Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.1793 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8123 | 0.8123 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.8123 | 0.8123 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8123 | 0.8123 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8123 | 0.8123 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.8123 | 0.7934 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0084 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.8123 | 0.8123 |
Schistosoma mansoni | chromobox protein | 0.0084 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8123 | 0.8123 |
Brugia malayi | RNA binding protein | 0.0076 | 0.8123 | 0.8123 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.1793 | 0.0969 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.0913 | 0.0913 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.8123 | 0.8123 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.8123 | 0.8123 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8123 | 0.8123 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.1793 | 0.0969 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.8123 | 0.7934 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.8123 | 0.7934 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 0.1458 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 0.5161 uM | PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Giardia lamblia |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.