Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0144 | 0.1254 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0144 | 0.1254 | 0.1254 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0079 | 0.0079 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0144 | 0.1254 | 0.1254 |
Echinococcus multilocularis | neuroligin | 0.0144 | 0.1254 | 0.1254 |
Onchocerca volvulus | 0.0144 | 0.1254 | 0.5 | |
Onchocerca volvulus | 0.0144 | 0.1254 | 0.5 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0144 | 0.1254 | 0.1254 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1254 | 0.1254 |
Echinococcus multilocularis | acetylcholinesterase | 0.0855 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0144 | 0.1254 | 0.1254 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 0.1254 | 0.1254 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1254 | 0.1254 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0144 | 0.1254 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0144 | 0.1254 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.0895 | 0.0895 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.037 | 0.037 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0144 | 0.1254 | 0.1254 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0855 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0855 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 0.1254 | 0.1254 |
Brugia malayi | Carboxylesterase family protein | 0.0855 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0079 | 0.0079 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.0603 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1254 | 0.1254 |
Schistosoma mansoni | gliotactin | 0.0144 | 0.1254 | 0.1254 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1254 | 0.1254 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0144 | 0.1254 | 0.1254 |
Onchocerca volvulus | 0.0144 | 0.1254 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0144 | 0.1254 | 0.1254 |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 0.1254 | 0.1254 |
Echinococcus granulosus | acetylcholinesterase | 0.0855 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0855 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0144 | 0.1254 | 0.1254 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0144 | 0.1254 | 0.1254 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0855 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0144 | 0.1254 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0144 | 0.1254 | 0.1254 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.0895 | 0.0895 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1254 | 0.1254 |
Echinococcus granulosus | acetylcholinesterase | 0.0855 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0218 | 0.0218 |
Onchocerca volvulus | 0.0144 | 0.1254 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0144 | 0.1254 | 0.1254 |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 0.1254 | 0.1254 |
Loa Loa (eye worm) | carboxylesterase | 0.0855 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0144 | 0.1254 | 0.1254 |
Onchocerca volvulus | 0.0144 | 0.1254 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0144 | 0.1254 | 0.1254 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.0895 | 0.0895 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0144 | 0.1254 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0144 | 0.1254 | 0.1254 |
Loa Loa (eye worm) | carboxylesterase | 0.0144 | 0.1254 | 0.1254 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1254 | 0.1254 |
Echinococcus granulosus | neuroligin | 0.0144 | 0.1254 | 0.1254 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0144 | 0.1254 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0855 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1254 | 0.1254 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.