Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1904 | 0.1904 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1904 | 0.1904 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.7205 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.7205 | 0.6547 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.577 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.7205 | 0.6547 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1904 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1904 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.577 | 0.4775 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.7205 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.7205 | 0.6547 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.7205 | 0.6547 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.7205 | 0.6547 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1904 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1904 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.577 | 0.4775 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1904 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.7205 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1904 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.7205 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1904 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1904 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.