TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 528.983 | Formula: C30H25ClN2O5
H donors: 0 H acceptors: 4 LogP: 7.16 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)c1c(C(=O)COC(=O)c2ccc(cc2)[N+](=O)[O-])n2c(c1c1ccccc1)CC(C2)(C)C
InChi: 1S/C30H25ClN2O5/c1-30(2)16-24-26(19-6-4-3-5-7-19)27(20-8-12-22(31)13-9-20)28(32(24)18-30)25(34)17-38-29(35)21-10-14-23(15-11-21)33(36)37/h3-15H,16-18H2,1-2H3
InChiKey: YKRMUGLLMHKHJD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.022	0.128	0.128
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.022	0.128	0.128
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.022	0.128	0.128
Schistosoma mansoni	nuclear receptor	0.0104	0.0569	0.0588
Brugia malayi	hypothetical protein	0.0104	0.0569	0.0569
Brugia malayi	tailless protein	0.0104	0.0569	0.0569
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0028	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0104	0.0569	0.0569
Trichomonas vaginalis	taga, putative	0.0011	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.022	0.128	0.128
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0014	0.0014
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.022	0.128	0.1323
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0104	0.0569	0.0635
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0014	0.0014
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0011	0	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.022	0.128	0.128
Brugia malayi	Nuclear hormone receptor-like 1	0.0116	0.0645	0.0645
Loa Loa (eye worm)	steroid hormone receptor	0.022	0.128	0.128
Schistosoma mansoni	coup transcription factor	0.022	0.128	0.1323
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0104	0.0569	0.0569
Brugia malayi	Nuclear hormone receptor E75	0.0104	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.1642	1	1
Entamoeba histolytica	P-glycoprotein-2, putative	0.0011	0	0.5
Brugia malayi	nuclear receptor NHR-88	0.0104	0.0569	0.0569
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0104	0.0569	0.0588
Schistosoma mansoni	nuclear receptor	0.0104	0.0569	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0104	0.0569	0.0569
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.022	0.128	0.1428
Plasmodium falciparum	multidrug resistance protein 1	0.0011	0	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.022	0.128	0.1323
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0	0.5
Onchocerca volvulus		0.022	0.128	0.128
Schistosoma mansoni	hypothetical protein	0.0047	0.0222	0.023
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0104	0.0569	0.0588
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.0014	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.022	0.128	0.128
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0011	0	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0104	0.0569	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.022	0.128	0.128
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0011	0	0.5
Brugia malayi	nuclear receptor NHR-67	0.0104	0.0569	0.0569
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0028	0.0032
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0	0.5
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0028	0.0032
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0104	0.0569	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0116	0.0645	0.0667
Trichomonas vaginalis	abcb9, putative	0.0011	0	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.022	0.128	0.1428
Plasmodium vivax	multidrug resistance protein 1, putative	0.0011	0	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.022	0.128	0.1428
Brugia malayi	Nuclear hormone receptor-like 1	0.0116	0.0645	0.0645
Trichomonas vaginalis	abcb9, putative	0.0011	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.022	0.128	0.128
Brugia malayi	hypothetical protein	0.023	0.1345	0.1345
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0104	0.0569	0.0588
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0232	0.0232
Echinococcus granulosus	ecdysone induced protein 78C	0.022	0.128	0.1323
Schistosoma mansoni	thyroid hormone receptor	0.022	0.128	0.1323
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.022	0.128	0.1323
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Brugia malayi	Steroid receptor seven-up type 2	0.022	0.128	0.128
Trichomonas vaginalis	ABC transporter, putative	0.0011	0	0.5
Entamoeba histolytica	P-glyco protein 6, putative	0.0011	0	0.5
Schistosoma mansoni	thyroid hormone receptor	0.022	0.128	0.1323
Schistosoma mansoni	hypothetical protein	0.0033	0.0138	0.0142
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.022	0.128	0.1323
Trichomonas vaginalis	ABC transporter, putative	0.0011	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.022	0.128	0.128
Schistosoma mansoni	retinoic acid receptor RXR	0.1589	0.9673	1
Schistosoma mansoni	nuclear hormone receptor	0.0104	0.0569	0.0588
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0028	0.0028
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0222	0.023
Brugia malayi	nuclear hormone receptor	0.022	0.128	0.128
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0014	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0028	0.0028
Loa Loa (eye worm)	DR-78	0.0104	0.0569	0.0569
Brugia malayi	nuclear receptor RXR	0.0116	0.0645	0.0645
Loa Loa (eye worm)	hypothetical protein	0.022	0.128	0.128
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.022	0.128	0.1323
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0014	0.0014
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0028	0.0028
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0014	0.5
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.022	0.128	0.128
Trichomonas vaginalis	abcb9, putative	0.0011	0	0.5
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0104	0.0569	0.0588
Brugia malayi	nuclear hormone receptor	0.0104	0.0569	0.0569
Brugia malayi	hypothetical protein	0.0104	0.0569	0.0569
Onchocerca volvulus		0.0104	0.0569	0.0569
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.022	0.128	0.1323
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0645	0.0645
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.022	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0645	0.0645
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.022	0.128	0.128
Schistosoma mansoni	zinc finger protein	0.0104	0.0569	0.0588
Trichomonas vaginalis	ABC transporter, putative	0.0011	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0645	0.0645
Brugia malayi	nuclear hormone receptor family member odr-7	0.0104	0.0569	0.0569
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0011	0	0.5
Entamoeba histolytica	P-glycoprotein-2	0.0011	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.022	0.128	0.128
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1473	0.8962	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.022	0.128	0.1323
Loa Loa (eye worm)	hypothetical protein	0.022	0.128	0.128
Echinococcus granulosus	FTZ F1 alpha	0.022	0.128	0.1323
Onchocerca volvulus		0.0104	0.0569	0.0569
Entamoeba histolytica	P-glycoprotein-1	0.0011	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.022	0.128	0.128
Brugia malayi	nuclear receptor RXR	0.0104	0.0569	0.0569
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0014	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.022	0.128	0.1428
Entamoeba histolytica	P-glycoprotein 5, putative	0.0011	0	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0232	0.0232
Onchocerca volvulus		0.0047	0.0222	0.0222
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0104	0.0569	0.0569
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.022	0.128	0.128
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0116	0.0645	0.0645
Loa Loa (eye worm)	hypothetical protein	0.023	0.1345	0.1345
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0116	0.0645	0.072
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.022	0.128	0.1323
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0011	0	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.1589	0.9673	1
Schistosoma mansoni	RAR-like nuclear receptor	0.022	0.128	0.1323
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.022	0.128	0.128
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.022	0.128	0.128
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0104	0.0569	0.0635
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.022	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.022	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0116	0.0645	0.0667
Schistosoma mansoni	hypothetical protein	0.0165	0.0945	0.0977
Brugia malayi	steroid hormone receptor	0.022	0.128	0.128
Echinococcus granulosus	GPCR family 2	0.0015	0.0028	0.0029
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0011	0	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.022	0.128	0.1428
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0104	0.0569	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0645	0.0645
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0232	0.0232
Loa Loa (eye worm)	hypothetical protein	0.022	0.128	0.128
Trichomonas vaginalis	ABC transporter, putative	0.0011	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Echinococcus granulosus	geminin	0.0165	0.0945	0.0977
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.022	0.128	0.128
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0104	0.0569	0.0569
Brugia malayi	orphan nuclear receptor NR2E1	0.0104	0.0569	0.0569
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0116	0.0645	0.0667
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0028	0.0029
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.022	0.128	0.128
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Echinococcus multilocularis	geminin	0.0165	0.0945	0.1054
Echinococcus multilocularis	nuclear receptor nhr 48	0.0104	0.0569	0.0635
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0	0.5
Echinococcus granulosus	nuclear receptor nhr 48	0.0104	0.0569	0.0588
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0104	0.0569	0.0588
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor	0.0104	0.0569	0.0569
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0104	0.0569	0.0588
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0014	0.0014
Schistosoma mansoni	hypothetical protein	0.0165	0.0945	0.0977
Brugia malayi	hypothetical protein	0.0116	0.0645	0.0645
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.022	0.128	0.1323
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0	0.5
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.0029
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0104	0.0569	0.0569
Leishmania major	cytochrome p450-like protein	0.0013	0.0014	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.022	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0011	0	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0104	0.0569	0.0588
Entamoeba histolytica	P-glycoprotein-5	0.0011	0	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.022	0.128	0.1428
Brugia malayi	conserved hypotetical protein	0.0104	0.0569	0.0569
Brugia malayi	photoreceptor-specific nuclear receptor	0.022	0.128	0.128
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0028	0.0029
Brugia malayi	hypothetical protein	0.0116	0.0645	0.0645
Echinococcus multilocularis	thyroid hormone receptor alpha	0.022	0.128	0.1428
Entamoeba histolytica	P-glycoprotein-2	0.0011	0	0.5
Brugia malayi	ecdysone receptor	0.0104	0.0569	0.0569
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0011	0	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.1642	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.022	0.128	0.128
Schistosoma mansoni	steroid hormone receptor ad4bp	0.022	0.128	0.1323
Echinococcus granulosus	survival motor neuron protein 1	0.023	0.1345	0.139
Loa Loa (eye worm)	hypothetical protein	0.022	0.128	0.128
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.022	0.128	0.128
Echinococcus multilocularis	survival motor neuron protein 1	0.023	0.1345	0.15
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0014	0.0014
Brugia malayi	nuclear receptor NHR-88	0.022	0.128	0.128
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.022	0.128	0.128
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.022	0.128	0.128
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0222	0.0222
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.022	0.128	0.1323
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0011	0	0.5
Schistosoma mansoni	nuclear receptor nhr-48	0.0104	0.0569	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.022	0.128	0.1323
Schistosoma mansoni	nuclear hormone receptor	0.0104	0.0569	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0645	0.0645
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0011	0	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0011	0	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.022	0.128	0.1428
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0569	0.0569
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0232	0.0232
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0011	0	0.5
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0011	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.022	0.128	0.1428
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.022	0.128	0.1323
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.022	0.128	0.1323
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0028	0.0028

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 4.8 uM	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs	ChEMBL.	21295381
IC50 (functional)	= 7.3 uM	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs	ChEMBL.	21295381
Inhibition (functional)	= 1.8 %	Antiinflammatory activity against xylene-induced ear edema in Kunming mouse assessed as reduction in ear swelling weight at 100 mg, ip administered 2 hrs post challenge measured after 30 mins	ChEMBL.	21295381
Inhibition (functional)	= 6.5 %	Antiinflammatory activity against xylene-induced ear edema in Kunming mouse assessed as reduction in ear swelling thickness at 100 mg, ip administered 2 hrs post challenge measured after 30 mins	ChEMBL.	21295381

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	21295381

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1689582

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1492890