Detailed information for compound 1494117

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.307 | Formula: C17H22BrN7
  • H donors: 2 H acceptors: 3 LogP: 1.67 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@@H]1CCC[C@@H](C1)Cc1nc2c(cnn2c(c1Br)N)c1cnn(c1)C
  • InChi: 1S/C17H22BrN7/c1-24-9-11(7-21-24)13-8-22-25-16(20)15(18)14(23-17(13)25)6-10-3-2-4-12(19)5-10/h7-10,12H,2-6,19-20H2,1H3/t10-,12+/m0/s1
  • InChiKey: WFPIRVVONIIHDU-CMPLNLGQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens checkpoint kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin A2 References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin A1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase Chk1, putative Get druggable targets OG5_130454 All targets in OG5_130454
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130454 All targets in OG5_130454
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.1018 0.0932
Loa Loa (eye worm) glutaminase 2 0.0266 1 1
Loa Loa (eye worm) hypothetical protein 0.024 0.8886 0.8876
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.1018 0.0932
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.1018 0.321
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.1018 0.147
Trichomonas vaginalis cyclin B, putative 0.009 0.2589 0.2295
Schistosoma mansoni hypothetical protein 0.0066 0.1594 0.1514
Echinococcus multilocularis cyclins 0.0038 0.0381 0.0455
Brugia malayi cell division control protein 2 homolog 0.0053 0.1018 0.0932
Entamoeba histolytica cyclin, putative 0.0038 0.0381 0.0452
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.018 0.6376 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.4058 0.4001
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.1018 0.147
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.4058 0.4001
Entamoeba histolytica cyclin family protein 0.0038 0.0381 0.0452
Trichomonas vaginalis cyclins, putative 0.009 0.2589 0.2295
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.2887 0.2818
Leishmania major cyclin 0.009 0.2589 1
Trichomonas vaginalis cyclins, putative 0.0062 0.1391 0.105
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.2589 1
Giardia lamblia Kinase, CMGC CDK 0.0053 0.1018 0.2888
Giardia lamblia Kinase, CMGC CDK 0.0053 0.1018 0.2888
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1018 0.0932
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1018 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0125 0.4058 0.4001
Loa Loa (eye worm) RNA binding protein 0.0125 0.4058 0.4001
Trichomonas vaginalis cyclin B, putative 0.009 0.2589 0.2295
Loa Loa (eye worm) hypothetical protein 0.009 0.2589 0.2518
Brugia malayi Protein kinase domain containing protein 0.0203 0.7329 0.7303
Schistosoma mansoni tar DNA-binding protein 0.0125 0.4058 0.4001
Schistosoma mansoni glutaminase 0.0266 1 1
Trichomonas vaginalis cyclins, putative 0.009 0.2589 0.2295
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.0381 0.0289
Echinococcus multilocularis cyclins 0.0038 0.0381 0.0455
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.1018 0.147
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.2589 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.4058 0.4001
Brugia malayi TAR-binding protein 0.0125 0.4058 0.4001
Echinococcus granulosus cyclins 0.0038 0.0381 0.0455
Echinococcus granulosus cyclins 0.0038 0.0381 0.0455
Brugia malayi Protein kinase domain containing protein 0.0053 0.1018 0.0932
Schistosoma mansoni cyclin B3 0.0038 0.0381 0.0289
Trypanosoma cruzi cyclin, putative 0.009 0.2589 1
Echinococcus multilocularis cyclins 0.0038 0.0381 0.0455
Loa Loa (eye worm) hypothetical protein 0.0052 0.101 0.0924
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0246 0.9168 0.916
Echinococcus multilocularis cyclins 0.0038 0.0381 0.0455
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.2589 0.2518
Echinococcus granulosus cyclin dependent kinase 0.0053 0.1018 0.147
Trypanosoma brucei mitotic cyclin 6 0.009 0.2589 1
Schistosoma mansoni cyclin B 0.009 0.2589 0.2518
Loa Loa (eye worm) hypothetical protein 0.0066 0.1594 0.1514
Mycobacterium ulcerans glutaminase 0.0266 1 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.018 0.6376 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.1018 0.147
Loa Loa (eye worm) hypothetical protein 0.0246 0.9168 0.916
Echinococcus multilocularis tar DNA binding protein 0.0125 0.4058 0.6309
Entamoeba histolytica cyclin family protein 0.0038 0.0381 0.0452
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0203 0.7329 0.7303
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.2887 0.2818
Loa Loa (eye worm) TAR-binding protein 0.0125 0.4058 0.4001
Brugia malayi RNA binding protein 0.0125 0.4058 0.4001
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.2589 1
Echinococcus granulosus tar DNA binding protein 0.0125 0.4058 0.6309
Trypanosoma cruzi cyclin, putative 0.009 0.2589 1
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.1594 0.1514
Trichomonas vaginalis cyclin A, putative 0.009 0.2589 0.2295
Trichomonas vaginalis glutaminase, putative 0.0266 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0276 0.0289
Echinococcus granulosus cyclins 0.0038 0.0381 0.0455
Loa Loa (eye worm) hypothetical protein 0.0052 0.0972 0.0885
Echinococcus multilocularis cyclin B3 1 0.0038 0.0381 0.0455
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0183
Echinococcus multilocularis cyclin B 0.009 0.2589 0.397
Trypanosoma cruzi cyclin 6, putative 0.009 0.2589 1
Onchocerca volvulus 0.009 0.2589 0.5
Echinococcus granulosus cyclins 0.0038 0.0381 0.0455
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.1018 0.147
Plasmodium falciparum protein kinase 5 0.0053 0.1018 1
Echinococcus multilocularis cyclins 0.0038 0.0381 0.0455
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0276 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0125 0.4058 0.4001
Echinococcus granulosus cyclin B3 1 0.0038 0.0381 0.0455
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.1018 0.321
Loa Loa (eye worm) cyclin domain-containing protein 0.0038 0.0381 0.0289
Trichomonas vaginalis cyclins, putative 0.009 0.2589 0.2295
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0038 0.0381 0.0455
Echinococcus granulosus cyclin B 0.009 0.2589 0.397
Plasmodium vivax protein kinase Crk2 0.0053 0.1018 0.5
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.1018 0.147
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1018 0.0663
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.2589 0.2518
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0276 0.0289
Brugia malayi photoreceptor-specific nuclear receptor 0.024 0.8886 0.8876
Schistosoma mansoni cyclins 0.0038 0.0381 0.0289
Echinococcus multilocularis cyclins 0.0038 0.0381 0.0455
Entamoeba histolytica cyclin, putative 0.009 0.2589 1
Trichomonas vaginalis cyclin B, putative 0.009 0.2589 0.2295
Loa Loa (eye worm) glutaminase 0.0266 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.7329 0.7303
Echinococcus multilocularis cyclins 0.0038 0.0381 0.0455
Trichomonas vaginalis cyclin B, putative 0.009 0.2589 0.2295
Brugia malayi hypothetical protein 0.0035 0.0276 0.0183
Echinococcus granulosus cyclin b3 0.0038 0.0381 0.0455
Echinococcus multilocularis cyclin b3 0.0038 0.0381 0.0455
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.4058 0.4001
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.1018 1
Loa Loa (eye worm) hypothetical protein 0.009 0.2589 0.2518
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1018 0.0663
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.1018 0.147
Echinococcus granulosus cyclins 0.0038 0.0381 0.0455
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0038 0.0381 0.0455
Trichomonas vaginalis cyclins, putative 0.009 0.2589 0.2295
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.1018 0.0932
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1018 0.0932

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.005 uM Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assay ChEMBL. 21094607
IC50 (binding) = 0.44 uM Inhibition of recombinant CDK2/Cyclin A expressed in insect Sf9 cells assessed as inhibition of [33P]-ATP incorporation into biotinylated histone H1 after 1 hr by liquid scintillation counting ChEMBL. 21094607

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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