Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.1098 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0532 | 0.5 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0532 | 0.5 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.1298 | 0.0998 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0333 | 0.4422 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.1298 | 0.1298 |
Schistosoma mansoni | DNA helicase recq5 | 0.0012 | 0.0333 | 0.3494 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0.00000000027976 | 0.5 |
Onchocerca volvulus | 0.0182 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.7927 | 0.7927 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0012 | 0.0333 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.002 | 0.0766 | 0.5 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.1298 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0012 | 0.0333 | 0.0333 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0952 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.1298 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.0532 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.1298 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0012 | 0.0333 | 0.3494 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.1298 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0752 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0333 | 0.4422 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0333 | 0.0333 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] | ChEMBL. | No reference |
Potency (functional) | 46.0615 uM | PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Potency (functional) | 223.8721 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.