Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Homo sapiens | v-ets avian erythroblastosis virus E26 oncogene homolog | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Brugia malayi | Fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Schistosoma mansoni | ets-related | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Schistosoma japonicum | ko:K09435 transcriptional regulator ERG, putative | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Loa Loa (eye worm) | fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0069 | 0.0268 |
Onchocerca volvulus | 0.006 | 0.0069 | 0.0069 | |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.4315 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0874 | 1 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0087 | 0.0407 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0874 | 1 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.4315 | 0.454 |
Schistosoma mansoni | ets-related | 0.0265 | 0.2578 | 1 |
Brugia malayi | Fli-1 protein | 0.0265 | 0.2578 | 0.2578 |
Loa Loa (eye worm) | fli-1 protein | 0.0265 | 0.2578 | 0.2578 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0252 | 0.0252 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.0407 | 0.0407 |
Schistosoma mansoni | gabp alpha | 0.0087 | 0.0407 | 0.1579 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0087 | 0.0407 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0087 | 0.0407 | 0.0407 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0834 | 0.9504 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.0407 | 0.0407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.