Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | trypanothione reductase | 0.0039 | 0.2288 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.465 | 0.465 |
Brugia malayi | glutathione reductase | 0.0039 | 0.2288 | 0.492 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.465 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.465 | 0.465 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.2335 | 0.5021 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0098 | 0.7665 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0088 | 0.6774 | 0.8837 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.1082 | 0.473 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.2288 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.1082 | 0.2327 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.465 | 0.465 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1082 | 0.473 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0088 | 0.6774 | 0.8837 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1082 | 0.473 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.465 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0013 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.2288 | 1 |
Treponema pallidum | NADH oxidase | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0088 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0088 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0088 | 0.6774 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0088 | 0.6774 | 0.8837 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.2288 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0098 | 0.7665 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0013 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1082 | 0.473 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0098 | 0.7665 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1082 | 0.473 |
Brugia malayi | RNA binding protein | 0.0065 | 0.465 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.2288 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.2335 | 0.5021 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.2288 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.2288 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.465 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.465 | 0.465 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0013 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.2288 | 0.2985 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.465 | 0.465 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.465 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.2288 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.465 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.2288 | 0.338 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0269 | 0.0578 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0098 | 0.7665 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.465 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.1082 | 0.473 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.2288 | 0.492 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.2288 | 0.338 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.1082 | 0.473 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.465 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.1082 | 0.473 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.