Detailed information for compound 149593

Basic information

Technical information
  • TDR Targets ID: 149593
  • Name: 3-methyl-1,3-di(naphthalen-1-yl)-1-phenylguan idine
  • MW: 401.502 | Formula: C28H23N3
  • H donors: 0 H acceptors: 0 LogP: 7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=N)N(c1cccc2c1cccc2)c1ccccc1)c1cccc2c1cccc2
  • InChi: 1S/C28H23N3/c1-30(26-19-9-13-21-11-5-7-17-24(21)26)28(29)31(23-15-3-2-4-16-23)27-20-10-14-22-12-6-8-18-25(22)27/h2-20,29H,1H3
  • InChiKey: AKEBYRRJXWLQGY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-methyl-1,3-bis(1-naphthyl)-1-phenyl-guanidine
  • 3-methyl-1,3-bis(1-naphthyl)-1-phenylguanidine
  • 3-methyl-1,3-di(naphthalen-1-yl)-1-phenyl-guanidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sigma non-opioid intracellular receptor 1 Starlite/ChEMBL References
Rattus norvegicus Glutamate NMDA receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hexokinase 1 0.0085 0.0709 0.2011
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0062 0.0067
Plasmodium vivax endoplasmin, putative 0.0127 0.1251 0.275
Leishmania major hypothetical protein, conserved 0.0077 0.0606 0.105
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0223 0.2494 0.7522
Echinococcus multilocularis heat shock protein 90 0.0107 0.0989 0.0969
Echinococcus multilocularis aldo keto reductase 0.0285 0.33 0.3285
Giardia lamblia Heat shock protein HSP 90-alpha 0.0107 0.0989 0.2896
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0248 0.2816 0.8512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0241 0.031
Brugia malayi hypothetical protein 0.0072 0.0535 0.0537
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0606 0.105
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0083 0.0678 0.0743
Echinococcus granulosus aldo keto reductase 0.0285 0.33 0.5233
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0098 0.0874 0.2541
Schistosoma mansoni jumonji/arid domain-containing protein 0.0133 0.1331 0.2058
Loa Loa (eye worm) jmjC domain-containing protein 0.0133 0.1331 0.1458
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.013 0.0107
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0455 0.1227
Leishmania major trypanothione reductase 0.0098 0.0874 0.1553
Plasmodium falciparum phd finger protein, putative 0.006 0.0389 0.078
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0606 0.1277
Echinococcus granulosus hexokinase 0.0085 0.0709 0.1096
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Mycobacterium leprae Conserved hypothetical protein 0.0202 0.2231 0.5922
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.013 0.0091
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0098 0.0076
Schistosoma mansoni hypothetical protein 0.0515 0.6286 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0285 0.33 1
Toxoplasma gondii heat shock protein 90, putative 0.0127 0.1251 0.275
Plasmodium vivax heat shock protein 86, putative 0.0127 0.1251 0.275
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0387 0.0638
Mycobacterium ulcerans heat shock protein 90 0.0114 0.1091 0.3209
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0083 0.0678 0.1046
Brugia malayi jmjC domain containing protein 0.0035 0.0062 0.0016
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0455 0.069
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285
Echinococcus granulosus voltage gated potassium channel subunit 0.0083 0.0678 0.1046
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0062 0.0039
Toxoplasma gondii hexokinase 0.0085 0.0709 0.1512
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0062 0.0067
Brugia malayi Hexokinase family protein 0.0085 0.0709 0.0729
Echinococcus multilocularis lysine specific demethylase 5A 0.0131 0.1306 0.1287
Treponema pallidum heat shock protein 90 0.0114 0.1091 1
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0062 0.0039
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0067
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285
Plasmodium falciparum heat shock protein 90, putative 0.0068 0.0492 0.1016
Entamoeba histolytica aldose reductase, putative 0.0285 0.33 1
Trypanosoma brucei heat shock protein 90, putative 0.0127 0.1251 0.2262
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.013 0.0171
Trichomonas vaginalis heat shock protein, putative 0.0068 0.0492 0.1367
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0062 0.0023
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0285 0.33 0.6112
Trypanosoma cruzi heat shock protein 85, putative 0.0127 0.1251 0.2262
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Echinococcus multilocularis aldo keto reductase 0.0285 0.33 0.3285
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0535 0.0782
Treponema pallidum hexokinase (hxk) 0.0085 0.0709 0.6341
Entamoeba histolytica heat shock protein 90, putative 0.0127 0.1251 0.3682
Schistosoma mansoni thyroid hormone receptor 0.004 0.013 0.0133
Trypanosoma brucei hexokinase 0.0085 0.0709 0.1244
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.013 0.0091
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0455 0.0766
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0047 0.0024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0387 0.1044
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0076 0.0594 0.1655
Echinococcus granulosus hypothetical protein 0.0285 0.33 0.5233
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1303 0.2014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.013 0.0142
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0069 0.0074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0067
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0146 0.0303
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0146 0.016
Echinococcus multilocularis hexokinase 0.0085 0.0709 0.0688
Loa Loa (eye worm) hexokinase 0.0085 0.0709 0.0776
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0285 0.33 0.3581
Trypanosoma cruzi heat shock protein 85, putative 0.0107 0.0989 0.177
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0455 0.0449
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.33 0.5233
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.33 0.5233
Trichomonas vaginalis heat shock protein, putative 0.0107 0.0989 0.2896
Trypanosoma cruzi trypanothione reductase, putative 0.0098 0.0874 0.1553
Plasmodium falciparum aldehyde reductase, putative 0.0083 0.0678 0.1441
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Schistosoma mansoni survival motor neuron protein 0.0048 0.0227 0.0288
Brugia malayi RNA binding protein 0.0131 0.1303 0.1383
Schistosoma mansoni heat shock protein 0.0127 0.1251 0.193
Echinococcus granulosus heat shock protein 90 0.0127 0.1251 0.1961
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0076 0.0594 0.065
Trichomonas vaginalis aldo/keto reductase, putative 0.0285 0.33 1
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0499 0.1389
Loa Loa (eye worm) hypothetical protein 0.0445 0.537 0.5881
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0057 0.0062
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0606 0.105
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.0142
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0069 0.0047
Trichomonas vaginalis heat shock protein, putative 0.0127 0.1251 0.3701
Trypanosoma cruzi hexokinase, putative 0.0085 0.0709 0.1244
Trypanosoma brucei hexokinase, putative 0.0085 0.0709 0.1244
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0076 0.0594 0.0572
Loa Loa (eye worm) hypothetical protein 0.0121 0.1179 0.1291
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0535 0.0818
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0387 0.1044
Echinococcus multilocularis tumor protein p63 0.0334 0.3939 0.3925
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.0142
Echinococcus granulosus thioredoxin glutathione reductase 0.0098 0.0874 0.1359
Schistosoma mansoni heat shock protein 0.0076 0.0594 0.0876
Brugia malayi ecdysteroid receptor 0.004 0.013 0.0091
Schistosoma mansoni aldo-keto reductase 0.0285 0.33 0.5214
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0083 0.0678 0.0695
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.013 0.0133
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.0142
Entamoeba histolytica alcohol dehydrogenase, putative 0.0083 0.0678 0.1915
Brugia malayi hypothetical protein 0.0438 0.5285 0.5766
Brugia malayi jmjC domain containing protein 0.0133 0.1331 0.1413
Onchocerca volvulus 0.0048 0.0227 0.0248
Echinococcus multilocularis endoplasmin 0.0114 0.1091 0.1071
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Echinococcus multilocularis peregrin 0.0063 0.0419 0.0397
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.013 0.0171
Plasmodium vivax thioredoxin reductase, putative 0.0098 0.0874 0.1888
Schistosoma mansoni potassium channel beta 0.0083 0.0678 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.003
Brugia malayi heat shock protein 90 0.0127 0.1251 0.1325
Echinococcus multilocularis heat shock protein 0.0127 0.1251 0.1231
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.0142
Brugia malayi TAR-binding protein 0.0131 0.1303 0.1383
Onchocerca volvulus 0.0049 0.0243 0.0266
Trichomonas vaginalis heat shock protein, putative 0.0114 0.1091 0.3209
Trichomonas vaginalis aldo-keto reductase, putative 0.0083 0.0678 0.1939
Schistosoma mansoni transcription factor btf3 0.0035 0.0057 0.0016
Loa Loa (eye worm) hypothetical protein 0.0151 0.1564 0.1713
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0062 0.0033
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.0142
Brugia malayi MH2 domain containing protein 0.0365 0.4332 0.4717
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.013 0.0133
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0243 0.0313
Schistosoma mansoni hypothetical protein 0.006 0.0389 0.0547
Onchocerca volvulus Bile acid receptor homolog 0.004 0.013 0.0142
Onchocerca volvulus Alhambra homolog 0.006 0.0389 0.0426
Onchocerca volvulus 0.0085 0.0709 0.0776
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0062 0.0023
Plasmodium falciparum heat shock protein 90, putative 0.0372 0.4425 1
Brugia malayi hypothetical protein 0.0151 0.1564 0.167
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.013 0.0133
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0255 0.2917 0.2901
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.013 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.013 0.0091
Brugia malayi hypothetical protein 0.0077 0.0606 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0108 0.0187
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Schistosoma mansoni thyroid hormone receptor 0.004 0.013 0.0133
Loa Loa (eye worm) hypothetical protein 0.0038 0.01 0.011
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0062 0.0039
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0083 0.0678 0.1441
Onchocerca volvulus 0.0285 0.33 0.3614
Onchocerca volvulus 0.004 0.013 0.0142
Leishmania major hexokinase, putative 0.0085 0.0709 0.1244
Trypanosoma brucei heat shock protein, putative 0.0127 0.1251 0.2262
Echinococcus granulosus transcription factor btf3 0.0035 0.0057 0.0054
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0083 0.0678 0.1185
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.013 0.0107
Trypanosoma cruzi hexokinase, putative 0.0085 0.0709 0.1244
Echinococcus granulosus aldehyde reductase 0.0202 0.2231 0.3526
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0223 0.2494 0.7522
Loa Loa (eye worm) hypothetical protein 0.007 0.0515 0.0564
Trypanosoma brucei aldo/keto reductase, putative 0.0083 0.0678 0.1185
Giardia lamblia Aldose reductase 0.0285 0.33 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0255 0.2917 0.4621
Trypanosoma brucei trypanothione reductase 0.0098 0.0874 0.1553
Entamoeba histolytica aldose reductase, putative 0.0285 0.33 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0223 0.2494 0.6926
Giardia lamblia Aldose reductase 0.0285 0.33 1
Brugia malayi hexokinase 0.0085 0.0709 0.0729
Echinococcus multilocularis chromobox protein 1 0.0069 0.0499 0.0477
Entamoeba histolytica hypothetical protein 0.0072 0.0535 0.1475
Onchocerca volvulus 0.0285 0.33 0.3614
Brugia malayi nuclear hormone receptor 0.004 0.013 0.0091
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.013 0.0107
Onchocerca volvulus 0.0151 0.1564 0.1713
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Loa Loa (eye worm) oxidoreductase 0.0285 0.33 0.3614
Echinococcus granulosus peregrin 0.0063 0.0419 0.0633
Trypanosoma cruzi Heat shock protein 83, putative 0.0127 0.1251 0.2262
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Trypanosoma brucei heat shock protein, putative 0.0127 0.1251 0.2262
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0374 0.056
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0606 0.1277
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0606 0.1277
Toxoplasma gondii heat shock protein HSP90 0.0127 0.1251 0.275
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0114 0.1091 0.1961
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1303 0.2014
Loa Loa (eye worm) hypothetical protein 0.0058 0.0359 0.0393
Trypanosoma cruzi heat shock protein 90, putative 0.0107 0.0989 0.177
Loa Loa (eye worm) hypothetical protein 0.0042 0.0155 0.017
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Brugia malayi Endoplasmin precursor 0.0127 0.1251 0.1325
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.1303 0.1427
Echinococcus multilocularis hexokinase 0.0085 0.0709 0.0688
Leishmania major heat shock protein, putative 0.0076 0.0594 0.1027
Loa Loa (eye worm) oxidoreductase 0.0285 0.33 0.3614
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0248 0.2816 0.8512
Trichomonas vaginalis aldo-keto reductase, putative 0.0083 0.0678 0.1939
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.013 0.0133
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.013 0.0107
Onchocerca volvulus 0.0085 0.0709 0.0776
Trypanosoma brucei heat shock protein 90, putative 0.0127 0.1251 0.2262
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.013 0.0142
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0389 0.0547
Echinococcus multilocularis FTZ F1 alpha 0.004 0.013 0.0107
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.013 0.0091
Giardia lamblia Heat shock protein HSP 90-alpha 0.0127 0.1251 0.3701
Trypanosoma cruzi heat shock protein 85, putative 0.0127 0.1251 0.2262
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.013 0.0142
Loa Loa (eye worm) TAR-binding protein 0.0131 0.1303 0.1427
Trypanosoma cruzi heat shock protein, putative 0.0076 0.0594 0.1027
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.33 0.5233
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0108 0.0118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0241 0.0348
Loa Loa (eye worm) steroid hormone receptor 0.004 0.013 0.0142
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.013 0.0107
Echinococcus granulosus hexokinase type 2 0.0085 0.0709 0.1096
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0387 0.0545
Trichomonas vaginalis heat shock protein, putative 0.0088 0.0754 0.2173
Loa Loa (eye worm) RNA binding protein 0.0131 0.1303 0.1427
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Schistosoma mansoni pol-related 0.0285 0.33 0.5214
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0062 0.0027
Plasmodium vivax hypothetical protein, conserved 0.006 0.0389 0.078
Schistosoma mansoni hypothetical protein 0.0515 0.6286 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0037 0.0086 0.0101
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0057 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0387 0.0545
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.013 0.0091
Trypanosoma brucei aldo-keto reductase, putative 0.0285 0.33 0.6112
Onchocerca volvulus 0.0083 0.0678 0.0743
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0455 0.0433
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0499 0.0546
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0056 0.0053
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0062 0.0062
Trypanosoma brucei heat shock protein, putative 0.0127 0.1251 0.2262
Leishmania major hexokinase, putative 0.0085 0.0709 0.1244
Echinococcus granulosus chromobox protein 1 0.0069 0.0499 0.076
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0241 0.0264
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.537 1
Trichomonas vaginalis endoplasmin, putative 0.0088 0.0754 0.2173
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.013 0.0091
Echinococcus multilocularis Protein lozenge 0.0055 0.0321 0.0299
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0535 0.0514
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0062 0.0023
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0285 0.33 0.3581
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.013 0.0142
Brugia malayi Bromodomain containing protein 0.0038 0.01 0.0058
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.0142
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0389 0.0584
Brugia malayi beta-NAC-like protein 0.0035 0.0057 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0365 0.4332 0.4745
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.013 0.0171
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0389 0.0367
Entamoeba histolytica heat shock protein 90, putative 0.0127 0.1251 0.3682
Brugia malayi jmjC domain containing protein 0.0035 0.0062 0.0016
Echinococcus granulosus phd:f box containing protein 0.0035 0.0062 0.0062
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0387 0.1044
Toxoplasma gondii thioredoxin reductase 0.0098 0.0874 0.1888
Echinococcus multilocularis tar DNA binding protein 0.0131 0.1303 0.1283
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0606 0.1277
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.013 0.0171
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.013 0.0142
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Schistosoma mansoni aldo-keto reductase 0.0285 0.33 0.5214
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0107 0.0989 0.1543
Plasmodium falciparum aldo-keto reductase, putative 0.0083 0.0678 0.1441
Trypanosoma cruzi aldo-keto reductase 0.0285 0.33 0.6112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.013 0.0142
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0499 0.1389
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0455 0.0498
Loa Loa (eye worm) hypothetical protein 0.0227 0.2553 0.2796
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.003
Giardia lamblia PHD finger protein 15 0.006 0.0389 0.105
Brugia malayi Bromodomain containing protein 0.0074 0.057 0.0575
Echinococcus granulosus chromobox protein 1 0.0069 0.0499 0.076
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.013 0.0171
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0083 0.0678 0.1441
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0062 0.0062
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0285 0.33 0.3581
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0285 0.33 0.3581
Schistosoma mansoni hypothetical protein 0.0072 0.0535 0.0782
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0098 0.0121
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.013 0.0133
Plasmodium vivax glutathione reductase, putative 0.0098 0.0874 0.1888
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0389 0.0426
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0062 0.0067
Onchocerca volvulus Huntingtin homolog 0.0121 0.1179 0.1291
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0057 0.0018
Brugia malayi hypothetical protein 0.0234 0.2639 0.2853
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.1303 0.1383
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1303 0.2014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.013 0.0133
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Toxoplasma gondii Hsp90 domain-containing protein 0.0372 0.4425 1
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0057 0.0022
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.537 0.5859
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.013 0.0171
Brugia malayi Heterochromatin protein 1 0.0069 0.0499 0.0497
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Schistosoma mansoni hypothetical protein 0.0048 0.0227 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0108 0.0187
Echinococcus granulosus aldo keto reductase 0.0285 0.33 0.5233
Loa Loa (eye worm) heat shock protein 90 0.0127 0.1251 0.137
Loa Loa (eye worm) thioredoxin reductase 0.0098 0.0874 0.0957
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Onchocerca volvulus 0.0053 0.0299 0.0327
Loa Loa (eye worm) hypothetical protein 0.0438 0.5285 0.5788
Echinococcus granulosus heat shock protein 0.0127 0.1251 0.1961
Mycobacterium tuberculosis Conserved protein 0.0083 0.0678 0.1939
Schistosoma mansoni chromobox protein 0.0069 0.0499 0.0724
Brugia malayi Hexokinase family protein 0.0053 0.0299 0.0277
Plasmodium falciparum endoplasmin, putative 0.0088 0.0754 0.1614
Mycobacterium tuberculosis Probable oxidoreductase 0.0285 0.33 1
Plasmodium falciparum thioredoxin reductase 0.0098 0.0874 0.1888
Loa Loa (eye worm) heat shock protein 75 0.0076 0.0594 0.065
Leishmania major hypothetical protein, conserved 0.0035 0.0062 0.0027
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0047 0.0039
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0455 0.0766
Plasmodium vivax hexokinase, putative 0.0085 0.0709 0.1512
Echinococcus granulosus hexokinase 0.0085 0.0709 0.1096
Brugia malayi jmjC domain containing protein 0.0035 0.0062 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.0248 0.2816 0.8512
Loa Loa (eye worm) oxidoreductase 0.0285 0.33 0.3614
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.013 0.0091
Trypanosoma brucei hexokinase 0.0085 0.0709 0.1244
Loa Loa (eye worm) hypothetical protein 0.0119 0.1147 0.1256
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0285 0.33 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0223 0.2494 0.7522
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0114 0.1091 1
Trypanosoma brucei heat shock protein, putative 0.0127 0.1251 0.2262
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0037 0.0086 0.0063
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0083 0.0678 0.1939
Onchocerca volvulus 0.0285 0.33 0.3614
Brugia malayi nuclear receptor NHR-88 0.004 0.013 0.0091
Schistosoma mansoni jumonji domain containing protein 0.0215 0.2392 0.3758
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0062 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0241 0.0348
Schistosoma mansoni hypothetical protein 0.0035 0.0056 0.0014
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.537 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.33 0.5233
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0455 0.0766
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0047 0.5
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0387 0.0581
Mycobacterium ulcerans hypothetical protein 0.0083 0.0678 0.1939
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.013 0.0091
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Echinococcus multilocularis jumonji domain containing protein 0.0084 0.0694 0.0673
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.013 0.0107
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Plasmodium vivax JmjC domain containing protein 0.0035 0.0062 0.0033
Loa Loa (eye worm) hexokinase 0.0053 0.0299 0.0327
Loa Loa (eye worm) hypothetical protein 0.0049 0.0243 0.0266
Echinococcus granulosus heat shock protein 90 0.0107 0.0989 0.1543
Brugia malayi NADH-dependent xylose reductase 0.0083 0.0678 0.0695
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0062 0.0023
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0057 0.0022
Trypanosoma cruzi heat shock protein 90, putative 0.0059 0.0368 0.0603
Leishmania major basic transcription factor 3a, putative 0.0035 0.0057 0.0018
Echinococcus multilocularis chromobox protein 1 0.0069 0.0499 0.0477
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.33 0.5233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0241 0.031
Plasmodium vivax aldehyde reductase, putative 0.0083 0.0678 0.1441
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0057 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0365 0.4332 0.4745
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0223 0.2494 0.7522
Trypanosoma brucei Heat shock protein 83, putative 0.0127 0.1251 0.2262
Onchocerca volvulus 0.0735 0.9131 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.013 0.0091
Loa Loa (eye worm) runx1 0.0055 0.0321 0.0351
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0062 0.0023
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0455 0.0653
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.013 0.0107
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0062 0.0062
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0146 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.013 0.0091
Plasmodium vivax heat shock protein, putative 0.0372 0.4425 1
Schistosoma mansoni bromodomain containing protein 0.0063 0.042 0.0597
Schistosoma mansoni chromobox protein 0.0069 0.0499 0.0724
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.33 0.5233
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Brugia malayi PHD-finger family protein 0.006 0.0389 0.0376
Echinococcus multilocularis aldo keto reductase 0.0285 0.33 0.3285
Echinococcus multilocularis thioredoxin glutathione reductase 0.0098 0.0874 0.0853
Entamoeba histolytica hypothetical protein 0.0072 0.0535 0.1475
Mycobacterium ulcerans oxidoreductase 0.0285 0.33 1
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.013 0.0091
Brugia malayi steroid hormone receptor 0.004 0.013 0.0091
Mycobacterium tuberculosis Probable reductase 0.0223 0.2494 0.7522
Brugia malayi jmjC domain containing protein 0.0255 0.2917 0.3159
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0083 0.0678 0.1441
Onchocerca volvulus Hexokinase homolog 0.0053 0.0299 0.0327
Toxoplasma gondii heat shock protein 75, putative 0.0076 0.0594 0.1249
Brugia malayi glutathione reductase 0.0098 0.0874 0.091
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0062 0.0039
Loa Loa (eye worm) pax transcription factor protein 2 0.0735 0.9131 1
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Loa Loa (eye worm) hypothetical protein 0.0234 0.2639 0.289
Loa Loa (eye worm) hypothetical protein 0.0077 0.0606 0.0664
Brugia malayi Thioredoxin reductase 0.0098 0.0874 0.091
Entamoeba histolytica alcohol dehydrogenase, putative 0.0083 0.0678 0.1915
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0606 0.105
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Echinococcus multilocularis voltage gated potassium channel subunit 0.0083 0.0678 0.0657
Loa Loa (eye worm) glutathione reductase 0.0098 0.0874 0.0957
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1303 0.2014
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0062 0.0033
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2639 0.2622
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.013 0.0133
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0285 0.33 0.6112
Loa Loa (eye worm) endoplasmin 0.0127 0.1251 0.137
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0114 0.1091 0.1574
Echinococcus granulosus hexokinase 0.0085 0.0709 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.013 0.0091
Brugia malayi Steroid receptor seven-up type 2 0.004 0.013 0.0091
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0387 0.0365
Schistosoma mansoni hexokinase 0.0085 0.0709 0.1061
Trypanosoma cruzi aldo/keto reductase, putative 0.0285 0.33 0.6112
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Echinococcus granulosus lysine specific demethylase 5A 0.0133 0.1331 0.2089
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0387 0.0776
Loa Loa (eye worm) oxidoreductase 0.0285 0.33 0.3614
Brugia malayi Bromodomain containing protein 0.0063 0.0419 0.0409
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0248 0.2816 0.8154
Schistosoma mansoni nuclear hormone receptor 0.004 0.013 0.0133
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.33 0.5233
Entamoeba histolytica hexokinase 2 0.0085 0.0709 0.2011
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.33 0.5233
Echinococcus multilocularis aldehyde reductase 0.0202 0.2231 0.2213
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0114 0.1091 0.3209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0241 0.0218
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0057 0.0018
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Schistosoma mansoni lozenge 0.0055 0.0321 0.0439
Trypanosoma brucei heat shock protein 84, putative 0.0076 0.0594 0.1027
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.0142
Brugia malayi Pax transcription factor protein 2 0.0735 0.9131 1
Schistosoma mansoni endoplasmin 0.0127 0.1251 0.193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.013 0.0142
Trypanosoma brucei heat shock protein, putative 0.0127 0.1251 0.2262
Schistosoma mansoni coup transcription factor 0.004 0.013 0.0133
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0374 0.0352
Echinococcus multilocularis heat shock protein 90 0.0127 0.1251 0.1231
Trichomonas vaginalis aldo-keto reductase, putative 0.0083 0.0678 0.1939
Echinococcus multilocularis transcription factor btf3 0.0035 0.0057 0.0034
Trypanosoma cruzi heat shock protein 90, putative 0.0127 0.1251 0.2262
Onchocerca volvulus 0.0438 0.5285 0.5788
Trichomonas vaginalis aldo/keto reductase, putative 0.0285 0.33 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.33 0.5233
Echinococcus granulosus geminin 0.0515 0.6286 1
Trypanosoma cruzi heat shock protein 85, putative 0.0127 0.1251 0.2262
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.013 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.013 0.0142
Schistosoma mansoni endoplasmin 0.0127 0.1251 0.193
Echinococcus granulosus tumor protein p63 0.0334 0.3939 0.6252
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.537 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0131 0.0143
Trypanosoma brucei heat shock protein, putative 0.0127 0.1251 0.2262
Onchocerca volvulus 0.0285 0.33 0.3614
Trypanosoma brucei heat shock protein, putative 0.0127 0.1251 0.2262
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.013 0.0171
Loa Loa (eye worm) hypothetical protein 0.0285 0.33 0.3614
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.013 0.0133
Echinococcus granulosus jumonji domain containing protein 0.0084 0.0694 0.1072
Loa Loa (eye worm) hypothetical protein 0.0039 0.0108 0.0118
Plasmodium vivax heat shock protein 90, putative 0.0076 0.0594 0.1249
Loa Loa (eye worm) oxidoreductase 0.0285 0.33 0.3614
Toxoplasma gondii aldose reductase, putative 0.0285 0.33 0.7431
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0389 0.078
Brugia malayi jmjC domain containing protein 0.0035 0.0062 0.0016
Onchocerca volvulus 0.0285 0.33 0.3614
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1303 0.2014
Plasmodium falciparum heat shock protein 90 0.0127 0.1251 0.275
Brugia malayi chromobox protein homolog 3 0.0039 0.0108 0.0067
Trichomonas vaginalis heat shock protein, putative 0.0114 0.1091 0.3209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0241 0.031
Trichomonas vaginalis aldo/keto reductase, putative 0.0285 0.33 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0083 0.0678 0.1185
Loa Loa (eye worm) hypothetical protein 0.004 0.013 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0241 0.0218
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0227 0.0198
Plasmodium falciparum glutathione reductase 0.0098 0.0874 0.1888
Entamoeba histolytica aldose reductase, putative 0.0285 0.33 1
Toxoplasma gondii aldo-keto reductase 0.0083 0.0678 0.1441
Echinococcus granulosus endoplasmin 0.0114 0.1091 0.1705
Loa Loa (eye worm) hexokinase type II 0.0085 0.0709 0.0776
Echinococcus granulosus aldo keto reductase 0.0285 0.33 0.5233
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0387 0.1044
Echinococcus multilocularis aldo keto reductase 0.0285 0.33 0.3285
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0285 0.33 1
Leishmania major aldo-keto reductase-like protein 0.0285 0.33 0.6112
Onchocerca volvulus 0.0085 0.0709 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.013 0.0091
Loa Loa (eye worm) hexokinase 0.0085 0.0709 0.0776
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0062 0.0027
Mycobacterium tuberculosis Probable dehydrogenase 0.0223 0.2494 0.7522
Brugia malayi Hsp90 protein 0.0076 0.0594 0.0602
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0455 0.0766
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0076 0.0594 0.0912
Brugia malayi hypothetical protein 0.005 0.0253 0.0226
Giardia lamblia Grp94/Hsp90 0.0114 0.1091 0.3209
Loa Loa (eye worm) hypothetical protein 0.0121 0.1179 0.1291
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.013 0.0171
Plasmodium falciparum hexokinase 0.0085 0.0709 0.1512
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2639 0.4177
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0285 0.33 1
Entamoeba histolytica hypothetical protein 0.0072 0.0535 0.1475
Leishmania major prostaglandin f synthase, putative 0.0285 0.33 0.6112
Brugia malayi hypothetical protein 0.0121 0.1179 0.1246
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0389 0.078
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0062 0.0027
Onchocerca volvulus 0.0285 0.33 0.3614
Leishmania major heat shock protein 83-1 0.0127 0.1251 0.2262
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.003
Entamoeba histolytica hypothetical protein 0.0072 0.0535 0.1475
Trypanosoma brucei prostaglandin f synthase 0.0285 0.33 0.6112
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0056 0.0033
Schistosoma mansoni heat shock protein 0.0127 0.1251 0.193
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.1219 0.1335
Trypanosoma brucei heat shock protein, putative 0.0127 0.1251 0.2262
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0678 0.1939
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285
Echinococcus granulosus tar DNA binding protein 0.0131 0.1303 0.2045
Echinococcus multilocularis hexokinase type 2 0.0085 0.0709 0.0688
Echinococcus granulosus FTZ F1 alpha 0.004 0.013 0.0171
Echinococcus multilocularis geminin 0.0515 0.6286 0.6277
Onchocerca volvulus Huntingtin homolog 0.0121 0.1179 0.1291
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0241 0.0213
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.33 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.013 0.0091
Echinococcus multilocularis hexokinase 0.0085 0.0709 0.0688
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.013 0.0142
Loa Loa (eye worm) hypothetical protein 0.006 0.0389 0.0426
Schistosoma mansoni jumonji/arid domain-containing protein 0.0133 0.1331 0.2058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.013 0.0133
Loa Loa (eye worm) hypothetical protein 0.0438 0.5285 0.5788
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.33 0.3285

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 470 nM In vitro concentration required to inhibit specific [3H]-MK-801 radioligand binding to N-methyl-D-aspartate (NMDA) receptor on rat brain membrane ChEMBL. 8295213
IC50 (binding) = 470 nM In vitro concentration required to inhibit specific [3H]-MK-801 radioligand binding to N-methyl-D-aspartate (NMDA) receptor on rat brain membrane ChEMBL. 8295213
IC50 (binding) = 11000 nM Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane ChEMBL. 8295213
IC50 (binding) = 11000 nM Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane ChEMBL. 8295213

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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