TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 379.248 | Formula: C17H19BrN2O3
H donors: 1 H acceptors: 2 LogP: 2.63 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C1=C(C)N(C(=O)NC1c1ccc(cc1)Br)CC1CC1
InChi: 1S/C17H19BrN2O3/c1-10-14(16(21)23-2)15(12-5-7-13(18)8-6-12)19-17(22)20(10)9-11-3-4-11/h5-8,11,15H,3-4,9H2,1-2H3,(H,19,22)
InChiKey: MIAXAKPUEPKLPU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0058	0.1573	0.3456
Toxoplasma gondii	histone deacetylase HDAC1	0.0025	0.045	0.1794
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0058	0.1573	0.5677
Echinococcus multilocularis	histone deacetylase 8	0.0025	0.045	0.045
Trypanosoma brucei	histone deacetylase 2	0.0025	0.045	0.0494
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0018	0.0239	0.0239
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0018	0.0239	0.0953
Brugia malayi	Papain family cysteine protease containing protein	0.0082	0.2349	0.3093
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2349	0.3093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.1095	0.3467
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1494	0.5525
Plasmodium falciparum	serine repeat antigen 3	0.0018	0.0239	0.0953
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0082	0.2349	0.2349
Schistosoma mansoni	cathepsin S (C01 family)	0.0018	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0484	0.0484
Loa Loa (eye worm)	histone deacetylase 1	0.0087	0.251	0.251
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.2175	0.2175
Loa Loa (eye worm)	histone deacetylase 11	0.0025	0.045	0.045
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0484	0.0637
Plasmodium vivax	vivapain-2	0.0082	0.2349	0.9359
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0239	0.0239
Brugia malayi	Sex muscle abnormal protein 5	0.0135	0.4127	0.5433
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Trypanosoma cruzi	cysteine proteinase, putative	0.0044	0.1095	0.2404
Brugia malayi	MH2 domain containing protein	0.0126	0.382	0.5029
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2349	0.9292
Echinococcus multilocularis	cathepsin L	0.0044	0.1095	0.1095
Echinococcus granulosus	histone deacetylase 8	0.0025	0.045	0.045
Echinococcus multilocularis	survival motor neuron protein 1	0.0239	0.7596	0.7596
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0018	0.0239	0.0239
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2175	0.2175
Schistosoma mansoni	cathepsin F (C01 family)	0.0056	0.1494	0.1494
Schistosoma mansoni	histone deacetylase 1 2 3	0.0025	0.045	0.045
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0082	0.2349	0.9359
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0018	0.0239	0.0953
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0058	0.1573	0.6269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.1095	0.1095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Trichomonas vaginalis	histone deacetylase, putative	0.0087	0.251	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0343	0.1368
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.1095	0.3767
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0239	0.0315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Echinococcus granulosus	cathepsin l1	0.0056	0.1494	0.1494
Brugia malayi	Importin beta-1 subunit	0.0029	0.06	0.079
Entamoeba histolytica	hypothetical protein	0.0024	0.0416	0.0779
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0018	0.0239	0.0239
Plasmodium vivax	unspecified product	0.0026	0.0484	0.1927
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0018	0.0239	0.0953
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.0239	0.0315
Onchocerca volvulus	Cathepsin L homolog	0.0082	0.2349	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0018	0.0239	0.0239
Echinococcus granulosus	cathepsin l1	0.0082	0.2349	0.2349
Echinococcus granulosus	cathepsin b	0.0148	0.4553	0.4553
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0018	0.0239	0.0953
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.06	0.1184
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0239	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0239	0.0239
Trypanosoma cruzi	major cysteine proteinase, putative	0.0018	0.0239	0.0526
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0148	0.4553	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0026	0.0484	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2349	0.2349
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0018	0.0239	0.0239
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0343	0.0459
Echinococcus granulosus	cysteine protease	0.0044	0.1095	0.1095
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0082	0.2349	0.9359
Echinococcus multilocularis	cysteine protease	0.0082	0.2349	0.2349
Onchocerca volvulus		0.0056	0.1494	0.6359
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Plasmodium vivax	importin-beta 2, putative	0.0029	0.06	0.239
Trypanosoma cruzi	histone deacetylase, putative	0.0025	0.045	0.0989
Schistosoma mansoni	histone deacetylase hda2	0.0025	0.045	0.045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2349	0.9292
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0082	0.2349	0.9359
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2349	0.9292
Giardia lamblia	Histone deacetylase	0.0087	0.251	1
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0343	0.1368
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0416	0.0779
Schistosoma mansoni	cathepsin F (C01 family)	0.0082	0.2349	0.2349
Schistosoma mansoni	histone deacetylase 4 5	0.0025	0.045	0.045
Trypanosoma cruzi	histone deacetylase 1, putative	0.0087	0.251	0.5513
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0148	0.4553	0.4553
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Plasmodium falciparum	serine repeat antigen 5	0.0018	0.0239	0.0953
Brugia malayi	hypothetical protein	0.0239	0.7596	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0239	0.0239
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.2175	0.2175
Echinococcus multilocularis	histone deacetylase 3	0.0087	0.251	0.251
Onchocerca volvulus		0.0082	0.2349	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0343	0.0343
Loa Loa (eye worm)	fibroinase	0.0082	0.2349	0.2349
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.06	0.1184
Brugia malayi	Cathepsin L-like precursor	0.0056	0.1494	0.1967
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.06	0.239
Loa Loa (eye worm)	hypothetical protein	0.0239	0.7596	0.7596
Schistosoma mansoni	growth factor receptor-bound protein	0.0135	0.4127	0.4127
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0343	0.0452
Echinococcus multilocularis	histone deacetylase 6	0.0025	0.045	0.045
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0416	0.0914
Brugia malayi	RNA, U transporter 1	0.0083	0.2391	0.3148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.1095	0.3767
Schistosoma mansoni	cathepsin C	0.0018	0.0239	0.0239
Brugia malayi	histone deacetylase 3 (HD3)	0.0087	0.251	0.3304
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0343	0.1368
Brugia malayi	TAR-binding protein	0.0076	0.2175	0.2863
Schistosoma mansoni	histone deacetylase	0.0087	0.251	0.251
Entamoeba histolytica	cysteine proteinase, putative	0.0082	0.2349	0.9292
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.0484	0.1062
Brugia malayi	RNA binding protein	0.0076	0.2175	0.2863
Plasmodium vivax	vivapain-2	0.0082	0.2349	0.9359
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0082	0.2349	0.2349
Schistosoma mansoni	cathepsin s	0.0026	0.0484	0.0484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0082	0.2349	0.9292
Loa Loa (eye worm)	MH2 domain-containing protein	0.0126	0.382	0.382
Loa Loa (eye worm)	hypothetical protein	0.0025	0.045	0.045
Echinococcus multilocularis	histone deacetylase 6	0.0025	0.045	0.045
Leishmania major	GTP-binding protein, putative	0.0021	0.0343	0.1368
Plasmodium falciparum	serine repeat antigen 1	0.0018	0.0239	0.0953
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2175	0.2175
Entamoeba histolytica	cysteine proteinase 2	0.0044	0.1095	0.3767
Trypanosoma cruzi	cruzipain precursor, putative	0.0082	0.2349	0.516
Schistosoma mansoni	importin beta-1	0.0029	0.06	0.06
Leishmania major	histone deacetylase, putative	0.0025	0.045	0.1794
Trypanosoma cruzi	histone deacetylase, putative	0.0025	0.045	0.0989
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0018	0.0239	0.0239
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0018	0.0239	0.0315
Trypanosoma cruzi	cysteine peptidase, putative	0.0082	0.2349	0.516
Schistosoma mansoni	ran	0.0021	0.0343	0.0343
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2349	0.9292
Entamoeba histolytica	cysteine protease, putative	0.0082	0.2349	0.9292
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.1095	0.2404
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Trypanosoma cruzi	cysteine protease, putative	0.0044	0.1095	0.2404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Brugia malayi	cathepsin B-like cysteine proteinase	0.0148	0.4553	0.5994
Leishmania major	cathepsin L-like protease	0.0082	0.2349	0.9359
Trypanosoma brucei	histone deacetylase 3	0.0025	0.045	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1494	0.1494
Toxoplasma gondii	cathepsin B	0.0058	0.1573	0.6269
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0416	0.1658
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.1095	0.3767
Echinococcus multilocularis	histone deacetylase 1	0.0087	0.251	0.251
Plasmodium falciparum	serine repeat antigen 4	0.0018	0.0239	0.0953
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0087	0.251	1
Echinococcus multilocularis	snurportin 1	0.0312	1	1
Trypanosoma cruzi	histone deacetylase, putative	0.0025	0.045	0.0989
Brugia malayi	Histone deacetylase 1	0.0087	0.251	0.3304
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0044	0.1095	0.4361
Plasmodium vivax	vivapain-3	0.0044	0.1095	0.4361
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0239	0.0239
Brugia malayi	fibroinase precursor	0.0018	0.0239	0.0315
Plasmodium falciparum	importin beta, putative	0.0029	0.06	0.239
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.1095	0.3767
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0082	0.2349	0.2349
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2349	0.3093
Echinococcus multilocularis	cysteine protease	0.0082	0.2349	0.2349
Echinococcus granulosus	cathepsin L	0.0018	0.0239	0.0239
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0018	0.0239	0.0239
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0018	0.0239	0.0953
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0087	0.251	1
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Echinococcus granulosus	cathepsin b	0.0148	0.4553	0.4553
Echinococcus granulosus	histone deacetylase 6	0.0025	0.045	0.045
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Brugia malayi	histone deacetylase 11	0.0025	0.045	0.0593
Schistosoma mansoni	histone deacetylase 4 5	0.0025	0.045	0.045
Giardia lamblia	Cathepsin B precursor	0.0058	0.1573	0.5875
Plasmodium vivax	histone deacetylase 2, putative	0.0025	0.045	0.1794
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0018	0.0239	0.0953
Echinococcus granulosus	growth factor receptor bound protein 2	0.0135	0.4127	0.4127
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.1095	0.3467
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0484	0.1062
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0018	0.0239	0.0239
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2349	0.9292
Trypanosoma brucei	histone deacetylase 1	0.0087	0.251	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0044	0.1095	0.3767
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0082	0.2349	0.2349
Entamoeba histolytica	cysteine proteinase, putative	0.0082	0.2349	0.9292
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0343	0.0754
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2175	0.2175
Echinococcus multilocularis	histone deacetylase	0.0025	0.045	0.045
Plasmodium vivax	serine-repeat antigen (SERA)	0.0018	0.0239	0.0953
Onchocerca volvulus		0.0082	0.2349	1
Plasmodium falciparum	histone deacetylase 1	0.0087	0.251	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0044	0.1095	0.2404
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.1573	0.1573
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2349	0.3093
Trypanosoma cruzi	histone deacetylase 1, putative	0.0087	0.251	0.5513
Brugia malayi	Histone deacetylase family protein	0.0025	0.045	0.0593
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0018	0.0239	0.0953
Schistosoma mansoni	growth factor receptor-bound protein	0.0135	0.4127	0.4127
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0343	0.0343
Schistosoma mansoni	histone deacetylase hda2	0.0025	0.045	0.045
Onchocerca volvulus		0.0018	0.0239	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0239	0.0239
Echinococcus multilocularis	histone deacetylase 7	0.0025	0.045	0.045
Loa Loa (eye worm)	ctsf protein	0.0082	0.2349	0.2349
Giardia lamblia	Cathepsin B precursor	0.0058	0.1573	0.5875
Plasmodium vivax	histone deacetylase, putative	0.0025	0.045	0.1794
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.1095	0.1095
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0018	0.0239	0.0953
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0239	0.0239
Echinococcus multilocularis	cathepsin L cysteine protease	0.0082	0.2349	0.2349
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0044	0.1095	0.2404
Trichomonas vaginalis	histone deacetylase, putative	0.0087	0.251	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Loa Loa (eye worm)	histone deacetylase 7A	0.0025	0.045	0.045
Plasmodium vivax	unspecified product	0.0044	0.1095	0.4361
Plasmodium vivax	histone deacetylase, putative	0.0025	0.045	0.1794
Plasmodium vivax	serine-repeat antigen (SERA)	0.0018	0.0239	0.0953
Brugia malayi	Histone deacetylase family protein	0.0025	0.045	0.0593
Plasmodium falciparum	serine repeat antigen 6	0.0018	0.0239	0.0953
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1494	0.1494
Echinococcus granulosus	histone deacetylase 3	0.0087	0.251	0.251
Onchocerca volvulus		0.0082	0.2349	1
Echinococcus granulosus	histone deacetylase 1	0.0087	0.251	0.251
Schistosoma mansoni	survival motor neuron protein	0.0049	0.1254	0.1254
Echinococcus granulosus	cathepsin L	0.0044	0.1095	0.1095
Brugia malayi	cathepsin L-like cysteine proteinase	0.0018	0.0239	0.0315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.1095	0.3767
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1494	0.5525
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.2175	0.2863
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Loa Loa (eye worm)	histone deacetylase	0.0025	0.045	0.045
Trypanosoma brucei	histone deacetylase 4	0.0025	0.045	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0029	0.06	0.06
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2349	0.3093
Plasmodium falciparum	histone deacetylase, putative	0.0025	0.045	0.1794
Echinococcus multilocularis	cathepsin b	0.0148	0.4553	0.4553
Plasmodium falciparum	serine repeat antigen 2	0.0018	0.0239	0.0953
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0018	0.0239	0.0953
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0018	0.0239	0.0953
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.1254	0.165
Loa Loa (eye worm)	hypothetical protein	0.0087	0.251	0.251
Echinococcus multilocularis	cathepsin L cysteine protease	0.0082	0.2349	0.2349
Echinococcus multilocularis	cathepsin b	0.0148	0.4553	0.4553
Onchocerca volvulus	Cathepsin F homolog	0.0082	0.2349	1
Brugia malayi	histone deacetylase 1 (HD1)	0.0087	0.251	0.3304
Trypanosoma cruzi	histone deacetylase, putative	0.0025	0.045	0.0989
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0018	0.0239	0.0953
Trypanosoma cruzi	cysteine peptidase, putative	0.0082	0.2349	0.516
Loa Loa (eye worm)	RNA binding protein	0.0076	0.2175	0.2175
Onchocerca volvulus		0.0049	0.1254	0.5336
Loa Loa (eye worm)	cathepsin B	0.0058	0.1573	0.1573
Loa Loa (eye worm)	cysteine protease	0.0082	0.2349	0.2349
Leishmania major	histone deacetylase, putative	0.0087	0.251	1
Leishmania major	cysteine peptidase A (CPA)	0.0082	0.2349	0.9359
Schistosoma mansoni	hypothetical protein	0.0049	0.1254	0.1254
Brugia malayi	cathepsin L precursor	0.0018	0.0239	0.0315
Entamoeba histolytica	histone deacetylase, putative	0.0087	0.251	1
Trypanosoma cruzi	histone deacetylase, putative	0.0025	0.045	0.0989
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0239	0.0239
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.06	0.06
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0058	0.1573	0.5875
Toxoplasma gondii	histone deacetylase HDAC2	0.0087	0.251	1
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0148	0.4553	0.4553
Echinococcus granulosus	importin subunit beta 1	0.0029	0.06	0.06
Echinococcus granulosus	histone deacetylase	0.0025	0.045	0.045
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.1494	0.3281
Leishmania major	cathepsin L-like protease	0.0082	0.2349	0.9359
Toxoplasma gondii	histone deacetylase HDAC4	0.0025	0.045	0.1794
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0056	0.1494	0.1967
Echinococcus granulosus	histone deacetylase 7	0.0025	0.045	0.045
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4553	0.4553
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0087	0.251	1
Echinococcus granulosus	histone deacetylase 6	0.0025	0.045	0.045
Leishmania major	histone deacetylase, putative	0.0025	0.045	0.1794
Giardia lamblia	Cathepsin B precursor	0.0058	0.1573	0.5875
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0312	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2175	0.2175
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0018	0.0239	0.0953
Onchocerca volvulus	Cathepsin L homolog	0.0082	0.2349	1
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2349	0.3093
Echinococcus granulosus	tar DNA binding protein	0.0076	0.2175	0.2175
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.1095	0.1095
Leishmania major	cathepsin L-like protease	0.0082	0.2349	0.9359
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Leishmania major	cathepsin L-like protease	0.0082	0.2349	0.9359
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Brugia malayi	cathepsin L-like precursor	0.0056	0.1494	0.1967
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.1095	0.1441
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0018	0.0239	0.0953
Schistosoma mansoni	histone deacetylase	0.0087	0.251	0.251
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.1095	0.1441
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Trypanosoma cruzi	cysteine peptidase, putative	0.0082	0.2349	0.516
Trichomonas vaginalis	histone deacetylase, putative	0.0087	0.251	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2349	0.9292
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0239	0.1019
Echinococcus granulosus	histone deacetylase 6	0.0025	0.045	0.045
Entamoeba histolytica	cysteine proteinase, putative	0.0056	0.1494	0.5525
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0082	0.2349	0.9292
Schistosoma mansoni	cathepsin B (C01 family)	0.0018	0.0239	0.0239
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2349	0.9292
Schistosoma mansoni	cathepsin F (C01 family)	0.0082	0.2349	0.2349
Echinococcus granulosus	survival motor neuron protein 1	0.0239	0.7596	0.7596
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2349	0.9292
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Toxoplasma gondii	histone deacetylase HDAC5	0.0025	0.045	0.1794
Leishmania major	cathepsin L-like protease	0.0082	0.2349	0.9359
Plasmodium vivax	vivapain-1	0.0044	0.1095	0.4361
Trypanosoma cruzi	cysteine peptidase, putative	0.0082	0.2349	0.516
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0484	0.0484
Leishmania major	histone deacetylase, putative	0.0087	0.251	1
Plasmodium falciparum	histone deacetylase 2	0.0025	0.045	0.1794
Onchocerca volvulus		0.0082	0.2349	1
Trichomonas vaginalis	histone deacetylase, putative	0.0087	0.251	1
Schistosoma mansoni	hypothetical protein	0.0312	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0082	0.2349	0.9258
Onchocerca volvulus		0.0082	0.2349	1
Trichomonas vaginalis	ran, putative	0.0021	0.0343	0.0459
Echinococcus granulosus	cathepsin L cysteine protease	0.0044	0.1095	0.1095
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0018	0.0239	0.0239
Trypanosoma brucei	histone deacetylase, putative	0.0025	0.045	0.0494
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0082	0.2349	0.2349
Loa Loa (eye worm)	transcription factor SMAD2	0.0126	0.382	0.382
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0018	0.0239	0.0953
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0484	0.0484
Echinococcus multilocularis	cathepsin L	0.0018	0.0239	0.0239
Plasmodium vivax	histone deacetylase 1, putative	0.0087	0.251	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Plasmodium falciparum	serine repeat antigen 9	0.0018	0.0239	0.0953
Brugia malayi	Cathepsin L-like precursor	0.0056	0.1494	0.1967
Leishmania major	cathepsin L-like protease	0.0082	0.2349	0.9359
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0082	0.2349	0.2349
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0135	0.4127	0.4127
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0148	0.4553	0.4553
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.1095	0.3767
Echinococcus multilocularis	histone deacetylase 6	0.0025	0.045	0.045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Toxoplasma gondii	cathepsin CPC2	0.0018	0.0239	0.0953
Plasmodium falciparum	serine repeat antigen 8	0.0018	0.0239	0.0953
Trichomonas vaginalis	histone deacetylase, putative	0.0087	0.251	1
Brugia malayi	Cathepsin L-like precursor	0.0082	0.2349	0.3093
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0018	0.0239	0.0315
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0148	0.4553	0.4553
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0416	0.0779
Brugia malayi	cathepsin F-like cysteine proteinase	0.0026	0.0484	0.0637
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Leishmania major	cathepsin L-like protease	0.0082	0.2349	0.9359
Loa Loa (eye worm)	histone deacetylase 3	0.0087	0.251	0.251
Trichomonas vaginalis	histone deacetylase, putative	0.0087	0.251	1
Onchocerca volvulus		0.0082	0.2349	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2175	0.2175
Toxoplasma gondii	cathepsin CPC1	0.0018	0.0239	0.0953
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0018	0.0239	0.0239
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0025	0.045	0.1917
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0082	0.2349	0.9292
Toxoplasma gondii	cathepsin CPL	0.0082	0.2349	0.9359
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1494	0.1494
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0416	0.0779
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0239	0.0239
Schistosoma mansoni	ran	0.0021	0.0343	0.0343
Onchocerca volvulus		0.0082	0.2349	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.2175	0.2175
Leishmania major	cathepsin L-like protease	0.0082	0.2349	0.9359
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0239	0.0315
Trypanosoma cruzi	major cysteine proteinase, putative	0.0018	0.0239	0.0526
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767
Plasmodium vivax	unspecified product	0.0018	0.0239	0.0953
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0082	0.2349	0.9292
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0135	0.4127	0.4127
Entamoeba histolytica	Ran family GTPase	0.0021	0.0343	0.0459
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0018	0.0239	0.0315
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0343	0.0754
Plasmodium falciparum	serine repeat antigen 7	0.0018	0.0239	0.0953
Toxoplasma gondii	histone deacetylase HDAC3	0.0087	0.251	1
Entamoeba histolytica	cysteine protease, putative	0.0044	0.1095	0.3767

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1713338

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1494727