Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0132 | 0.1432 | 0.1432 |
Echinococcus granulosus | acetylcholinesterase | 0.0251 | 0.333 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0132 | 0.1432 | 0.1432 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0251 | 0.333 | 0.333 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0132 | 0.1432 | 0.4301 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0132 | 0.1432 | 0.4301 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0251 | 0.333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.333 | 0.333 |
Echinococcus multilocularis | acetylcholinesterase | 0.0251 | 0.333 | 1 |
Plasmodium vivax | polyprenol reductase, putative | 0.0132 | 0.1432 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0251 | 0.333 | 1 |
Onchocerca volvulus | 0.0132 | 0.1432 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.333 | 0.333 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0132 | 0.1432 | 0.4301 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0668 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0251 | 0.333 | 0.333 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.1432 | 0.1432 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0132 | 0.1432 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1432 | 0.1432 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0132 | 0.1432 | 0.4301 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.333 | 0.333 |
Echinococcus multilocularis | acetylcholinesterase | 0.0251 | 0.333 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0132 | 0.1432 | 0.1432 |
Echinococcus granulosus | acetylcholinesterase | 0.0251 | 0.333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1432 | 0.1432 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0251 | 0.333 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0668 | 1 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0132 | 0.1432 | 0.1432 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0668 | 1 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0132 | 0.1432 | 0.5 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0132 | 0.1432 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0132 | 0.1432 | 0.1432 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0668 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0668 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.1432 | 0.1432 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0132 | 0.1432 | 0.4301 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.333 | 0.333 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0668 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0132 | 0.1432 | 0.4301 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0668 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0668 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0668 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0668 | 1 | 1 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0132 | 0.1432 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0668 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.