Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.012 | 0.5305 | 0.5305 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0576 | 0.0576 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0107 | 0.4587 | 0.4587 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0576 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0576 | 0.0576 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0576 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0576 | 0.0576 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.012 | 0.5305 | 0.5305 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Onchocerca volvulus | 0.0182 | 0.877 | 1 | |
Brugia malayi | hypothetical protein | 0.0035 | 0.0576 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.877 | 1 |
Brugia malayi | hypothetical protein | 0.0182 | 0.877 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0576 | 0.0576 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0576 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0576 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.092 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.