Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Niemann Pick C1 protein | 0.0105 | 0.6853 | 0.6853 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0105 | 0.6853 | 0.6853 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0105 | 0.6853 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0099 | 0.6408 | 0.6408 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0695 | 0.0695 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.3387 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0273 | 0.0398 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0273 | 0.0273 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0273 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0741 | 0.1082 |
Onchocerca volvulus | 0.0023 | 0.1155 | 1 | |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0695 | 0.0695 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.3387 | 0.4862 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0273 | 0.0398 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0273 | 0.0273 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.1155 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0695 | 0.0997 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.1155 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1155 | 0.3409 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1155 | 0.1685 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0273 | 0.0392 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0273 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0741 | 0.1082 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2674 | 0.2674 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0055 | 0.3387 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0273 | 0.0273 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0273 | 0.0273 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0273 | 0.0398 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0273 | 0.0392 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0741 | 0.6421 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.1155 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0055 | 0.3387 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0675 | 0.5844 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0273 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1155 | 0.1685 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0055 | 0.3387 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0273 | 0.0398 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0055 | 0.3387 | 0.3387 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0273 | 0.0398 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0273 | 0.0398 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.1155 | 0.1685 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2674 | 0.3902 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0273 | 0.0398 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0045 | 0.2667 | 0.2667 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2553 | 0.3665 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2674 | 0.3838 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0398 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2674 | 0.2674 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0105 | 0.6853 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1155 | 0.1685 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.2058 | 0.3003 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.3233 | 0.4718 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0055 | 0.3387 | 0.4943 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.3387 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.1155 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0273 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.6853 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0055 | 0.3387 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0273 | 0.0273 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0273 | 0.2363 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0055 | 0.3387 | 0.3387 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.1155 | 0.1685 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0273 | 0.0273 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0273 | 0.0398 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0055 | 0.3387 | 0.3387 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.3387 | 1 |
Schistosoma mansoni | patched 1 | 0.0045 | 0.2667 | 0.3828 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0273 | 0.0398 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1155 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0273 | 0.0273 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2674 | 0.2674 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.1155 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.1155 | 0.1685 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0273 | 0.0273 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.1155 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.3387 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1155 | 0.1685 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0398 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0055 | 0.3387 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0273 | 0.0273 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2553 | 0.3665 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0273 | 0.0398 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0045 | 0.2667 | 0.2667 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0273 | 0.0398 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0055 | 0.3387 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0273 | 0.0273 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1155 | 0.3409 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0741 | 0.1082 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0273 | 0.0398 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.2667 | 0.7873 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0273 | 0.0392 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0273 | 0.0398 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2553 | 0.3665 |
Onchocerca volvulus | 0.0011 | 0.0273 | 0.2363 | |
Echinococcus granulosus | expressed conserved protein | 0.0099 | 0.6408 | 0.6408 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0398 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0273 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2667 | 0.3892 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0273 | 0.0398 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0273 | 0.0273 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0045 | 0.2667 | 0.2667 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0273 | 0.0392 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2674 | 0.2674 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0695 | 0.0695 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0675 | 0.5844 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0273 | 0.0398 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0695 | 0.0997 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0273 | 0.0392 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0695 | 0.0695 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0695 | 0.1014 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0273 | 0.0392 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.3233 | 0.4718 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2674 | 0.3902 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0273 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0273 | 0.0398 |
Echinococcus multilocularis | protein dispatched 1 | 0.0051 | 0.3112 | 0.3112 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.1155 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0273 | 0.2363 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.1155 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.015 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0398 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0273 | 0.0392 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.3387 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.1155 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0055 | 0.3387 | 0.3387 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0741 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0695 | 0.1014 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0741 | 0.1082 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0741 | 0.6421 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0741 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0695 | 0.0695 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0273 | 0.0392 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0675 | 0.5844 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0273 | 0.0392 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0695 | 0.1014 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0273 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0398 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0106 | 0.6967 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0675 | 0.5844 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0695 | 0.0997 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0273 | 0.0273 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.2667 | 0.3892 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.2058 | 0.3003 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0273 | 0.0273 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0273 | 0.0273 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0273 | 0.0392 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0695 | 0.1014 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0273 | 0.0273 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1155 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1155 | 0.1685 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2674 | 0.3838 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2674 | 0.3838 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0695 | 0.0997 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0741 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0273 | 0.0398 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1155 | 0.3409 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0055 | 0.3387 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0273 | 0.0392 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1155 | 0.1685 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0741 | 0.1082 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0398 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0273 | 0.2363 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0273 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0273 | 0.0398 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0273 | 0.0398 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2058 | 0.2955 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3375 | 0.4925 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0273 | 0.0398 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0055 | 0.3387 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0695 | 0.0695 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2553 | 0.3665 |
Echinococcus multilocularis | protein patched | 0.0045 | 0.2667 | 0.2667 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.3233 | 0.4718 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0273 | 0.0398 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.3387 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0273 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0273 | 0.0398 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0273 | 0.0392 |
Brugia malayi | MAP kinase sur-1 | 0.0055 | 0.3387 | 0.4943 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0273 | 0.0398 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.3233 | 0.4718 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0273 | 0.0398 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.2667 | 0.3892 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 252 uM | Inhibition of Mdm2 -p53 protein interaction by ELISA | ChEMBL. | 21314128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.