Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.6989 | 1 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.6989 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.6989 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.6989 | 0.6989 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0355 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.6989 | 0.6989 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0355 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.6989 | 0.6989 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.5325 | 0.7619 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0781 | 0.1118 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0355 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.6989 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0781 | 0.0781 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.6989 | 0.6989 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0355 | 0.0508 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0355 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0355 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0781 | 0.0781 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.6989 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0781 | 0.0781 |
Brugia malayi | RNA binding protein | 0.0128 | 0.6989 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0781 | 0.0781 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.6989 | 0.6989 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.6989 | 0.6989 |
Echinococcus multilocularis | geminin | 0.0174 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0355 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0355 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.3222 | 0.461 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0781 | 0.0781 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0781 | 0.0781 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0355 | 0.0508 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0781 | 0.1118 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.3222 | 0.3222 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0781 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.5325 | 0.7619 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.5325 | 0.7619 |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0 | 0.5 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.5325 | 0.7619 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0781 | 0.0781 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.3222 | 0.461 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0355 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0781 | 0.0781 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0781 | 0.1118 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.6989 | 0.6989 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0781 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0781 | 0.1118 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 4.42 uM | Antimalarial activity against chloroquine-sensetive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 72 hrs | ChEMBL. | 21243104 |
EC50 (ADMET) | = 19 uM | Cytotoxicity against human HepG2 cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
EC50 (ADMET) | = 22 uM | Cytotoxicity against human BJ cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
EC50 (ADMET) | > 25 uM | Cytotoxicity against human HEK293 cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
EC50 (ADMET) | > 25 uM | Cytotoxicity against human Raji cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21243104 | |
Homo sapiens | ChEMBL23 | 21243104 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.