Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Caenorhabditis elegans | Protein SKN-1, isoform B | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0087 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.4164 | 0.4164 |
Brugia malayi | RNA binding protein | 0.0076 | 0.7727 | 0.7727 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.7727 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.7727 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0087 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.4164 | 0.5389 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7727 | 0.7727 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.7727 | 0.7727 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.7727 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.4164 | 0.4164 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0087 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7727 | 0.7727 |
Entamoeba histolytica | hypothetical protein | 0.0087 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7727 | 0.7727 |
Entamoeba histolytica | hypothetical protein | 0.0087 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0087 | 1 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.7727 | 0.7727 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.4164 | 0.5389 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0087 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7727 | 0.7727 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7727 | 0.7727 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 12.4 uM | PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | = 19.1 uM | PubChem BioAssay. Dose ResponseConfirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay - Set 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | > 64 uM | PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits via a heat-shock counterscreen assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.3548 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.