Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | transient receptor potential cation channel, subfamily C, member 4 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | short transient receptor potential channel 6 | transient receptor potential cation channel, subfamily C, member 4 | 890 aa | 799 aa | 31.2 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4469 | 0.343 |
Toxoplasma gondii | cytochrome b | 0.0073 | 0.3972 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0078 | 0.4609 | 0.4609 |
Brugia malayi | cytochrome b | 0.0073 | 0.3972 | 0.8887 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4469 | 0.4469 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4469 | 0.4469 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0117 | 1 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0078 | 0.4609 | 0.4609 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0113 | 0.9469 | 0.9469 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0117 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1582 | 0.3539 |
Plasmodium vivax | cytochrome b | 0.0073 | 0.3972 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4469 | 0.343 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4469 | 0.343 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1582 | 0.1582 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4469 | 0.4469 |
Schistosoma mansoni | transient receptor potential channel | 0.0078 | 0.4609 | 0.3596 |
Loa Loa (eye worm) | cytochrome b | 0.0073 | 0.3972 | 0.3972 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1582 | 0.1582 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0078 | 0.4609 | 0.4609 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0073 | 0.3972 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2256 | 0.5047 |
Schistosoma mansoni | transient receptor potential channel | 0.0117 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4469 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2256 | 0.2256 |
Schistosoma mansoni | transient receptor potential channel | 0.0078 | 0.4609 | 0.3596 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4469 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2256 | 0.2256 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1582 | 0.1582 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4469 | 0.4469 |
Schistosoma mansoni | cytochrome b | 0.0073 | 0.3972 | 0.284 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4469 | 0.343 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1582 | 0.1582 |
Schistosoma mansoni | cytochrome b | 0.0073 | 0.3972 | 0.284 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0113 | 0.9469 | 0.9469 |
Plasmodium falciparum | cytochrome b | 0.0073 | 0.3972 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4469 | 1 |
Echinococcus granulosus | cytochrome B | 0.0073 | 0.3972 | 0.3972 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0078 | 0.4609 | 0.4609 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1582 | 0.1582 |
Toxoplasma gondii | apocytochrome b, putative | 0.0073 | 0.3972 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2256 | 0.5047 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.4079 | 0.4079 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4469 | 0.343 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4469 | 0.4469 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0.944 uM | PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that activate transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2237, AID2259] | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 21.1923 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.