Detailed information for compound 149664

Basic information

Technical information
  • TDR Targets ID: 149664
  • Name: N-[2-(4-tert-butylphenyl)-4-oxo-3,1-benzoxazi n-6-yl]benzenesulfonamide
  • MW: 434.507 | Formula: C24H22N2O4S
  • H donors: 1 H acceptors: 3 LogP: 5.12 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1oc(nc2c1cc(cc2)NS(=O)(=O)c1ccccc1)c1ccc(cc1)C(C)(C)C
  • InChi: 1S/C24H22N2O4S/c1-24(2,3)17-11-9-16(10-12-17)22-25-21-14-13-18(15-20(21)23(27)30-22)26-31(28,29)19-7-5-4-6-8-19/h4-15,26H,1-3H3
  • InChiKey: KSFIJIURZUSTFE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-tert-butylphenyl)-4-keto-3,1-benzoxazin-6-yl]benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0051 0.0987 0.0933
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0051 0.0987 0.2646
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0179 0.395 0.3919
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0334 0.7533 0.752
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0701 0.1499
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0158 0.3446 0.3412
Onchocerca volvulus Glucosylceramidase homolog 0.013 0.2805 0.3439
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0169 0.3698 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Loa Loa (eye worm) nuclear receptor NHR-67 0.0158 0.3446 0.3412
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0169 0.3698 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0198 0.4381 0.4352
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0051 0.0987 0.2549
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0051 0.0987 0.2646
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0018 0.0207 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0334 0.7533 0.752
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0437 0.0437
Echinococcus multilocularis peptidase Clp (S14 family) 0.0034 0.0577 0.0528
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0158 0.3446 0.4329
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0334 0.7533 0.752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0334 0.7533 0.752
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0334 0.7533 0.752
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0334 0.7533 0.752
Schistosoma mansoni zinc finger protein 0.0158 0.3446 0.3446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Toxoplasma gondii exonuclease III APE 0.0011 0.006 0.0131
Schistosoma mansoni nuclear receptor 0.0158 0.3446 0.3446
Brugia malayi Pre-SET motif family protein 0.016 0.3491 0.3457
Loa Loa (eye worm) transcription factor SMAD2 0.0072 0.1468 0.1424
Brugia malayi ecdysteroid receptor 0.0334 0.7533 0.752
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0158 0.3446 0.4329
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0177 0.3884 0.3884
Schistosoma mansoni nuclear hormone receptor 0.0334 0.7533 0.7533
Schistosoma mansoni hypothetical protein 0.0022 0.0317 0.0317
Brugia malayi tailless protein 0.0158 0.3446 0.3412
Brugia malayi nuclear hormone receptor 0.0334 0.7533 0.752
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0056 0.1088 0.1041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0334 0.7533 0.7533
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0334 0.7533 0.752
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0134 0.0189
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0158 0.3446 0.3412
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.002 0.0264 0.049
Loa Loa (eye worm) hypothetical protein 0.0334 0.7533 0.752
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0071 0.144 0.1396
Loa Loa (eye worm) hypothetical protein 0.0334 0.7533 0.752
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0158 0.3446 0.3412
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0158 0.3446 0.3412
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.002 0.0264 0.0562
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0334 0.7533 0.752
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0039 0.0701 0.187
Brugia malayi hypothetical protein 0.0158 0.3446 0.3412
Loa Loa (eye worm) MH2 domain-containing protein 0.0072 0.1468 0.1424
Trichomonas vaginalis glucosylceramidase, putative 0.013 0.2805 0.6358
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0158 0.3446 0.3446
Echinococcus multilocularis thyroid hormone receptor alpha 0.0334 0.7533 0.752
Schistosoma mansoni dihydrofolate reductase 0.0441 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0701 0.1499
Schistosoma mansoni hypothetical protein 0.0022 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0016 0.0171 0.0119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0028 0.0437 0.0387
Schistosoma mansoni voltage-gated potassium channel 0.0061 0.1206 0.1206
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0134 0.0189
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0022 0.0317 0.0266
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0011 0.006 0.0008
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.002 0.0264 0.0264
Loa Loa (eye worm) steroid hormone receptor 0.0334 0.7533 0.752
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.002 0.0264 0.049
Brugia malayi Nuclear hormone receptor-like 1 0.0334 0.7533 0.752
Echinococcus granulosus thyroid hormone receptor alpha 0.0158 0.3446 0.3412
Brugia malayi hypothetical protein 0.0177 0.3884 0.3852
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0334 0.7533 0.752
Echinococcus granulosus Nuclear hormone receptor HR96 0.0158 0.3446 0.3412
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.4381 1
Loa Loa (eye worm) hypothetical protein 0.0334 0.7533 0.752
Toxoplasma gondii hypothetical protein 0.0018 0.0207 0.0529
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0177 0.3884 0.3852
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0334 0.7533 0.752
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.002 0.0264 0.0213
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0334 0.7533 0.752
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0171 0.0119
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0198 0.4381 0.4352
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0018 0.0207 0.0404
Brugia malayi Pre-SET motif family protein 0.0023 0.0326 0.0276
Loa Loa (eye worm) hypothetical protein 0.0334 0.7533 0.752
Chlamydia trachomatis dihydrofolate reductase 0.0441 1 1
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0441 1 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0056 0.1088 0.1041
Loa Loa (eye worm) hypothetical protein 0.0177 0.3884 0.3852
Echinococcus granulosus Nuclear hormone receptor HR96 0.0158 0.3446 0.3412
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Brugia malayi Nuclear hormone receptor-like 1 0.0177 0.3884 0.3852
Brugia malayi nuclear receptor RXR 0.0177 0.3884 0.3852
Onchocerca volvulus 0.0158 0.3446 0.4329
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0051 0.0987 0.094
Brugia malayi latrophilin 2 splice variant baaae 0.0049 0.092 0.0873
Brugia malayi conserved hypotetical protein 0.0158 0.3446 0.3412
Schistosoma mansoni peptidase Clp (S14 family) 0.0051 0.0987 0.0987
Onchocerca volvulus 0.0158 0.3446 0.4329
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0023 0.0326 0.0276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0334 0.7533 0.752
Loa Loa (eye worm) hypothetical protein 0.0177 0.3884 0.3852
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0179 0.395 0.3919
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0441 1 1
Mycobacterium ulcerans putative regulatory protein 0.0015 0.0134 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0334 0.7533 0.752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0334 0.7533 0.752
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0056 0.1088 0.1041
Trichomonas vaginalis ap endonuclease, putative 0.0011 0.006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0053 0.103 0.0984
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0051 0.0987 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0052 0.1003 0.2196
Brugia malayi orphan nuclear receptor NR2E1 0.0158 0.3446 0.3412
Schistosoma mansoni ap endonuclease 0.0011 0.006 0.006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0334 0.7533 0.7533
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0171 0.0119
Onchocerca volvulus 0.0334 0.7533 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0051 0.0987 1
Schistosoma mansoni hypothetical protein 0.0102 0.2169 0.2169
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0051 0.0987 0.094
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0028 0.0437 0.0387
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0051 0.0987 0.0865
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0052 0.0052
Schistosoma mansoni steroid hormone receptor ad4bp 0.0334 0.7533 0.7533
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Brugia malayi nuclear hormone receptor family member nhr-6 0.0158 0.3446 0.3412
Brugia malayi MH2 domain containing protein 0.0072 0.1468 0.1424
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0169 0.3698 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0169 0.3698 1
Toxoplasma gondii hypothetical protein 0.0015 0.0134 0.0332
Loa Loa (eye worm) hypothetical protein 0.0174 0.382 0.3788
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0039 0.0701 0.1763
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.002 0.0264 0.049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0158 0.3446 0.3412
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0022 0.0317 0.0266
Schistosoma mansoni nuclear hormone receptor 0.0158 0.3446 0.3446
Brugia malayi nuclear receptor NHR-88 0.0334 0.7533 0.752
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0034 0.0577 0.052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0022 0.0317 0.0266
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0056 0.1088 0.1041
Schistosoma mansoni RAR-like nuclear receptor 0.0334 0.7533 0.7533
Brugia malayi hypothetical protein 0.0158 0.3446 0.3412
Loa Loa (eye worm) hypothetical protein 0.0177 0.3884 0.3852
Toxoplasma gondii hypothetical protein 0.0015 0.0134 0.0332
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0701 0.1499
Trichomonas vaginalis glucosylceramidase, putative 0.013 0.2805 0.6358
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0326 0.0326
Echinococcus multilocularis nuclear receptor nhr 48 0.0158 0.3446 0.3412
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.002 0.0264 0.049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0326 0.0326
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0334 0.7533 0.752
Giardia lamblia Kinase, CMGC MAPK 0.0039 0.0701 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.4381 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0039 0.0701 0.0652
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Schistosoma mansoni eyes absent homolog 0.0053 0.103 0.103
Brugia malayi Nuclear hormone receptor E75 0.0158 0.3446 0.3412
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0169 0.3698 1
Trichomonas vaginalis glucosylceramidase, putative 0.0137 0.2967 0.6733
Brugia malayi Dihydrofolate reductase 0.0441 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0052 0.1003 0.2196
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0158 0.3446 0.3446
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0334 0.7533 0.752
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0334 0.7533 0.752
Trypanosoma brucei cAMP-specific phosphodiesterase 0.002 0.0264 0.0562
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0179 0.395 0.3919
Brugia malayi ecdysone receptor 0.0158 0.3446 0.3412
Toxoplasma gondii hypothetical protein 0.0015 0.0134 0.0332
Schistosoma mansoni nuclear receptor nhr-48 0.0158 0.3446 0.3446
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0039 0.0701 0.1763
Loa Loa (eye worm) hypothetical protein 0.0022 0.0317 0.0266
Loa Loa (eye worm) hypothetical protein 0.0023 0.0326 0.0276
Echinococcus granulosus peptidase Clp S14 family 0.0034 0.0577 0.0528
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0028 0.0437 0.0387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0051 0.0987 0.094
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0171 0.0119
Brugia malayi nuclear receptor RXR 0.0158 0.3446 0.3412
Loa Loa (eye worm) dihydrofolate reductase 0.0441 1 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.3884 0.3852
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0334 0.7533 0.752
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0039 0.0701 0.1763
Trichomonas vaginalis set domain proteins, putative 0.0182 0.4002 0.9123
Echinococcus granulosus dihydrofolate reductase 0.0441 1 1
Brugia malayi Probable ClpP-like protease 0.0051 0.0987 0.094
Loa Loa (eye worm) hypothetical protein 0.002 0.0264 0.0213
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0334 0.7533 0.752
Loa Loa (eye worm) hypothetical protein 0.0334 0.7533 0.752
Loa Loa (eye worm) hypothetical protein 0.0334 0.7533 0.752
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0034 0.0577 0.0449
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.002 0.0264 0.049
Loa Loa (eye worm) latrophilin receptor protein 2 0.0022 0.0317 0.0266
Trichomonas vaginalis glucosylceramidase, putative 0.0137 0.2967 0.6733
Mycobacterium ulcerans putative regulatory protein 0.0015 0.0134 0.0075
Schistosoma mansoni thyroid hormone receptor 0.0334 0.7533 0.7533
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.4381 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Brugia malayi nuclear receptor NHR-88 0.0158 0.3446 0.3412
Brugia malayi exodeoxyribonuclease III family protein 0.0011 0.006 0.0008
Echinococcus granulosus GPCR family 2 0.0022 0.0317 0.0266
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0701 0.1499
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0039 0.0701 0.1763
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0334 0.7533 0.752
Brugia malayi Latrophilin receptor protein 2 0.0022 0.0317 0.0266
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.002 0.0264 0.049
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0011 0.006 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0334 0.7533 0.752
Loa Loa (eye worm) hypothetical protein 0.0048 0.0917 0.087
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0022 0.0317 0.0266
Brugia malayi nuclear hormone receptor family member odr-7 0.0158 0.3446 0.3412
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0177 0.3884 0.3852
Brugia malayi steroid hormone receptor 0.0334 0.7533 0.752
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0134 0.0204
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0334 0.7533 0.7533
Loa Loa (eye worm) nuclear hormone receptor 0.0158 0.3446 0.3412
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0334 0.7533 0.752
Echinococcus granulosus geminin 0.0102 0.2169 0.2129
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0334 0.7533 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0015 0.0134 0.0075
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Brugia malayi nuclear receptor NHR-67 0.0158 0.3446 0.3412
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0441 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0102 0.2169 0.2169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0334 0.7533 0.752
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0334 0.7533 0.7533
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0011 0.006 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0051 0.0987 0.0933
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0023 0.0326 0.0276
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0158 0.3446 0.3412
Schistosoma mansoni retinoic acid receptor RXR 0.0334 0.7533 0.7533
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0326 0.0326
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0169 0.3698 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0334 0.7533 0.752
Loa Loa (eye worm) hypothetical protein 0.0177 0.3884 0.3852
Trichomonas vaginalis glucosylceramidase, putative 0.013 0.2805 0.6358
Echinococcus multilocularis GPCR, family 2 0.0022 0.0317 0.0266
Trichomonas vaginalis glucosylceramidase, putative 0.013 0.2805 0.6358
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0028 0.0437 0.0387
Brugia malayi Nuclear hormone receptor-like 1 0.0177 0.3884 0.3852
Onchocerca volvulus Protein ultraspiracle homolog 0.0334 0.7533 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0158 0.3446 0.3412
Plasmodium vivax SET domain protein, putative 0.0023 0.0326 0.0733
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.4381 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0334 0.7533 0.752
Onchocerca volvulus 0.0182 0.4002 0.51
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0307 0.0256
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0158 0.3446 0.3412
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0052 0.0052
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0049 0.092 0.0873
Plasmodium falciparum GAF domain-related protein, putative 0.0015 0.0134 0.0204
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Loa Loa (eye worm) hypothetical protein 0.0334 0.7533 0.752
Brugia malayi hypothetical protein 0.0053 0.103 0.0984
Schistosoma mansoni voltage-gated potassium channel 0.0061 0.1206 0.1206
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Echinococcus granulosus nuclear receptor nhr 48 0.0158 0.3446 0.3412
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.002 0.0264 0.0213
Echinococcus granulosus mitogen activated protein kinase 0.0039 0.0701 0.0652
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Echinococcus granulosus mitogen activated protein kinase 3 0.0039 0.0701 0.0652
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0071 0.144 0.1396
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0052 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.4381 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Echinococcus granulosus ecdysone induced protein 78C 0.0334 0.7533 0.752
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0022 0.0317 0.0266
Schistosoma mansoni hypothetical protein 0.0022 0.0317 0.0317
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0334 0.7533 0.7533
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0171 0.0119
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Echinococcus multilocularis mitogen activated protein kinase 3 0.0039 0.0701 0.0652
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.002 0.0264 0.049
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0018 0.0207 0.0074
Echinococcus multilocularis dihydrofolate reductase 0.0441 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0326 0.0326
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0028 0.0437 0.0387
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.002 0.0264 0.049
Trypanosoma brucei protein kinase, putative 0.0039 0.0701 0.1763
Loa Loa (eye worm) hypothetical protein 0.0159 0.3483 0.3449
Trichomonas vaginalis glucosylceramidase, putative 0.013 0.2805 0.6358
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0039 0.0701 0.1763
Brugia malayi nuclear hormone receptor 0.0158 0.3446 0.3412
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0334 0.7533 0.752
Brugia malayi hypothetical protein 0.0177 0.3884 0.3852
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Schistosoma mansoni hypothetical protein 0.0022 0.0317 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.4381 1
Schistosoma mansoni nuclear hormone receptor 0.0158 0.3446 0.3446
Brugia malayi Calcitonin receptor-like protein seb-1 0.0071 0.144 0.1396
Echinococcus multilocularis FTZ F1 alpha 0.0334 0.7533 0.752
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0039 0.0701 0.1763
Brugia malayi Steroid receptor seven-up type 2 0.0334 0.7533 0.752
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0018 0.0207 0.1583
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.002 0.0264 0.0562
Echinococcus multilocularis geminin 0.0102 0.2169 0.2129
Loa Loa (eye worm) DR-78 0.0158 0.3446 0.3412
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0334 0.7533 0.752
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.002 0.0264 0.049
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0177 0.3884 0.3852
Loa Loa (eye worm) hypothetical protein 0.0053 0.103 0.0984
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.002 0.0264 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0134 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0701 0.0701
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0051 0.0987 0.2549
Schistosoma mansoni coup transcription factor 0.0334 0.7533 0.7533
Brugia malayi Nuclear hormone receptor E75 0.0158 0.3446 0.3412
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.002 0.0264 0.0213
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0023 0.0326 0.0854
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0034 0.0577 0.052
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0264 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0334 0.7533 0.752
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0334 0.7533 0.752
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0334 0.7533 0.752
Toxoplasma gondii GAF domain-containing protein 0.0015 0.0134 0.0332
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0177 0.3884 0.3884
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0134 0.0189
Schistosoma mansoni thyroid hormone receptor 0.0334 0.7533 0.7533
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0334 0.7533 0.752
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0015 0.0134 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.0334 0.7533 0.752
Echinococcus granulosus histone lysine methyltransferase setb 0.0023 0.0326 0.0276
Loa Loa (eye worm) hypothetical protein 0.0071 0.144 0.1396
Trypanosoma brucei cAMP-specific phosphodiesterase 0.002 0.0264 0.0562
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0334 0.7533 0.752
Trichomonas vaginalis glucosylceramidase, putative 0.013 0.2805 0.6358
Onchocerca volvulus Bile acid receptor homolog 0.0334 0.7533 1
Brugia malayi MAP kinase sur-1 0.0039 0.0701 0.0652
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.002 0.0264 0.049
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.002 0.0264 0.0562
Trichomonas vaginalis glucosylceramidase, putative 0.013 0.2805 0.6358
Trichomonas vaginalis ap endonuclease, putative 0.0011 0.006 0.0018
Schistosoma mansoni nuclear receptor 0.0158 0.3446 0.3446
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0334 0.7533 0.752
Loa Loa (eye worm) hypothetical protein 0.0158 0.3446 0.3412
Schistosoma mansoni ap endonuclease 0.0011 0.006 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0334 0.7533 0.752
Echinococcus granulosus FTZ F1 alpha 0.0334 0.7533 0.752
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.002 0.0264 0.0264
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.002 0.0264 0.049
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0015 0.0134 0.0075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0011 0.006 0.0008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.016 0.3491 0.3457
Schistosoma mansoni hypothetical protein 0.0049 0.092 0.092
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0158 0.3446 0.3412
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0334 0.7533 0.7533
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0334 0.7533 0.752
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.0171 0.0119
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0028 0.0437 0.0387
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0052 0.0052
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0039 0.0701 0.1763
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.002 0.0264 0.049
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0171 0.0171
Echinococcus multilocularis mitogen activated protein kinase 0.0039 0.0701 0.0652

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -7 % Percent change in plasma triglycerides in cholesterol-fed rats at 200 mg/kg dose given in a period of 3 days ChEMBL. 2909740
Change (functional) = 5 % Change in plasma total cholesterol in normocholesterolemic rats at 0.2 % composition of dose with diet given in a period of 3 days. ChEMBL. 2909740
Change (functional) = 7 % Percent change in plasma total cholesterol in cholesterol-fed rats at 200 mg/kg dose given in a period of 3 days ChEMBL. 2909740
Change (functional) = 27 % Change in plasma triglycerides in normocholesterolemic rats at 0.2 % composition of dose with diet given in a period of 3 days. ChEMBL. 2909740
Change (functional) = 30 % Percent change in plasma HDL cholesterol in cholesterol-fed rats at 200 mg/kg dose given in a period of 3 days ChEMBL. 2909740
Ratio (functional) = 35 Ratio of plasma HDL cholesterol/total cholesterol at 200 g/kg for 3 days ChEMBL. 2909740

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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