Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2501 | 0.2501 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.7041 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0925 | 0.0925 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.314 | 0.6092 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5155 | 0.5155 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.468 | 0.9079 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2501 | 0.3552 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5155 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0925 | 0.1313 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5155 | 0.5155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.1721 | 0.1721 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2501 | 0.3552 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0925 | 0.0925 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5155 | 0.5155 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2501 | 0.2501 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5155 | 0.5155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.1721 | 0.1721 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2501 | 0.4851 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2501 | 0.2501 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2501 | 0.2501 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5155 | 0.5155 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0925 | 0.1313 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5155 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2501 | 0.2501 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0925 | 0.0925 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2501 | 0.3552 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0925 | 0.1794 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.