Detailed information for compound 1498168

Basic information

Technical information
  • TDR Targets ID: 1498168
  • Name: [(1E,3E)-4-phenylsulfonylbuta-1,3-dienyl]sulf onylbenzene
  • MW: 334.41 | Formula: C16H14O4S2
  • H donors: 0 H acceptors: 4 LogP: 2.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S(=O)(c1ccccc1)/C=C/C=C/S(=O)(=O)c1ccccc1
  • InChi: 1S/C16H14O4S2/c17-21(18,15-9-3-1-4-10-15)13-7-8-14-22(19,20)16-11-5-2-6-12-16/h1-14H/b13-7+,14-8+
  • InChiKey: DEXCOBKOWPYHFL-FNCQTZNRSA-N  


Substructure search Similarity search

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Synonyms

  • 4-phenylsulfonylbuta-1,3-dienylsulfonylbenzene
  • Benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis
  • ((4-(Phenylsulfonyl)-1,3-butadienyl)sulfonyl)benzene
  • AIDS-143111
  • AIDS143111
  • Benzene, {1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis}
  • NSC662781
  • NCI60_021688

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Herpes simplex virus (type 1 / strain 17) Alpha trans-inducing protein (VP16) Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens toll-like receptor 9 Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 2, group E, member 3 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135311 All targets in OG5_135311
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi photoreceptor-specific nuclear receptor Get druggable targets OG5_135311 All targets in OG5_135311
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Brugia malayi Nuclear hormone receptor family member nhr-49 nuclear receptor subfamily 2, group E, member 3 410 aa 384 aa 28.1 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0222 0.056
Plasmodium falciparum thioredoxin reductase 0.002 0.017 0.2517
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0008 0.0028
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.017 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0102 0.0321
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.006 0.0143
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0222 0.0217
Brugia malayi jmjC domain containing protein 0.0103 0.124 0.3184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Plasmodium vivax vivapain-1 0.0009 0.0035 0.0417
Echinococcus granulosus cysteine protease 0.0009 0.0035 0.0031
Brugia malayi tailless protein 0.0011 0.006 0.0143
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.006 0.0143
Plasmodium falciparum thioredoxin reductase 0.0057 0.0649 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0222 0.0222
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2346 0.7527
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0114 0.048
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0127 0.0127
Onchocerca volvulus 0.0033 0.0334 0.1061
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0185 0.0465
Schistosoma mansoni topbp1 0.0012 0.0068 0.0068
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0035 0.0035
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0031 0.031 0.0787
Brugia malayi hypothetical protein 0.0011 0.006 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0185 0.0588
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0334 0.033
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0042 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0031 0.032 0.4861
Loa Loa (eye worm) glutathione reductase 0.0057 0.0649 0.1661
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.004 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.056
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0185 0.0181
Toxoplasma gondii Alpha-galactosidase 0.0016 0.0127 0.0802
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.056
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0444 0.1419
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0452 0.0452
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0035 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0444 0.1885
Schistosoma mansoni cpg binding protein 0.0064 0.0739 0.0739
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0068 0.0213
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0444 0.1862
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1768 0.4545
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0193 0.0189
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.017 0.0716
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0068 0.2897
Trypanosoma cruzi DNA polymerase eta, putative 0.0007 0.0008 0.0028
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.017 0.2517
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0222 0.0217
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0215 0.0336
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1589 0.8844
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.08 0.3406
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0306 0.13
Onchocerca volvulus Serine\/threonine kinase homolog 0.0189 0.2346 0.7525
Trypanosoma brucei polo-like protein kinase 0.0189 0.2346 1
Schistosoma mansoni cpg binding protein 0.0068 0.0786 0.0786
Onchocerca volvulus 0.0064 0.0739 0.236
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.08 0.3406
Brugia malayi Cathepsin L-like precursor 0.0018 0.0148 0.0369
Loa Loa (eye worm) hypothetical protein 0.0013 0.0077 0.0188
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0222 0.0222
Entamoeba histolytica hypothetical protein 0.0008 0.0012 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2346 0.7527
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.006 0.0143
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0222 0.0699
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0148 0.0468
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0444 0.1132
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0222 0.0217
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.017 0.0716
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0222 0.0222
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.017 0.069
Schistosoma mansoni hypothetical protein 0.001 0.0047 0.0047
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0068 0.0404
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.006 0.006
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0069 0.0167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0222 0.0222
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1776 1
Leishmania major cathepsin L-like protease 0.0018 0.0148 0.0596
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.004 0.0092
Echinococcus multilocularis cysteine protease 0.0018 0.0148 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0444 0.1419
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0167 0.248
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0164 0.1052
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0222 0.056
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.017 0.1089
Schistosoma mansoni dep domain containing protein 0.001 0.004 0.004
Echinococcus multilocularis GPCR, family 2 0.0019 0.016 0.0156
Schistosoma mansoni smad1 5 8 and 0.001 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.006 0.0689 0.1764
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.017 0.1089
Leishmania major cathepsin L-like protease 0.0069 0.08 0.3388
Loa Loa (eye worm) hypothetical protein 0.0015 0.0112 0.0277
Trichomonas vaginalis set domain proteins, putative 0.0249 0.3116 1
Schistosoma mansoni DNA helicase recq5 0.0012 0.0069 0.0069
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0193 0.0486
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0243 0.3657
Schistosoma mansoni nuclear receptor 0.0011 0.006 0.006
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.006 0.0143
Onchocerca volvulus 0.0018 0.0148 0.046
Echinococcus granulosus cathepsin l1 0.0012 0.0071 0.0066
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0102 0.0252
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0405 0.0401
Onchocerca volvulus 0.0249 0.3116 1
Brugia malayi isocitrate dehydrogenase 0.0019 0.016 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0122 0.0512
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0185 0.0185
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.017 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0185 0.0588
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0724 0.3079
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0148 0.2174
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0068 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.016 0.0156
Brugia malayi Cathepsin L-like precursor 0.0012 0.0071 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0222 0.056
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.006 0.0056
Echinococcus granulosus peregrin 0.0031 0.032 0.0316
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0068 0.0213
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Loa Loa (eye worm) hypothetical protein 0.0013 0.0077 0.0188
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0171
Leishmania major hypothetical protein, conserved 0.001 0.0046 0.0161
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0112 0.047
Brugia malayi Nuclear hormone receptor E75 0.0011 0.006 0.0143
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0444 0.1419
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0102 0.0321
Plasmodium vivax JmjC domain containing protein 0.001 0.0046 0.0587
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0306 0.13
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0193 0.0486
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0042 0.0096
Trypanosoma cruzi cysteine protease, putative 0.0009 0.0035 0.0142
Trypanosoma brucei trypanothione reductase 0.0057 0.0649 0.2761
Plasmodium vivax vivapain-2 0.0018 0.0148 0.2174
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0148 0.0596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0035 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0185 0.0588
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0452 0.0448
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0148 0.0612
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.001
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0008 0.0028
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0185 0.0465
Leishmania major cathepsin L-like protease 0.0018 0.0148 0.0596
Brugia malayi Pre-SET motif family protein 0.0219 0.273 0.7022
Brugia malayi MH2 domain containing protein 0.001 0.0042 0.0096
Brugia malayi Latrophilin receptor protein 2 0.0019 0.016 0.0401
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.016 0.2375
Loa Loa (eye worm) hypothetical protein 0.0156 0.1922 0.4942
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0148 0.046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.016 0.0156
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0148 0.0143
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0004 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.016 0.0677
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0185 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0068 0.0213
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0288 0.0919
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0068 0.0934
Echinococcus granulosus neuropeptide receptor A26 0.0526 0.6673 0.6672
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.0164
Plasmodium falciparum cysteine proteinase falcipain 1 0.0009 0.0035 0.0417
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0185 0.0181
Echinococcus granulosus muscleblind protein 0.0156 0.1922 0.1919
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0069 0.0065
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0008 0.0028
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0222 0.0217
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0215 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Toxoplasma gondii cathepsin CPL 0.0018 0.0148 0.094
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0452 0.1153
Onchocerca volvulus 0.0012 0.0068 0.0205
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0148 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Brugia malayi Smad1 0.001 0.0042 0.0096
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0071 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0122 0.0512
Onchocerca volvulus 0.0182 0.226 0.725
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0068 0.0068
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.017 0.0716
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0004 0.0008
Brugia malayi hypothetical protein 0.0182 0.226 0.5813
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0222 0.0217
Brugia malayi hypothetical protein 0.0012 0.0068 0.0164
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0185 0.0588
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.006 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2346 0.7527
Entamoeba histolytica cysteine proteinase 2 0.0009 0.0035 0.0131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0148 0.0468
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0112 0.0354
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0069 0.0065
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0102 0.0321
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0148 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0185 0.0181
Echinococcus multilocularis geminin 0.0532 0.6752 0.6751
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0102 0.0252
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2346 0.7527
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0193 0.0193
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0189 0.2346 0.2343
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0649 0.1661
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0288 0.073
Schistosoma mansoni hypothetical protein 0.0019 0.016 0.016
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.004 0.0036
Trichomonas vaginalis glutathione reductase, putative 0.002 0.017 0.0539
Brugia malayi hypothetical protein 0.0011 0.006 0.0143
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0222 0.0217
Loa Loa (eye worm) hypothetical protein 0.0023 0.0215 0.0542
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0078 0.0913 0.2927
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.0164
Schistosoma mansoni hypothetical protein 0.0019 0.016 0.016
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0185 0.0181
Brugia malayi DKFZp564C0469 protein 0.0012 0.0068 0.0164
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Schistosoma mansoni hypothetical protein 0.0014 0.0091 0.0091
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.016 0.0677
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0649 0.0645
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0444 0.1419
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.017 0.0716
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0069 0.041
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.017 0.2517
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0444 0.1876
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0222 0.0222
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.0046 0.0254
Onchocerca volvulus 0.0012 0.0074 0.0224
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0478 0.0474
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.016 0.0651
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0068 0.0164
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0185 0.0181
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0222 0.0222
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.017 0.0716
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0452 0.0452
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0215 0.0211
Onchocerca volvulus 0.001 0.004 0.0115
Entamoeba histolytica serine/threonine protein kinase, putative 0.0189 0.2346 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0112 0.047
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0047 0.0265
Schistosoma mansoni smad1 5 8 and 0.001 0.0042 0.0042
Schistosoma mansoni nuclear receptor 0.0011 0.006 0.006
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0444 0.1876
Plasmodium falciparum zinc finger protein, putative 0.0008 0.0012 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0102 0.0321
Trypanosoma brucei glucosidase, putative 0.0041 0.0444 0.1885
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0209 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Leishmania major cathepsin L-like protease 0.0069 0.08 0.3388
Brugia malayi N-terminal motif family protein 0.0198 0.2454 0.6313
Loa Loa (eye worm) hypothetical protein 0.0033 0.0334 0.085
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.017 1
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0046 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0148 0.0468
Entamoeba histolytica cysteine protease, putative 0.0018 0.0148 0.0612
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0314 0.0797
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0035 0.0107
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0068 0.0064
Schistosoma mansoni alpha-glucosidase 0.0159 0.1965 0.1965
Giardia lamblia DINP protein human, muc B family 0.0023 0.0215 0.0884
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0077 0.0188
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0649 0.2761
Brugia malayi Cathepsin L-like precursor 0.0018 0.0148 0.0369
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0112 0.0354
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0222 0.0222
Onchocerca volvulus 0.0018 0.0148 0.046
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0222 0.0217
Leishmania major cathepsin L-like protease 0.0018 0.0148 0.0596
Brugia malayi topoisomerase 0.0012 0.0068 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0148 0.0468
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0093 0.0088
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.006 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0222 0.0217
Echinococcus multilocularis muscleblind protein 0.0156 0.1922 0.1919
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0069 0.0949
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0068 0.0213
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0185 0.0181
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0046 0.0041
Brugia malayi PHD-finger family protein 0.0031 0.032 0.0813
Brugia malayi nuclear hormone receptor 0.0024 0.0222 0.056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0148 0.0612
Schistosoma mansoni hypothetical protein 0.0532 0.6752 0.6752
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0625 0.0621
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0102 0.0321
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0334 0.2201
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.2346 1
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0035 0.0131
Brugia malayi CXXC zinc finger family protein 0.0064 0.0739 0.1893
Echinococcus multilocularis smad 0.001 0.0042 0.0037
Trypanosoma brucei unspecified product 0.0016 0.0122 0.0512
Brugia malayi Isocitrate dehydrogenase 0.0019 0.016 0.0402
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Giardia lamblia Replication factor C, subunit 1 0.0012 0.0068 0.0256
Brugia malayi Muscleblind-like protein 0.0156 0.1922 0.4942
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0222 0.0699
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0077 0.0188
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0302 0.0297
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0185 0.0181
Schistosoma mansoni phd/f-box containing protein 0.001 0.0046 0.0046
Onchocerca volvulus 0.0018 0.0148 0.046
Brugia malayi steroid hormone receptor 0.0024 0.0222 0.056
Schistosoma mansoni nuclear hormone receptor 0.0011 0.006 0.006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0015 0.0044
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0112 0.0277
Brugia malayi Thioredoxin reductase 0.0057 0.0649 0.1661
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0689 0.1764
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.017 0.069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0222 0.056
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0068 0.0213
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0014 0.0098 0.1396
Loa Loa (eye worm) hypothetical protein 0.0078 0.0913 0.2342
Brugia malayi MH1 domain containing protein 0.001 0.0042 0.0096
Leishmania major hypothetical protein, conserved 0.003 0.0306 0.1276
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0222 0.0217
Brugia malayi MH2 domain containing protein 0.001 0.0042 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.08 0.3406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0035 0.0142
Entamoeba histolytica hypothetical protein 0.0021 0.0185 0.0771
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0102 0.0321
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.2296 0.5905
Schistosoma mansoni z-protein (S1r protein) 0.0031 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.006 0.0143
Echinococcus multilocularis peregrin 0.0031 0.032 0.0316
Schistosoma mansoni dishevelled 0.001 0.004 0.004
Echinococcus granulosus cpg binding protein 0.0068 0.0786 0.0782
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0042 0.0037
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0148 0.0369
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0069 0.041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0135 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0625 0.0625
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0112 0.0354
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0071 0.0171
Brugia malayi cathepsin L-like precursor 0.0012 0.0071 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0222 0.056
Toxoplasma gondii hypothetical protein 0.001 0.004 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0222 0.0217
Brugia malayi hypothetical protein 0.001 0.004 0.0092
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0004 0.0004
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0047 0.0265
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0069 0.0065
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0444 0.1419
Onchocerca volvulus 0.0018 0.0148 0.046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.016 0.0401
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0649 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0334 0.033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0185 0.0465
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0004 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0222 0.056
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0107
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.006 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0306 0.4653
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0008 0.0028
Leishmania major DNA polymerase kappa, putative 0.0023 0.0215 0.0884
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.017 0.2517
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0046 0.0188
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0148 0.0143
Echinococcus granulosus cathepsin L 0.0009 0.0035 0.0031
Schistosoma mansoni jumonji domain containing protein 0.001 0.0046 0.0046
Brugia malayi regulator of G-protein signaling egl-10 0.0031 0.031 0.0787
Loa Loa (eye worm) hypothetical protein 0.0156 0.1922 0.4942
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0077 0.0077
Echinococcus granulosus dnaJ subfamily B 0.0471 0.5971 0.5969
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0689 0.1764
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0185 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.017 0.2517
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.016 0.0156
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.056
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0102 0.0321
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0148 0.0622
Schistosoma mansoni zinc finger protein 0.0011 0.006 0.006
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0135 0.013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0222 0.056
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.004 0.0092
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0077 0.0073
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0215 0.0909
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.2346 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.017 1
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0071 0.0284
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0198 0.2454 0.7873
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.016 0.0156
Loa Loa (eye worm) hypothetical protein 0.0031 0.031 0.0787
Echinococcus granulosus dna polymerase kappa 0.0023 0.0215 0.0211
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0185 0.0181
Echinococcus granulosus Smad4 0.001 0.0042 0.0037
Echinococcus multilocularis regulator of G protein signaling 7 0.0031 0.031 0.0306
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.006 0.0178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0625 0.0625
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0222 0.056
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0222 0.0222
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0215 0.0909
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0222 0.056
Brugia malayi Nuclear hormone receptor E75 0.0011 0.006 0.0143
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.017 0.069
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0148 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0625 0.0621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0625 0.0621
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.124 0.1236
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0077 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Echinococcus multilocularis neuropeptide s receptor 0.0526 0.6673 0.6672
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0649 0.0645
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0028
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0222 0.056
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0444 0.1419
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0185 0.0185
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.032 0.0316
Brugia malayi hypothetical protein 0.001 0.004 0.0092
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0035 0.0079
Loa Loa (eye worm) RecQ helicase 0.0029 0.0288 0.073
Plasmodium falciparum JmjC domain-containing protein, putative 0.001 0.0046 0.0587
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0189 0.2346 0.6034
Loa Loa (eye worm) hypothetical protein 0.0031 0.032 0.0813
Trypanosoma brucei unspecified product 0.0023 0.0215 0.0909
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0968 0.0968
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1589 0.8844
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0042 0.0042
Brugia malayi hypothetical protein 0.0013 0.0077 0.0188
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0008 0.0008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.2296 0.2293
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0222 0.056
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0042 0.0037
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0222 0.0222
Brugia malayi jmjC domain containing protein 0.001 0.0046 0.0107
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0068 0.0283
Plasmodium vivax unspecified product 0.0009 0.0035 0.0417
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0185 0.0185
Echinococcus multilocularis muscleblind protein 1 0.0156 0.1922 0.1919
Trichomonas vaginalis hypothetical protein 0.0008 0.0015 0.0044
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0185 0.0181
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.004 0.0036
Leishmania major cathepsin L-like protease 0.0018 0.0148 0.0596
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.016 0.0156
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0148 0.0369
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0215 0.0909
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0078 0.0913 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0102 0.0321
Toxoplasma gondii thioredoxin reductase 0.0057 0.0649 0.4324
Echinococcus multilocularis Smad4 0.001 0.0042 0.0037
Loa Loa (eye worm) cysteine protease 0.0018 0.0148 0.0369
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0185 0.0181
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0112 0.0354
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0215 0.0684
Loa Loa (eye worm) Smad1 0.001 0.0042 0.0096
Brugia malayi MH1 domain containing protein 0.001 0.0042 0.0096
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0267 0.0267
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0185 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0008 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0068 0.0213
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.017 0.0165
Brugia malayi nuclear hormone receptor 0.0011 0.006 0.0143
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0112 0.0354
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0035 0.0131
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1119 0.3586
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.006 0.0056
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0069 0.0167
Brugia malayi PHD-finger family protein 0.0014 0.0094 0.0232
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.017 0.0056
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0611 0.2598
Schistosoma mansoni smad1 5 8 and 0.001 0.0042 0.0042
Echinococcus multilocularis neuropeptide receptor A26 0.0526 0.6673 0.6672
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.017 0.0716
Schistosoma mansoni myst-related protein 0.0008 0.0012 0.0012
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.004 0.0036
Schistosoma mansoni DNA ligase IV 0.0012 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0054 0.0609 0.1557
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0068 0.0283
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1589 0.8906
Schistosoma mansoni hypothetical protein 0.0019 0.016 0.016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0625 0.0621
Loa Loa (eye worm) hypothetical protein 0.0198 0.2454 0.6313
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.016 0.0677
Loa Loa (eye worm) hypothetical protein 0.0182 0.226 0.5813
Brugia malayi hypothetical protein 0.0141 0.1729 0.4444
Echinococcus granulosus geminin 0.0532 0.6752 0.6751
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.004 0.0115
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.006 0.0143
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0444 0.1133
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Loa Loa (eye worm) hypothetical protein 0.0041 0.0444 0.1133
Echinococcus multilocularis dnaJ subfamily B 0.0471 0.5971 0.5969
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0068 0.0213
Loa Loa (eye worm) hypothetical protein 0.0021 0.0185 0.0465
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0444 0.1419
Brugia malayi nuclear receptor NHR-88 0.0024 0.0222 0.056
Echinococcus multilocularis cysteine protease 0.0018 0.0148 0.0143
Trypanosoma cruzi hypothetical protein 0.0007 0.0004 0.0011
Schistosoma mansoni DNA polymerase eta 0.0023 0.0215 0.0215
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.016 0.1027
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0444 0.1419
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0776 0.9886 0.9886
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.016 0.0156
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.006 0.0143
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.016 0.0156
Schistosoma mansoni alpha glucosidase 0.0041 0.0444 0.0444
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.124 0.1236
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0102 0.0321
Brugia malayi PXA domain containing protein 0.0021 0.0185 0.0465
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0112 0.0354
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0046 0.0107
Plasmodium falciparum phd finger protein, putative 0.0031 0.032 0.4861
Entamoeba histolytica hypothetical protein 0.0021 0.0185 0.0771
Onchocerca volvulus 0.0018 0.0148 0.046
Echinococcus granulosus smad 0.001 0.0042 0.0037
Schistosoma mansoni dishevelled 0.001 0.004 0.004
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1776 1
Onchocerca volvulus 0.0024 0.0222 0.0699
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1589 0.8844
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0008 0.0028
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.149 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0008 0.0028
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0047 0.0195
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0171
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0739 0.1893
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.017 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0122 0.0512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0185 0.0465
Loa Loa (eye worm) hypothetical protein 0.0141 0.1729 0.4444
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0193 0.0486
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0689 0.1764
Brugia malayi nuclear receptor RXR 0.0013 0.0077 0.0188
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.016 0.0401
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.016 0.0156
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2346 0.7527
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0222 0.0222
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0185 0.0181
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0444 0.2937
Echinococcus granulosus regulator of G protein signaling 7 0.0031 0.031 0.0306
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.0035 0.0142
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0222 0.0217
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.017 0.069
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.2346 0.2346
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0444 0.0439
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.006 0.0056
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0077 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0148 0.046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.056
Echinococcus granulosus bloom syndrome protein 0.0029 0.0288 0.0284
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0171
Brugia malayi glutathione reductase 0.0057 0.0649 0.1661
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0068 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0222 0.056
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0222 0.056
Loa Loa (eye worm) DR-78 0.0011 0.006 0.0143
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0444 0.1885
Onchocerca volvulus 0.0011 0.006 0.0178
Brugia malayi ecdysteroid receptor 0.0024 0.0222 0.056
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0288 0.0284
Onchocerca volvulus 0.0018 0.0148 0.046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0185 0.0465
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0306 0.4653
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0215 0.0899
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0148 0.0369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0334 0.0334
Schistosoma mansoni microtubule-associated protein tau 0.0785 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0102 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0222 0.056
Giardia lamblia Kinase, PLK 0.0189 0.2346 1
Brugia malayi jmjC domain containing protein 0.001 0.0046 0.0107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.016 0.0156
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.017 0.7811
Leishmania major cathepsin L-like protease 0.0069 0.08 0.3388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0102 0.0321
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.006 0.0056
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0215 0.0211
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0046 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0306 0.13
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.001 0.0046 0.0188
Trichomonas vaginalis helicase, putative 0.0015 0.0102 0.0321
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0114 0.0454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0102 0.0321
Plasmodium vivax glutathione reductase, putative 0.0057 0.0649 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0078 0.0913 0.0913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.017 0.0716
Echinococcus granulosus expressed protein 0.0409 0.5165 0.5163
Echinococcus granulosus GPCR family 2 0.0019 0.016 0.0156
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0193 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0185 0.0588
Onchocerca volvulus 0.0107 0.1292 0.4139
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0015 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0222 0.056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.017 0.0716
Echinococcus granulosus regulator of G protein signaling 7 0.0031 0.031 0.0306
Schistosoma mansoni protein phosphatase 2C 0.001 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0532 0.6752 0.6752
Treponema pallidum NADH oxidase 0.002 0.017 1
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0112 0.0444
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.006 0.0056
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0112 0.0354
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0222 0.0222
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0478 0.0474
Schistosoma mansoni coup transcription factor 0.0024 0.0222 0.0222
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.2296 0.2293
Leishmania major trypanothione reductase 0.0057 0.0649 0.2741
Echinococcus multilocularis regulator of G protein signaling 7 0.0031 0.031 0.0306
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0091 0.0086
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0148 0.0148
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0046 0.0107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0625 0.16
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.004 0.0036
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0112 0.0354
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.1412 0.1412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0137 0.1677 0.1677
Onchocerca volvulus 0.0018 0.0148 0.046
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0444 0.1419
Onchocerca volvulus Alhambra homolog 0.0031 0.032 0.1014
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0185 0.0181
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0046 0.0041
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0114 0.0361
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.004 0.0036
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0035 0.0079
Onchocerca volvulus 0.0012 0.0071 0.0213
Loa Loa (eye worm) hypothetical protein 0.0013 0.0077 0.0188
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0189 0.2346 1
Schistosoma mansoni DNA helicase recq1 0.0012 0.0069 0.0069
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0215 1
Schistosoma mansoni hypothetical protein 0.0031 0.032 0.032
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.017 0.0716
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0008 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0222 0.0217
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.2296 0.5905
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.032 0.2102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Brugia malayi polk-prov protein 0.0007 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.056
Brugia malayi hypothetical protein 0.0021 0.0185 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0102 0.0321
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0114 0.048
Echinococcus multilocularis cpg binding protein 0.0068 0.0786 0.0782
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0215 0.0211
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0215 0.0336
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0046 0.0041
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.017 0.7811
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0222 0.0217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0148 0.0468
Leishmania major cathepsin L-like protease 0.0018 0.0148 0.0596
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0193 0.0193
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0046 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2346 0.7527
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1776 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1119 0.3586
Brugia malayi DIX domain containing protein 0.001 0.004 0.0092
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0222 0.0217
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0035 0.0035
Echinococcus granulosus nibrin 0.0012 0.0068 0.0064
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0046 0.0041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0222 0.0217
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.1412 0.1412
Onchocerca volvulus 0.0011 0.006 0.0178
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0306 0.2012
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0112 0.046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0222 0.0217
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.1412 0.1412
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.032 0.0813
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.006 0.0056
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.0004 0.0011
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0185 0.0185
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0185 0.0185
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.016 0.0677
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.032 0.032
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.006 0.0056
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0185 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0222 0.056
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.016 0.0156
Schistosoma mansoni kinase 0.0096 0.1151 0.1151
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0035 0.0131
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0112 0.047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0334 0.0334
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.1412 0.1412
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0625 0.0625
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1589 0.8844
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0185 0.0185
Brugia malayi Cathepsin L-like precursor 0.0018 0.0148 0.0369
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0068 0.0283
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.016 0.0402
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0215 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1776 1
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0222 0.056
Trypanosoma cruzi hypothetical protein 0.0007 0.0004 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0222 0.0217
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Brugia malayi Cathepsin L-like precursor 0.0018 0.0148 0.0369
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0069 0.0167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0222 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0148 0.2174
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0215 0.0215
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0042 0.0037
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0071 0.0071
Brugia malayi hypothetical protein 0.003 0.0306 0.0778
Echinococcus multilocularis dna polymerase eta 0.0023 0.0215 0.0211
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0042 0.0096
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0185 0.0465
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0288 0.0919
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0116 0.1412 0.1408
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0098 0.1396
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0102 0.0321
Schistosoma mansoni smad 0.001 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0222 0.056
Brugia malayi nuclear receptor NHR-88 0.0011 0.006 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.0164
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0215 0.0684
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0068 0.0164
Echinococcus multilocularis expressed protein 0.0409 0.5165 0.5163
Brugia malayi Cathepsin L-like precursor 0.0012 0.0071 0.0171
Brugia malayi jmjC domain containing protein 0.0042 0.0452 0.1153
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0232
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.2346 0.7527
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0009 0.0035 0.0142
Loa Loa (eye worm) fibroinase 0.0018 0.0148 0.0369
Brugia malayi hypothetical protein 0.0021 0.0185 0.0465
Loa Loa (eye worm) hypothetical protein 0.0141 0.1729 0.4444
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0625 0.16
Loa Loa (eye worm) hypothetical protein 0.003 0.0306 0.0778
Echinococcus multilocularis cathepsin L 0.0009 0.0035 0.0031
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0114 0.047
Schistosoma mansoni myst-related protein 0.0008 0.0012 0.0012
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0035 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0185 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0102 0.0321
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.016 0.2375
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.004 0.0036
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0077 0.0073
Plasmodium falciparum glutathione reductase 0.002 0.017 0.2517
Brugia malayi AF-10 protein 0.001 0.0047 0.0111
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0215 0.0542
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0334 0.0334
Brugia malayi photoreceptor-specific nuclear receptor 0.0309 0.3885 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Schistosoma mansoni hypothetical protein 0.0471 0.5971 0.5971
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0093 0.0088
Plasmodium falciparum glutathione reductase 0.0057 0.0649 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.017 0.0716
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0004 0.0004
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0069 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0649 0.3025
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Plasmodium vivax SET domain protein, putative 0.0033 0.0334 0.5089
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0148 0.0143
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0146 0.1791 0.4603
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0008 0.0028
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.032 0.2102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0035 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0148 0.0468
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0167
Brugia malayi jmjC domain containing protein 0.001 0.0046 0.0107
Brugia malayi conserved hypotetical protein 0.0011 0.006 0.0143
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.017 1
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0185 0.0185
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0306 0.4653
Plasmodium vivax vivapain-2 0.0018 0.0148 0.2174
Echinococcus granulosus cathepsin l1 0.0018 0.0148 0.0143
Onchocerca volvulus Huntingtin homolog 0.0141 0.1729 0.5542
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0116 0.1412 0.1408
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0008 0.0028
Schistosoma mansoni topbp1 0.0012 0.0068 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.017 0.0716
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.056
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Brugia malayi PXA domain containing protein 0.0021 0.0185 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0092
Brugia malayi Cathepsin L-like precursor 0.0018 0.0148 0.0369
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0068 0.0283
Brugia malayi serine/threonine-protein kinase plk-2 0.0189 0.2346 0.6034
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0215 0.0542
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.016 0.016
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0215 0.0909
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0222 0.0222
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0444 0.0439
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0189 0.2346 0.2343
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0035 0.0035
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.032 0.0316
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0135 0.013
Loa Loa (eye worm) hypothetical protein 0.0019 0.016 0.0401
Schistosoma mansoni hypothetical protein 0.0019 0.016 0.016
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0112 0.0346
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.006 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.056
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Loa Loa (eye worm) ctsf protein 0.0018 0.0148 0.0369
Loa Loa (eye worm) hypothetical protein 0.0013 0.0077 0.0188
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0046 0.0046
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0046 0.0046
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.2296 0.2293
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1768 0.4545
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0193 0.0189
Loa Loa (eye worm) hypothetical protein 0.0013 0.0077 0.0188
Echinococcus granulosus dna polymerase eta 0.0023 0.0215 0.0211
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1589 0.8844
Loa Loa (eye worm) hypothetical protein 0.0309 0.3885 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0215 0.0909
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.0046 0.0254
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.00000000020362
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0185 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0071 0.0222
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.017 0.7811
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0102 0.0321
Brugia malayi Cathepsin L-like precursor 0.0018 0.0148 0.0369
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0185 0.0465
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.017 0.0716
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0215 0.0909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0334 0.033
Toxoplasma gondii melibiase subfamily protein 0.0116 0.1412 0.9472
Plasmodium vivax vivapain-3 0.0009 0.0035 0.0417
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.016 0.1027
Echinococcus multilocularis microtubule associated protein 2 0.0785 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.006 0.0056
Brugia malayi Pre-SET motif family protein 0.0033 0.0334 0.085
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0046 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0148 0.0468
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.273 0.7022
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0068 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.08 0.3406
Brugia malayi hypothetical protein 0.0012 0.0068 0.0164
Entamoeba histolytica hypothetical protein 0.0021 0.0185 0.0771
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0222 0.056
Onchocerca volvulus Huntingtin homolog 0.0141 0.1729 0.5542
Loa Loa (eye worm) hypothetical protein 0.0021 0.0185 0.0465
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.006 0.006
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0148 0.2174
Brugia malayi jmjC domain containing protein 0.001 0.0046 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0148 0.0468
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0069 0.0065
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0215 0.0542
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0048 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.006 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0222 0.056
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0047 0.0195
Schistosoma mansoni Smad4 0.001 0.0042 0.0042
Trypanosoma brucei unspecified product 0.0016 0.0122 0.0512
Echinococcus multilocularis nibrin 0.0012 0.0068 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0148 0.0468
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0185 0.0465
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.0164
Brugia malayi ecdysone receptor 0.0011 0.006 0.0143
Loa Loa (eye worm) hypothetical protein 0.0021 0.0185 0.0465
Brugia malayi Bromodomain containing protein 0.0031 0.032 0.0813
Echinococcus multilocularis phd:f box containing protein 0.001 0.0046 0.0041
Brugia malayi hypothetical protein 0.002 0.0168 0.0421
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0334 0.0334
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0091 0.0086
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0068 0.0934
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0222 0.0699
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0444 0.1132
Echinococcus granulosus phd:f box containing protein 0.001 0.0046 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0222 0.056
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0035 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0068 0.0213
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0068 0.0064
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.017 0.0165
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0035 0.0142
Schistosoma mansoni nuclear hormone receptor 0.0011 0.006 0.006
Brugia malayi nuclear receptor NHR-67 0.0011 0.006 0.0143
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0185 0.0181
Brugia malayi MH2 domain containing protein 0.0144 0.1768 0.4545
Leishmania major DNA polymerase eta, putative 0.0023 0.0215 0.0884
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.004 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0148 0.0468
Loa Loa (eye worm) hypothetical protein 0.0018 0.0148 0.0369
Echinococcus granulosus neuropeptide s receptor 0.0526 0.6673 0.6672
Brugia malayi nuclear receptor RXR 0.0011 0.006 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0185 0.0588
Loa Loa (eye worm) hypothetical protein 0.0011 0.006 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0222 0.056
Mycobacterium tuberculosis Probable reductase 0.013 0.1589 0.8844
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0148 0.0468
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.017 0.069
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.075 0.1922
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0148 0.0468
Schistosoma mansoni hypothetical protein 0.0041 0.0444 0.0444
Brugia malayi hypothetical protein 0.0013 0.0077 0.0188
Schistosoma mansoni alpha-glucosidase 0.0159 0.1965 0.1965
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Schistosoma mansoni regulator of G protein signaling 0.0031 0.031 0.031
Entamoeba histolytica cysteine protease, putative 0.0009 0.0035 0.0131
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0135 0.013
Giardia lamblia PHD finger protein 15 0.0031 0.032 0.1332
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0148 0.0143
Brugia malayi Melibiase family protein 0.0078 0.0913 0.2342
Schistosoma mansoni cpg binding protein 0.0068 0.0786 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0102 0.0321
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0116 0.1412 0.1408
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0068 0.0213
Entamoeba histolytica hypothetical protein 0.0012 0.0068 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0222 0.056
Trichomonas vaginalis mercuric reductase, putative 0.002 0.017 0.0539
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.08 0.3406
Entamoeba histolytica cysteine proteinase 1, putative 0.0009 0.0035 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0068 0.0283

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.591 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.114 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.93 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.908 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.869 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.862 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.836 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.698 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.411 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.837 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 1.606 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 8.262 uM PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for inhibitors of TLR9-MyD88 binding. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504734, AID504750, AID540250, AID540251] ChEMBL. No reference
IC50 (functional) 11.746 uM PubChem BioAssay. Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3):Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 49.76 uM PUBCHEM_BIOASSAY: Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504734, AID504750, AID540250, AID540251] ChEMBL. No reference
Potency (functional) 0.4611 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6679 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.5193 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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