Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.326 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.326 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.326 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.326 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1817 | 0.5574 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1817 | 0.1817 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.3 | 0.3 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1817 | 0.1817 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.3 | 0.9202 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.326 | 0.326 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1817 | 0.1817 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.2207 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.326 | 0.1763 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1817 | 0.1116 |
Brugia malayi | hypothetical protein | 0.0051 | 0.2207 | 0.154 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.326 | 0.2683 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.326 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.3 | 0.3 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.326 | 0.1763 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.326 | 0.326 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.3 | 0.9202 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.2207 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1817 | 0.5574 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1817 | 0.1817 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.3 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.3 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2207 | 0.0476 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.3 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.326 | 0.2683 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.2207 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.3 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.326 | 0.2683 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.3 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1817 | 0.5574 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.326 | 0.1763 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.3 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.2207 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.2207 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.2207 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.