Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1768 | 0.1768 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.7653 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4592 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.1768 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.1768 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.1768 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4592 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5371 | 0.7018 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.4592 | 0.6 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.7653 | 0.7653 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.4592 | 0.6 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.7653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.1768 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.1768 | 0.1768 |
Brugia malayi | hypothetical protein | 0.0038 | 0.4592 | 0.4592 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.1768 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.1768 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5371 | 0.5371 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.7653 | 0.7653 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.7653 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.7653 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4592 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.4592 | 0.6 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.1768 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.7653 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.7653 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5371 | 0.5371 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.1768 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.4592 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.4592 | 0.6 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.7653 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5221 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.7375 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.