TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 422.538 | Formula: C21H30N2O5S
H donors: 1 H acceptors: 3 LogP: 2.45 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CSCCC(C(=O)N1CCC(CC1)C(=O)OCC)NC(=O)c1ccccc1OC
InChi: 1S/C21H30N2O5S/c1-4-28-21(26)15-9-12-23(13-10-15)20(25)17(11-14-29-3)22-19(24)16-7-5-6-8-18(16)27-2/h5-8,15,17H,4,9-14H2,1-3H3,(H,22,24)
InChiKey: VLGMPSSZRLUOGI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.003	0.0083	0.0083
Loa Loa (eye worm)	steroid hormone receptor	0.0081	0.0602	0.0602
Schistosoma mansoni	thyroid hormone receptor	0.0081	0.0602	0.1787
Trichomonas vaginalis	abcb9, putative	0.0071	0.0506	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0038	0.0162	0.0482
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0071	0.0506	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0038	0.0162	0.0162
Schistosoma mansoni	zinc finger protein	0.0038	0.0162	0.0482
Brugia malayi	hypothetical protein	0.0043	0.0209	0.0209
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0038	0.0162	0.0482
Leishmania major	hypothetical protein, conserved	0.003	0.0083	0.165
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0022	0	0.5
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0038	0.0162	0.0554
Giardia lamblia	ABC transporter, putative	0.0022	0	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0038	0.0162	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Echinococcus granulosus	multidrug resistance protein 1	0.0071	0.0506	0.1502
Entamoeba histolytica	P-glycoprotein-2	0.0071	0.0506	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0081	0.0602	0.1787
Trichomonas vaginalis	ABC transporter, putative	0.0071	0.0506	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.0071	0.0506	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0071	0.0506	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0022	0	0.5
Brugia malayi	ecdysone receptor	0.0038	0.0162	0.0162
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0081	0.0602	0.2056
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0071	0.0506	0.1502
Giardia lamblia	MRP-like ABC transporter	0.0022	0	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0071	0.0506	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0071	0.0506	1
Brugia malayi	nuclear receptor RXR	0.0043	0.0209	0.0209
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0038	0.0162	0.0162
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0083	0.165
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0081	0.0602	0.1787
Onchocerca volvulus	Bile acid receptor homolog	0.0993	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0081	0.0602	0.0602
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0081	0.0602	0.1787
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0071	0.0506	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0083	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0081	0.0602	0.1787
Leishmania major	p-glycoprotein	0.0071	0.0506	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0071	0.0506	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0071	0.0506	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0071	0.0506	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0209	0.0209
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0071	0.0506	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0498	0.0498
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0022	0	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0071	0.0506	1
Brugia malayi	nuclear hormone receptor	0.0081	0.0602	0.0602
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0071	0.0506	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Brugia malayi	conserved hypotetical protein	0.0038	0.0162	0.0162
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0081	0.0602	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0081	0.0602	0.1787
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0071	0.0506	1
Echinococcus granulosus	FTZ F1 alpha	0.0081	0.0602	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Schistosoma mansoni	smdr2	0.0071	0.0506	0.1502
Brugia malayi	hypothetical protein	0.0043	0.0209	0.0209
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0022	0	0.5
Brugia malayi	hypothetical protein	0.003	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0506	0.0506
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0071	0.0506	1
Trichomonas vaginalis	ABC transporter, putative	0.0071	0.0506	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0081	0.0602	0.2056
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0602	0.0602
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0071	0.0498	0.1479
Schistosoma mansoni	multidrug resistance protein	0.0071	0.0506	0.1502
Onchocerca volvulus		0.0081	0.0602	0.0447
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0071	0.0506	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0071	0.0506	0.1728
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0022	0	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0071	0.0506	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0081	0.0602	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0602	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Entamoeba histolytica	P-glycoprotein-1	0.0071	0.0506	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0071	0.0506	0.1502
Schistosoma mansoni	thyroid hormone receptor	0.0081	0.0602	0.1787
Echinococcus multilocularis	multidrug resistance protein 1	0.0071	0.0506	0.1728
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0081	0.0602	0.0602
Echinococcus multilocularis	ATP binding cassette sub family B	0.0071	0.0498	0.1701
Entamoeba histolytica	P-glycoprotein-5	0.0071	0.0506	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Schistosoma mansoni	nuclear hormone receptor	0.0038	0.0162	0.0482
Brugia malayi	nuclear receptor NHR-88	0.0081	0.0602	0.0602
Entamoeba histolytica	P-glycoprotein-2	0.0071	0.0506	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0081	0.0602	0.0447
Plasmodium vivax	multidrug resistance protein 1, putative	0.0071	0.0506	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0083	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0506	0.0506
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0071	0.0506	1
Brugia malayi	tailless protein	0.0038	0.0162	0.0162
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0081	0.0602	0.0602
Schistosoma mansoni	multidrug resistance protein	0.0071	0.0506	0.1502
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0038	0.0162	0.0162
Echinococcus granulosus	multidrug resistance protein 1	0.005	0.0283	0.0842
Brugia malayi	nuclear receptor NHR-67	0.0038	0.0162	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0209	0.0209
Entamoeba histolytica	P-glyco protein 6, putative	0.0071	0.0506	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0081	0.0602	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0602	0.0602
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0209	0.0209
Giardia lamblia	Multidrug resistance-associated protein 1	0.0022	0	0.5
Brugia malayi	nuclear receptor NHR-88	0.0038	0.0162	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0602	0.0602
Brugia malayi	photoreceptor-specific nuclear receptor	0.0081	0.0602	0.0602
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0038	0.0162	0.0162
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0081	0.0602	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0071	0.0506	0.0506
Brugia malayi	hypothetical protein	0.0038	0.0162	0.0162
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0081	0.0602	0.1787
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0038	0.0162	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0209	0.0209
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0071	0.0506	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Echinococcus granulosus	multidrug resistance protein 1	0.0071	0.0506	0.1502
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0043	0.0209	0.0715
Echinococcus granulosus	ecdysone induced protein 78C	0.0081	0.0602	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Loa Loa (eye worm)	multidrug resistance protein 3	0.0071	0.0506	0.0506
Trichomonas vaginalis	ABC transporter, putative	0.0071	0.0506	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0038	0.0162	0.0482
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0081	0.0602	0.0602
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0081	0.0602	0.0447
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0071	0.0506	0.1728
Echinococcus granulosus	thyroid hormone receptor alpha	0.0038	0.0162	0.0482
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0081	0.0602	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Brugia malayi	Nuclear hormone receptor E75	0.0038	0.0162	0.0162
Brugia malayi	nuclear hormone receptor	0.0038	0.0162	0.0162
Echinococcus multilocularis	multidrug resistance protein 1	0.0071	0.0506	0.1728
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0038	0.0162	0.0554
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0081	0.0602	0.2056
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0081	0.0602	0.0602
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0081	0.0602	0.0602
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0081	0.0602	0.1787
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0349	0.3366	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0083	0.165
Echinococcus multilocularis	nuclear receptor nhr 48	0.0038	0.0162	0.0554
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0081	0.0602	0.1787
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0081	0.0602	0.0602
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0081	0.0602	0.1787
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0081	0.0602	0.2056
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0306	0.2927	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0038	0.0162	0.0482
Brugia malayi	Nuclear hormone receptor-like 1	0.0043	0.0209	0.0209
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0083	1
Echinococcus granulosus	multidrug resistance protein 1	0.005	0.0283	0.0842
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0038	0.0162	0.0482
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0071	0.0506	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0081	0.0602	0.0602
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0043	0.0209	0.0622
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0071	0.0506	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0071	0.0506	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0038	0.0162	0.0482
Brugia malayi	hypothetical protein	0.0038	0.0162	0.0162
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0071	0.0506	1
Brugia malayi	Steroid receptor seven-up type 2	0.0081	0.0602	0.0602
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0038	0.0162	0.0482
Schistosoma mansoni	nuclear receptor	0.0038	0.0162	0.0482
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0038	0.0162	0.0162
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0081	0.0602	0.1787
Loa Loa (eye worm)	nuclear hormone receptor	0.0038	0.0162	0.0162
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0022	0	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0081	0.0602	0.2056
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0071	0.0506	0.1728
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0081	0.0602	0.0602
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0071	0.0506	1
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0022	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0081	0.0602	0.1787
Plasmodium falciparum	multidrug resistance protein 1	0.0071	0.0506	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0081	0.0602	0.1787
Brugia malayi	Nuclear hormone receptor-like 1	0.0043	0.0209	0.0209
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0081	0.0602	0.0602
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0071	0.0506	0.1728
Echinococcus multilocularis	FTZ F1 alpha	0.0081	0.0602	0.2056
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0083	0.165
Loa Loa (eye worm)	hypothetical protein	0.0993	1	1
Brugia malayi	nuclear receptor RXR	0.0038	0.0162	0.0162
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0038	0.0162	0.0554
Brugia malayi	multidrug resistance protein 3	0.0071	0.0506	0.0506
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.005	0.0283	0.5606
Loa Loa (eye worm)	DR-78	0.0038	0.0162	0.0162
Trichomonas vaginalis	abcb9, putative	0.0071	0.0506	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0081	0.0602	0.0602
Echinococcus multilocularis	multidrug resistance protein 1	0.005	0.0283	0.0969
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0038	0.0162	0.0554
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0081	0.0602	0.0602
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0071	0.0506	0.1502
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0071	0.0506	1
Trichomonas vaginalis	ABC transporter, putative	0.0071	0.0506	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0071	0.0506	1
Schistosoma mansoni	nuclear receptor	0.0038	0.0162	0.0482
Trichomonas vaginalis	taga, putative	0.0071	0.0506	1
Brugia malayi	steroid hormone receptor	0.0081	0.0602	0.0602
Schistosoma mansoni	multidrug resistance protein	0.0071	0.0506	0.1502
Entamoeba histolytica	P-glycoprotein-2, putative	0.0071	0.0506	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0071	0.0506	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0081	0.0602	0.1787
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0081	0.0602	0.1787
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0043	0.0209	0.0622
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0022	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0038	0.0162	0.0482
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0083	0.165
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0209	0.0209
Brugia malayi	orphan nuclear receptor NR2E1	0.0038	0.0162	0.0162
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0081	0.0602	0.0602
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0071	0.0506	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0602	0.0602
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0043	0.0209	0.0209
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0022	0	0.5
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0071	0.0506	0.1502
Brugia malayi	ABC transporter family protein	0.0071	0.0506	0.0506
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0081	0.0602	0.0602
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0081	0.0602	0.2056
Echinococcus granulosus	multidrug resistance protein 1	0.0071	0.0506	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0602	0.0602
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0081	0.0602	0.0602
Schistosoma mansoni	coup transcription factor	0.0081	0.0602	0.1787
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0043	0.0209	0.0622
Schistosoma mansoni	retinoic acid receptor RXR	0.0349	0.3366	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0081	0.0602	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0162	0.0162
Onchocerca volvulus		0.0071	0.0506	0.0349
Trichomonas vaginalis	abcb9, putative	0.0071	0.0506	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0071	0.0506	0.1728
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0071	0.0506	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0081	0.0602	0.0602
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0081	0.0602	0.2056
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0602	0.0602
Echinococcus multilocularis	ecdysone induced protein 78C	0.0081	0.0602	0.2056

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.8913 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1718675

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1497975