasma gondii transporter, cation channel family protein 0.0204 0.0512 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0091 0.0186 0.0186
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0204 0.0512 0.0512
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0046 0.0058 0.0887
Brugia malayi GnHR receptor homolog 0.0091 0.0186 0.0186
Toxoplasma gondii transporter, cation channel family protein 0.0204 0.0512 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Echinococcus multilocularis potassium channel subfamily K 0.0031 0.0013 0.0013
Schistosoma mansoni transient receptor potential channel 0.0204 0.0512 0.0512
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0222 0.0567 0.0567
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0186 0.0186
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0222 0.0567 0.0567
Echinococcus granulosus sodium and chloride dependent glycine 0.0046 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0592 0.1633 0.1633
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0046 0.0058 0.0058
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.012 0.027 0.027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0204 0.0512 1
Brugia malayi follicle stimulating hormone receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) uncoordinated protein 58 0.0031 0.0013 0.0013
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0204 0.0512 0.0512
Schistosoma mansoni sodium/chloride dependent transporter 0.0272 0.071 0.071
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.0149 0.0355 0.6841
Onchocerca volvulus 0.0204 0.0512 0.3138
Loa Loa (eye worm) hypothetical protein 0.012 0.027 0.027
Loa Loa (eye worm) latrophilin receptor protein 2 0.016 0.0386 0.0386
Brugia malayi hypothetical protein 0.0103 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0272 0.071 0.071
Echinococcus multilocularis sodium channel protein 0.1289 0.3646 0.3646
Brugia malayi Tachykinin-like peptides receptor 99D 0.0091 0.0186 0.0186
Brugia malayi hypothetical protein 0.0091 0.0186 0.0186
Echinococcus granulosus glycine receptor subunit alpha 1 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0091 0.0186 0.0186
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0364 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Echinococcus granulosus glycine receptor subunit alpha 1 0.0222 0.0567 0.0567
Echinococcus multilocularis voltage dependent calcium channel 0.0204 0.0512 0.0512
Echinococcus multilocularis transient receptor potential cation channel 0.0204 0.0512 0.0512
Brugia malayi hypothetical protein 0.0091 0.0186 0.0186
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0046 0.0058 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.012 0.027 0.027
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.3339 0.9569 0.9569
Onchocerca volvulus 0.0091 0.0186 0.1142
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0046 0.0058 0.0887
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0149 0.0355 0.6841
Echinococcus granulosus potassium large conductance calcium activated 0.0204 0.0512 0.0512
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.0186 0.0186
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0204 0.0512 0.0512
Echinococcus granulosus potassium voltage gated channel protein 0.0353 0.0943 0.0943
Echinococcus multilocularis somatostatin receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Brugia malayi Dopamine receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis potassium voltage gated channel protein 0.0353 0.0943 0.0943
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0204 0.0512 0.0512
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.0186 0.0186
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0222 0.0567 0.0567
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0031 0.0013 0.0013
Echinococcus granulosus two pore calcium channel protein 2 0.0204 0.0512 0.0512
Onchocerca volvulus Neuropeptide F receptor homolog 0.0091 0.0186 0.1142
Echinococcus granulosus transient receptor potential cation channel 0.0204 0.0512 0.0512
Onchocerca volvulus Putative nachr subunit 0.0364 0.0975 0.5973
Schistosoma mansoni nAChR subunit 0.0222 0.0567 0.0567
Onchocerca volvulus 0.0046 0.0058 0.0353
Echinococcus granulosus potassium voltage gated channel protein 0.0204 0.0512 0.0512
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0103 0.0221 0.0221
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0204 0.0512 0.0512
Echinococcus granulosus 7TM GPCR rhodopsin 0.0091 0.0186 0.0186
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0813 0.2273 0.2273
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0046 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.0186 0.0186
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.012 0.027 0.027
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0204 0.0512 0.0512
Brugia malayi hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0046 0.0058 0.0058
Brugia malayi Transient-receptor-potential like protein 0.0204 0.0512 0.0512
Schistosoma mansoni hypothetical protein 0.016 0.0386 0.0386
Brugia malayi G-protein coupled receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0091 0.0186 0.0186
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0222 0.0567 0.0567
Trypanosoma brucei btb/poz domain containing protein, putative 0.0149 0.0355 0.6841
Brugia malayi cation channel family protein 0.0204 0.0512 0.0512
Brugia malayi K+ channel tetramerisation domain containing protein 0.0149 0.0355 0.0355
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0149 0.0355 0.0355
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0204 0.0512 0.0512
Echinococcus multilocularis sodium and chloride dependent glycine 0.0046 0.0058 0.0058
Echinococcus granulosus sodium leak channel non selective protein 0.0204 0.0512 0.0512
Echinococcus multilocularis G-protein coupled receptor, putative 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0285 0.0747 0.0747
Echinococcus multilocularis transient receptor potential cation channel 0.0204 0.0512 0.0512
Echinococcus granulosus hyperpolarization activated cyclic 0.0204 0.0512 0.0512
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0013 0.0013
Echinococcus granulosus voltage gated potassium channel 0.0353 0.0943 0.0943
Schistosoma mansoni opsin-like receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Echinococcus granulosus neuropeptide s receptor 0.0091 0.0186 0.0186
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0013 0.0013
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0272 0.071 0.071
Echinococcus granulosus voltage dependent calcium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0159 0.0383 0.0383
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0364 0.0975 0.0975
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0046 0.0058 0.0058
Schistosoma mansoni voltage-gated potassium channel 0.0353 0.0943 0.0943
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0345 0.0921 0.0921
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) TWK-7 protein 0.0031 0.0013 0.0013
Brugia malayi larval opioid receptor 0.0091 0.0186 0.0186
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0204 0.0512 0.0512
Schistosoma mansoni acetylcholine receptor subunit beta 0.0103 0.0221 0.0221
Loa Loa (eye worm) solute carrier family 6 member 4 0.0272 0.071 0.071
Schistosoma mansoni growth hormone secretagogue receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus granulosus short transient receptor potential channel 6 0.0204 0.0512 0.0512
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.0149 0.0355 1
Brugia malayi ion channel NompC 0.0204 0.0512 0.0512
Echinococcus multilocularis transient receptor potential gamma protein 0.0204 0.0512 0.0512
Echinococcus granulosus shaker cognate 0.0353 0.0943 0.0943
Echinococcus multilocularis serotonin receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0355 0.6841
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) voltage-gated potassium channel 0.0353 0.0943 0.0943
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0512 0.0512
Echinococcus multilocularis fmrfamide receptor 0.0091 0.0186 0.0186
Echinococcus granulosus two pore calcium channel protein 1 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus granulosus voltage dependent calcium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0091 0.0186 0.0186
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0186 0.0186
Loa Loa (eye worm) voltage-gated potassium channel 0.0204 0.0512 0.0512
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0204 0.0512 0.0512
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0149 0.0355 0.2173
Brugia malayi latrophilin 2 splice variant baaae 0.0345 0.0921 0.0921
Brugia malayi sulfakinin receptor protein 0.0091 0.0186 0.0186
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0204 0.0512 0.0512
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0091 0.0186 0.0186
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0031 0.0013 0.0013
Schistosoma mansoni calcium-activated potassium channel 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0204 0.0512 0.0512
Brugia malayi A-macroglobulin complement component family protein 0.0034 0.0023 0.0023
Echinococcus granulosus peptide allatostatin:somatostatin 0.0091 0.0186 0.0186
Echinococcus multilocularis cd109 antigen 0.0032 0.0016 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0225 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0149 0.0355 0.0355
Onchocerca volvulus 0.0091 0.0186 0.1142
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0222 0.0567 0.0567
Brugia malayi hypothetical protein 0.0031 0.0013 0.0013
Echinococcus multilocularis orexin receptor type 2 0.0091 0.0186 0.0186
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0204 0.0512 0.0512
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0353 0.0943 0.0943
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0031 0.0013 0.0013
Trypanosoma brucei potassium voltage-gated channel, putative 0.0149 0.0355 0.6841
Schistosoma mansoni biogenic amine receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0364 0.0975 0.0975
Brugia malayi G protein-coupled receptor F59B2.13 0.0091 0.0186 0.0186
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.1144 0.323 1
Schistosoma mansoni nAChR subunit 0.0222 0.0567 0.0567
Echinococcus granulosus neuropeptide FF receptor 2 0.0091 0.0186 0.0186
Echinococcus granulosus allatostatin A receptor 0.0091 0.0186 0.0186
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.012 0.027 0.027
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0222 0.0567 0.3471
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) 0.1144 0.323 0.5
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.1289 0.3646 0.3646
Echinococcus granulosus transient receptor potential cation channel 0.0204 0.0512 0.0512
Schistosoma mansoni voltage-gated ion channel 0.0204 0.0512 0.0512
Schistosoma mansoni neurotransmitter gated ion channel 0.012 0.027 0.027
Onchocerca volvulus 0.0031 0.0013 0.0081
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0512 0.0512
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0149 0.0355 0.6841
Loa Loa (eye worm) hypothetical protein 0.0046 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Schistosoma mansoni myosin xvIII 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Echinococcus multilocularis calcium activated potassium channel variant 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Echinococcus granulosus tachykinin peptides receptor 99D 0.0091 0.0186 0.0186
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0353 0.0943 0.0943
Schistosoma mansoni neuropeptide receptor 0.0091 0.0186 0.0186
Brugia malayi putative neuropeptide receptor NPR1 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0222 0.0567 0.0567
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0222 0.0567 0.0567
Schistosoma mansoni amine GPCR 0.0091 0.0186 0.0186
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0204 0.0512 0.0512
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0091 0.0186 0.0186
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0204 0.0512 0.0512
Brugia malayi Melatonin receptor type 1A 0.0091 0.0186 0.0186
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0353 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0317 0.0841 0.0841
Echinococcus multilocularis fmrfamide receptor 0.0091 0.0186 0.0186
Echinococcus multilocularis two pore calcium channel protein 1 0.0204 0.0512 0.0512
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0204 0.0512 0.0512
Schistosoma mansoni voltage-dependent calcium channel 0.0204 0.0512 0.0512
Brugia malayi hypothetical protein 0.0103 0.0221 0.0221
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0505 0.1383 0.1383
Schistosoma mansoni alpha-1 adrenergic receptor 0.0091 0.0186 0.0186
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Schistosoma mansoni voltage-gated cation channel 0.0204 0.0512 0.0512
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0046 0.0058 0.0058
Onchocerca volvulus 0.0149 0.0355 0.2173
Plasmodium vivax amine transporter, putative 0.0046 0.0058 0.1297
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0204 0.0512 0.0512
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0091 0.0186 0.0186
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0103 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Schistosoma mansoni sodium/chloride dependent transporter 0.0046 0.0058 0.0058
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0031 0.0013 0.0013
Echinococcus granulosus voltage gated potassium channel 0.0204 0.0512 0.0512
Brugia malayi hypothetical protein 0.0091 0.0186 0.0186
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0031 0.0013 0.0013
Echinococcus granulosus glycine receptor subunit alpha 1 0.0222 0.0567 0.0567
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0468 0.1275 0.1275
Onchocerca volvulus 0.0031 0.0013 0.0081
Brugia malayi Latrophilin receptor protein 2 0.016 0.0386 0.0386
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.1144 0.323 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0204 0.0512 0.0512
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0353 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0364 0.0975 0.0975
Brugia malayi Angiotensin-converting enzyme family protein 0.0159 0.0383 0.0383
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0353 0.0943 0.0943
Onchocerca volvulus 0.0031 0.0013 0.0081
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0031 0.0013 0.0013
Schistosoma mansoni amine GPCR 0.0091 0.0186 0.0186
Echinococcus multilocularis serotonin receptor 0.0091 0.0186 0.0186
Echinococcus granulosus potassium voltage gated channel subfamily A 0.3488 1 1
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0204 0.0512 0.0512
Loa Loa (eye worm) serotonin transporter b 0.0272 0.071 0.071
Loa Loa (eye worm) hypothetical protein 0.0103 0.0221 0.0221
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0031 0.0013 0.0013
Echinococcus granulosus GPCR family 2 0.016 0.0386 0.0386
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0103 0.0221 0.0221
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.0186 0.0186
Leishmania major potassium voltage-gated channel, putative 0.0149 0.0355 0.094
Onchocerca volvulus 0.0091 0.0186 0.1142
Brugia malayi hypothetical protein 0.0091 0.0186 0.0186
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0149 0.0355 0.0355
Echinococcus granulosus dro:myosuppressin receptor 0.0091 0.0186 0.0186
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0353 0.0943 0.0943
Schistosoma mansoni edp1-related 0.0149 0.0355 0.0355
Brugia malayi Cyclic-nucleotide gated cation channel 0.0204 0.0512 0.0512
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.0186 0.0186
Schistosoma mansoni calcium-activated potassium channel 0.0858 0.2404 0.2404
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0222 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0186 0.0186
Onchocerca volvulus 0.0046 0.0058 0.0353
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0512 0.0512
Schistosoma mansoni sodium-dependent amino acid transporter 0.0046 0.0058 0.0058
Trypanosoma brucei btb/poz domain containing protein, putative 0.0149 0.0355 0.6841
Toxoplasma gondii hypothetical protein 0.0046 0.0058 0.0887
Echinococcus multilocularis alpha 2 macroglobulin 0.0034 0.0023 0.0023
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0204 0.0512 1
Echinococcus granulosus hypothetical protein 0.0091 0.0186 0.0186
Schistosoma mansoni amine GPCR 0.0091 0.0186 0.0186
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0149 0.0355 0.0355
Echinococcus multilocularis neuropeptide FF receptor 2 0.0091 0.0186 0.0186
Echinococcus multilocularis transient receptor potential cation channel 0.0204 0.0512 0.0512
Toxoplasma gondii hypothetical protein 0.0046 0.0058 0.0887
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0031 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Leishmania major hypothetical protein, conserved 0.0149 0.0355 0.094
Giardia lamblia Hypothetical protein 0.0031 0.0013 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0186 0.0186
Schistosoma mansoni neuropeptide f receptor 76f 0.0091 0.0186 0.0186
Brugia malayi AKH receptor 0.0091 0.0186 0.0186
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.0186 0.0186
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0186 0.0186
Echinococcus granulosus nAChR subunit 0.012 0.027 0.027
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0204 0.0512 0.3138
Echinococcus granulosus potassium channel subfamily K 0.0031 0.0013 0.0013
Onchocerca volvulus 0.0031 0.0013 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0204 0.0512 0.3138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.012 0.027 0.027
Trypanosoma brucei btb/poz domain containing protein, putative 0.0149 0.0355 0.6841
Loa Loa (eye worm) hypothetical protein 0.0046 0.0058 0.0058
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0091 0.0186 0.0186
Schistosoma mansoni neuropeptide receptor 0.1365 0.3866 0.3866
Schistosoma mansoni biogenic amine receptor 0.0091 0.0186 0.0186
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0031 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel protein 0.0353 0.0943 0.0943
Schistosoma mansoni hypothetical protein 0.016 0.0386 0.0386
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0149 0.0355 0.0355
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0046 0.0058 0.0058
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0046 0.0058 0.0058
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0091 0.0186 0.0186
Brugia malayi Cation transporter family protein 0.0362 0.0969 0.0969
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0222 0.0567 0.0567
Loa Loa (eye worm) ACC-1 protein 0.0222 0.0567 0.0567
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0186 0.0186
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.0186 0.0186
Toxoplasma gondii hypothetical protein 0.0204 0.0512 1
Echinococcus multilocularis shaker cognate 0.0353 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.012 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0222 0.0567 0.0567
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0149 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0204 0.0512 0.0512
Schistosoma mansoni hypothetical protein 0.0345 0.0921 0.0921
Loa Loa (eye worm) hypothetical protein 0.0091 0.0186 0.0186
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0222 0.0567 0.0567
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0091 0.0186 0.1142
Loa Loa (eye worm) calcium channel 0.0204 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0259 0.0673 0.0673
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0204 0.0512 0.0512

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antiparasitic activity against Schistosoma mansoni adult worm assessed as reduction of body contractility and movement at 50 ug/ml ChEMBL. 19596887
Activity (functional) Antiparasitic activity against Schistosoma mansoni adult worm assessed as reduction of body contractility and movement at 5 ug/ml within 7 hrs ChEMBL. 19596887
Activity (functional) Antiparasitic activity against Schistosoma mansoni larva assessed as reduction of body contractility and movement at 50 ug/ml ChEMBL. 19596887
Activity (functional) Antiparasitic activity against Schistosoma mansoni larva assessed as reduction of body contractility and movement at 5 ug/ml ChEMBL. 19596887
Activity (functional) Antiparasitic activity against Schistosoma mansoni adult worm assessed as reduction of body contractility and movement at 5 ug/ml ChEMBL. 19596887

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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