TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 497.457 | Formula: C23H23N5O8
H donors: 2 H acceptors: 5 LogP: -0.06 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C1CC23C(=NC(=C(C2Nc2c3cccc2)C(=O)OC)C(=O)OC)N1C(=O)N1CCNC1=O
InChi: 1S/C23H23N5O8/c1-34-17(29)13-10-23-11-6-4-5-7-12(11)25-16(23)14(18(30)35-2)15(19(31)36-3)26-20(23)28(13)22(33)27-9-8-24-21(27)32/h4-7,13,16,25H,8-10H2,1-3H3,(H,24,32)
InChiKey: MGGUSICOMOJADC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cytochrome P450 family protein	0.0037	0.0283	0.0447
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.015	0.1724	0.8851
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.015	0.1724	0.2641
Echinococcus granulosus	GPCR family 2	0.0065	0.0639	0.0963
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0042	0.0344	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0096	0.0152
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0042	0.0344	0.0545
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.003	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0639	0.1011
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.0364	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0272	0.0257
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0042	0.0344	0.1704
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.0364	1
Onchocerca volvulus		0.0036	0.0272	0.0513
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Echinococcus multilocularis	FTZ F1 alpha	0.0042	0.0344	0.0329
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0066	0.0078
Trichomonas vaginalis	esterase, putative	0.0036	0.0272	0.0337
Brugia malayi	conserved hypotetical protein	0.002	0.0066	0.0105
Schistosoma mansoni	nuclear receptor	0.002	0.0066	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0272	0.0431
Echinococcus multilocularis	ecdysone induced protein 78C	0.0042	0.0344	0.0329
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0042	0.0344	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0344	0.0545
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0061	0.0236
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	0.632	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0426	0.2128
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0066	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0272	0.0431
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0066	0.0051
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.002	0.0066	0.0051
Echinococcus granulosus	geminin	0.0168	0.1945	0.2983
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	0.632	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.003	0.0359
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.003	0.0014
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0158	0.025
Schistosoma mansoni	hypothetical protein	0.0168	0.1945	1
Brugia malayi	MH2 domain containing protein	0.0127	0.1422	0.2251
Entamoeba histolytica	hypothetical protein	0.0074	0.0755	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0047	0.0414	0.0564
Echinococcus multilocularis	musashi	0.0027	0.0158	0.0143
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0138	0.4782
Echinococcus granulosus	dna polymerase eta	0.0019	0.0061	0.007
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0755	0.3833
Loa Loa (eye worm)	hypothetical protein	0.0207	0.2438	0.3858
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.002	0.0066	0.0261
Schistosoma mansoni	nuclear receptor	0.002	0.0066	0.0261
Brugia malayi	nuclear receptor NHR-88	0.0042	0.0344	0.0545
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0042	0.0344	0.1704
Brugia malayi	nuclear hormone receptor family member odr-7	0.002	0.0066	0.0105
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.4084	0.6427
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0042	0.0344	0.0329
Mycobacterium ulcerans	lipase LipD	0.0036	0.0272	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0355	0.4314	0.6795
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0061	0.1775
Echinococcus granulosus	intermediate filament protein	0.0027	0.0158	0.022
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0022	0.0096	0.0416
Echinococcus multilocularis	nuclear receptor nhr 48	0.002	0.0066	0.0051
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0042	0.0344	0.0545
Brugia malayi	nuclear hormone receptor	0.002	0.0066	0.0105
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0272	0.0948
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0061	0.1775
Brugia malayi	follicle stimulating hormone receptor	0.0253	0.3027	0.4789
Onchocerca volvulus		0.0027	0.0158	0.0229
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0061	0.0046
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.003	0.0558
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.4084	0.6427
Echinococcus granulosus	lamin	0.0027	0.0158	0.022
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0065	0.0639	0.0624
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0061	0.0046
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Onchocerca volvulus	Protein ultraspiracle homolog	0.0042	0.0344	0.0693
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0272	0.0431
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0272	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0127	0.1422	0.2251
Loa Loa (eye worm)	cytochrome P450	0.0016	0.0016	0.0025
Schistosoma mansoni	hypothetical protein	0.0168	0.1945	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0272	0.0431
Echinococcus granulosus	neuropeptide receptor A26	0.0526	0.6484	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.015	0.1724	0.8851
Brugia malayi	Latrophilin receptor protein 2	0.0065	0.0639	0.1011
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0272	0.0948
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.003	0.0022
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.003	0.0014
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Schistosoma mansoni	coup transcription factor	0.0042	0.0344	0.1704
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0226	0.2687	0.2675
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.003	0.0558
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Echinococcus multilocularis	lamin dm0	0.0027	0.0158	0.0143
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0042	0.0344	0.0508
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0158	0.025
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.016	0.1846	0.1833
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0344	0.0545
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Loa Loa (eye worm)	DR-78	0.002	0.0066	0.0105
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0272	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0205	0.2413	0.3818
Onchocerca volvulus	Bile acid receptor homolog	0.0042	0.0344	0.0693
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0061	0.1775
Echinococcus multilocularis	lamin	0.0027	0.0158	0.0143
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0016	0.0025
Schistosoma mansoni	RAR-like nuclear receptor	0.0042	0.0344	0.1704
Loa Loa (eye worm)	CYP4Cod1	0.0025	0.0138	0.0219
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0344	0.0329
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.015	0.1724	0.2727
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0272	0.0396
Echinococcus granulosus	lamin dm0	0.0027	0.0158	0.022
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0017	0.003	0.0053
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0344	0.0545
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0042	0.0344	0.0545
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0272	0.0431
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.002	0.0066	0.0105
Schistosoma mansoni	hypothetical protein	0.0065	0.0639	0.3229
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0755	0.0741
Brugia malayi	nuclear receptor RXR	0.002	0.0066	0.0105
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0061	0.0236
Echinococcus granulosus	nuclear receptor nhr 48	0.002	0.0066	0.0078
Onchocerca volvulus		0.0027	0.0158	0.0229
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0047	0.0414	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.003	0.0048
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.015	0.1724	0.8851
Schistosoma mansoni	retinoic acid receptor RXR	0.0042	0.0344	0.1704
Schistosoma mansoni	hypothetical protein	0.0074	0.0755	0.3833
Trypanosoma cruzi	cytochrome P450, putative	0.0025	0.0138	0.4782
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.002	0.0066	0.0078
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0042	0.0344	0.0545
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0205	0.2413	0.3818
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0042	0.0344	0.1704
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.4084	0.6427
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0066	0.0105
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.015	0.1724	0.1711
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.002	0.0066	0.0051
Echinococcus granulosus	ecdysone induced protein 78C	0.0042	0.0344	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0344	0.0545
Onchocerca volvulus		0.0036	0.0272	0.0513
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	0.632	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0272	0.1329
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0344	0.1704
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0205	0.2413	0.3818
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	0.632	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.4084	0.6427
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0272	0.0948
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0061	0.1775
Schistosoma mansoni	zinc finger protein	0.002	0.0066	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0272	0.0431
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0272	0.0431
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.2802	0.4308
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0096	0.0416
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0022	0.0096	0.008
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0042	0.0344	0.1704
Brugia malayi	nuclear hormone receptor family member nhr-6	0.002	0.0066	0.0105
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0042	0.0344	0.0545
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0061	0.1775
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.015	0.1724	0.2727
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0272	0.1329
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0065	0.0639	0.1011
Leishmania major	DNA polymerase eta, putative	0.0019	0.0061	0.1775
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0025	0.0138	0.4782
Brugia malayi	hypothetical protein	0.0252	0.3011	0.4764
Toxoplasma gondii	ABC1 family protein	0.0036	0.0272	0.6436
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0061	0.0046
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0061	0.0097
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0042	0.0344	0.0508
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0158	0.025
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.0364	0.4367
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0065	0.0639	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0061	0.0097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0042	0.0344	0.0545
Brugia malayi	hypothetical protein	0.0022	0.0096	0.0152
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0272	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.003	0.0359
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0138	0.0219
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0042	0.0344	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2413	0.3818
Onchocerca volvulus		0.0036	0.0272	0.0513
Brugia malayi	Steroid receptor seven-up type 2	0.0226	0.2687	0.4251
Echinococcus granulosus	thyroid hormone receptor alpha	0.002	0.0066	0.0078
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0047	0.0414	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0096	0.0152
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0066	0.0078
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.0344	0.1704
Brugia malayi	steroid hormone receptor	0.0042	0.0344	0.0545
Schistosoma mansoni	hypothetical protein	0.014	0.1592	0.8167
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0061	0.0236
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0272	0.0337
Schistosoma mansoni	hypothetical protein	0.0065	0.0639	0.3229
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0344	0.0545
Brugia malayi	hypothetical protein	0.0022	0.0096	0.0152
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.2802	0.2791
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0344	0.0508
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.003	0.0558
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0061	0.0097
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0061	0.007
Brugia malayi	acetyltransferase, GNAT family protein	0.016	0.1846	0.292
Brugia malayi	orphan nuclear receptor NR2E1	0.002	0.0066	0.0105
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0065	0.0639	0.0963
Brugia malayi	cytochrome P450	0.0016	0.0016	0.0025
Brugia malayi	intermediate filament protein	0.0027	0.0158	0.025
Echinococcus multilocularis	neuropeptide receptor A26	0.0526	0.6484	0.6478
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0272	0.0948
Schistosoma mansoni	hypothetical protein	0.0065	0.0639	0.3229
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.0096	0.0152
Loa Loa (eye worm)	MH2 domain-containing protein	0.0127	0.1422	0.2251
Loa Loa (eye worm)	nuclear hormone receptor	0.0204	0.2409	0.3811
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.003	0.0014
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0022	0.0096	0.0124
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0047	0.0414	0.0616
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0272	0.0948
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.015	0.1724	0.1711
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	0.632	1
Brugia malayi	hypothetical protein	0.0074	0.0755	0.1195
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0272	0.0337
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0138	0.0219
Trypanosoma brucei	unspecified product	0.0019	0.0061	0.1775
Echinococcus multilocularis	GPCR, family 2	0.0065	0.0639	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0344	0.0545
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.003	0.0074
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0272	0.0948
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0156	0.1789	0.2741
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0272	0.0948
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0344	0.0545
Echinococcus multilocularis	geminin	0.0168	0.1945	0.1933
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0096	0.0152
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0061	0.0097
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0344	0.0545
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0061	0.1775
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Onchocerca volvulus	Huntingtin homolog	0.0252	0.3011	0.7328
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0042	0.0344	0.0545
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0272	0.0948
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0066	0.0051
Onchocerca volvulus		0.0048	0.0426	0.0897
Leishmania major	cytochrome p450-like protein	0.0025	0.0138	0.4782
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.003	0.0558
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.003	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0344	0.0545
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0042	0.0344	0.0329
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0047	0.0414	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.4084	0.6427
Brugia malayi	beta-lactamase family protein	0.0036	0.0272	0.0431
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0272	0.0948
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0042	0.0344	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0344	0.0545
Loa Loa (eye worm)	acetyltransferase	0.016	0.1846	0.292
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.015	0.1724	0.2641
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.002	0.0066	0.0051
Trichomonas vaginalis	glucosylceramidase, putative	0.0513	0.632	1
Onchocerca volvulus	Glucosylceramidase homolog	0.0337	0.4084	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.003	0.0558
Echinococcus multilocularis	neuropeptide s receptor	0.0526	0.6484	0.6478
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0096	0.0152
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0272	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0042	0.0344	0.0545
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0061	0.0168
Trypanosoma brucei	cytochrome P450, putative	0.0025	0.0138	0.4782
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0138	0.0219
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0061	0.007
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.4084	0.6427
Brugia malayi	nuclear receptor NHR-67	0.002	0.0066	0.0105
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0042	0.0344	0.0329
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0272	1
Brugia malayi	nuclear hormone receptor	0.0042	0.0344	0.0545
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.002	0.0066	0.0261
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0138	0.0219
Brugia malayi	nuclear receptor NHR-88	0.002	0.0066	0.0105
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0042	0.0344	0.0329
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0272	0.0948
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0152	0.024
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Brugia malayi	Nuclear hormone receptor E75	0.002	0.0066	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0236	0.2802	0.4434
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0042	0.0344	0.0545
Brugia malayi	photoreceptor-specific nuclear receptor	0.0042	0.0344	0.0545
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0344	0.0545
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0272	0.6303
Trichomonas vaginalis	glucosylceramidase, putative	0.0337	0.4084	0.6427
Echinococcus granulosus	Nuclear hormone receptor HR96	0.002	0.0066	0.0078
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0344	0.0329
Entamoeba histolytica	hypothetical protein	0.0074	0.0755	1
Brugia malayi	isocitrate dehydrogenase	0.0017	0.003	0.0048
Loa Loa (eye worm)	hypothetical protein	0.014	0.1592	0.2519
Schistosoma mansoni	nuclear receptor nhr-48	0.002	0.0066	0.0261
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0096	0.0152
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0042	0.0344	0.0545
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0042	0.0344	0.0508
Brugia malayi	ecdysteroid receptor	0.0042	0.0344	0.0545
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0272	0.0337
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.2721	1
Brugia malayi	tailless protein	0.002	0.0066	0.0105
Schistosoma mansoni	lamin	0.0027	0.0158	0.0737
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0066	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0252	0.3011	0.4764
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0096	0.0152
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0272	1
Brugia malayi	beta-lactamase	0.0036	0.0272	0.0431
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0426	0.2128
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0344	0.0545
Brugia malayi	Cytochrome P450 family protein	0.0037	0.0283	0.0447
Echinococcus granulosus	neuropeptide s receptor	0.0526	0.6484	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0061	0.1775
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.003	0.0014
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0344	0.1704
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0755	0.1143
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0272	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0272	0.0431
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0272	0.0337
Loa Loa (eye worm)	nuclear receptor NHR-67	0.002	0.0066	0.0105
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0272	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0344	0.0545
Schistosoma mansoni	hypothetical protein	0.0065	0.0639	0.3229
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0065	0.0639	0.0963
Brugia malayi	latrophilin 2 splice variant baaae	0.014	0.1592	0.2519
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.002	0.0066	0.0105
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0042	0.0344	0.0508
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0344	0.1704
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0344	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0252	0.3011	0.4764
Brugia malayi	hypothetical protein	0.002	0.0066	0.0105
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Schistosoma mansoni	lamin	0.0027	0.0158	0.0737
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0344	0.0508
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0272	1
Echinococcus granulosus	FTZ F1 alpha	0.0042	0.0344	0.0508
Brugia malayi	hypothetical protein	0.0236	0.2802	0.4434
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0226	0.2687	0.413
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1775
Brugia malayi	hypothetical protein	0.002	0.0066	0.0105
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0061	0.1775
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0065	0.0639	0.0624
Brugia malayi	nuclear receptor RXR	0.0022	0.0096	0.0152
Loa Loa (eye worm)	steroid hormone receptor	0.0042	0.0344	0.0545
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0042	0.0344	0.1704
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0061	0.0168
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0344	0.0545
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0426	0.0675
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0047	0.0414	0.0564
Brugia malayi	ecdysone receptor	0.002	0.0066	0.0105
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Leishmania major	hypothetical protein, conserved	0.0036	0.0272	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0355	0.4314	0.6795
Loa Loa (eye worm)	hypothetical protein	0.002	0.0066	0.0105
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0272	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.016	0.1846	0.9483
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0272	0.0431
Onchocerca volvulus		0.0042	0.0344	0.0693
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0513	0.632	1
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0158	0.0737
Entamoeba histolytica	hypothetical protein	0.0074	0.0755	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0158	0.025
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0253	0.3027	0.4789
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0042	0.0344	0.1704
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0513	0.632	1
Onchocerca volvulus	Huntingtin homolog	0.0252	0.3011	0.7328
Entamoeba histolytica	hypothetical protein	0.0074	0.0755	1
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0272	0.0431
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0042	0.0344	0.0545

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1698913

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1497885