Detailed information for compound 149321

Basic information

Technical information
  • TDR Targets ID: 149321
  • Name: N-(4-methylphenyl)-4-pyridin-4-ylpyrimidin-2- amine
  • MW: 262.309 | Formula: C16H14N4
  • H donors: 1 H acceptors: 3 LogP: 3.03 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Nc1nccc(n1)c1ccncc1
  • InChi: 1S/C16H14N4/c1-12-2-4-14(5-3-12)19-16-18-11-8-15(20-16)13-6-9-17-10-7-13/h2-11H,1H3,(H,18,19,20)
  • InChiKey: ZWYSAOHUBQJWCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(p-tolyl)-4-(4-pyridyl)pyrimidin-2-amine
  • N-(p-tolyl)-4-(4-pyridyl)-2-pyrimidinamine
  • N-(4-methylphenyl)-4-pyridin-4-yl-pyrimidin-2-amine
  • p-tolyl-[4-(4-pyridyl)pyrimidin-2-yl]amine
  • N-(4-methylphenyl)-4-(4-pyridyl)pyrimidin-2-amine
  • N-(4-methylphenyl)-4-(4-pyridyl)-2-pyrimidinamine
  • (4-methylphenyl)-[4-(4-pyridyl)pyrimidin-2-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cell adhesion molecule 0.0072 0.0047 0.0047
Schistosoma mansoni pyruvate carboxylase 0.1659 0.3735 0.3735
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0072 0.0047 0.0049
Schistosoma mansoni tyrosine kinase 0.0067 0.0038 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0142 0.0142
Brugia malayi SH2 domain containing protein 0.0067 0.0038 0.0039
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0047 0.0049
Schistosoma mansoni cell adhesion molecule 0.0125 0.0172 0.0172
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.1659 0.3735 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.0235 0.0244
Schistosoma mansoni tyrosine kinase 0.0115 0.0148 0.0148
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.1659 0.3735 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0047 0.0049
Loa Loa (eye worm) hypothetical protein 0.1269 0.2829 0.2933
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0398 0.0805 0.0835
Schistosoma mansoni acetyl-CoA carboxylase 0.4355 1 1
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.059 0.1252 0.2905
Schistosoma mansoni cell adhesion molecule 0.0072 0.0047 0.0047
Brugia malayi hypothetical protein 0.0173 0.0282 0.0292
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0047 0.0049
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0408 0.083 0.083
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.059 0.1252 0.2905
Loa Loa (eye worm) hypothetical protein 0.0072 0.0047 0.0049
Schistosoma mansoni tyrosine kinase 0.0113 0.0144 0.0144
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.009 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0072 0.0047 0.0049
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.1659 0.3735 1
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0375 0.0752 0.0742
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0115 0.0148 0.0148
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0153 0.0235 0.0235
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0072 0.0047 0.0047
Schistosoma mansoni tyrosine kinase 0.0115 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0072 0.0047 0.0049
Loa Loa (eye worm) hypothetical protein 0.0153 0.0235 0.0244
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0153 0.0235 0.0244
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0072 0.0047 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0036 0.0036
Onchocerca volvulus 0.0173 0.0282 0.0869
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0115 0.0148 0.0148
Echinococcus granulosus tyrosine protein kinase HCK 0.0064 0.0029 0.0029
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0375 0.0752 0.0752
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.059 0.1252 0.3233
Brugia malayi Tyrosine-protein kinase abl-1 0.0093 0.0096 0.01
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.059 0.1252 0.2905
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0375 0.0752 0.1476
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0153 0.0235 0.0235
Schistosoma mansoni roundabout 0.0072 0.0047 0.0047
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.059 0.1252 0.1041
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.04 0.0811 0.0811
Schistosoma mansoni septate junction protein 0.0072 0.0047 0.0047
Schistosoma mansoni neuroglian 0.0072 0.0047 0.0047
Brugia malayi Protein kinase domain containing protein 0.0067 0.0038 0.0039
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0067 0.0038 0.0038
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.059 0.1252 0.2905
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.3152 0.7204 1
Brugia malayi Carboxyl transferase domain containing protein 0.4203 0.9646 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.0272 0.0282
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0142 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.0107 0.0111
Brugia malayi Prion-like- 0.0072 0.0047 0.0049
Echinococcus granulosus tyrosine kinase 0.009 0.0089 0.0089
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.0038 0.0039
Loa Loa (eye worm) TK protein kinase 0.0085 0.0078 0.0081
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0112 0.0142 0.0142
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0743 0.1607 1
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.1659 0.3735 1
Echinococcus multilocularis peroxidasin 0.0072 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0097 0.0106 0.011
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.1659 0.3735 1
Trypanosoma brucei acetyl-CoA carboxylase 0.4355 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0047 0.0049
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0072 0.0047 0.0047
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.059 0.1252 0.2905
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.0038 0.0039
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0112 0.0142 0.0142
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0115 0.0148 0.0148
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0743 0.1607 0.5
Echinococcus multilocularis tyrosine kinase 0.0067 0.0038 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0097 0.0106 0.011
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0067 0.0038 0.0038
Mycobacterium ulcerans pyruvate carboxylase 0.1659 0.3735 1
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.059 0.1252 0.1252
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0153 0.0235 0.0235
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0047 0.0049
Loa Loa (eye worm) hypothetical protein 0.0097 0.0106 0.011
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0398 0.0805 0.0805
Echinococcus multilocularis lachesin 0.0072 0.0047 0.0047
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1659 0.3735 0.3735
Echinococcus granulosus contactin 0.0072 0.0047 0.0047
Treponema pallidum pyruvate carboxylase subunit B 0.0153 0.0235 0.5
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0142 0.5
Echinococcus granulosus peroxidasin 0.0072 0.0048 0.0048
Onchocerca volvulus 0.0173 0.0282 0.0869
Leishmania major propionyl-coa carboxylase beta chain, putative 0.059 0.1252 0.1041
Brugia malayi Peroxidasin 0.0072 0.0048 0.005
Brugia malayi Protein kinase domain containing protein 0.0067 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0097 0.0106 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.0038 0.0039
Schistosoma mansoni tyrosine kinase 0.0067 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0085 0.0078 0.0078
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.0078 0.0081
Chlamydia trachomatis biotin carboxylase 0.1506 0.3381 1
Schistosoma mansoni cell adhesion molecule 0.0072 0.0047 0.0047
Onchocerca volvulus 0.1193 0.2652 0.9299
Loa Loa (eye worm) TK protein kinase 0.009 0.0089 0.0093
Schistosoma mansoni vesicular amine transporter 0.0097 0.0106 0.0106
Brugia malayi SH2 domain containing protein 0.0067 0.0038 0.0039
Echinococcus granulosus hemicentin 1 0.0072 0.0047 0.0047
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.059 0.1252 0.2905
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0125 0.0172 0.0172
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0153 0.0235 0.0244
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0115 0.0148 0.0148
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0072 0.0047 0.0049
Onchocerca volvulus Tyrosine kinase homolog 0.1278 0.2849 1
Schistosoma mansoni hypothetical protein 0.0173 0.0282 0.0282
Plasmodium falciparum carbamoyl phosphate synthetase 0.0375 0.0752 0.0742
Schistosoma mansoni titin 0.0072 0.0047 0.0047
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0153 0.0235 0.0235
Echinococcus granulosus roundabout 2 0.0072 0.0047 0.0047
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0047 0.0049
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0112 0.0142 0.0147
Echinococcus multilocularis neuroglian 0.014 0.0207 0.0207
Brugia malayi SRC-1 0.0115 0.0148 0.0154
Schistosoma mansoni septate junction protein 0.0072 0.0047 0.0047
Echinococcus granulosus tyrosine protein kinase Fyn 0.0115 0.0148 0.0148
Echinococcus multilocularis hemicentin 1 0.0072 0.0047 0.0047
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.059 0.1252 0.2905
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0097 0.0106 0.0106
Loa Loa (eye worm) TK/ABL protein kinase 0.0067 0.0038 0.0039
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1659 0.3735 0.3584
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0047 0.0049
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.059 0.1252 0.172
Echinococcus granulosus neuroglian 0.014 0.0207 0.0207
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.059 0.1252 0.2905
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0067 0.0038 0.0038
Echinococcus multilocularis roundabout 2 0.0072 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0173 0.0282 0.0292
Schistosoma mansoni nephrin 0.0072 0.0047 0.0047
Echinococcus multilocularis Immunoglobulin 0.0097 0.0106 0.0106
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.059 0.1252 0.2905
Echinococcus multilocularis hemicentin 1 0.0072 0.0047 0.0047
Echinococcus multilocularis tyrosine protein kinase Blk 0.009 0.0089 0.0089
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.3152 0.7204 1
Leishmania major carbamoyl-phosphate synthase, putative 0.0375 0.0752 0.0529
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.0038 0.0039
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.059 0.1252 0.2905
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.4203 0.9646 1
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.1659 0.3735 0.3735
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0072 0.0047 0.0047
Entamoeba histolytica protein kinase, putative 0.0112 0.0142 0.0712
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.059 0.1252 0.172
Echinococcus multilocularis tyrosine protein kinase HCK 0.0064 0.0029 0.0029
Echinococcus granulosus Immunoglobulin 0.0097 0.0106 0.0106
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0142 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.0048 0.005
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0153 0.0235 0.0235
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1659 0.3735 0.5922
Brugia malayi protein-tyrosine kinase 0.009 0.0089 0.0093
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0115 0.0148 0.0148
Echinococcus multilocularis neuroglian 0.0072 0.0047 0.0047
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0097 0.0106 0.0106
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.0038 0.0039
Echinococcus multilocularis MAM 0.0173 0.0282 0.0282
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0093 0.0096 0.0096
Brugia malayi phosphoinositide-dependent protein kinase I 0.0112 0.0142 0.0147
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0375 0.0752 0.1476
Brugia malayi hypothetical protein 0.0097 0.0106 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.0038 0.0039
Echinococcus granulosus tyrosine protein kinase shark 0.0067 0.0038 0.0038
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.059 0.1252 0.2905
Schistosoma mansoni tyrosine kinase 0.0093 0.0096 0.0096
Trypanosoma brucei unspecified product 0.1091 0.2415 0.2232
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0047 0.0049
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0115 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0168 0.0272 0.0282
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0072 0.0047 0.0047
Brugia malayi Immunoglobulin I-set domain containing protein 0.1359 0.3039 0.3151
Brugia malayi Protein kinase domain containing protein 0.0112 0.0142 0.0147
Echinococcus granulosus MAM 0.0173 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0153 0.0235 0.0244
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.0038 0.0039
Echinococcus multilocularis tyrosine protein kinase otk 0.0072 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0173 0.0282 0.0282
Echinococcus multilocularis tyrosine protein kinase shark 0.0067 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0067 0.0038 0.0039
Echinococcus multilocularis roundabout 2 0.0168 0.0272 0.0272
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.059 0.1252 0.1252
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.059 0.1252 0.1041
Leishmania major acetyl-CoA carboxylase, putative 0.4355 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0047 0.0049
Loa Loa (eye worm) hypothetical protein 0.0173 0.0282 0.0292
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0072 0.0047 0.0047
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.1659 0.3735 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0115 0.0148 0.0148
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.0038 0.0039
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.059 0.1252 0.172
Echinococcus granulosus tyrosine protein kinase Srms 0.0067 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Fyn 0.0115 0.0148 0.0148
Brugia malayi Protein kinase domain containing protein 0.1484 0.3328 0.345
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1359 0.3039 0.3151
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0072 0.0047 0.0049
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0153 0.0235 0.0235
Echinococcus granulosus roundabout 2 0.0072 0.0047 0.0047
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0375 0.0752 0.0874
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0067 0.0038 0.0054
Echinococcus granulosus tyrosine protein kinase Fyn 0.0115 0.0148 0.0148
Brugia malayi hypothetical protein 0.0067 0.0038 0.0039
Toxoplasma gondii carbamoylphosphate synthetase 0.0375 0.0752 0.0529
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.059 0.1252 0.2905
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0375 0.0752 0.0874
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.0038 0.0039
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.1659 0.3735 0.3584
Echinococcus granulosus tyrosine protein kinase Lyn 0.0117 0.0153 0.0153
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0115 0.0148 0.0148
Echinococcus multilocularis tyrosine protein kinase Srms 0.009 0.0089 0.0089
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0097 0.0106 0.0106
Echinococcus granulosus c src tyrosine kinase 0.0093 0.0096 0.0096
Schistosoma mansoni tyrosine kinase 0.0093 0.0096 0.0096
Echinococcus granulosus roundabout 2 0.0168 0.0272 0.0272
Echinococcus multilocularis Immunoglobulin 0.0097 0.0106 0.0106
Echinococcus multilocularis tyrosine protein kinase Abl 0.0093 0.0096 0.0096
Brugia malayi Protein kinase domain containing protein 0.0398 0.0805 0.0835
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.4355 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0115 0.0148 0.0148
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0093 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0072 0.0047 0.0049
Brugia malayi Fibronectin type III domain containing protein 0.0097 0.0106 0.011
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1659 0.3735 0.3735
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0072 0.0047 0.0047
Schistosoma mansoni aspartate carbamoyltransferase 0.0375 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0097 0.0106 0.011
Trypanosoma cruzi acetyl-CoA carboxylase 0.2696 0.6146 1
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1659 0.3735 0.3584
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1659 0.3735 0.5922
Loa Loa (eye worm) TK/ROR protein kinase 0.0085 0.0078 0.0081
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0085 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Src42A 0.0115 0.0148 0.0148
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.4355 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0047 0.0049
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0375 0.0752 0.0529
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0072 0.0047 0.0047
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.059 0.1252 0.1041
Loa Loa (eye worm) hypothetical protein 0.0173 0.0282 0.0292
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0153 0.0235 0.0244
Echinococcus multilocularis Biotin lipoyl attachment 0.0153 0.0235 0.0235
Loa Loa (eye worm) TK protein kinase 0.0064 0.0029 0.003
Brugia malayi Protein kinase domain containing protein 0.0067 0.0038 0.0039
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0112 0.0142 0.0147
Loa Loa (eye worm) hypothetical protein 0.0097 0.0106 0.011
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0153 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0125 0.0172 0.0178
Leishmania major carboxylase, putative 0.1659 0.3735 0.3584
Echinococcus granulosus tyrosine protein kinase Src64B 0.0115 0.0148 0.0148
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0074 0.0052 0.0054
Toxoplasma gondii pyruvate carboxylase 0.1659 0.3735 0.3584
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0072 0.0047 0.0033
Echinococcus granulosus neuroglian 0.0072 0.0047 0.0047
Echinococcus granulosus tyrosine protein kinase ABL1 0.0067 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Blk 0.009 0.0089 0.0089
Echinococcus granulosus Biotin lipoyl attachment 0.0153 0.0235 0.0235
Loa Loa (eye worm) SRC-1 0.0115 0.0148 0.0154
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0115 0.0148 0.0148
Echinococcus granulosus tyrosine protein kinase otk 0.0072 0.0047 0.0047
Echinococcus multilocularis roundabout 2 0.0072 0.0047 0.0047
Brugia malayi Protein kinase domain containing protein 0.0067 0.0038 0.0039
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.4355 1 1
Schistosoma mansoni nephrin 0.014 0.0207 0.0207
Echinococcus granulosus lachesin 0.0072 0.0047 0.0047
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.1659 0.3735 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0047 0.0049
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0072 0.0047 0.0049
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0093 0.0096 0.0096
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.1659 0.3735 0.3735
Echinococcus multilocularis tyrosine protein kinase Fyn 0.009 0.0089 0.0089
Brugia malayi Protein kinase domain containing protein 0.0067 0.0038 0.0039
Echinococcus granulosus twitchin 0.0142 0.0212 0.0212
Echinococcus multilocularis c src tyrosine kinase 0.0093 0.0096 0.0096
Loa Loa (eye worm) TK/ALK protein kinase 0.1483 0.3327 0.3449
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0153 0.0235 0.0235
Echinococcus granulosus tyrosine kinase 0.0067 0.0038 0.0038
Echinococcus granulosus defective proboscis extension response 0.0097 0.0106 0.0106
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0115 0.0148 0.0148
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.059 0.1252 0.1252
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0375 0.0752 0.0752

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) ND 0 uM In vitro inhibition of histamine release from human basophils. ChEMBL. 8410986

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.