Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3495 | 0.3976 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1359 | 0.1061 |
Onchocerca volvulus | 0.0182 | 0.8792 | 0.5 | |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0321 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.152 | 0.1729 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1203 | 0.1091 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3777 | 0.3969 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0195 | 0.0222 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0321 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1364 | 0.1552 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.3005 | 0.2916 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1203 | 0.1091 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2769 | 0.2677 |
Brugia malayi | hypothetical protein | 0.0182 | 0.8792 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1646 | 0.1872 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0321 | 0.0198 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2769 | 0.2677 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0195 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.8792 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 64.586 uM | PUBCHEM_BIOASSAY: TRFRET-based cell-based high throughput dose response assay for biased ligands (antagonists) of the melanocortin 4 receptor (MC4R). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.