Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.1314 | 0.0339 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0583 | 0.0606 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.2082 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.1009 | 0.1048 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.6822 | 0.6897 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.1314 | 0.0339 |
Brugia malayi | RNA binding protein | 0.0066 | 0.298 | 0.3095 |
Echinococcus multilocularis | geminin | 0.0181 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.6822 | 0.7085 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0107 | 0.5484 | 0.5418 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.298 | 0.3095 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0107 | 0.5484 | 0.5696 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.2082 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.3413 | 0.3545 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0583 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1314 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.6822 | 0.6897 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.9629 | 0.9587 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.9329 | 0.9254 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.9629 | 0.9587 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.9629 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.182 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.1314 | 0.1364 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.298 | 0.265 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0583 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.2082 | 0.1193 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.9629 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.1009 | 0.1048 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.298 | 0.2192 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0107 | 0.5484 | 0.5696 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.2082 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.298 | 0.2192 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.298 | 0.2192 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.298 | 0.2192 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0583 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.1314 | 0.0339 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.2082 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.182 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.298 | 0.265 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1009 | 0.0471 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.298 | 0.265 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.182 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.5484 | 0.5418 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.3413 | 0.2674 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.298 | 0.2192 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.1009 | 0.0471 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.2082 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3413 | 0.3128 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.298 | 0.2192 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0583 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.298 | 0.2192 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.298 | 0.3095 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.