Detailed information for compound 1496000

Basic information

Technical information
  • TDR Targets ID: 1496000
  • Name: N-(1,3-benzodioxol-5-yl)-N-(2-oxo-2-piperidin -1-ylethyl)methanesulfonamide
  • MW: 340.395 | Formula: C15H20N2O5S
  • H donors: 0 H acceptors: 3 LogP: 1.26 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCCC1)CN(S(=O)(=O)C)c1ccc2c(c1)OCO2
  • InChi: 1S/C15H20N2O5S/c1-23(19,20)17(10-15(18)16-7-3-2-4-8-16)12-5-6-13-14(9-12)22-11-21-13/h5-6,9H,2-4,7-8,10-11H2,1H3
  • InChiKey: VVXWQEQINCEIRA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(1,3-benzodioxol-5-yl)-N-[2-oxo-2-(1-piperidyl)ethyl]methanesulfonamide
  • N-(1,3-benzodioxol-5-yl)-N-(2-keto-2-piperidino-ethyl)methanesulfonamide
  • N-(1,3-benzodioxol-5-yl)-N-(2-oxo-2-piperidin-1-yl-ethyl)methanesulfonamide
  • ZINC00614748
  • MLS000065038
  • N-1,3-benzodioxol-5-yl-N-[2-oxo-2-(1-piperidinyl)ethyl]methanesulfonamide (non-preferred name)
  • SMR000078400

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor family member nhr-6 0.0052 0.0066 0.0066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0059 0.0059
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.011 0.0517 0.183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0027 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.0517 0.0517
Brugia malayi Steroid receptor seven-up type 2 0.011 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.006 0.0126 0.0126
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0114 0.0455
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.0066 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.011 0.0517 0.0517
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0027 0.0095
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0066 0.0263
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.011 0.0517 0.183
Brugia malayi nuclear receptor NHR-88 0.011 0.0517 0.0517
Brugia malayi follicle stimulating hormone receptor 0.0238 0.1505 0.1505
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.011 0.0517 0.2061
Echinococcus multilocularis thyroid hormone receptor alpha 0.011 0.0517 0.183
Toxoplasma gondii ABC1 family protein 0.0043 0 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0367 0.251 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.0066 0.0233
Brugia malayi hypothetical protein 0.0058 0.0114 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-14 0.011 0.0517 0.0517
Echinococcus multilocularis ecdysone induced protein 78C 0.011 0.0517 0.183
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.011 0.0517 0.0517
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0066 0.0263
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0027 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0 0.5
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0126 0.0502
Brugia malayi Nuclear hormone receptor E75 0.0052 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.011 0.0517 0.0517
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0 0.5
Onchocerca volvulus 0.0052 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.011 0.0517 0.0517
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Brugia malayi tailless protein 0.0052 0.0066 0.0066
Onchocerca volvulus Bile acid receptor homolog 0.1334 1 1
Mycobacterium ulcerans hypothetical protein 0.0043 0 0.5
Brugia malayi hypothetical protein 0.0052 0.0066 0.0066
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0052 0.0066 0.0066
Echinococcus multilocularis FTZ F1 alpha 0.011 0.0517 0.183
Echinococcus granulosus tumor protein p63 0.0408 0.2826 1
Brugia malayi hypothetical protein 0.0052 0.0066 0.0066
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.011 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0058 0.0114 0.0114
Schistosoma mansoni thyroid hormone receptor 0.011 0.0517 0.2061
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.1505 0.1505
Brugia malayi nuclear hormone receptor family member odr-7 0.0052 0.0066 0.0066
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0114 0.0114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0027 0.0107
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.0517 0.0517
Brugia malayi orphan nuclear receptor NR2E1 0.0052 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Schistosoma mansoni nuclear hormone receptor 0.011 0.0517 0.2061
Schistosoma mansoni zinc finger protein 0.0052 0.0066 0.0263
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.011 0.0517 0.183
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0059 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.0517 0.183
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.011 0.0517 0.2061
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.011 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.011 0.0517 0.0517
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0058 0.0114 0.0455
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.0066 0.0066
Onchocerca volvulus Protein ultraspiracle homolog 0.011 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.1334 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0052 0.0066 0.0233
Brugia malayi hypothetical protein 0.0058 0.0114 0.0114
Plasmodium vivax hypothetical protein, conserved 0.0043 0 0.5
Loa Loa (eye worm) hypothetical protein 0.011 0.0517 0.0517
Brugia malayi nuclear hormone receptor 0.0052 0.0066 0.0066
Schistosoma mansoni steroid hormone receptor ad4bp 0.011 0.0517 0.2061
Echinococcus granulosus thyroid hormone receptor alpha 0.0052 0.0066 0.0233
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Trypanosoma brucei hypothetical protein, conserved 0.0043 0 0.5
Onchocerca volvulus 0.0052 0.0066 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0027 0.0027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0027 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.011 0.0517 0.0517
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.0517 0.183
Echinococcus multilocularis tumor protein p63 0.0408 0.2826 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0027 0.0095
Loa Loa (eye worm) hypothetical protein 0.0051 0.0059 0.0059
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1816 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.011 0.0517 0.183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.011 0.0517 0.0517
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0052 0.0066 0.0263
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.011 0.0517 0.2061
Mycobacterium ulcerans beta-lactamase 0.0043 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.011 0.0517 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-40 0.011 0.0517 0.0517
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.0066 0.0233
Schistosoma mansoni retinoid-x-receptor (RXR) 0.011 0.0517 0.2061
Loa Loa (eye worm) steroid hormone receptor 0.011 0.0517 0.0517
Mycobacterium ulcerans lipase LipD 0.0043 0 0.5
Echinococcus multilocularis nuclear receptor nhr 48 0.0052 0.0066 0.0233
Brugia malayi nuclear receptor NHR-67 0.0052 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-1 0.011 0.0517 0.0517
Brugia malayi photoreceptor-specific nuclear receptor 0.011 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-41 0.011 0.0517 0.0517
Echinococcus granulosus ecdysone induced protein 78C 0.011 0.0517 0.183
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0 0.5
Brugia malayi steroid hormone receptor 0.011 0.0517 0.0517
Brugia malayi nuclear receptor RXR 0.0052 0.0066 0.0066
Schistosoma mansoni nuclear receptor 0.0052 0.0066 0.0263
Loa Loa (eye worm) hypothetical protein 0.0058 0.0114 0.0114
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.011 0.0517 0.183
Loa Loa (eye worm) hypothetical protein 0.011 0.0517 0.0517
Brugia malayi nuclear hormone receptor 0.011 0.0517 0.0517
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0058 0.0114 0.0114
Schistosoma mansoni nuclear receptor 0.0052 0.0066 0.0263
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0052 0.0066 0.0066
Schistosoma mansoni coup transcription factor 0.011 0.0517 0.2061
Loa Loa (eye worm) hypothetical protein 0.0058 0.0114 0.0114
Schistosoma mansoni RAR-like nuclear receptor 0.011 0.0517 0.2061
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0052 0.0066 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-3 0.011 0.0517 0.0517
Loa Loa (eye worm) nuclear hormone receptor 0.0052 0.0066 0.0066
Mycobacterium leprae conserved hypothetical protein 0.0043 0 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.0517 0.0517
Loa Loa (eye worm) nuclear receptor NHR-67 0.0052 0.0066 0.0066
Onchocerca volvulus 0.011 0.0517 0.0517
Loa Loa (eye worm) DR-78 0.0052 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.011 0.0517 0.0517
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0367 0.251 0.8882
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.0066 0.0233
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0058 0.0114 0.0404
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0027 0.0095
Echinococcus granulosus FTZ F1 alpha 0.011 0.0517 0.183
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Brugia malayi nuclear receptor RXR 0.0058 0.0114 0.0114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0066 0.0233
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.0066 0.0066
Brugia malayi ecdysone receptor 0.0052 0.0066 0.0066
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.011 0.0517 0.183
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.0517 0.183
Brugia malayi conserved hypotetical protein 0.0052 0.0066 0.0066
Leishmania major hypothetical protein, conserved 0.0043 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0114 0.0114
Schistosoma mansoni Tr4/Tr2 (homologue) 0.011 0.0517 0.2061
Loa Loa (eye worm) hypothetical protein 0.0052 0.0066 0.0066
Onchocerca volvulus 0.006 0.0126 0.0126
Mycobacterium leprae Probable lipase LipE 0.0043 0 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.011 0.0517 0.183
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0058 0.0114 0.0114
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0052 0.0066 0.0263
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0052 0.0066 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.011 0.0517 0.0517
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0 0.5
Brugia malayi Nuclear hormone receptor E75 0.0052 0.0066 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.0517 0.183
Schistosoma mansoni thyroid hormone receptor 0.011 0.0517 0.2061
Brugia malayi Nuclear hormone receptor family member nhr-49 0.011 0.0517 0.0517
Trichomonas vaginalis esterase, putative 0.0043 0 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0052 0.0066 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.011 0.0517 0.0517
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0058 0.0114 0.0404
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0309 0.2059 0.7285
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.011 0.0517 0.183
Brugia malayi nuclear receptor NHR-88 0.0052 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.011 0.0517 0.0517
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.011 0.0517 0.2061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0066 0.0233
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.011 0.0517 0.0517

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2239 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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