Detailed information for compound 1494278

Basic information

Technical information
  • TDR Targets ID: 1494278
  • Name: 1-[3-[(4-chlorophenyl)sulfamoyl]-4-morpholin- 4-ylphenyl]-3-(2-methoxyethyl)thiourea
  • MW: 485.02 | Formula: C20H25ClN4O4S2
  • H donors: 3 H acceptors: 2 LogP: 2.28 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=S)Nc1ccc(c(c1)S(=O)(=O)Nc1ccc(cc1)Cl)N1CCOCC1
  • InChi: 1S/C20H25ClN4O4S2/c1-28-11-8-22-20(30)23-17-6-7-18(25-9-12-29-13-10-25)19(14-17)31(26,27)24-16-4-2-15(21)3-5-16/h2-7,14,24H,8-13H2,1H3,(H2,22,23,30)
  • InChiKey: GOZICDMIRLMSPJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-[(4-chlorophenyl)sulfamoyl]-4-morpholino-phenyl]-3-(2-methoxyethyl)thiourea
  • 1-[3-[(4-chlorophenyl)sulfamoyl]-4-morpholinophenyl]-3-(2-methoxyethyl)thiourea
  • 1-[3-[(4-chlorophenyl)sulfamoyl]-4-morpholin-4-yl-phenyl]-3-(2-methoxyethyl)thiourea
  • T5403790

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii Glucose-6-phosphate dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Treponema pallidum glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Theileria parva glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania infantum glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) Get druggable targets OG5_127121 All targets in OG5_127121
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania braziliensis glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C) Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K00036 glucose-6-phosphate 1-dehydrogenase [EC1.1.1.49], putative Get druggable targets OG5_127121 All targets in OG5_127121
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49), related Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania mexicana glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani glucose-6-phosphate 1-dehydrogenase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Brugia malayi glucose-6-phosphate dehydrogenase Get druggable targets OG5_127121 All targets in OG5_127121
Trichomonas vaginalis 6-phosphogluconolactonase, putative Get druggable targets OG5_127121 All targets in OG5_127121
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase Get druggable targets OG5_127121 All targets in OG5_127121
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei polo-like protein kinase 0.0114 0.338 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni myosin xvIII 0.0055 0.062 0.1833
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi neuropeptide F receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni kinase 0.0058 0.078 0.2307
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi hypothetical protein 0.0055 0.062 0.1833
Brugia malayi Dopamine receptor protein 1 0.0055 0.062 0.1833
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.338 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.338 0.8706
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.062 0.1833
Brugia malayi Melatonin receptor type 1A 0.0055 0.062 0.1833
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.062 0.1833
Brugia malayi follicle stimulating hormone receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.062 0.1833
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.006 0.0883 0.2612
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.338 0.0101
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.062 0.1833
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0113 0.3312 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.062 0.1833
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.062 0.1833
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0123 0.3777 1
Schistosoma mansoni biogenic amine receptor 0.0055 0.062 0.1833
Schistosoma mansoni opsin-like receptor 0.0055 0.062 0.1833
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.3777 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi glucose-6-phosphate dehydrogenase 0.0113 0.3312 0.98
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.338 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.062 0.1833
Brugia malayi G-protein coupled receptor 0.0055 0.062 0.1833
Schistosoma mansoni neuropeptide receptor 0.0055 0.062 0.1833
Schistosoma mansoni histamine h1 receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni amine GPCR 0.0055 0.062 0.1833
Schistosoma mansoni neuropeptide receptor 0.0055 0.062 0.1833
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0113 0.3312 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.062 0.1833
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.338 0.8706
Schistosoma mansoni amine GPCR 0.0055 0.062 0.1833
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.338 1
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni neuropeptide receptor 0.0055 0.062 0.1833
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.338 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi GnHR receptor homolog 0.0055 0.062 0.1833
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.062 0.1833
Brugia malayi larval opioid receptor 0.0055 0.062 0.1833
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.338 1
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0113 0.3312 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0883 0.2612
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.062 0.1833
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.3777 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.062 0.1833
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0123 0.3777 1
Brugia malayi hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0883 0.2612
Brugia malayi hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni amine GPCR 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni biogenic amine receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.062 0.1833
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.062 0.1833
Brugia malayi neuropeptide F receptor 0.0055 0.062 0.1833
Brugia malayi hypothetical protein 0.0055 0.062 0.1833
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.338 0.8706
Schistosoma mansoni hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.062 0.1833
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0123 0.3777 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.062 0.1833
Schistosoma mansoni opsin-like receptor 0.0055 0.062 0.1833
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.062 0.1833
Schistosoma mansoni hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni opsin-like receptor 0.0055 0.062 0.1833
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0113 0.3312 0.9755
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.062 0.1833
Schistosoma mansoni neuropeptide receptor 0.0055 0.062 0.1833
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.062 0.1833
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.062 0.1833
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.062 0.1833
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0113 0.3312 0.9755
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi Dopamine receptor protein 2 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.062 0.1833
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.062 0.1833
Brugia malayi putative neuropeptide receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.062 0.1833
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.062 0.1833
Schistosoma mansoni biogenic amine receptor 0.0055 0.062 0.1833
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.338 0.8706
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0123 0.3777 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.338 0.8706
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi AKH receptor 0.0055 0.062 0.1833
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0113 0.3312 0.98
Brugia malayi hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni adenoreceptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.062 0.1833
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.062 0.1833
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.338 1
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0113 0.3312 0.98
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.338 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.062 0.1833
Brugia malayi hypothetical protein 0.0055 0.062 0.1833
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.338 0.5
Brugia malayi G protein-coupled receptor 0.0055 0.062 0.1833
Brugia malayi RE15519p 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.062 0.1833
Schistosoma mansoni amine GPCR 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Trypanosoma brucei hypothetical protein, conserved 0.0257 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi Dopamine receptor 0.0055 0.062 0.1833
Schistosoma mansoni amine GPCR 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.338 0.0101
Schistosoma mansoni hypothetical protein 0.0055 0.062 0.1833
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.062 0.1833
Brugia malayi sulfakinin receptor protein 0.0055 0.062 0.1833
Brugia malayi Serotonin receptor 0.0055 0.062 0.1833
Trypanosoma cruzi hypothetical protein, conserved 0.0257 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi Serotonin receptor 0.0055 0.062 0.1833
Trypanosoma cruzi hypothetical protein, conserved 0.0257 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.062 0.1833
Brugia malayi G-protein coupled receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi hypothetical protein 0.0055 0.062 0.1833
Brugia malayi hypothetical protein 0.0055 0.062 0.1833
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.338 0.8706
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0883 0.2612
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0123 0.3777 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.338 0.8706
Brugia malayi ORL1-like opioid receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.062 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.062 0.1833

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 19.4 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
Potency (functional) 2.3778 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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