Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glycine transporter 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0571 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0571 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0571 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0571 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0096 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0571 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0096 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0096 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0096 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0571 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0096 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0571 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0571 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0571 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0096 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0571 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.