Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | titin | 0.0008 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0763 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Echinococcus granulosus | nephrin | 0.0008 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0763 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | cell adhesion molecule | 0.0008 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0008 | 0.0763 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0008 | 0.0763 | 0.0763 |
Echinococcus multilocularis | roundabout 2 | 0.0008 | 0.0763 | 0.0763 |
Echinococcus granulosus | roundabout 2 | 0.0008 | 0.0763 | 0.0763 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | titin | 0.0008 | 0.0763 | 0.0763 |
Onchocerca volvulus | 0.0008 | 0.0763 | 1 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | myosin-binding protein-related | 0.0008 | 0.0763 | 0.0763 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0005 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0008 | 0.0763 | 1 |
Onchocerca volvulus | 0.0008 | 0.0763 | 1 | |
Schistosoma mansoni | titin | 0.0008 | 0.0763 | 0.0763 |
Echinococcus multilocularis | roundabout 2 | 0.0008 | 0.0763 | 0.0763 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | ephrin receptor | 0.0005 | 0.0188 | 0.0188 |
Schistosoma mansoni | nephrin | 0.0008 | 0.0763 | 0.0763 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0008 | 0.0763 | 0.0763 |
Echinococcus granulosus | contactin | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | cell adhesion molecule | 0.0008 | 0.0763 | 0.0763 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0008 | 0.0763 | 0.0763 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0008 | 0.0763 | 1 |
Schistosoma mansoni | neuroglian | 0.0008 | 0.0763 | 0.0763 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0008 | 0.0763 | 0.0763 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0008 | 0.0763 | 0.0763 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0008 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0008 | 0.0763 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0008 | 0.0763 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0008 | 0.0763 | 0.0763 |
Echinococcus granulosus | roundabout 2 | 0.0008 | 0.0763 | 0.0763 |
Echinococcus granulosus | neuroglian | 0.0008 | 0.0763 | 0.0763 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0008 | 0.0763 | 0.0763 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | nephrin | 0.0008 | 0.0763 | 0.0763 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0008 | 0.0763 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0008 | 0.0763 | 0.0763 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0005 | 0.0188 | 0.0188 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0008 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0763 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0008 | 0.0763 | 0.0763 |
Onchocerca volvulus | 0.0008 | 0.0763 | 1 | |
Brugia malayi | protein unc-22 | 0.0008 | 0.0763 | 0.0763 |
Echinococcus granulosus | titin | 0.0008 | 0.0763 | 0.0763 |
Echinococcus multilocularis | neuroglian | 0.0008 | 0.0763 | 0.0763 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0008 | 0.0763 | 0.0763 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0008 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0008 | 0.0763 | 1 |
Loa Loa (eye worm) | projectin | 0.0008 | 0.0763 | 1 |
Echinococcus multilocularis | titin | 0.0008 | 0.0763 | 0.0763 |
Schistosoma mansoni | hemicentin | 0.0008 | 0.0763 | 0.0763 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0008 | 0.0763 | 0.0763 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.1995 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.