Detailed information for compound 1496272

Basic information

Technical information
  • TDR Targets ID: 1496272
  • Name: (5-methyl-2-phenyl-4-phenylsulfonylpyrazol-3- yl) 2-fluorobenzoate
  • MW: 436.455 | Formula: C23H17FN2O4S
  • H donors: 0 H acceptors: 4 LogP: 4.93 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1C(=O)Oc1n(nc(c1S(=O)(=O)c1ccccc1)C)c1ccccc1
  • InChi: 1S/C23H17FN2O4S/c1-16-21(31(28,29)18-12-6-3-7-13-18)22(26(25-16)17-10-4-2-5-11-17)30-23(27)19-14-8-9-15-20(19)24/h2-15H,1H3
  • InChiKey: BRQDHLAIYGPZOF-UHFFFAOYSA-N  


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Synonyms

  • (5-methyl-2-phenyl-4-phenylsulfonyl-pyrazol-3-yl) 2-fluorobenzoate
  • 2-fluorobenzoic acid (5-methyl-2-phenyl-4-phenylsulfonyl-3-pyrazolyl) ester
  • 2-fluorobenzoic acid (5-methyl-2-phenyl-4-phenylsulfonyl-pyrazol-3-yl) ester
  • C263-0284
  • NCGC00106707-01
  • EU-0091292

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0128 0.0474 0.1129
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.0074 0.6401
Echinococcus granulosus protein tyrosine phosphatase n9 0.0027 0.0074 0.0176
Onchocerca volvulus 0.0029 0.008 0.046
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0047 0.4029
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.0018
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0128 0.0474 0.0474
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0116 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.076 0.2966 0.2966
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0194 0.0731 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.008 1
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0108 0.9298
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0018
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0027 0.0074 0.6401
Brugia malayi Carboxylesterase family protein 0.0128 0.0474 0.1129
Onchocerca volvulus 0.0027 0.0074 0.0427
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0043 0.0245
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0047 0.4029
Brugia malayi Protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0194 0.0731 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.008 0.1092
Brugia malayi Carboxylesterase family protein 0.076 0.2966 0.707
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1072 0.4196 1
Loa Loa (eye worm) hypothetical protein 0.076 0.2966 0.707
Trichomonas vaginalis glycogen phosphorylase, putative 0.0448 0.1734 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Schistosoma mansoni DNA helicase recq5 0.002 0.0047 0.0047
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0074 0.0176
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0027 0.0074 0.0176
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0006 0.0545
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0122
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Schistosoma mansoni acetylcholinesterase 0.0128 0.0474 0.0474
Onchocerca volvulus 0.0027 0.0074 0.0427
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0018
Onchocerca volvulus 0.0128 0.0474 0.2732
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0047 0.0111
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0027 0.0074 0.0176
Schistosoma mansoni DNA helicase recq1 0.002 0.0047 0.0047
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.008 0.1092
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0047 0.4274
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0027 0.0074 0.0427
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0116 1
Onchocerca volvulus 0.0027 0.0074 0.0427
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Entamoeba histolytica glycogen phosphorylase, putative 0.0448 0.1734 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1095 0.6319
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0638
Echinococcus multilocularis bloom syndrome protein 0.002 0.0047 0.0111
Onchocerca volvulus 0.0027 0.0074 0.0427
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0108 0.0621
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0109 0.0109
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0043 0.3677
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0007 0.0687
Giardia lamblia Protein tyrosine phosphatase 0.0027 0.0074 0.0186
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0108 0.0621
Onchocerca volvulus 0.0027 0.0074 0.0427
Schistosoma mansoni neuroligin 3 (S09 family) 0.0128 0.0474 0.0474
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0008
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0074 0.0074
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0027 0.0074 0.0176
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0958 0.2284
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.008 0.1092
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0074 0.0074
Onchocerca volvulus 0.0027 0.0074 0.0427
Echinococcus granulosus BC026374 protein S09 family 0.0128 0.0474 0.1129
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0018
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0043 0.0101
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0108 0.9863
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.008 0.046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Onchocerca volvulus 0.0027 0.0074 0.0427
Schistosoma mansoni ap endonuclease 0.0019 0.0043 0.0043
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0047 0.0111
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0638
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0018
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0051 0.4763
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0074 0.0176
Onchocerca volvulus 0.0027 0.0074 0.0427
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0276
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0116 0.0667
Loa Loa (eye worm) hypothetical protein 0.0128 0.0474 0.1129
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0027 0.0074 0.0074
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0051 0.4698
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0027 0.0074 0.0176
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0008 0.0043
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0074 0.0176
Trichomonas vaginalis pten, drome, putative 0.0027 0.0074 0.0427
Brugia malayi Carboxylesterase family protein 0.0128 0.0474 0.1129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0018
Onchocerca volvulus 0.0286 0.1095 0.6319
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0104 0.0247
Echinococcus granulosus acetylcholinesterase 0.076 0.2966 0.707
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0108 0.0256
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0074 0.0176
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0109 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0018
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0008 0.0008
Echinococcus multilocularis Glycosyl transferase, family 35 0.0448 0.1734 0.4132
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0074 0.0176
Onchocerca volvulus 0.0027 0.0074 0.0427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0018
Onchocerca volvulus 0.0027 0.0074 0.0427
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0008 0.0008
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.0074 0.6401
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.008 0.1092
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Echinococcus granulosus Glycosyl transferase family 35 0.0448 0.1734 0.4132
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0018
Onchocerca volvulus 0.0027 0.0074 0.0427
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0047 0.4333
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0043 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0122
Echinococcus multilocularis neuroligin 0.0128 0.0474 0.1129
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0047 0.4333
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0047 0.0269
Brugia malayi Carboxylesterase family protein 0.076 0.2966 0.707
Onchocerca volvulus 0.0027 0.0074 0.0427
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.008 0.6897
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0043 0.3677
Loa Loa (eye worm) hypothetical protein 0.0128 0.0474 0.1129
Schistosoma mansoni BC026374 protein (S09 family) 0.0128 0.0474 0.0474
Onchocerca volvulus 0.001 0.0008 0.0043
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0008 0.0018
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0116 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1072 0.4196 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0128 0.0474 0.1129
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0018
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0047 0.0111
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0018
Entamoeba histolytica recQ family helicase, putative 0.002 0.0047 0.0269
Entamoeba histolytica recQ family helicase, putative 0.001 0.0006 0.0034
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0008 0.0008
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Schistosoma mansoni gliotactin 0.0128 0.0474 0.0474
Echinococcus granulosus para nitrobenzyl esterase 0.0128 0.0474 0.1129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Onchocerca volvulus 0.0128 0.0474 0.2732
Brugia malayi beta-NAC-like protein 0.0036 0.0108 0.0256
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0008 0.0043
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0047 0.4274
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0116 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0108 0.0621
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0116 0.0667
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0074 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.008 0.6897
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0043 0.0245
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0116 0.0276
Onchocerca volvulus 0.0027 0.0074 0.0427
Onchocerca volvulus 0.0036 0.0109 0.0629
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0027 0.0074 0.0074
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.008 0.1092
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0008 0.0043
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0007 0.0648
Brugia malayi hypothetical protein 0.0027 0.0074 0.0176
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0008 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0018
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0027 0.0074 0.0074
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0027 0.0074 0.0176
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.0074 0.0074
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.008 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.019
Echinococcus multilocularis carboxylesterase 5A 0.076 0.2966 0.707
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0047 0.0111
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0116 1
Schistosoma mansoni glycogen phosphorylase 0.0194 0.0731 0.0731
Loa Loa (eye worm) acetylcholinesterase 1 0.076 0.2966 0.707
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Leishmania major tyrosine specific protein phosphatase, putative 0.0027 0.0074 0.6401
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0043 0.0101
Onchocerca volvulus 0.0027 0.0074 0.0427
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0027 0.0074 0.0176
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0047 0.0111
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0047 0.0269
Onchocerca volvulus 0.0027 0.0074 0.0427
Mycobacterium tuberculosis Carboxylesterase LipT 0.0128 0.0474 0.6482
Entamoeba histolytica glycogen phosphorylase, putative 0.0194 0.0731 0.4215
Onchocerca volvulus 0.0128 0.0474 0.2732
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0116 0.0667
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0108 0.9863
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1072 0.4196 1
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0027 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0047 0.0024
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0128 0.0474 0.0474
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0116 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0027 0.0074 0.0427
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Echinococcus granulosus transcription factor btf3 0.0036 0.0108 0.0256
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0108 0.9298
Echinococcus multilocularis glycogen phosphorylase 0.0448 0.1734 0.4132
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0027 0.0074 0.0176
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0051 0.0701
Onchocerca volvulus 0.0128 0.0474 0.2732
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) carboxylesterase 0.0128 0.0474 0.1129
Trichomonas vaginalis spcc417.12 protein, putative 0.0128 0.0474 0.2732
Brugia malayi Protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0109 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0638
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0027 0.0074 0.0176
Onchocerca volvulus 0.0128 0.0474 0.2732
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0122
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0018
Onchocerca volvulus 0.0027 0.0074 0.0427
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0108 0.0621
Plasmodium vivax SET domain protein, putative 0.0036 0.0109 1
Echinococcus multilocularis glycogen phosphorylase 0.0448 0.1734 0.4132
Chlamydia trachomatis glycogen phosphorylase 0.0448 0.1734 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Brugia malayi AMP-binding enzyme family protein 0.0029 0.008 0.019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0018
Onchocerca volvulus 0.0027 0.0074 0.0427
Brugia malayi steroid hormone receptor 0.001 0.0008 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0018
Entamoeba histolytica recQ family DNA helicase 0.001 0.0007 0.0043
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0027 0.0074 0.0074
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0116 0.0276
Schistosoma mansoni transcription factor btf3 0.0036 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0116 0.0667
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0128 0.0474 0.0474
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.019
Echinococcus granulosus acetylcholinesterase 0.076 0.2966 0.707
Mycobacterium ulcerans carboxylesterase, LipT 0.0128 0.0474 0.6482
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0074 0.0176
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.0074 0.0074
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0043 0.3954
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.076 0.2966 0.707
Echinococcus granulosus carboxylesterase 5A 0.076 0.2966 0.707
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.0018
Entamoeba histolytica glycogen phosphorylase, putative 0.0448 0.1734 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0128 0.0474 0.6482
Mycobacterium ulcerans hypothetical protein 0.0029 0.008 0.1092
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.0018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0007 0.0687
Onchocerca volvulus 0.0027 0.0074 0.0427
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.008 0.1092
Echinococcus granulosus glycogen phosphorylase 0.0448 0.1734 0.4132
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0027 0.0074 0.0074
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0027 0.0074 0.0176
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0462 0.1791 0.1791
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0111
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1072 0.4196 1
Brugia malayi hypothetical protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0036 0.0109 0.026
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Brugia malayi hypothetical protein 0.0027 0.0074 0.0176
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0018
Echinococcus multilocularis hypothetical protein 0.0027 0.0074 0.0176
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.008 0.046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0018
Brugia malayi Pre-SET motif family protein 0.0036 0.0109 0.026
Brugia malayi hypothetical protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0109 0.026
Schistosoma mansoni pcd6 interacting protein-related 0.0027 0.0074 0.0074
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0051 0.0701
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0027 0.0074 0.0074
Onchocerca volvulus 0.0027 0.0074 0.0427
Onchocerca volvulus 4.1 G protein, putative homolog 0.0027 0.0074 0.0427
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0027 0.0074 0.0176
Trichomonas vaginalis glycogen phosphorylase, putative 0.0448 0.1734 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0027 0.0074 0.0176
Schistosoma mansoni coup transcription factor 0.001 0.0008 0.0008
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0043 0.0582
Schistosoma mansoni nuclear hormone receptor 0.001 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0018
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0108 0.9298
Schistosoma mansoni glycogen phosphorylase 0.0448 0.1734 0.1734
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0109 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0109 0.0109
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0128 0.0474 0.1129
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0043 0.39
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0047 0.0269
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0128 0.0474 0.6482
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Leishmania major basic transcription factor 3a, putative 0.0036 0.0108 0.9298
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0018
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0008 0.0018
Echinococcus granulosus FTZ F1 alpha 0.001 0.0008 0.0018
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.0074 0.6401
Echinococcus multilocularis transcription factor btf3 0.0036 0.0108 0.0256
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0008 0.0008
Giardia lamblia Glycogen phosphorylase 0.0448 0.1734 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0109 0.0109
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0027 0.0074 0.0176
Schistosoma mansoni glycogen phosphorylase 0.0448 0.1734 0.1734
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0043 0.5
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0027 0.0074 0.0176
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0008 0.0008
Brugia malayi Protein-tyrosine phosphatase 1 0.0027 0.0074 0.0176
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0018
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.0074 0.0176
Echinococcus multilocularis 0.0027 0.0074 0.0176
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0027 0.0074 0.0427
Echinococcus multilocularis acetylcholinesterase 0.076 0.2966 0.707
Echinococcus multilocularis BC026374 protein (S09 family) 0.0128 0.0474 0.1129
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0043 0.0101
Loa Loa (eye worm) hypothetical protein 0.0128 0.0474 0.1129
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.008 0.1092
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.0018
Onchocerca volvulus 0.0027 0.0074 0.0427
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0122
Loa Loa (eye worm) hypothetical protein 0.0128 0.0474 0.1129
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0008 0.0018
Loa Loa (eye worm) protein tyrosine phosphatase 0.0027 0.0074 0.0176
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0108 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0194 0.0731 0.4215
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0074 0.0176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0638
Echinococcus granulosus bloom syndrome protein 0.002 0.0047 0.0111
Trypanosoma brucei protein tyrosine phosphatase 1 0.0027 0.0074 0.6401
Echinococcus granulosus neuroligin 0.0128 0.0474 0.1129
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0047 0.4029
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.0074 0.0176
Loa Loa (eye worm) glycogen phosphorylase 0.0448 0.1734 0.4132
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0074 0.0176
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0116 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0027 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0043 0.3677
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.008 0.6897
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0116 0.0433
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.0018
Loa Loa (eye worm) carboxylesterase 0.076 0.2966 0.707
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0027 0.0074 0.0176
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0047 0.0111
Loa Loa (eye worm) RecQ helicase 0.002 0.0047 0.0111
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.008 0.046
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0027 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Brugia malayi AMP-binding enzyme family protein 0.0029 0.008 0.019
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0128 0.0474 0.2732
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0027 0.0074 0.0074
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0043 0.0582
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0018
Echinococcus multilocularis acetylcholinesterase 0.076 0.2966 0.707
Onchocerca volvulus Glycogen phosphorylase homolog 0.0448 0.1734 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0018
Brugia malayi hypothetical protein 0.0128 0.0474 0.1129
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0008 0.0008
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0116 0.0276
Loa Loa (eye worm) hypothetical protein 0.0128 0.0474 0.1129
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.008 0.1092
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0006 0.0006
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0006 0.0545
Onchocerca volvulus 0.0027 0.0074 0.0427
Brugia malayi carbohydrate phosphorylase 0.0448 0.1734 0.4132
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0116 0.0116
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0047 0.0111
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.008 0.1092
Brugia malayi Pre-SET motif family protein 0.0251 0.0958 0.2284
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0018
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0007 0.0648
Echinococcus multilocularis para nitrobenzyl esterase 0.0128 0.0474 0.1129
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0074 0.0074
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0074 0.0176
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0008 0.0018
Schistosoma mansoni ap endonuclease 0.0019 0.0043 0.0043
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.0074 0.0074
Brugia malayi Carboxylesterase family protein 0.0128 0.0474 0.1129
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0043 0.3677
Brugia malayi AMP-binding enzyme family protein 0.0029 0.008 0.019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0176
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0027 0.0074 0.0176
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0008 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.0074 0.0176
Brugia malayi Carboxylesterase family protein 0.0128 0.0474 0.1129
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0008 0.0008
Echinococcus granulosus glycogen phosphorylase 0.0448 0.1734 0.4132
Entamoeba histolytica hypothetical protein 0.0036 0.0108 0.0621
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0043 0.0101
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0047 0.0111
Brugia malayi hypothetical protein 0.0027 0.0074 0.0176
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0116 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.0074 0.0176
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0043 0.0245
Onchocerca volvulus 0.0027 0.0074 0.0427
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1072 0.4196 0.4196
Onchocerca volvulus 0.0027 0.0074 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0018
Loa Loa (eye worm) carboxylesterase 0.0128 0.0474 0.1129
Toxoplasma gondii exonuclease III APE 0.0019 0.0043 0.39
Entamoeba histolytica glycogenphosphorylase, putative 0.0194 0.0731 0.4215
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.0074 0.0176
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0116 0.0276
Loa Loa (eye worm) hypothetical protein 0.0128 0.0474 0.1129
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0027 0.0074 0.0176

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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