Detailed information for compound 1494761

Basic information

Technical information
  • TDR Targets ID: 1494761
  • Name: [2-oxo-2-(oxolan-2-ylmethylamino)ethyl] (2S)- 2-(benzoylamino)-3-methylbutanoate
  • MW: 362.42 | Formula: C19H26N2O5
  • H donors: 2 H acceptors: 3 LogP: 2.24 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COC(=O)[C@H](C(C)C)NC(=O)c1ccccc1)NCC1CCCO1
  • InChi: 1S/C19H26N2O5/c1-13(2)17(21-18(23)14-7-4-3-5-8-14)19(24)26-12-16(22)20-11-15-9-6-10-25-15/h3-5,7-8,13,15,17H,6,9-12H2,1-2H3,(H,20,22)(H,21,23)/t15?,17-/m0/s1
  • InChiKey: CWPWUUBUUDBQEF-LWKPJOBUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-oxo-2-(tetrahydrofuran-2-ylmethylamino)ethyl] (2S)-2-(benzoylamino)-3-methyl-butanoate
  • (2S)-3-methyl-2-[(oxo-phenylmethyl)amino]butanoic acid [2-oxo-2-(2-tetrahydrofuranylmethylamino)ethyl] ester
  • [2-oxo-2-(oxolan-2-ylmethylamino)ethyl] (2S)-3-methyl-2-(phenylcarbonylamino)butanoate
  • T0515-0620

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cytochrome b 0.0421 0.2661 1
Echinococcus multilocularis neurogenic locus protein delta 0.0081 0.034 0.0492
Onchocerca volvulus 0.0081 0.034 0.027
Brugia malayi EGF-like domain containing protein 0.0081 0.034 0.2208
Schistosoma mansoni hypothetical protein 0.0042 0.0072 0.0155
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0042 0.0072 0.0077
Echinococcus multilocularis tyrosine protein kinase shark 0.05 0.3202 0.4929
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Brugia malayi EGF-like domain containing protein 0.0081 0.034 0.2208
Toxoplasma gondii cytochrome b 0.0421 0.2661 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Schistosoma mansoni hypothetical protein 0.0081 0.034 0.0999
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0065 0.023 0.0651
Schistosoma mansoni cell polarity protein 0.0081 0.034 0.0999
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0439
Brugia malayi EGF-like domain containing protein 0.0081 0.034 0.2208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0439
Schistosoma mansoni hypothetical protein 0.0081 0.034 0.0999
Echinococcus multilocularis Tolloid protein 1 0.0213 0.1241 0.1888
Echinococcus multilocularis enteropeptidase 0.0042 0.0072 0.0077
Brugia malayi cytochrome b 0.0257 0.1541 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0213 0.1241 0.5339
Echinococcus granulosus protein jagged 2 0.0081 0.034 0.0999
Echinococcus multilocularis protein jagged 1 0.0081 0.034 0.0492
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Brugia malayi hypothetical protein 0.0042 0.0072 0.0469
Brugia malayi Fibulin-1 precursor 0.0213 0.1241 0.8048
Echinococcus multilocularis neurogenic locus protein delta 0.0081 0.034 0.0492
Toxoplasma gondii EGF family domain-containing protein 0.0081 0.034 0.1204
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0065 0.023 0.0321
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0207 0.1199 0.3699
Brugia malayi Importin beta-1 subunit 0.0035 0.0023 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0162 0.0216
Loa Loa (eye worm) hypothetical protein 0.0042 0.0072 0.0311
Schistosoma mansoni notch 0.0081 0.034 0.0999
Loa Loa (eye worm) hypothetical protein 0.0213 0.1241 0.5339
Plasmodium falciparum hexose transporter 0.0065 0.023 0.0785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0162 0.0439
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Brugia malayi Trypsin family protein 0.0042 0.0072 0.0469
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0042 0.0072 0.0469
Echinococcus multilocularis laminin 0.0213 0.1241 0.1888
Schistosoma mansoni notch 0.0081 0.034 0.0999
Schistosoma mansoni septate junction protein 0.0081 0.034 0.0999
Echinococcus granulosus snurportin 1 0.0372 0.2324 0.7238
Giardia lamblia High cysteine protein 0.0081 0.034 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0023 0.0098
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0023 0.5
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0081 0.034 0.027
Loa Loa (eye worm) hypothetical protein 0.0042 0.0072 0.0311
Brugia malayi Cadherin domain containing protein 0.0081 0.034 0.2208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0162 0.0439
Onchocerca volvulus Putative cubilin 0.0081 0.034 0.027
Schistosoma mansoni glucose transport protein 0.0065 0.023 0.0651
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0065 0.023 0.0651
Echinococcus granulosus delta-like protein 1 0.0081 0.034 0.0999
Loa Loa (eye worm) hypothetical protein 0.0042 0.0072 0.0311
Schistosoma mansoni hypothetical protein 0.0081 0.034 0.0999
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Loa Loa (eye worm) hypothetical protein 0.0213 0.1241 0.5339
Echinococcus multilocularis protein jagged 2 0.0081 0.034 0.0492
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0081 0.034 0.0999
Schistosoma mansoni egf-like domain protein 0.0213 0.1241 0.383
Echinococcus multilocularis slit 2 protein 0.0081 0.034 0.0492
Loa Loa (eye worm) Notch2 0.0081 0.034 0.1465
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus multilocularis neurogenic locus notch protein 4 0.0081 0.034 0.0492
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0162 0.1053
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0072 0.0155
Schistosoma mansoni hypothetical protein 0.0042 0.0072 0.0155
Schistosoma mansoni hypothetical protein 0.0372 0.2324 0.7238
Brugia malayi Trypsin family protein 0.0042 0.0072 0.0469
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0072 0.0155
Loa Loa (eye worm) hypothetical protein 0.0042 0.0072 0.0311
Loa Loa (eye worm) hypothetical protein 0.0213 0.1241 0.5339
Echinococcus multilocularis neural cadherin 0.0081 0.034 0.0492
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2324 1
Echinococcus granulosus laminin 0.0213 0.1241 0.383
Echinococcus granulosus fibropellin Ia 0.0081 0.034 0.0999
Schistosoma mansoni notch 0.0081 0.034 0.0999
Brugia malayi Calcium binding EGF domain containing protein 0.0081 0.034 0.2208
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Echinococcus multilocularis snurportin 1 0.0372 0.2324 0.3567
Echinococcus granulosus notch 0.0081 0.034 0.0999
Brugia malayi Delta serrate ligand family protein 0.0081 0.034 0.2208
Toxoplasma gondii apocytochrome b, putative 0.0164 0.0904 0.3342
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0213 0.1241 0.8048
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.023 0.5
Echinococcus multilocularis neurogenic locus notch protein 0.0081 0.034 0.0492
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus multilocularis Mastin 0.0042 0.0072 0.0077
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0042 0.0072 0.0155
Echinococcus granulosus slit 2 protein 0.0081 0.034 0.0999
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0042 0.0072 0.0155
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus granulosus Desert hedgehog protein 0.0116 0.0576 0.1741
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Schistosoma mansoni laminin gamma-3 chain 0.0081 0.034 0.0999
Schistosoma mansoni notch 0.0081 0.034 0.0999
Echinococcus granulosus neurogenic locus notch protein 0.0081 0.034 0.0999
Brugia malayi Cadherin domain containing protein 0.0081 0.034 0.2208
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Schistosoma mansoni notch 0.0081 0.034 0.0999
Loa Loa (eye worm) hypothetical protein 0.0042 0.0072 0.0311
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Brugia malayi EGF-like domain containing protein 0.0081 0.034 0.2208
Schistosoma mansoni cytochrome b 0.0421 0.2661 0.8298
Echinococcus granulosus protein jagged 1 0.0081 0.034 0.0999
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0162 0.0699
Schistosoma mansoni hypothetical protein 0.0081 0.034 0.0999
Loa Loa (eye worm) trypsin family protein 0.0042 0.0072 0.0311
Loa Loa (eye worm) sugar transporter 0.0065 0.023 0.0989
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0162 0.0439
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0072 0.0155
Onchocerca volvulus Neurogenic locus notch homolog 0.0081 0.034 0.027
Wolbachia endosymbiont of Brugia malayi cytochrome b subunit of the bc complex 0.0421 0.2661 0.5
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus multilocularis fibropellin Ia 0.0081 0.034 0.0492
Echinococcus granulosus Mastin 0.0042 0.0072 0.0155
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0213 0.1241 0.383
Schistosoma mansoni cytochrome b 0.0257 0.1541 0.4777
Echinococcus multilocularis transmembrane protease serine 3 0.0042 0.0072 0.0077
Echinococcus granulosus tyrosine protein kinase shark 0.05 0.3202 1
Echinococcus granulosus protein jagged 2 0.0081 0.034 0.0999
Echinococcus granulosus General substrate transporter 0.0056 0.0167 0.0454
Brugia malayi Calcium binding EGF domain containing protein 0.0213 0.1241 0.8048
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Brugia malayi notch-like transmembrane receptor 0.0081 0.034 0.2208
Loa Loa (eye worm) hypothetical protein 0.0207 0.1199 0.5159
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0213 0.1241 0.5339
Echinococcus granulosus Tolloid protein 1 0.0213 0.1241 0.383
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0065 0.023 0.0651
Schistosoma mansoni tyrosine kinase 0.0489 0.3123 0.9753
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6473 1
Mycobacterium ulcerans ubiquinol-cytochrome C reductase QcrB 0.1496 1 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0065 0.023 0.0321
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0023 0.5
Schistosoma mansoni hypothetical protein 0.0084 0.0361 0.1065
Brugia malayi Muscle positioning protein 4 0.0081 0.034 0.2208
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus granulosus neurogenic locus notch protein 4 0.0081 0.034 0.0999
Brugia malayi EGF-like domain containing protein 0.0081 0.034 0.2208
Onchocerca volvulus Slit protein homolog 0.0081 0.034 0.027
Brugia malayi Calcium binding EGF domain containing protein 0.0081 0.034 0.2208
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0081 0.034 0.2208
Plasmodium vivax cytochrome b 0.0421 0.2661 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0042 0.0072 0.0077
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Schistosoma mansoni glucose transport protein 0.0065 0.023 0.0651
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Schistosoma mansoni glucose transport protein 0.0065 0.023 0.0651
Plasmodium vivax hexose transporter 0.0065 0.023 0.0785
Brugia malayi Trypsin family protein 0.0042 0.0072 0.0469
Onchocerca volvulus 0.0081 0.034 0.027
Echinococcus granulosus transmembrane protease serine 3 0.0042 0.0072 0.0155
Schistosoma mansoni hypothetical protein 0.0081 0.034 0.0999
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus multilocularis General substrate transporter 0.0056 0.0167 0.0224
Onchocerca volvulus 0.1496 1 1
Echinococcus granulosus neurogenic locus notch protein 0.0081 0.034 0.0999
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0072 0.0155
Onchocerca volvulus 0.0081 0.034 0.027
Echinococcus multilocularis protein jagged 1 0.0081 0.034 0.0492
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus multilocularis notch 0.0081 0.034 0.0492
Brugia malayi GCC2 and GCC3 family protein 0.0081 0.034 0.2208
Brugia malayi Trypsin-like protease protein 5 0.0042 0.0072 0.0469
Onchocerca volvulus Arrow homolog 0.0213 0.1241 0.1177
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0213 0.1241 0.5339
Echinococcus multilocularis fibrillin 1 0.0213 0.1241 0.1888
Schistosoma mansoni slit 0.0081 0.034 0.0999
Toxoplasma gondii calcium binding egf domain-containing protein 0.0213 0.1241 0.4616
Loa Loa (eye worm) hypothetical protein 0.0207 0.1199 0.5159
Echinococcus multilocularis fat cadherin tumor suppressor 0.0081 0.034 0.0492
Brugia malayi Trypsin family protein 0.0042 0.0072 0.0469
Onchocerca volvulus 0.0081 0.034 0.027
Loa Loa (eye worm) hypothetical protein 0.0184 0.1039 0.4472
Schistosoma mansoni tyrosine kinase 0.05 0.3202 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Echinococcus granulosus enteropeptidase 0.0042 0.0072 0.0155
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0065 0.023 0.0321
Brugia malayi EGF-like domain containing protein 0.0081 0.034 0.2208
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0072 0.0077
Echinococcus multilocularis hedgehog 0.0116 0.0576 0.0858
Schistosoma mansoni hypothetical protein 0.0081 0.034 0.0999
Echinococcus granulosus glycoprotein Antigen 5 0.0042 0.0072 0.0155
Echinococcus multilocularis neurogenic locus notch protein 0.0081 0.034 0.0492
Mycobacterium tuberculosis Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) 0.1496 1 0.5
Echinococcus granulosus protein jagged 1 0.0081 0.034 0.0999
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Loa Loa (eye worm) hypothetical protein 0.0213 0.1241 0.5339
Echinococcus granulosus neurogenic locus protein delta 0.0081 0.034 0.0999
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0042 0.0072 0.0155
Brugia malayi Sugar transporter family protein 0.0065 0.023 0.1491
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0072 0.0155
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0207 0.1199 0.7777
Loa Loa (eye worm) cytochrome b 0.0257 0.1541 0.6634
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0072 0.0155
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.1465
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0162 0.0216
Loa Loa (eye worm) hypothetical protein 0.0042 0.0072 0.0311
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0065 0.023 0.0651
Loa Loa (eye worm) hypothetical protein 0.0213 0.1241 0.5339
Echinococcus granulosus cytochrome B 0.0421 0.2661 0.8298
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0065 0.023 0.0321
Schistosoma mansoni hypothetical protein 0.0065 0.023 0.0651
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0072 0.0155
Onchocerca volvulus 0.0081 0.034 0.027
Loa Loa (eye worm) hypothetical protein 0.0042 0.0072 0.0311
Brugia malayi Calcium binding EGF domain containing protein 0.0081 0.034 0.2208
Loa Loa (eye worm) notch protein 0.0081 0.034 0.1465
Toxoplasma gondii calcium binding egf domain-containing protein 0.0213 0.1241 0.4616
Schistosoma mansoni hypothetical protein 0.0081 0.034 0.0999
Schistosoma mansoni notch 0.0081 0.034 0.0999
Toxoplasma gondii facilitative glucose transporter GT1 0.0065 0.023 0.0785
Echinococcus granulosus neural cadherin 0.0081 0.034 0.0999
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0072 0.0155
Brugia malayi RNA, U transporter 1 0.0099 0.0461 0.2993
Toxoplasma gondii apocytochrome b, putative 0.0421 0.2661 1
Brugia malayi EGF-like domain containing protein 0.0081 0.034 0.2208

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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