Detailed information for compound 1496088

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 571.549 | Formula: C32H26FNO8
  • H donors: 0 H acceptors: 3 LogP: 4.53 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc2CC3(CCCCN4C(=O)c5c(C4=O)cccc5)OC(c2cc1OC)c1c(O3)c2cc(F)ccc2oc1=O
  • InChi: 1S/C32H26FNO8/c1-38-24-13-17-16-32(11-5-6-12-34-29(35)19-7-3-4-8-20(19)30(34)36)41-27(21(17)15-25(24)39-2)26-28(42-32)22-14-18(33)9-10-23(22)40-31(26)37/h3-4,7-10,13-15,27H,5-6,11-12,16H2,1-2H3
  • InChiKey: JCXFUKQXQCCLRL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0066 0.0184 0.4613
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0112 0.0336 0.0336
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0052 0.0136 0.0235
Loa Loa (eye worm) pyruvate kinase 0.0035 0.008 0.0218
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.004 0.0097 0.0831
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.009 0.1117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0535 0.4576
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0145 0.1555
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0176 0.0546 0.7168
Plasmodium falciparum thioredoxin reductase 0.0028 0.0058 0.1452
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0227
Schistosoma mansoni nuclear hormone receptor 0.0112 0.0336 0.0582
Giardia lamblia PHD finger protein 15 0.0022 0.0039 0.2688
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Toxoplasma gondii patched family protein 0.0018 0.0024 0.0751
Echinococcus granulosus thyroid hormone receptor alpha 0.0053 0.014 0.0243
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0136 0.1162
Echinococcus multilocularis tar DNA binding protein 0.0115 0.0346 0.0346
Echinococcus multilocularis cpg binding protein 0.0058 0.0155 0.0155
Brugia malayi nuclear receptor RXR 0.0053 0.014 0.0379
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0134 0.115
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0015 0.0125
Schistosoma mansoni chromobox protein 0.0054 0.0142 0.0246
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0052 0.0136 0.1729
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0242
Echinococcus granulosus pyruvate kinase 0.0035 0.008 0.0139
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Trypanosoma cruzi trypanothione reductase, putative 0.0081 0.0233 0.1994
Entamoeba histolytica hypothetical protein 0.0019 0.0029 0.0204
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0112 0.0336 0.0336
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0376 0.4907
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0031 0.0067 0.0067
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0015 0.0126
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0015 0.0015
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0054 0.0145 0.455
Loa Loa (eye worm) pyruvate kinase 0.0035 0.008 0.0218
Brugia malayi hypothetical protein 0.0018 0.0024 0.0065
Toxoplasma gondii patched family protein 0.0018 0.0024 0.0751
Schistosoma mansoni tar DNA-binding protein 0.0115 0.0346 0.0598
Toxoplasma gondii FATC domain-containing protein 0.0019 0.0029 0.0925
Brugia malayi Isocitrate dehydrogenase 0.0012 0.0005 0.0014
Onchocerca volvulus 0.0038 0.009 0.0242
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0092
Onchocerca volvulus 0.0018 0.0024 0.0065
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0014 0.0012 0.0103
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0036 0.0084 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0115 0.0346 0.0598
Schistosoma mansoni hypothetical protein 0.0121 0.0366 0.0633
Echinococcus granulosus Protein patched homolog 1 0.0126 0.0381 0.0659
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Loa Loa (eye worm) hypothetical protein 0.0176 0.0546 0.1478
Loa Loa (eye worm) thioredoxin reductase 0.0081 0.0233 0.0631
Echinococcus granulosus Niemann Pick C1 protein 0.0294 0.0934 0.1616
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0193 0.1616
Echinococcus granulosus lamin dm0 0.007 0.0198 0.0342
Entamoeba histolytica hypothetical protein 0.019 0.0593 0.6306
Loa Loa (eye worm) patched family protein 0.0018 0.0024 0.0065
Echinococcus multilocularis lysine specific demethylase 5A 0.0135 0.041 0.041
Brugia malayi DKFZp564C0469 protein 0.0021 0.0034 0.0092
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0034 0.1068
Echinococcus granulosus methyl CpG binding domain protein 2 0.0031 0.0067 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0206 0.0356
Chlamydia trachomatis pyruvate kinase 0.0035 0.008 0.1272
Leishmania major 4-coumarate:coa ligase-like protein 0.0176 0.0546 0.465
Brugia malayi jmjC domain containing protein 0.0181 0.0563 0.1523
Onchocerca volvulus 0.009 0.0261 0.0708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Onchocerca volvulus Protein patched homolog 0.0018 0.0024 0.0065
Trypanosoma brucei importin beta-1 subunit, putative 0.0023 0.004 0.0341
Toxoplasma gondii target of rapamycin (TOR), putative 0.0014 0.0012 0.0376
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.008 0.0229 0.062
Brugia malayi nuclear receptor NHR-88 0.0112 0.0336 0.091
Brugia malayi jmjC domain containing protein 0.0141 0.0431 0.1167
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0058 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0035 0.035
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.004 0.0097 0.0831
Brugia malayi CHD4 protein 0.0015 0.0015 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1168 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.009 0.0947
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0012 0.0032
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0056 0.0151 0.4753
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0014 0.0012 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0035 0.035
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0012 0.0005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0056 0.0151 0.0409
Echinococcus multilocularis pyruvate kinase 0.0028 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0112 0.0336 0.091
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0913 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0141 0.0431 0.0746
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.009 0.0155
Leishmania major hypothetical protein, conserved 0.006 0.0162 0.1344
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.009 0.0947
Echinococcus granulosus chromobox protein 1 0.0054 0.0142 0.0246
Schistosoma mansoni hypothetical protein 0.0121 0.0366 0.0633
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Loa Loa (eye worm) jmjC domain-containing protein 0.0141 0.0431 0.1167
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.0026 0.0244
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.009 0.0947
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0019 0.0027 0.0027
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0053 0.014 0.0379
Plasmodium vivax SET domain containing protein 0.0011 0.0002 0.004
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0034 0.0291
Echinococcus multilocularis jumonji domain containing 1A 0.0036 0.0084 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0857 0.9392
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0123
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0037 0.0087 0.1086
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.018 0.0312
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0136 0.1729
Brugia malayi ecdysteroid receptor 0.1131 0.3695 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0014 0.0012 0.0015
Echinococcus granulosus pyruvate kinase 0.0018 0.0024 0.0042
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0012 0.0005 0.0005
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0024 0.061
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0034 0.0291
Echinococcus granulosus peptidase Clp S14 family 0.0037 0.0087 0.0151
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0053 0.014 0.0243
Echinococcus multilocularis isocitrate dehydrogenase 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0436
Toxoplasma gondii patched family protein 0.0018 0.0024 0.0751
Onchocerca volvulus 0.0052 0.0136 0.0367
Onchocerca volvulus 0.007 0.0198 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0381 0.4151
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0053 0.014 0.0379
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0019 0.0027 0.0231
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.029 0.0501
Schistosoma mansoni DNA ligase IV 0.0021 0.0034 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.0059 0.0161 0.0436
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0034 0.033
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0014 0.0012 0.0103
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0052 0.0136 0.1162
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.0058 0.0496
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0066 0.0184 0.0319
Loa Loa (eye worm) hypothetical protein 0.0112 0.0336 0.091
Brugia malayi hypothetical protein 0.0021 0.0034 0.0092
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Schistosoma mansoni pyruvate kinase 0.0035 0.008 0.0139
Brugia malayi RNA binding protein 0.0115 0.0346 0.0936
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0121 0.834
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0092
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Echinococcus granulosus snurportin 1 0.0241 0.0762 0.1318
Plasmodium vivax acetyl-CoA synthetase, putative 0.0052 0.0136 0.34
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0019 0.0029 0.0252
Loa Loa (eye worm) isocitrate dehydrogenase 0.0012 0.0005 0.0014
Brugia malayi Importin beta-1 subunit 0.0023 0.004 0.0108
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.008 0.0218
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0034 0.0077 0.0134
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0112 0.0336 0.0582
Onchocerca volvulus 0.0051 0.0134 0.0364
Echinococcus granulosus FTZ F1 alpha 0.0112 0.0336 0.0582
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0012 0.0005 0.0009
Brugia malayi Probable ClpP-like protease 0.0056 0.0151 0.0409
Schistosoma mansoni hypothetical protein 0.0098 0.029 0.0501
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0084 0.0227
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0535 0.4551
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0054 0.0145 0.124
Toxoplasma gondii patched family protein 0.0018 0.0024 0.0751
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0034 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Leishmania major phosphatidylinositol 3-kinase, putative 0.0014 0.0012 0.0058
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0032 0.0072 0.0194
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0136 0.2072
Toxoplasma gondii exonuclease III APE 0.0015 0.0015 0.0462
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0028 0.0058 0.0741
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Schistosoma mansoni importin beta-1 0.0023 0.004 0.0069
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0097 0.0097
Plasmodium falciparum thioredoxin reductase 0.0081 0.0233 0.5836
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0046 0.0123
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0112 0.0336 0.0582
Loa Loa (eye worm) hypothetical protein 0.0068 0.019 0.0514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0241 0.0762 0.2061
Leishmania major phosphatidylinositol kinase related protein, putative 0.0014 0.0012 0.0058
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0 0.0001
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.009 0.1117
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.009 0.1281
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0136 0.2072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.029 0.029
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0024 0.0765
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0118 0.0319
Leishmania major acetyl-CoA synthetase, putative 0.0052 0.0136 0.1122
Leishmania major hypothetical protein, conserved 0.0036 0.0084 0.0675
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.0318 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0028 0.0058 0.1452
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0015 0.0126
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0052 0.0136 0.1729
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.014 0.0243
Echinococcus granulosus expressed conserved protein 0.0276 0.0875 0.1514
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.004 0.0097 0.079
Loa Loa (eye worm) hypothetical protein 0.1131 0.3695 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0112 0.0336 0.0582
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0027 0.0053 0.0053
Brugia malayi hypothetical protein 0.006 0.0162 0.0437
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0136 0.1731
Loa Loa (eye worm) patched family protein 0.0018 0.0024 0.0065
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.008 0.0229 0.1925
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0058 0.0496
Echinococcus granulosus jumonji domain containing protein 0.0031 0.0068 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0058 0.0496
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0005 0.0005
Echinococcus multilocularis lamin 0.007 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Leishmania major hypothetical protein, conserved 0.0038 0.009 0.0725
Plasmodium falciparum acyl-CoA synthetase 0.0132 0.0399 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0012 0.0005 0.0132
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0242
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0034 0.0092
Leishmania major acetyl-CoA synthetase, putative 0.0052 0.0136 0.1122
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0112 0.0336 0.0582
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0056 0.0151 0.2338
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0112 0.0336 0.091
Echinococcus multilocularis geminin 0.0389 0.1248 0.1248
Onchocerca volvulus 0.0024 0.0043 0.0116
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.0136 0.0367
Loa Loa (eye worm) hypothetical protein 0.0069 0.0193 0.0524
Loa Loa (eye worm) DR-78 0.0053 0.014 0.0379
Onchocerca volvulus 0.0018 0.0024 0.0065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0034 0.0335
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0019 0.0027 0.0677
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Toxoplasma gondii hypothetical protein 0.0018 0.0024 0.0751
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0056 0.0149 0.1602
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0029 0.0252
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0022 0.0039 0.0068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Echinococcus multilocularis importin subunit beta 1 0.0023 0.004 0.004
Echinococcus multilocularis nibrin 0.0021 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0551 0.6017
Echinococcus multilocularis protein dispatched 1 0.0144 0.044 0.044
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0056 0.0151 0.379
Brugia malayi RNA recognition motif domain containing protein 0.0115 0.0346 0.0936
Onchocerca volvulus Protein patched homolog 0.0018 0.0024 0.0065
Echinococcus granulosus dual specificity 0.008 0.0229 0.0396
Brugia malayi T-complex protein 1, beta subunit 0.0019 0.0027 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Loa Loa (eye worm) hypothetical protein 0.0132 0.0399 0.108
Echinococcus granulosus dnaJ subfamily B 0.073 0.2374 0.4108
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0136 0.1162
Mycobacterium tuberculosis Conserved protein 0.0038 0.009 0.1117
Brugia malayi ecdysone receptor 0.0053 0.014 0.0379
Echinococcus multilocularis dual specificity 0.008 0.0229 0.0229
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.005 0.0514
Echinococcus granulosus GPCR family 2 0.0098 0.029 0.0501
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Brugia malayi hypothetical protein 0.0018 0.0024 0.0065
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.0058 0.0599
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0857 0.9392
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0112 0.0336 0.0582
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.0857 0.232
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0058 0.0496
Schistosoma mansoni hypothetical protein 0.019 0.0593 0.1026
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0039 0.098
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0012 0.0032
Brugia malayi hypothetical protein 0.0021 0.0034 0.0092
Brugia malayi Nuclear hormone receptor E75 0.0053 0.014 0.0379
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0242
Loa Loa (eye worm) glutathione reductase 0.0081 0.0233 0.0631
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0136 0.2072
Schistosoma mansoni pyruvate kinase 0.0035 0.008 0.0139
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.0551 0.149
Loa Loa (eye worm) hypothetical protein 0.0052 0.0136 0.0367
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0117 0.0202
Brugia malayi tailless protein 0.0053 0.014 0.0379
Echinococcus multilocularis pyruvate kinase 0.0018 0.0024 0.0024
Brugia malayi protein C24B5.3 0.0018 0.0024 0.0065
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0056 0.0151 0.4753
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0526 0.0911
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0014 0.0012 0.0012
Schistosoma mansoni lamin 0.007 0.0198 0.0342
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0027 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0174
Loa Loa (eye worm) intermediate filament protein 0.007 0.0198 0.0535
Echinococcus granulosus ecdysone induced protein 78C 0.0112 0.0336 0.0582
Echinococcus granulosus pyruvate kinase 0.0035 0.008 0.0139
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0046 0.0379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0112 0.0336 0.091
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.008 0.0229 0.1961
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0112 0.0336 0.091
Echinococcus granulosus hypothetical protein 0.0053 0.0141 0.0244
Schistosoma mansoni tar DNA-binding protein 0.0115 0.0346 0.0598
Schistosoma mansoni cpg binding protein 0.0058 0.0155 0.0269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0318
Brugia malayi hypothetical protein 0.0018 0.0024 0.0065
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0015 0.0368
Schistosoma mansoni hypothetical protein 0.0028 0.0057 0.0098
Plasmodium falciparum T-complex protein 1 subunit beta 0.0019 0.0027 0.0677
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.0058 0.0599
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.076 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0012 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0112 0.0336 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Trypanosoma cruzi ISWI complex protein 0.0028 0.0057 0.0486
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0136 0.2072
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0033 0.009
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0066 0.0184 0.1576
Brugia malayi nuclear receptor NHR-88 0.0053 0.014 0.0379
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0015 0.0998
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0019 0.0029 0.0734
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0176 0.0546 0.8404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.0206 0.0206
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0 0.0001
Plasmodium falciparum glutathione reductase 0.0081 0.0233 0.5836
Schistosoma mansoni tar DNA-binding protein 0.0115 0.0346 0.0598
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.008 0.0218
Loa Loa (eye worm) hypothetical protein 0.0112 0.0336 0.091
Loa Loa (eye worm) hypothetical protein 0.0112 0.0336 0.091
Echinococcus granulosus transcription factor Dp 1 0.004 0.0097 0.0168
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.0058 0.0453
Leishmania major hypothetical protein, conserved 0.0028 0.0057 0.0443
Brugia malayi nuclear hormone receptor family member nhr-6 0.0053 0.014 0.0379
Plasmodium falciparum protein serine/threonine kinase-1 0.0054 0.0145 0.3628
Brugia malayi Calcitonin receptor-like protein seb-1 0.0311 0.0991 0.2683
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.008 0.0218
Giardia lamblia GTOR 0.0014 0.0012 0.0809
Brugia malayi Augmenter of liver regeneration 0.0066 0.0184 0.0498
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0052 0.0136 0.0136
Leishmania major 4-coumarate:coa ligase-like protein 0.0176 0.0546 0.465
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.008 0.0688
Brugia malayi AMP-binding enzyme family protein 0.0176 0.0546 0.1478
Schistosoma mansoni bromodomain containing protein 0.0122 0.0368 0.0637
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0012 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0098 0.029 0.0784
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0112 0.0336 0.0582
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0021 0.0034 0.0076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0112 0.0336 0.0336
Toxoplasma gondii LsmAD domain-containing protein 0.006 0.0162 0.5075
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0181 0.0563 0.0563
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0059 0.0161 0.0279
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.011 0.019
Echinococcus multilocularis microtubule associated protein 2 0.1763 0.578 0.578
Brugia malayi intermediate filament protein 0.007 0.0198 0.0535
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0029 0.008
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0034 0.0077 0.0077
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0053 0.014 0.0243
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Toxoplasma gondii hypothetical protein 0.0059 0.0159 0.5002
Trypanosoma cruzi importin beta-1 subunit, putative 0.0018 0.0026 0.022
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0052 0.0136 0.1729
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.019 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0092
Entamoeba histolytica hypothetical protein 0.019 0.0593 0.6306
Schistosoma mansoni hypothetical protein 0.0098 0.029 0.0501
Loa Loa (eye worm) RecQ helicase 0.0026 0.005 0.0136
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0034 0.0034
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0057 0.0154
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0052 0.0136 0.0367
Loa Loa (eye worm) hypothetical protein 0.0023 0.004 0.0108
Echinococcus multilocularis mitogen activated protein kinase 0.004 0.0097 0.0097
Plasmodium vivax serine/threonine kinase-1, putative 0.0054 0.0145 0.3628
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0085 0.023
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0097 0.103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0092
Echinococcus granulosus pyruvate kinase 0.0018 0.0024 0.0042
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.008 0.0218
Mycobacterium ulcerans pyruvate kinase 0.0035 0.008 0.1125
Plasmodium falciparum JmjC domain-containing protein, putative 0.0036 0.0084 0.21
Trichomonas vaginalis chromobox protein, putative 0.0032 0.0072 0.0751
Loa Loa (eye worm) pyruvate kinase 0.0035 0.008 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.014 0.0243
Schistosoma mansoni hypothetical protein 0.0389 0.1248 0.2158
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.009 0.1281
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0185 0.0576 0.7565
Brugia malayi photoreceptor-specific nuclear receptor 0.0112 0.0336 0.091
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.008 0.0218
Schistosoma mansoni retinoic acid receptor RXR 0.0112 0.0336 0.0582
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0151 0.379
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Brugia malayi Thioredoxin reductase 0.0081 0.0233 0.0631
Brugia malayi acetyltransferase, GNAT family protein 0.0179 0.0557 0.1507
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0318
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0034 0.0291
Echinococcus multilocularis muscleblind protein 0.023 0.0722 0.0722
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0022 0.0059
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0034 0.0291
Brugia malayi Patched protein homolog 1 0.0018 0.0024 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0136 0.0367
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0022 0.0022
Leishmania major protein kinase, putative 0.0054 0.0145 0.12
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0028 0.0058 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Onchocerca volvulus 0.0046 0.0117 0.0316
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0176 0.0546 0.9095
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0436
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0056 0.0149 0.3737
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0015 0.0123
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0092
Mycobacterium ulcerans beta-lactamase 0.0038 0.009 0.1281
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0011 0.0091
Loa Loa (eye worm) hepatopoietin HPO2 0.0066 0.0184 0.0498
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0039 0.1229
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0179 0.0557 0.0963
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0 0.0009
Brugia malayi hypothetical protein 0.019 0.0593 0.1604
Echinococcus granulosus intermediate filament protein 0.007 0.0198 0.0342
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0582 0.6364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Loa Loa (eye worm) hypothetical protein 0.0132 0.0399 0.108
Giardia lamblia TCP-1 chaperonin subunit beta 0.0019 0.0027 0.1851
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0092
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0136 0.2072
Schistosoma mansoni RAR-like nuclear receptor 0.0112 0.0336 0.0582
Brugia malayi steroid hormone receptor 0.0112 0.0336 0.091
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0857 0.9392
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0064 0.0668
Onchocerca volvulus 0.0112 0.0336 0.091
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0019 0.0027 0.0047
Mycobacterium leprae conserved hypothetical protein 0.0038 0.009 0.098
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0034 0.1068
Echinococcus multilocularis pyruvate kinase 0.0018 0.0024 0.0024
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.0058 0.0453
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1168 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0112 0.0336 0.091
Plasmodium falciparum glutathione reductase 0.0028 0.0058 0.1452
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0019 0.0027 0.0047
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0054 0.0145 0.124
Mycobacterium tuberculosis Probable dehydrogenase 0.0185 0.0576 0.7565
Echinococcus granulosus cpg binding protein 0.0058 0.0155 0.0269
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0034 0.0335
Schistosoma mansoni nuclear receptor 0.0053 0.014 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0551 0.6017
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.009 0.1117
Schistosoma mansoni patched 1 0.0126 0.0381 0.0659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Onchocerca volvulus 0.0138 0.0421 0.1139
Echinococcus granulosus peregrin 0.0031 0.0067 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Echinococcus granulosus pyruvate kinase 0.0018 0.0024 0.0042
Schistosoma mansoni hypothetical protein 0.073 0.2374 0.4108
Onchocerca volvulus 0.0056 0.0149 0.0403
Brugia malayi PHD-finger family protein 0.0014 0.001 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0229 0.0396
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.0005 0.0165
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0294 0.0934 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0193 0.1654
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.019 0.019
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0037 0.0087 0.1086
Trypanosoma cruzi PAB1-binding protein , putative 0.006 0.0162 0.1383
Schistosoma mansoni bromodomain containing protein 0.0015 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0079 0.0225 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Schistosoma mansoni methyl-cpg binding protein mbd 0.0031 0.0067 0.0117
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.011 0.019
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0116 0.0347 0.0347
Onchocerca volvulus Alhambra homolog 0.0022 0.0039 0.0106
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0136 0.2072
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0021 0.0034 0.1412
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0011 0.0078
Loa Loa (eye worm) heterochromatin protein 1 0.0054 0.0142 0.0384
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.008 0.0831
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.018 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0112 0.0336 0.091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Loa Loa (eye worm) hypothetical protein 0.023 0.0722 0.1955
Schistosoma mansoni topbp1 0.0021 0.0034 0.0059
Echinococcus multilocularis nuclear receptor nhr 48 0.0053 0.014 0.014
Schistosoma mansoni survival motor neuron protein 0.0138 0.0421 0.0728
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0176 0.0546 0.8404
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0014 0.0012 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0112 0.0336 0.091
Plasmodium vivax SET domain protein, putative 0.0037 0.0088 0.2199
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0193 0.1978
Brugia malayi nuclear hormone receptor family member odr-7 0.0053 0.014 0.0379
Brugia malayi Myosin head containing protein 0.0018 0.0024 0.0065
Plasmodium vivax patched family protein, putative 0.0018 0.0024 0.0599
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0185 0.0576 0.7565
Loa Loa (eye worm) hypothetical protein 0.0053 0.0141 0.0382
Brugia malayi hypothetical protein 0.0018 0.0024 0.0065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0051 0.0134 0.0364
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0206 0.0644 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.004
Echinococcus granulosus nibrin 0.0021 0.0034 0.0059
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0042 0.0105 0.0181
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0034 0.0335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0112 0.0336 0.091
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0052 0.0136 0.0367
Schistosoma mansoni topbp1 0.0021 0.0034 0.0059
Loa Loa (eye worm) hypothetical protein 0.0677 0.2199 0.5951
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0032 0.0318
Echinococcus multilocularis mitogen activated protein kinase 3 0.004 0.0097 0.0097
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0019 0.0027 0.0259
Echinococcus multilocularis neuropeptide s receptor 0.0692 0.2247 0.2247
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0052 0.0136 0.1162
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0193 0.1654
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0052 0.0136 0.34
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0193 0.0193
Trichomonas vaginalis antibiotic synthetase, putative 0.0052 0.0136 0.1455
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0112 0.0336 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0034 0.0335
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0084 0.0227
Onchocerca volvulus 0.0038 0.009 0.0242
Entamoeba histolytica hypothetical protein 0.0018 0.0026 0.0163
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0185 0.0576 0.7565
Schistosoma mansoni pyruvate kinase 0.0018 0.0024 0.0042
Loa Loa (eye worm) beta-lactamase 0.0038 0.009 0.0242
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0073 0.0206 0.0558
Loa Loa (eye worm) patched family protein 0.0018 0.0024 0.0065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Leishmania major importin beta-1 subunit, putative 0.0018 0.0026 0.0176
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0798 0.216
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.009 0.0767
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.014 0.014
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0019 0.0027 0.0047
Schistosoma mansoni methyl-cpg binding protein mbd 0.0031 0.0067 0.0117
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0088 0.2758
Brugia malayi AMP-binding enzyme family protein 0.0176 0.0546 0.1478
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0242
Loa Loa (eye worm) hypothetical protein 0.0176 0.0546 0.1478
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0012 0.0005 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0036 0.0062
Leishmania major protein kinase, putative 0.0054 0.0145 0.12
Brugia malayi jmjC domain containing protein 0.0036 0.0084 0.0227
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0012 0.0103
Echinococcus granulosus JmjC domain containing protein 4 0.0036 0.0084 0.0145
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.005 0.0136
Schistosoma mansoni chromobox protein 0.0054 0.0142 0.0246
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0022 0.0691
Echinococcus multilocularis serine protein kinase ATM 0.0019 0.0029 0.0029
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0066 0.0184 0.1576
Loa Loa (eye worm) hypothetical protein 0.0213 0.0667 0.1804
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0019 0.0029 0.0051
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0014 0.0012 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.006 0.0162 0.1383
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0012 0.002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0015 0.0081
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0015 0.004
Schistosoma mansoni hypothetical protein 0.0389 0.1248 0.2158
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0242
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0005 0.0005
Brugia malayi chromobox protein homolog 3 0.003 0.0064 0.0174
Trichomonas vaginalis esterase, putative 0.0038 0.009 0.0947
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0136 0.1729
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0037 0.0087 0.0941
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0058 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0059 0.0161 0.0161
Onchocerca volvulus Heterochromatin protein 1 homolog 0.003 0.0064 0.0174
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0028 0.0058 0.0157
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0058 0.0453
Onchocerca volvulus 0.0052 0.0136 0.0367
Plasmodium falciparum pyruvate kinase 0.0035 0.008 0.2015
Trypanosoma brucei importin beta-1 subunit, putative 0.0023 0.004 0.0341
Brugia malayi Nuclear hormone receptor-like 1 0.0059 0.0161 0.0436
Trichomonas vaginalis antibiotic synthetase, putative 0.0052 0.0136 0.1455
Schistosoma mansoni hypothetical protein 0.0027 0.0053 0.0092
Echinococcus multilocularis survival motor neuron protein 1 0.0677 0.2199 0.2199
Schistosoma mansoni zinc finger protein 0.0028 0.0057 0.0098
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0193 0.0523
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.009 0.0767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0058 0.3168
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0066 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0213 0.0667 0.1153
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0857 0.9392
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.009 0.0767
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Giardia lamblia Replication factor C, subunit 1 0.0021 0.0034 0.2332
Brugia malayi hypothetical protein 0.0053 0.014 0.0379
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0185 0.0576 0.8891
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0112 0.0336 0.091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0136 0.1729
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0059 0.0161 0.0279
Leishmania major hypothetical protein, conserved 0.0066 0.0184 0.1538
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0012 0.0103
Trichomonas vaginalis chromobox protein, putative 0.0054 0.0142 0.1523
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0056 0.0151 0.3212
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Brugia malayi Bromodomain containing protein 0.0031 0.0067 0.0183
Onchocerca volvulus 0.0018 0.0024 0.0065
Echinococcus multilocularis tumor protein p63 0.0614 0.1989 0.1989
Echinococcus granulosus dual specificity protein kinase clk2 0.0054 0.0145 0.0251
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0028 0.0058 0.0058
Schistosoma mansoni zinc finger protein 0.0053 0.014 0.0243
Echinococcus multilocularis peregrin 0.0031 0.0067 0.0067
Schistosoma mansoni cellular tumor antigen P53 0.009 0.0261 0.0452
Schistosoma mansoni acetyl-CoA synthetase 0.0052 0.0136 0.0235
Onchocerca volvulus 0.0176 0.0546 0.1478
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0227
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0015 0.004
Echinococcus granulosus Niemann Pick C1 protein 0.042 0.1349 0.2335
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.009 0.0947
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.004 0.0097 0.0831
Trichomonas vaginalis chaperonin, putative 0.0019 0.0027 0.0259
Brugia malayi hypothetical protein 0.0059 0.0161 0.0436
Brugia malayi Pre-SET motif family protein 0.0037 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0123
Echinococcus multilocularis muscleblind protein 1 0.023 0.0722 0.0722
Toxoplasma gondii NADPH-glutathione reductase 0.0028 0.0058 0.1821
Brugia malayi Protein kinase domain containing protein 0.0054 0.0145 0.0392
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0084 0.0227
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.008 0.0229 0.1961
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.014 0.014
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0014 0.0012 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0318
Loa Loa (eye worm) nuclear hormone receptor 0.0053 0.014 0.0379
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0229 0.2367
Echinococcus granulosus chromobox protein 1 0.0054 0.0142 0.0246
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0054 0.0145 0.124
Trichomonas vaginalis chromobox protein, putative 0.0054 0.0142 0.1523
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0176 0.0546 0.9095
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0066 0.0184 0.1576
Mycobacterium tuberculosis Probable oxidoreductase 0.0206 0.0644 0.8469
Schistosoma mansoni hypothetical protein 0.0121 0.0366 0.0633
Entamoeba histolytica hypothetical protein 0.0021 0.0034 0.0253
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0014 0.0012 0.0058
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.029 0.029
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.009 0.0242
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0052 0.0136 0.2072
Mycobacterium ulcerans acyl-CoA synthetase 0.0176 0.0546 0.9095
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0034 0.0335
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1168 1
Trypanosoma brucei pyruvate kinase 1 0.0035 0.008 0.0688
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Echinococcus multilocularis musashi 0.007 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0112 0.0336 0.091
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0176 0.0546 0.465
Loa Loa (eye worm) hypothetical protein 0.0311 0.0991 0.2683
Mycobacterium ulcerans acyl-CoA synthetase 0.0176 0.0546 0.9095
Loa Loa (eye worm) hypothetical protein 0.0098 0.029 0.0784
Loa Loa (eye worm) patched family protein 0.0018 0.0024 0.0065
Leishmania major pyruvate kinase 0.0035 0.008 0.0646
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0112 0.0336 0.091
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0056 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Giardia lamblia Kinase, CMGC CLK 0.0054 0.0145 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0045 0.0112 0.1415
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0092
Brugia malayi nuclear receptor RXR 0.0059 0.0161 0.0436
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Loa Loa (eye worm) hypothetical protein 0.0079 0.0225 0.061
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0052 0.0136 0.1729
Onchocerca volvulus 0.0018 0.0024 0.0065
Toxoplasma gondii t-complex protein beta subunit 0.0019 0.0027 0.0849
Plasmodium vivax pyruvate kinase, putative 0.0035 0.008 0.2015
Schistosoma mansoni thyroid hormone receptor 0.0112 0.0336 0.0582
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0015 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0059 0.0161 0.0279
Schistosoma mansoni protein phosphatase 2C 0.0036 0.0084 0.0145
Echinococcus granulosus histone acetyltransferase KAT2B 0.0056 0.0149 0.0258
Echinococcus multilocularis pyruvate kinase 0.0035 0.008 0.008
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0034 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Schistosoma mansoni coup transcription factor 0.0112 0.0336 0.0582
Onchocerca volvulus 0.0052 0.0136 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0112 0.0336 0.091
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0551 0.6017
Schistosoma mansoni intermediate filament proteins 0.007 0.0198 0.0342
Schistosoma mansoni nuclear hormone receptor 0.0053 0.014 0.0243
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.008 0.0846
Echinococcus multilocularis ecdysone induced protein 78C 0.0112 0.0336 0.0336
Toxoplasma gondii Erv1 / Alr family protein 0.0066 0.0184 0.5785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Brugia malayi Niemann-Pick C1 protein precursor 0.0294 0.0934 0.2527
Brugia malayi SET domain containing protein 0.0011 0.0002 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0112 0.0336 0.0336
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0028 0.0058 0.1452
Brugia malayi Nuclear hormone receptor E75 0.0053 0.014 0.0379
Echinococcus granulosus sterol regulatory element binding protein 0.0126 0.0381 0.0659
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0376 0.4907
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0036 0.0084 0.2633
Brugia malayi conserved hypotetical protein 0.0053 0.014 0.0379
Echinococcus granulosus lysine specific demethylase 6a 0.0036 0.0084 0.0145
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.009 0.1117
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0033 0.009
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0014 0.0012 0.0021
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.004 0.0097 0.3051
Trichomonas vaginalis importin beta-1, putative 0.0018 0.0026 0.0244
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0311 0.0991 0.2683
Brugia malayi hypothetical protein 0.0059 0.0161 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Onchocerca volvulus 0.0021 0.0034 0.0092
Mycobacterium tuberculosis Conserved protein 0.0038 0.009 0.1117
Echinococcus multilocularis chromobox protein 1 0.0054 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.009 0.0261 0.0708
Brugia malayi jmjC domain containing protein 0.0036 0.0084 0.0227
Echinococcus multilocularis zinc finger protein 0.0043 0.0106 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0134 0.115
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0056 0.0149 0.4686
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0015 0.0025
Echinococcus granulosus muscleblind protein 0.023 0.0722 0.125
Echinococcus multilocularis dnaJ subfamily B 0.073 0.2374 0.2374
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0015 0.0368
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.009 0.1117
Loa Loa (eye worm) hypothetical protein 0.0112 0.0336 0.091
Echinococcus multilocularis phd:f box containing protein 0.0036 0.0084 0.0084
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0015 0.0123
Echinococcus granulosus phd:f box containing protein 0.0036 0.0084 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.019 0.0329
Brugia malayi Pre-SET motif family protein 0.0252 0.0798 0.216
Echinococcus multilocularis peptidase Clp (S14 family) 0.0037 0.0087 0.0087
Echinococcus multilocularis PHD finger protein rhinoceros 0.0022 0.0039 0.0039
Plasmodium vivax importin-beta 2, putative 0.0023 0.004 0.0997
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0136 0.2072
Onchocerca volvulus 0.0053 0.014 0.0379
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0038 0.009 0.0243
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0193 0.0334
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0126 0.0381 0.1031
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0052 0.0136 0.2072
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0053 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0138 0.0421 0.0728
Plasmodium falciparum phd finger protein, putative 0.0022 0.0039 0.098
Echinococcus granulosus zinc finger protein 0.0043 0.0106 0.0184
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0242
Brugia malayi beta-lactamase family protein 0.0038 0.009 0.0242
Trypanosoma brucei ISWI complex protein 0.0028 0.0057 0.0486
Echinococcus granulosus lamin 0.007 0.0198 0.0342
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Brugia malayi nuclear hormone receptor 0.0053 0.014 0.0379
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0053 0.014 0.0243
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0052 0.0136 0.1729
Plasmodium vivax ataxin-2 like protein, putative 0.006 0.0162 0.4047
Schistosoma mansoni nuclear receptor nhr-48 0.0053 0.014 0.0243
Echinococcus multilocularis Niemann Pick C1 protein 0.042 0.1349 0.1349
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0176 0.0546 0.9095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0058 0.0496
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0015 0.0044
Giardia lamblia NADH oxidase lateral transfer candidate 0.0028 0.0058 0.3992
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0857 0.9392
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0034 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0176 0.0546 0.1478
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0136 0.1122
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0028 0.0058 0.01
Loa Loa (eye worm) PHD-finger family protein 0.0037 0.0089 0.024
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0084 0.0717
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0399 0.108
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0121 0.3027
Brugia malayi Bromodomain containing protein 0.0074 0.0209 0.0565
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0052 0.0136 0.2072
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0136 0.2072
Schistosoma mansoni zinc finger protein 0.0043 0.0106 0.0184
Schistosoma mansoni jumonji domain containing protein 0.0166 0.0513 0.0887
Brugia malayi isocitrate dehydrogenase 0.0012 0.0005 0.0014
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0112 0.0336 0.0582
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0171 0.1467
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.019 0.0329
Loa Loa (eye worm) hypothetical protein 0.0078 0.0223 0.0605
Brugia malayi PHD-finger family protein 0.0022 0.0039 0.0106
Brugia malayi hypothetical protein 0.0038 0.0092 0.0249
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.007 0.0198 0.0535
Echinococcus multilocularis bloom syndrome protein 0.0026 0.005 0.005
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0024 0.0599
Entamoeba histolytica protein kinase, putative 0.008 0.0229 0.2367
Loa Loa (eye worm) patched family protein 0.0018 0.0024 0.0065
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0036 0.0084 0.0717
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0551 0.6017
Brugia malayi jmjC domain containing protein 0.0036 0.0084 0.0227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0037 0.0089 0.0154
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.008 0.0688
Toxoplasma gondii thioredoxin reductase 0.0081 0.0233 0.7318
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.0005 0.0165
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0052 0.0136 0.1731
Brugia malayi MH2 domain containing protein 0.0095 0.028 0.0757
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0136 0.2072
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0039 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Brugia malayi Muscleblind-like protein 0.023 0.0722 0.1955
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0019 0.0029 0.1069
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0015 0.0126
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0012 0.0005 0.0132
Mycobacterium ulcerans hypothetical protein 0.0176 0.0546 0.9095
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0034 0.0852
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0011 0.0046
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0132 0.0399 0.6582
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0112 0.0336 0.091
Loa Loa (eye worm) TAR-binding protein 0.0115 0.0346 0.0936
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0034 0.0335
Echinococcus granulosus mitogen activated protein kinase 3 0.004 0.0097 0.0168
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0115 0.0346 0.0936
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0015 0.0026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0311 0.0991 0.2683
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0028 0.0058 0.01
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0121 0.1194
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.029 0.0784
Echinococcus multilocularis dual specificity protein kinase clk2 0.0054 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0126 0.0381 0.1031
Schistosoma mansoni ap endonuclease 0.0015 0.0015 0.0025
Schistosoma mansoni hypothetical protein 0.0241 0.0762 0.1318
Toxoplasma gondii propionate-CoA ligase 0.0052 0.0136 0.4264
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0193 0.0523
Onchocerca volvulus 0.0018 0.0024 0.0065
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0551 0.6017
Brugia malayi orphan nuclear receptor NR2E1 0.0053 0.014 0.0379
Trypanosoma cruzi ISWI complex protein 0.0028 0.0057 0.0486
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0052 0.0136 0.1729
Trichomonas vaginalis bromodomain-containing protein, putative 0.0056 0.0149 0.1602
Echinococcus multilocularis snurportin 1 0.0241 0.0762 0.0762
Toxoplasma gondii hypothetical protein 0.0019 0.0029 0.0921
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0056 0.0151 0.0262
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.009 0.0242
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0039 0.1229
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0034 0.0059
Loa Loa (eye worm) hypothetical protein 0.0112 0.0336 0.091
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.019 0.0329
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0134 0.115
Trichomonas vaginalis chromobox protein, putative 0.0032 0.0072 0.0751
Brugia malayi RNA, U transporter 1 0.0064 0.0177 0.048
Loa Loa (eye worm) oxidoreductase 0.0052 0.0136 0.0367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0206 0.0356
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0028 0.0058 0.0496
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0097 0.103
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.008 0.0688
Echinococcus granulosus lysine specific demethylase 5A 0.0141 0.0431 0.0746
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0064 0.0668
Brugia malayi Intermediate filament tail domain containing protein 0.007 0.0198 0.0535
Plasmodium vivax acyl-CoA synthetase, putative 0.0132 0.0399 1
Onchocerca volvulus 0.007 0.0198 0.0535
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0181 0.0563 0.0974
Loa Loa (eye worm) hypothetical protein 0.0033 0.0073 0.0198
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Onchocerca volvulus 0.0018 0.0024 0.0065
Schistosoma mansoni hypothetical protein 0.0098 0.029 0.0501
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0318
Brugia malayi cytoplasmic intermediate filament protein 0.0038 0.009 0.0243
Loa Loa (eye worm) hypothetical protein 0.0067 0.0187 0.0505
Brugia malayi protein C24B5.3 0.0018 0.0024 0.0065
Brugia malayi Patched related family protein 4 0.0018 0.0024 0.0065
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0179 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0112 0.0336 0.0582
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0112 0.0336 0.091
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0014 0.0012 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.0206 0.0356
Plasmodium vivax hypothetical protein, conserved 0.0038 0.009 0.2243
Schistosoma mansoni ap endonuclease 0.0015 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0294 0.0934 0.2527
Toxoplasma gondii HEAT repeat-containing protein 0.0023 0.004 0.125
Trypanosoma brucei trypanothione reductase 0.0081 0.0233 0.1994
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0145 0.0251
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0023 0.0568
Toxoplasma gondii ABC1 family protein 0.0038 0.009 0.2813
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0012 0.0005 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.0692 0.2247 0.2247
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0132 0.0399 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0112 0.0336 0.0336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.029 0.0501
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0112 0.0336 0.091
Trypanosoma brucei PAB1-binding protein , putative 0.006 0.0162 0.1383
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Echinococcus granulosus geminin 0.0389 0.1248 0.2158
Giardia lamblia Pyruvate kinase 0.0018 0.0024 0.1664
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0014 0.0012 0.0103
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.008 0.0138
Schistosoma mansoni jumonji/arid domain-containing protein 0.0141 0.0431 0.0746
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0052 0.0136 0.1731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Mycobacterium ulcerans lipase LipD 0.0038 0.009 0.1281
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.004 0.0999
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0436
Schistosoma mansoni microtubule-associated protein tau 0.1763 0.578 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0112 0.0336 0.091
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0136 0.0367
Loa Loa (eye worm) steroid hormone receptor 0.0112 0.0336 0.091
Brugia malayi T-complex protein 1, beta subunit 0.0019 0.0027 0.0073
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.008 0.0846
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0024 0.061
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0073 0.0206 0.0558
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0112 0.0336 0.091
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0052 0.0136 0.2072
Brugia malayi jmjC domain containing protein 0.0036 0.0084 0.0227
Entamoeba histolytica hypothetical protein 0.008 0.0229 0.2367
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0084 0.0717
Leishmania major trypanothione reductase 0.0081 0.0233 0.1958
Brugia malayi Bromodomain containing protein 0.0143 0.0438 0.1186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.0106
Leishmania major T-complex protein 1, beta subunit, putative 0.0019 0.0027 0.0187
Loa Loa (eye worm) hypothetical protein 0.007 0.0198 0.0535
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0.0058 0.0657
Echinococcus granulosus mitogen activated protein kinase 0.004 0.0097 0.0168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0176 0.0546 0.7168
Entamoeba histolytica acyl-coA synthetase, putative 0.0176 0.0546 0.58
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0097 0.103
Brugia malayi glutathione reductase 0.0081 0.0233 0.0631
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0535 0.4576
Brugia malayi beta-lactamase 0.0038 0.009 0.0242
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0599 0.7868
Loa Loa (eye worm) hypothetical protein 0.006 0.0162 0.0437
Brugia malayi Patched related family protein 10 0.0018 0.0024 0.0065
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0054 0.0145 0.124
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0052 0.0136 0.1162
Brugia malayi beta-lactamase family protein 0.0038 0.009 0.0242
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0298 0.0949 0.1641
Brugia malayi nuclear receptor NHR-67 0.0053 0.014 0.0379
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.0026 0.0244
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.002 0.0175
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0012 0.002
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1168 1
Brugia malayi hypothetical protein 0.0053 0.014 0.0379
Schistosoma mansoni nuclear receptor 0.0053 0.014 0.0243
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0116 0.0347 0.06
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0376 0.4907
Echinococcus granulosus nuclear receptor nhr 48 0.0053 0.014 0.0243
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.014 0.0243
Echinococcus multilocularis protein patched 0.0126 0.0381 0.0381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0019 0.0027 0.0231
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Echinococcus multilocularis thioredoxin glutathione reductase 0.0082 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0121 0.0366 0.0633
Loa Loa (eye worm) hypothetical protein 0.023 0.0722 0.1955
Mycobacterium ulcerans acyl-CoA synthetase 0.0176 0.0546 0.9095
Onchocerca volvulus 0.0038 0.009 0.0242
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.005 0.0514
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0056 0.0149 0.4686
Schistosoma mansoni thyroid hormone receptor 0.0112 0.0336 0.0582
Brugia malayi CXXC zinc finger family protein 0.0051 0.0134 0.0364
Brugia malayi CHE-14 protein 0.0126 0.0381 0.1031
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0034 0.0335
Loa Loa (eye worm) acetyltransferase 0.0179 0.0557 0.1507
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0056 0.0151 0.2338
Schistosoma mansoni tar DNA-binding protein 0.0115 0.0346 0.0598
Schistosoma mansoni phd/f-box containing protein 0.0036 0.0084 0.0145
Brugia malayi hypothetical protein 0.0677 0.2199 0.5951
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.0857 0.232
Loa Loa (eye worm) RNA binding protein 0.0115 0.0346 0.0936
Onchocerca volvulus Bile acid receptor homolog 0.1131 0.3695 1
Mycobacterium ulcerans hypothetical protein 0.0192 0.0599 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0028 0.0058 0.1452
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0014 0.0012 0.0058
Schistosoma mansoni nuclear hormone receptor 0.0053 0.014 0.0243
Loa Loa (eye worm) hypothetical protein 0.0132 0.0399 0.108
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0145 0.0251
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0058 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0034 0.0335
Echinococcus granulosus neuropeptide receptor A26 0.0692 0.2247 0.3888
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0058 0.3168
Schistosoma mansoni transcription factor LCR-F1 0.019 0.0593 0.1026
Loa Loa (eye worm) hypothetical protein 0.0128 0.0389 0.1052
Schistosoma mansoni jumonji domain containing protein 0.0036 0.0084 0.0145
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0132 0.0399 0.5221
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0005 0.0045
Trypanosoma brucei protein kinase, putative 0.004 0.0097 0.0831
Echinococcus granulosus PHD finger protein rhinoceros 0.0022 0.0039 0.0068
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0019 0.0029 0.0734
Trypanosoma cruzi target of rapamycin kinase 3 0.0014 0.0012 0.0103
Loa Loa (eye worm) MH2 domain-containing protein 0.0095 0.028 0.0757
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.0206 0.0356
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0014 0.0012 0.0012
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0012 0.0032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.019 0.0593 0.1026
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.009 0.0947
Plasmodium falciparum ataxin-2 like protein, putative 0.006 0.0162 0.4047
Echinococcus multilocularis FTZ F1 alpha 0.0112 0.0336 0.0336
Mycobacterium ulcerans acetyl-CoA synthetase 0.0052 0.0136 0.2072
Echinococcus multilocularis 0.0053 0.0141 0.0141
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.004 0.0097 0.079
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0066 0.0184 0.4613
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.0206 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.0206 0.0356
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0014 0.0012 0.0103
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0014 0.0012 0.0103
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0056 0.0151 0.1984
Mycobacterium tuberculosis Probable reductase 0.0185 0.0576 0.7565
Entamoeba histolytica protein kinase, putative 0.008 0.0229 0.2367
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0042 0.0105 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0112 0.0336 0.0582
Loa Loa (eye worm) hypothetical protein 0.0034 0.0077 0.021
Schistosoma mansoni steroid hormone receptor ad4bp 0.0112 0.0336 0.0582
Treponema pallidum DNA ligase (lig) 0.0021 0.0034 0.1412
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0015 0.0123
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.008 0.2527
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0582 0.6364
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0112 0.0336 0.0336
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0028 0.0058 0.0741
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.0667 0.1804
Echinococcus multilocularis expressed conserved protein 0.0276 0.0875 0.0875
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0028 0.0058 0.0699
Schistosoma mansoni mixed-lineage leukemia protein mll 0.011 0.0328 0.0568
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0112 0.0336 0.091
Plasmodium falciparum ataxin-2 like protein, putative 0.006 0.0162 0.4047
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0058 0.0453
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0134 0.115
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0052 0.0136 0.1729
Brugia malayi TAR-binding protein 0.0115 0.0346 0.0936
Brugia malayi PHD-finger family protein 0.0052 0.0138 0.0374
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0097 0.0168
Echinococcus granulosus bloom syndrome protein 0.0026 0.005 0.0087
Schistosoma mansoni hypothetical protein 0.0022 0.0039 0.0068
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0052 0.0136 0.1355
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0014 0.0012 0.0103
Echinococcus granulosus serine protein kinase ATM 0.0019 0.0029 0.0051
Echinococcus multilocularis chromobox protein 1 0.0054 0.0142 0.0142
Entamoeba histolytica acyl-CoA synthetase, putative 0.0176 0.0546 0.58
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0014 0.0012 0.0058
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0032 0.0318
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.009 0.009
Echinococcus multilocularis lamin dm0 0.007 0.0198 0.0198
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.009 0.1117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.029 0.0784
Loa Loa (eye worm) T-complex protein 1 0.0019 0.0027 0.0073
Toxoplasma gondii Erv1 / Alr family protein 0.0066 0.0184 0.5785
Loa Loa (eye worm) hypothetical protein 0.0154 0.0474 0.1284
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0097 0.103
Brugia malayi MAP kinase sur-1 0.004 0.0097 0.0263
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Echinococcus granulosus survival motor neuron protein 1 0.0677 0.2199 0.3804
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0054 0.0145 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0112 0.0336 0.091
Loa Loa (eye worm) hypothetical protein 0.0085 0.0244 0.0662
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0857 0.9392
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.004 0.0097 0.0831
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.004 0.0097 0.0831
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Schistosoma mansoni hypothetical protein 0.0098 0.029 0.0501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Loa Loa (eye worm) nuclear receptor NHR-67 0.0053 0.014 0.0379
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Echinococcus granulosus importin subunit beta 1 0.0023 0.004 0.0069
Entamoeba histolytica acyl-CoA synthetase, putative 0.0176 0.0546 0.58
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0052 0.0136 0.4264
Echinococcus multilocularis pyruvate kinase 0.0035 0.008 0.008
Schistosoma mansoni lamin 0.007 0.0198 0.0342
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0019 0.0027 0.0047
Echinococcus multilocularis pyruvate kinase 0.0018 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0073 0.0198
Onchocerca volvulus 0.0018 0.0024 0.0065
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0053 0.014 0.0379
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0005 0.0045
Echinococcus multilocularis Niemann Pick C1 protein 0.0294 0.0934 0.0934
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0112 0.0336 0.0582
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0318
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0136 0.1162
Treponema pallidum NADH oxidase 0.0028 0.0058 0.3168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.009 0.0155
Brugia malayi Nuclear hormone receptor-like 1 0.0112 0.0336 0.091
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0052 0.0136 0.2072
Leishmania major pyruvate kinase 0.0035 0.008 0.0646
Plasmodium vivax thioredoxin reductase, putative 0.0081 0.0233 0.5836
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0032 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0206 0.0644 0.8469
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.007 0.0195 0.0528
Schistosoma mansoni peptidase Clp (S14 family) 0.0056 0.0151 0.0262
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0551 0.6017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Brugia malayi topoisomerase 0.0021 0.0034 0.0092
Mycobacterium leprae Probable lipase LipE 0.0038 0.009 0.098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0058 0.0496
Loa Loa (eye worm) hypothetical protein 0.0053 0.014 0.0379
Loa Loa (eye worm) hypothetical protein 0.0132 0.0399 0.108
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Onchocerca volvulus 0.0287 0.0913 0.247
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0059 0.0161 0.0436
Brugia malayi Patched related family protein 12 0.0018 0.0024 0.0065
Echinococcus granulosus jumonji domain containing 1A 0.0036 0.0084 0.0145
Echinococcus multilocularis sterol regulatory element binding protein 0.0126 0.0381 0.0381
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.004 0.0097 0.0263
Plasmodium vivax JmjC domain containing protein 0.0036 0.0084 0.21
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0089
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0138 0.0421 0.1139
Brugia malayi Heterochromatin protein 1 0.0054 0.0142 0.0384
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0112 0.0336 0.091
Echinococcus granulosus tumor protein p63 0.0614 0.1989 0.3442
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0054 0.0145 0.124
Loa Loa (eye worm) hypothetical protein 0.0024 0.0043 0.0116
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0011 0.0091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0088 0.0152
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0052 0.0136 0.4264
Onchocerca volvulus Protein ultraspiracle homolog 0.0112 0.0336 0.091
Echinococcus multilocularis lysine specific demethylase 6a 0.0036 0.0084 0.0084
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.008 0.0229 0.1961
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0193 0.1654
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0028 0.0058 0.0741
Giardia lamblia Kinase, CMGC MAPK 0.004 0.0097 0.67
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0436
Loa Loa (eye worm) hypothetical protein 0.0112 0.0336 0.091
Mycobacterium tuberculosis Conserved protein 0.0038 0.009 0.1117
Plasmodium falciparum importin beta, putative 0.0023 0.004 0.0997
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0058 0.0496
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0112 0.0336 0.091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0376 0.4907
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0054 0.0145 0.124
Echinococcus granulosus thioredoxin glutathione reductase 0.0082 0.0235 0.0407
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0053 0.014 0.0379
Entamoeba histolytica hypothetical protein 0.019 0.0593 0.6306
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0014 0.0012 0.0103
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0176 0.0546 0.9095
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0034 0.0092
Echinococcus multilocularis JmjC domain containing protein 4 0.0036 0.0084 0.0084
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0185 0.0576 0.7565
Echinococcus multilocularis GPCR, family 2 0.0098 0.029 0.029
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0056 0.0151 0.3212
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0052 0.0136 0.0367
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0551 0.6017
Brugia malayi Steroid receptor seven-up type 2 0.0112 0.0336 0.091
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.011 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0034 0.0291
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0112 0.0336 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0034 0.0335
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0052 0.0136 0.2072
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0081 0.0233 0.3018
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.009 0.0155
Loa Loa (eye worm) transcription factor SMAD2 0.0095 0.028 0.0757
Echinococcus granulosus tar DNA binding protein 0.0115 0.0346 0.0598
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.009 0.1117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0112 0.0336 0.091
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.008 0.0996
Schistosoma mansoni cpg binding protein 0.0058 0.0155 0.0269
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0136 0.0367
Echinococcus granulosus neuropeptide s receptor 0.0692 0.2247 0.3888
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0028 0.0058 0.1821
Loa Loa (eye worm) hypothetical protein 0.0052 0.0136 0.0367
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0218
Echinococcus multilocularis jumonji domain containing protein 0.0031 0.0068 0.0068
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0034 0.0852
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0019 0.0027 0.0178
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0206 0.0644 0.8469
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0056 0.0151 1
Plasmodium vivax glutathione reductase, putative 0.0081 0.0233 0.5836
Onchocerca volvulus 0.0053 0.014 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0029 0.0285
Loa Loa (eye worm) hypothetical protein 0.0176 0.0546 0.1478
Mycobacterium ulcerans hypothetical protein 0.0038 0.009 0.1281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0012 0.0093
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0058 0.0496
Brugia malayi nuclear hormone receptor 0.0112 0.0336 0.091
Loa Loa (eye worm) hypothetical protein 0.0059 0.0161 0.0436
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0015 0.0026
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0112 0.0336 0.0582
Brugia malayi Protein kinase domain containing protein 0.008 0.0229 0.062
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0136 0.0367
Giardia lamblia Pyruvate kinase 0.0035 0.008 0.5545
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0053 0.014 0.014
Brugia malayi Patched family protein 0.0018 0.0024 0.0065
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0193 0.0334
Schistosoma mansoni phosphatidylserine receptor 0.0036 0.0084 0.0145
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0066 0.0184 0.1576
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0032 0.0318
Entamoeba histolytica hypothetical protein 0.019 0.0593 0.6306
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0022 0.0038
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0028 0.0058 0.1452
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0052 0.0136 0.2072
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0028
Echinococcus granulosus microtubule associated protein 2 0.1763 0.578 1
Schistosoma mansoni cpg binding protein 0.0051 0.0134 0.0232
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0136 0.1729
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0014 0.0012 0.0021
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0036 0.0084 0.2633
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0151 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.3715 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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