TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 449.345 | Formula: C19H25BrN6O2
H donors: 3 H acceptors: 5 LogP: 2.35 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OCCN(c1nc(NCc2ccc(cc2)Br)c2c(n1)n(cn2)C(C)C)CCO
InChi: 1S/C19H25BrN6O2/c1-13(2)26-12-22-16-17(21-11-14-3-5-15(20)6-4-14)23-19(24-18(16)26)25(7-9-27)8-10-28/h3-6,12-13,27-28H,7-11H2,1-2H3,(H,21,23,24)
InChiKey: KXWPJLNSYQKTCM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin E2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0072	0.1437	0.2199
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.0461	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1437	0.3785
Giardia lamblia	Hypothetical protein	0.0021	0.0317	1
Trichomonas vaginalis	cyclins, putative	0.0021	0.0317	0.1508
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0072	0.1437	0.2199
Echinococcus granulosus	dro:myosuppressin receptor	0.0072	0.1437	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1437	0.3785
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1437	0.2199
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0016	0.0205	0.0975
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0016	0.0205	0.0975
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0072	0.1424	0.6778
Echinococcus multilocularis	dro:myosuppressin receptor	0.0072	0.1437	0.2199
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1277	0.6079
Brugia malayi	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	neuropeptide receptor	0.0072	0.1437	0.3785
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0072	0.1437	1
Onchocerca volvulus		0.0072	0.1437	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Brugia malayi	Carboxylesterase family protein	0.0035	0.0622	0.296
Echinococcus granulosus	cyclins	0.0021	0.0317	0.2204
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0072	0.1424	0.375
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1437	1
Brugia malayi	Dopamine receptor protein 2	0.0072	0.1437	0.6841
Onchocerca volvulus		0.0072	0.1437	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0021	0.0317	0.1508
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0072	0.1424	0.6778
Loa Loa (eye worm)	melatonin receptor type 1A	0.0072	0.1437	0.6841
Trypanosoma brucei	mitotic cyclin 6	0.0021	0.0317	0.2225
Brugia malayi	G-protein coupled receptor	0.0072	0.1437	0.6841
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0072	0.1437	0.3785
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0072	0.1437	0.2199
Loa Loa (eye worm)	G-protein coupled receptor	0.0072	0.1437	0.6841
Onchocerca volvulus		0.0072	0.1437	1
Loa Loa (eye worm)	TYRA-2 protein	0.0072	0.1437	0.6841
Brugia malayi	G-protein coupled receptor	0.0072	0.1437	0.6841
Echinococcus multilocularis	g protein coupled receptor	0.0072	0.1437	0.2199
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Brugia malayi	putative neuropeptide receptor	0.0072	0.1437	0.6841
Giardia lamblia	G2/mitotic-specific cyclin B	0.0021	0.0317	1
Onchocerca volvulus		0.0072	0.1437	1
Echinococcus multilocularis	neuropeptide receptor	0.0072	0.1437	0.2199
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0072	0.1437	0.2199
Schistosoma mansoni	opsin-like receptor	0.0072	0.1437	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0072	0.1437	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0282	0.6047	1
Schistosoma mansoni	biogenic amine receptor	0.0072	0.1437	0.3785
Entamoeba histolytica	cyclin family protein	0.0021	0.0317	1
Echinococcus granulosus	carbonic anhydrase	0.0016	0.0205	0.1425
Schistosoma mansoni	opsin-like receptor	0.0072	0.1437	0.3785
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0317	0.1508
Brugia malayi	glutaminase DH11.1	0.0102	0.2101	1
Mycobacterium tuberculosis	3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS)	0.0179	0.3798	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0072	0.1437	0.3785
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0072	0.1437	0.2199
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0016	0.0205	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1437	0.2199
Brugia malayi	putative neuropeptide receptor NPR1	0.0072	0.1437	0.6841
Echinococcus granulosus	serotonin receptor	0.0072	0.1437	1
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0021	0.0317	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus granulosus	single minded 2	0.0014	0.0161	0.1119
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0021	0.0317	0.1508
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.0461	1	1
Schistosoma mansoni	neuropeptide receptor	0.0072	0.1437	0.3785
Trypanosoma brucei	carbonic anhydrase-like protein	0.0072	0.1424	1
Onchocerca volvulus		0.0072	0.1437	1
Trichomonas vaginalis	cyclin B3, putative	0.0021	0.0317	0.1508
Echinococcus granulosus	g protein coupled receptor	0.0072	0.1437	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0072	0.1437	1
Echinococcus granulosus	acetylcholinesterase	0.0035	0.0622	0.4327
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0072	0.1424	0.6778
Brugia malayi	hypoxia-induced factor 1	0.006	0.1166	0.5551
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0072	0.1437	0.2199
Schistosoma mansoni	hypothetical protein	0.0072	0.1437	0.3785
Entamoeba histolytica	cyclin, putative	0.0021	0.0317	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0072	0.1437	0.2199
Echinococcus granulosus	cyclins	0.0021	0.0317	0.2204
Brugia malayi	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	neuropeptide F-like receptor	0.0072	0.1437	0.3785
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0072	0.1437	0.6841
Schistosoma mansoni	adenoreceptor	0.0072	0.1437	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Loa Loa (eye worm)	carboxylesterase	0.0035	0.0622	0.296
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0205	0.0975
Echinococcus multilocularis	carbonic anhydrase II	0.0072	0.1424	0.2178
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus multilocularis	g protein coupled receptor	0.0072	0.1437	0.2199
Onchocerca volvulus		0.0072	0.1437	1
Echinococcus granulosus	neuropeptide receptor A26	0.0072	0.1437	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0016	0.0205	0.0975
Trichomonas vaginalis	cyclin D, putative	0.0021	0.0317	0.1508
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0072	0.1437	1
Echinococcus multilocularis	carboxylesterase 5A	0.0035	0.0622	0.0951
Echinococcus multilocularis	allatostatin A receptor	0.0072	0.1437	0.2199
Brugia malayi	Carboxylesterase family protein	0.0035	0.0622	0.296
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0072	0.1437	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0072	0.1437	0.2199
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1437	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Onchocerca volvulus		0.0072	0.1437	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Toxoplasma gondii	hypothetical protein	0.0016	0.0203	0.0203
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0072	0.1424	1
Schistosoma mansoni	biogenic amine receptor	0.0072	0.1437	0.3785
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0072	0.1437	0.3785
Brugia malayi	follicle stimulating hormone receptor	0.0072	0.1437	0.6841
Schistosoma mansoni	hypothetical protein	0.0072	0.1437	0.3785
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0023	0.0348	0.2423
Mycobacterium ulcerans	3-dehydroquinate synthase	0.0179	0.3798	0.3798
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0072	0.1437	0.6841
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0072	0.1437	0.3785
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1437	0.3785
Echinococcus granulosus	carbonic anhydrase	0.0016	0.0205	0.1425
Echinococcus granulosus	hypothetical protein	0.0072	0.1437	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0072	0.1437	0.2199
Schistosoma mansoni	carbonic anhydrase-related	0.0016	0.0205	0.0539
Echinococcus granulosus	g-protein coupled receptor	0.0072	0.1437	1
Echinococcus granulosus	cyclins	0.0021	0.0317	0.2204
Echinococcus granulosus	neuropeptide Y receptor	0.0072	0.1437	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1437	0.3785
Onchocerca volvulus		0.0072	0.1437	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1437	1
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0021	0.0317	0.2225
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0021	0.0314	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0072	0.1437	0.3785
Echinococcus multilocularis	cyclins	0.0021	0.0317	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Brugia malayi	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus multilocularis	neuropeptide Y receptor	0.0072	0.1437	0.2199
Leishmania major	cyclin	0.0021	0.0317	0.2225
Brugia malayi	neuropeptide F receptor	0.0072	0.1437	0.6841
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1437	1
Echinococcus multilocularis	somatostatin receptor	0.0072	0.1437	0.2199
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0072	0.1437	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0205	0.0975
Echinococcus multilocularis	fmrfamide receptor	0.0072	0.1437	0.2199
Brugia malayi	Melatonin receptor type 1A	0.0072	0.1437	0.6841
Trichomonas vaginalis	glutaminase, putative	0.0102	0.2101	1
Echinococcus multilocularis	sex peptide receptor	0.0072	0.1437	0.2199
Echinococcus granulosus	neuropeptide s receptor	0.0072	0.1437	1
Trichomonas vaginalis	cyclin B, putative	0.0021	0.0317	0.1508
Trichomonas vaginalis	cyclin D, putative	0.0021	0.0317	0.1508
Loa Loa (eye worm)	carbonic anhydrase 3	0.0072	0.1424	0.6778
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0072	0.1437	0.3785
Echinococcus multilocularis	neuropeptides capa receptor	0.0072	0.1437	0.2199
Loa Loa (eye worm)	G-protein coupled receptor	0.0072	0.1437	0.6841
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0072	0.1437	0.3785
Echinococcus granulosus	cyclin B3 1	0.0021	0.0317	0.2204
Echinococcus multilocularis	carbonic anhydrase	0.0016	0.0205	0.0313
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0282	0.6047	0.6047
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus granulosus	neuropeptides capa receptor	0.0072	0.1437	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0072	0.1437	0.6841
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0072	0.1437	1
Schistosoma mansoni	amine GPCR	0.0072	0.1437	0.3785
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0072	0.1437	1
Echinococcus multilocularis	g-protein coupled receptor	0.0072	0.1437	0.2199
Schistosoma mansoni	cyclin B	0.0021	0.0317	0.0834
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0072	0.1437	0.2199
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0072	0.1437	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0035	0.0622	0.1638
Echinococcus multilocularis	neuropeptide Y receptor	0.0072	0.1437	0.2199
Trichomonas vaginalis	cyclin B, putative	0.0021	0.0317	0.1508
Brugia malayi	ORL1-like opioid receptor	0.0072	0.1437	0.6841
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0072	0.1437	0.6841
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	amine GPCR	0.0072	0.1437	0.3785
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0072	0.1437	1
Trichomonas vaginalis	cyclins, putative	0.0021	0.0317	0.1508
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0072	0.1424	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0072	0.1437	0.6841
Echinococcus granulosus	carbonic anhydrase	0.0016	0.0205	0.1425
Echinococcus multilocularis	neuropeptide receptor	0.0072	0.1437	0.2199
Echinococcus granulosus	allatostatin A receptor	0.0072	0.1437	1
Toxoplasma gondii	hypothetical protein	0.0016	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	amine GPCR	0.0072	0.1437	0.3785
Echinococcus granulosus	g protein coupled receptor	0.0072	0.1437	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Entamoeba histolytica	cyclin family protein	0.0021	0.0317	1
Brugia malayi	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus multilocularis	transfer RNA-Lys	0.0014	0.0161	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Onchocerca volvulus		0.0072	0.1437	1
Echinococcus multilocularis	carbonic anhydrase	0.0016	0.0205	0.0313
Echinococcus multilocularis	cyclins	0.0021	0.0317	0.0485
Echinococcus multilocularis	cyclins	0.0021	0.0317	0.0485
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0023	0.0348	0.0917
Schistosoma mansoni	single-minded	0.0019	0.0272	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus granulosus	tm gpcr rhodopsin	0.0072	0.1437	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0304	0.6537	1
Schistosoma mansoni	opsin-like receptor	0.0072	0.1437	0.3785
Echinococcus granulosus	tm gpcr rhodopsin	0.0072	0.1437	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Brugia malayi	PAS domain containing protein	0.0019	0.0272	0.1293
Echinococcus granulosus	neuropeptides capa receptor	0.0072	0.1437	1
Echinococcus multilocularis	orexin receptor type 2	0.0072	0.1437	0.2199
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1437	1
Brugia malayi	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus granulosus	neuropeptide Y receptor	0.0072	0.1437	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0072	0.1437	1
Echinococcus granulosus	carboxylesterase 5A	0.0035	0.0622	0.4327
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1437	0.2199
Echinococcus multilocularis	cyclin b3	0.0021	0.0317	0.0485
Echinococcus granulosus	tm gpcr rhodopsin	0.0072	0.1437	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0072	0.1437	0.2199
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0072	0.1437	0.2199
Brugia malayi	hypothetical protein	0.0072	0.1437	0.6841
Mycobacterium ulcerans	glutaminase	0.0102	0.2101	0.2101
Brugia malayi	neuropeptide F receptor	0.0072	0.1437	0.6841
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	carbonic anhydrase-related	0.0016	0.0205	0.0539
Onchocerca volvulus		0.0072	0.1437	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0072	0.1437	0.6841
Brugia malayi	RE15519p	0.0072	0.1437	0.6841
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1437	1
Schistosoma mansoni	hypothetical protein	0.0072	0.1437	0.3785
Plasmodium falciparum	carbonic anhydrase	0.0016	0.0205	0.6465
Echinococcus granulosus	cyclin b3	0.0021	0.0317	0.2204
Echinococcus granulosus	acetylcholinesterase	0.0035	0.0622	0.4327
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0072	0.1437	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0072	0.1437	0.2199
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0072	0.1437	0.3785
Mycobacterium tuberculosis	3-dehydroquinate synthase AroB	0.0179	0.3798	1
Loa Loa (eye worm)	glutaminase	0.0102	0.2101	1
Chlamydia trachomatis	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0282	0.6047	0.3627
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0072	0.1437	0.6841
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1437	0.3785
Brugia malayi	Dopamine receptor	0.0072	0.1437	0.6841
Echinococcus multilocularis	cyclins	0.0021	0.0317	0.0485
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0072	0.1437	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0072	0.1437	0.6841
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0072	0.1437	0.2199
Trypanosoma cruzi	cyclin, putative	0.0021	0.0317	0.2225
Leishmania major	carbonic anhydrase-like protein	0.0072	0.1424	1
Echinococcus granulosus	neuropeptide receptor	0.0072	0.1437	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1437	0.3785
Echinococcus granulosus	G protein coupled receptor 139	0.0072	0.1437	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0072	0.1437	0.6841
Trichomonas vaginalis	cyclin B, putative	0.0021	0.0317	0.1508
Brugia malayi	bHLH-PAS transcription factor	0.0014	0.0161	0.0765
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0023	0.0348	0.0533
Echinococcus multilocularis	cyclin B	0.0021	0.0317	0.0485
Echinococcus multilocularis	serotonin receptor	0.0072	0.1437	0.2199
Trichomonas vaginalis	cyclins, putative	0.0021	0.0317	0.1508
Trichomonas vaginalis	cyclin B, putative	0.0021	0.0317	0.1508
Echinococcus granulosus	neuropeptide receptor	0.0072	0.1437	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1437	0.2199
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Brugia malayi	Dopamine receptor protein 1	0.0072	0.1437	0.6841
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Loa Loa (eye worm)	cyclin domain-containing protein	0.0021	0.0317	0.1508
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0021	0.0317	0.2204
Schistosoma mansoni	myosin xvIII	0.0072	0.1437	0.3785
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0023	0.0348	0.2446
Onchocerca volvulus		0.0072	0.1437	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0205	0.0539
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0072	0.1437	1
Echinococcus multilocularis	cyclins	0.0021	0.0317	0.0485
Onchocerca volvulus		0.0072	0.1437	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1437	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Brugia malayi	sulfakinin receptor protein	0.0072	0.1437	0.6841
Entamoeba histolytica	cyclin, putative	0.0021	0.0317	1
Brugia malayi	AKH receptor	0.0072	0.1437	0.6841
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus multilocularis	g protein coupled receptor	0.0072	0.1437	0.2199
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0021	0.0317	0.1508
Brugia malayi	Serotonin receptor	0.0072	0.1437	0.6841
Echinococcus granulosus	somatostatin receptor	0.0072	0.1437	1
Schistosoma mansoni	neuropeptide receptor	0.0072	0.1437	0.3785
Brugia malayi	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	aryl hydrocarbon receptor	0.0019	0.0272	0.0715
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0072	0.1437	0.2199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1437	0.2199
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Onchocerca volvulus		0.0072	0.1437	1
Brugia malayi	GnHR receptor homolog	0.0072	0.1437	0.6841
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0072	0.1437	0.3785
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0016	0.0205	0.0975
Echinococcus multilocularis	cyclins	0.0021	0.0317	0.0485
Schistosoma mansoni	cyclin B3	0.0021	0.0317	0.0834
Trichomonas vaginalis	cyclins, putative	0.0021	0.0317	0.1508
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0021	0.0317	0.2225
Echinococcus multilocularis	acetylcholinesterase	0.0035	0.0622	0.0951
Loa Loa (eye worm)	hypoxia-induced factor 1	0.006	0.1166	0.5551
Brugia malayi	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1437	0.2199
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1437	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0072	0.1437	1
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0023	0.0348	0.1658
Onchocerca volvulus		0.0021	0.0317	0.1222
Echinococcus multilocularis	acetylcholinesterase	0.0035	0.0622	0.0951
Loa Loa (eye worm)	acetylcholinesterase 1	0.0035	0.0622	0.296
Schistosoma mansoni	cyclins	0.0021	0.0317	0.0834
Echinococcus granulosus	biogenic amine 5HT receptor	0.0072	0.1437	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0072	0.1437	0.2199
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0072	0.1437	0.3785
Loa Loa (eye worm)	glutaminase 2	0.0102	0.2101	1
Echinococcus multilocularis	serotonin receptor	0.0072	0.1437	0.2199
Onchocerca volvulus		0.0072	0.1437	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0622	0.296
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0023	0.0348	0.0348
Schistosoma mansoni	growth hormone secretagogue receptor	0.0072	0.1437	0.3785
Echinococcus multilocularis	carbonic anhydrase	0.0016	0.0205	0.0313
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0072	0.1437	0.3785
Echinococcus granulosus	cyclins	0.0021	0.0317	0.2204
Brugia malayi	hypothetical protein	0.0072	0.1437	0.6841
Mycobacterium ulcerans	putative regulatory protein	0.0014	0.0161	0.0161
Echinococcus multilocularis	neuropeptide s receptor	0.0072	0.1437	0.2199
Echinococcus granulosus	fmrfamide receptor	0.0072	0.1437	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	carbonic anhydrase	0.0016	0.0205	0.0539
Brugia malayi	Serotonin receptor	0.0072	0.1437	0.6841
Plasmodium falciparum	cyclin	0.0021	0.0317	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0205	0.0975
Echinococcus granulosus	cyclins	0.0021	0.0317	0.2204
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus granulosus	cyclin B	0.0021	0.0317	0.2204
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0023	0.0348	0.0917
Schistosoma mansoni	glutaminase	0.0102	0.2101	0.5532
Trichomonas vaginalis	cyclins, putative	0.0021	0.0317	0.1508
Echinococcus granulosus	7TM GPCR rhodopsin	0.0072	0.1437	1
Schistosoma mansoni	amine GPCR	0.0072	0.1437	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0072	0.1424	0.375
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0273	0.1299
Echinococcus granulosus	orexin receptor type 2	0.0072	0.1437	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0072	0.1437	0.6841
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0072	0.1437	0.3785
Echinococcus granulosus	g protein coupled receptor	0.0072	0.1437	1
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.0461	1	1
Brugia malayi	hypothetical protein	0.0072	0.1437	0.6841
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0317	0.1508
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0016	0.0205	0.0975
Trichomonas vaginalis	cyclin A, putative	0.0021	0.0317	0.1508
Brugia malayi	G protein-coupled receptor	0.0072	0.1437	0.6841
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0072	0.1437	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0072	0.1437	1
Brugia malayi	hypothetical protein	0.0065	0.1277	0.6079
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Onchocerca volvulus		0.0072	0.1437	1
Trypanosoma cruzi	cyclin, putative	0.0021	0.0317	0.2225
Echinococcus granulosus	carbonic anhydrase II	0.0072	0.1424	0.9907
Schistosoma mansoni	hypothetical protein	0.0072	0.1437	0.3785
Echinococcus granulosus	rhodopsin orphan GPCR	0.0072	0.1437	1
Onchocerca volvulus		0.0072	0.1437	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1437	0.2199
Schistosoma mansoni	neuropeptide f receptor 76f	0.0072	0.1437	0.3785
Trichomonas vaginalis	cyclin B, putative	0.0021	0.0317	0.1508
Loa Loa (eye worm)	neuropeptide F receptor	0.0072	0.1437	0.6841
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0273	0.1299
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0072	0.1437	0.2199
Schistosoma mansoni	amine GPCR	0.0072	0.1437	0.3785
Onchocerca volvulus		0.0072	0.1437	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0072	0.1437	0.6841
Schistosoma mansoni	histamine h1 receptor	0.0072	0.1437	0.3785
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0622	0.296
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0072	0.1437	0.3785
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0023	0.0348	0.0348
Echinococcus multilocularis	cyclins	0.0021	0.0317	0.0485
Schistosoma mansoni	neuropeptide receptor	0.0072	0.1437	0.3785
Giardia lamblia	Cyclin A	0.0021	0.0317	1
Echinococcus multilocularis	fmrfamide receptor	0.0072	0.1437	0.2199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0072	0.1437	0.2199
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.0282	0.6047	1
Trypanosoma cruzi	cyclin 6, putative	0.0021	0.0317	0.2225
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0072	0.1437	0.2199
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Schistosoma mansoni	3-dehydroquinate synthase	0.0179	0.3798	1
Brugia malayi	larval opioid receptor	0.0072	0.1437	0.6841
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0072	0.1437	0.6841
Schistosoma mansoni	carbonic anhydrase-related	0.0016	0.0205	0.0539
Schistosoma mansoni	biogenic amine receptor	0.0072	0.1437	0.3785
Echinococcus granulosus	sex peptide receptor	0.0072	0.1437	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0317	0.1508
Echinococcus multilocularis	cyclin B3 1	0.0021	0.0317	0.0485
Schistosoma mansoni	neuropeptide F-like receptor	0.0072	0.1437	0.3785
Loa Loa (eye worm)	neuropeptide F receptor	0.0072	0.1437	0.6841
Echinococcus granulosus	biogenic amine 5HT receptor	0.0072	0.1437	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1437	0.6841
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0072	0.1437	0.2199

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2 uM	Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E	ChEMBL.	No reference
IC50 (binding)	= 2 uM	Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 149230