Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Serotonin receptor | 0.0479 | 0.5576 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0391 | 0.4447 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0569 | 0.1279 |
Mycobacterium tuberculosis | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) | 0.0823 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0089 | 0.0569 | 0.1279 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0391 | 0.4447 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0089 | 0.0569 | 0.102 |
Plasmodium falciparum | carbonic anhydrase | 0.0089 | 0.0569 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0089 | 0.0569 | 0.102 |
Toxoplasma gondii | hypothetical protein | 0.0089 | 0.0569 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0089 | 0.0569 | 0.1279 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0391 | 0.4447 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0569 | 0.1279 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0391 | 0.4447 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.0569 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0569 | 0.1279 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0391 | 0.4447 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0089 | 0.0569 | 0.102 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0391 | 0.4447 | 0.7975 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0089 | 0.0569 | 0.1279 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0391 | 0.4447 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0391 | 0.4447 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0391 | 0.4447 | 0.7975 |
Mycobacterium ulcerans | secreted antigen 85-C FbpC | 0.0823 | 1 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0391 | 0.4447 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0391 | 0.4447 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0089 | 0.0569 | 0.102 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0089 | 0.0569 | 0.102 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0391 | 0.4447 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Echinococcus granulosus | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Echinococcus granulosus | carbonic anhydrase | 0.0089 | 0.0569 | 0.1279 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 500 uM | Compound was tested for its ability to inhibit the thrombin-induced platelet aggregation in washed human platelets | ChEMBL. | 9873606 |
IC50 (functional) | > 500 uM | Compound was tested for its ability to inhibit the thrombin-induced platelet aggregation in washed human platelets | ChEMBL. | 9873606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.